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This case study provides an overview of the seminal experimental work that led to the discovery of DNA structure and the confirmation of the semi-conservative model of DNA replication. By guiding students through a chronological series of historic experiments and discussing some of the collaborations and controversies involved in the original research, students learn about the history and nature of science in addition to several important biological concepts. A number of recommended videos, including one created by the author, enable instructors to use the "flipped-classroom" mode of instruction according to which students read primary literature and watch videos on their own before group discussions and activities. The case study was developed for use in an introductory undergraduate biology course, and would also be appropriate for use in a high school biology course. Some prior knowledge or instruction may be required, depending on the level and learning objectives of the course.

The article "The difference makers" (10.9 readability score) gives an overview of transposons, or "jumping genes," and how these bits of genetic material have affected genetic variety and evolution in humans and other organisms. Students can focus on details reported in the article, follow connections to earlier articles about transposons and human evolution, explore crosscurricular connections to other major science topics, and construct a phylogenetic tree of primate evolution based on the locations of retroviral sequence insertions in chromosome 21

This directed case study was developed to introduce students to the CRISPR-Cas9 system for genome editing. CRISPR-Cas9 has made numerous headlines in both the scientific and popular press, and thus serves as an excellent model for learning current biotechnology and applying concepts from biology courses. After providing a general overview of CRISPR-Cas9, the majority of the case focuses on the clinical applications of the system as experienced by a carrier for the X-linked recessive allele underlying Duchenne Muscular Dystrophy. The case is structured so that students use a variety of popular and scientific sources (some of which may require a subscription to access-check with your institution), increasing in difficulty as they move through each part of the case. The goals are for students to learn the molecular mechanisms of CRISPR-Cas9, the benefits and limitations of the system, and the clinical applications of the technology. Open-ended questions are included to spark discussion of ethical considerations, societal impacts, and the overall implications of the technology.

3:48 video flu virus video Discusses history of flu virus.

Glycolysis video summary  3:50

Data rich simulation where students adjust parameters and run simulator for 100 iterations and see how 1) two plant species compete for a niche or 2) how composition of a food web changes over time Links to online textbook, videos, visuals, scientists.

We create interactive lessons for high school and college educators to engage their students in discussions of ethics and personal genetics. The lessons are relevant to multiple subjects, including biology, health, social studies, law, physical education and psychology. All of our lesson plans contain background reading for teachers and students, a selection of classroom activities, discussion points, in some cases a slide presentation or video clip, and an evaluation. Each lesson can stand alone, or all the lessons can be taught as a unit.

The Ethics Primer provides engaging, interactive, and classroom-friendly lesson ideas for integrating ethical issues into a science classroom. It also provides basic background on ethics as a discipline, with straightforward descriptions of major ethical theories. Several decision-making frameworks are included to help students apply reasoned analysis to ethical issues. Although the Primer is designed for secondary school science classrooms, it has been used by teachers in a variety of classes and grade levels. It is particularly suited to social studies and integrated/interdisciplinary classrooms. It has also been used with adults. The Primer is not designed to be used cover to cover. Teachers should review materials and select lessons that fit their needs. The Primer is also intended to be used as a general resource, with a wide variety of topics.

This lab will let you explore various diseases: Kold, a caricature of the common cold; Impfluenza, which resembles influenza; Neasles, with the high transmission rate of measles; and Red Death, a fast-spreading epidemic with a high mortality rate. What factors come into play in the spread of these diseases? And what can we do to counter them?

Human and animal disease are often caused by viruses or bacteria. Over the past two hundred or so years, vaccines have eradicated some of these diseases. Others have returned to haunt humans with new and ever-mutating strains. Communicable diseases may spread in different ways: through blood, air, feces/urine, food, or water. The World Health Organization (WHO) and the Center for Disