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Dennis OConnor

The Quantification of Placebo Effects Within a General Model of Health Care Outcomes - 1 views

www.ncbi.nlm.nih.gov/...PMC3162378

placebo research positivity

shared by Dennis OConnor on 04 Jul 20 - No Cached
  • It is proposed that the integration of a scientific model of placebo effects within a general model of health care outcomes could finally end the placebo debate and help to integrate these powerful effects into the health care system.
  • Positive expectancy is recognized as a central component of placebo phenomena by all placebo theorists
  • The proposed model emphasizes that the search for a placebo personality factor must be combined with the measurement of situational expectancy.
  • ...47 more annotations...
  • an individual who has negative expectations regarding treatment effectiveness would likely produce a stronger than average “nocebo” effec
  • placebo-prone personality
  • Absorption
  • receptivity to sensory experiences and a propensity for sustained, focused attention.
  • Absorption has a genetic basis and is higher in women compared to men
  • Absorption can go in either a positive or negative direction, depending on the situation,
  • Subjects were randomly
  • outcome measures
  • based on three scales
  • includes scales measuring fatigue, pain, and spasticity
  • Judgment that the placebo was the active device resulted in a positive score with a magnitude of the confidence rating.
  • if judgment was that the placebo was the placebo device, the confidence rating of the placebo was a negative score, with the magnitude of the rating.
  • scored in the upper quintile on improved quality of life, as measured by the 3 QLI (an average of three symptom scales measuring pain, fatigue, and spasticity) after receiving treatment with a sham device.
  • placebo responders
  • Placebo responders scored higher on Absorptio
  • Placebo responders gave higher confidence ratings that the placebo was the active device
  • This study provides support for a two-factor model of placebo responding.
  • importance of positive expectancy
  • both cognitive and emotional factors mediate these effects
  • Positive beliefs or confidence in the treatment coupled with a desire to feel better activate processes that result in positive outcomes.
  • positive expectancy is an essential factor
  • disease-specific pathways that are activated by positive expectancies have helped to transform this “soft” psychologic factor into a “hard” physiologic factor with physically measurable effects.
  • the unresolved issue of why some people respond to placebos whereas others do not
  • Numerous research studies have reliably shown that Absorption is modestly (yet very consistently) correlated with hypnotizability.
  • Hypnotizability is often associated with “suggestibility,” with perhaps the sense of a weak-willed character or unbridled fantasy-proneness, the “unreality factor” that has plagued placebo theory for decades.
  • enlightening to view these individual differences as a natural endowment in self-regulation skills: a potential innate strength rather than a simple weakness with a natural ability for self-directed healing in response to health challenges.
  • Decades of research have reliably demonstrated that individuals scoring high in Absorption can skillfully modulate an impressive array of physiologic processes in laboratory settings.
  • The literature suggests that the mind–body control of high Absorption scorers is similar to the self-regulation skills that many are seeking to develop with meditation, mindfulness, yoga, and qigong.
  • The regular practice of mind–body control and the cultivation of positive attitudes may enhance regulation at higher levels, improving the regularity of circadian and other rhythms,
  • points to the role of both expectation and conditioning, with conditioning playing a greater role in certain pathways such as immune modulation.
  • somatic vulnerability of high Absorption individuals who suffer from negative biases in perception.
  • nocebo phenomena described by these researchers are important for our model as they directly illustrate the power of a negative interaction of the two factors.
  • Many physicians admit to prescribing placebos to contribute to patient wellness, even though this “dark secret” is not condoned and is considered to be ethically questionable.
  • High Absorption individuals may benefit from encouragement to utilize their innate self-regulation skills toward maximum therapeutic effect.
  • ersons with average Absorption scores can be encouraged to become more skilled at self-regulation through mind–body therapies
  • The model does not specifically address the many factors that contribute to confidence in the treatment, such as cost, pill color, pill size, or confidence-enhancing paraphernalia.
  • The role of provider and patient interaction are also not specifically addressed.
  • he model also does not directly address the role of stress reduction
  • The strength of placebo responding in domains such as pain and depression clearly indicate the importance of the shift from a negative to a positive state.
  • While the shift from negative to positive affect may be the hallmark of placebo responding, negative affect alone is not sufficient and can play a role in people who worsen as well (nocebo effects).
  • asic two-factor model can be further tested with the basic measurement tools of expectancy and Absorption,
  • Conclusions
  • the recognition that positive expectancy and expert self-regulation skills significantly contribute to health outcomes can help to integrate these powerful effects into the health care system
  • The “positive psychology” movement is shifting attention to the power of positive expectation
  • undermining nature of negative expectancy and pessimistic language, especially in vulnerable populations such as those with pain and depression
  • Practitioners of the art of health care have always recognized the importance of motivated and empowered patients and the power of a kind word and a ray of hope.
  • This is the time to quantify these factors, integrating art and science, and finally solving (and forgiving Descartes for) the mind–body problem.
  • Dennis OConnor on 04 Jul 20
     
    "The topic of placebo effects is distinguished by decades of keen scientific interest1-4 coupled with a general skepticism regarding the ultimate significance of these phenomena. The importance of psychologic factors in mediating these effects may contribute to the attitude that placebo effects are not as substantial as a therapeutic effect produced by a drug. Complementary and alternative therapies have sometimes been dismissed as "mere placebos." However, recent studies have provided compelling evidence that placebo effects are physiologically measurable with condition-specific pathways.5"
  • Dennis OConnor on 04 Jul 20
     
    Dr. Jake Fleming recently suggested these potent keywords: quantifiable placebo The keywords led to this article. I find it affirming and empowering.
Dennis OConnor

(12) Pelin Wood Thorogood | LinkedIn - 0 views

www.linkedin.com/pelin

wholistic-research cbd donor apollo

shared by Dennis OConnor on 06 Jun 18 - No Cached
  • Dennis OConnor on 06 Jun 18
     
    new project apollo patient. Co-Founder & President Company NameWholistic Research and Education Foundation Dates EmployedMay 2017 - Present Employment Duration1 yr 2 mos LocationGreater San Diego Area Wholistic Research and Education Foundation is a California-based nonprofit dedicated to exploring the health benefits of CBD-rich therapeutics. Our mission is to fund clinical and scientific research to better understand the "if, how and why" behind the potential healing power of hemp and cannabis across a multitude of ailments, as well as work to increase safe and legal access to those in need via advocacy and education. Co-Founder Company NameMana Artisan Botanics Dates EmployedMay 2017 - Present Employment Duration1 yr 2 mos LocationKona, Hawaii Mana Artisan Botanics is a purpose-driven hemp company based on the Big Island of Hawaii. We offer pure hemp extracts infused with sustainably grown Hawaiian herbs and spices - nature's mana. Each product is hand crafted artisan style, in small batches. We take great care to source our ingredients from conscientious farmers, supporting local and organic whenever available. All of our products are simple, pure and good for body and soil.
Dennis OConnor

https://peoplescience.health - 0 views

peoplescience.health

alternative-medicine Integrative-spaces

shared by Dennis OConnor on 15 May 21 - No Cached
  • Dennis OConnor on 15 May 21
     
    "People Science is a tech-led platform that will connect health minded people, research scientists, and healthcare providers in an effort to unlock the potential of alternative medicines. Too little is known about alternative medicines like medical cannabis, prebiotics and probiotics, nutritional supplements, psychedelics, and other plant-based medicines. That's about to change. Our goal is to help people understand which alternative medicines can best help them on their path to wellness. Doctors will learn more too. By connecting health minded people with doctors and research scientists on our cutting edge platform, C.H.L.O.E., we will advance our collective knowledge of alternative medicines. This will also assist manufacturers to develop better products backed by rigorous scientific testing and research."
Dennis OConnor

Love 2.0 - Online Tools - 1 views

www.positivityresonance.com/survey.php

love positivity wellness Love2.0

shared by Dennis OConnor on 28 Sep 19 - No Cached
  • Given your ever-shifting emotional landscape, any single measure of your positivity ratio can only capture so much.
  • view your score for any given day with some skepticism
  • more trustworthy
  • Dennis OConnor on 28 Sep 19
     
    "Kabir Recommends: The Positivity Self Test is a brief, 20-item survey that asks you to report on your experiences of several emotions over the past 24 hours. Each item on the test includes a trio of words that are related, but not quite the same, for example, "hopeful, optimistic, or encouraged" and "sad, downhearted, or unhappy." With this strategy, each item captures a set of emotions that share a key resemblance and this short test becomes that much more accurate. Keep in mind that the Positivity Self Test merely provides a snapshot of your emotions. Everybody's emotions change by the day, hour, and minute. Some scientists would say that they change by the millisecond. Given your ever-shifting emotional landscape, any single measure of your positivity ratio can only capture so much. One way to overcome such measurement hurdles is to measure repeatedly. Even if you complete the Positivity Self Test as honestly as possible, you should view your score for any given day with some skepticism. Was this particular day representative? Probably not. Days vary. So the more days you can average together to create your estimate, the more trustworthy that estimate becomes. You can get a clear picture of your typical positivity ratio by completing the Positivity Self Test every evening for two weeks. Take the Positivity Self Test In the scientific literature, the Positivity Self Test is also know as the modified Differential Emotions Scale, or mDES, created by Dr. Fredrickson based on an earlier scale developed by pioneering emotion scientist, Carroll Izard. The scholarly references are: Fredrickson, B. L. (in press). Positive emotions broaden and build. In E. Ashby Plant & P. G. Devine (Eds.) Advances in Experimental Social Psychology. Elsevier. Fredrickson, B. L., Tugade, M. M., Waugh, C. E., & Larkin, G. (2003). What good are positive emotions in crises? A prospective study of resilience and emotions following the terrorist attacks on the United States on September 11
Dennis OConnor

10 medical research trends we'll be watching in 2020 and beyond | LinkedIn - 0 views

www.linkedin.com/...ching-2020-beyond-beth-meagher

research patient-centered AI

shared by Dennis OConnor on 11 Feb 20 - No Cached
  • 1.   Making patients the priority
  • 2.   Listening and learning from patients
  • 3.   Increased focus on long-term commitments (rather than short-term wins
  • ...7 more annotations...
  • 4.   More inclusive medical research
  • 5.   More health data in the cloud
  • 7.   Greater focus on preventing disease, rather than treating it
  • 6.   A (much) bigger role for AI
  • 8.   More mysteries of the brain unlocked
  • 9.   Patient registries will continue aiding scientific discovery
  • 10. Continued optimism about the future
Dennis OConnor

Hunyuan Qi Therapy - Unique in the world - 0 views

hunyuanqitherapy.com

Qigong ecosystem Master-Liu

shared by Dennis OConnor on 10 Jul 18 - No Cached
  • Dennis OConnor on 10 Jul 18
     
    "hineng Qigong is a life practice that inexorably leads to improved health, an experience of inner peace, balance, joy and the flowering of inherent wisdom. Hunyuan Qi Therapy as part of the Zhineng Qigong system does not treat only the symptoms of disease, but addresses maladies at their root. Its approach is both holistic and scientifically proven. It is recognized in China as the most effective natural energy-healing modalities on the planet, and while its methods were a well-kept secret for many years, it is now being taught around the world by Master Yuantong Liu with aspirant energy healers in the West. The program is especially designed for students interested in this system dedicated to the principles of evolution, regeneration and holistic health transformation."
Dennis OConnor

Researchers Cast Doubt On Theory Of Coronavirus Lab Accident : Goats and Soda : NPR - 1 views

www.npr.org/...ry-of-coronavirus-lab-accident

covid research origins-covid-19

shared by Dennis OConnor on 24 Apr 20 - No Cached
  • April 23, 2020
  • Virus researchers say there is virtually no chance that the new coronavirus was released as result of a laboratory accident in China or anywhere else.
  • after corresponding with 10 leading scientists who collect samples of viruses from animals in the wild, study virus genomes and understand how lab accidents can happen, NPR found that an accidental release would have required a remarkable series of coincidences and deviations from well-established experimental protocols.
  • ...12 more annotations...
  • All of the evidence points to this not being a laboratory accident," says Jonna Mazet, a professor of epidemiology at the University of California, Davis and director of a global project to watch for emerging viruses called PREDICT.
  • all believe that the virus was transmitted between animals and humans in nature, as has happened in previous outbreaks — from Ebola to the Marburg virus — and with other known coronaviruses such as SARS and MERS.
  • Regardless, genetic analysis shows the virus began to spread sometime in the fall or winter of 2019, says Robert Garry, a microbiologist at Tulane University. Those same analyses refuted an earlier theory that the virus was genetically engineered in a laboratory.
  • the exact route from nature to people remains a mystery,
  • Rather than a laboratory misstep, researchers believe that this new coronavirus reached humans in the same way that other coronaviruses have: through "zoonotic spillover," or humans picking up pathogens from wildlife.
  • The CDC estimates that 6 out of 10 infectious diseases in people come from animals, including diseases caused by coronaviruses.
  • "As we change the landscape to suit our purposes, we come more and more into contact with viruses and other pathogens that we don't have much exposure to," says Dr. Brian Bird, associate director of the OneHealth Institute at UC Davis School of Veterinary Medicine and a former CDC scientist.
  • "Zoonotic transmission" or "zoonotic spillover" generally happens three ways: through excretion (feces that comes into contact with humans), slaughter (meat consumed by humans) and vector-borne (an animal biting a human). But even under these circumstances, the virus must then overcome barriers within the human body, defeating the immune system, to successfully replicate and transmit between humans themselves.
  • Despite the evidence, misinformation about the virus's origins continue to proliferate. For Daszak, who has worked on other outbreaks, the pattern is all too familiar: "Every time we get a new virus emerging, we have people that say, 'This could have come from a lab,' " he says.
  • "It's a real shame that the conspiracy theories can get to the level they've got with policymakers,"
  • The political heat has strained the very scientific collaborations meant to detect these viruses as they emerge, warns Jonna Mazet.
  • Daszak says the time for finger-pointing is over. "We have a bat virus in my neighborhood in New York killing people," he says. "Let's get real about this."
  • Dennis OConnor on 24 Apr 20
     
    "April 23, 2020"
Dennis OConnor

Reimagine Brain Health - YouTube - 0 views

www.youtube.com/watch

alzheimers brainhq brain-health scientific-wellness precision-medicine

shared by Dennis OConnor on 12 Dec 20 - No Cached
  • Dennis OConnor on 12 Dec 20
     
    Our 2020 virtual Reimagine event highlighted ISB's cutting-edge brain health research and our unique approach to studying and treating Alzheimer's and other diseases. Specifically, we featured some of our latest findings, the promise of multimodal therapies to slow and even reverse dementia, and testimony from caregivers who watched their loved ones succumb to Alzheimer's disease.
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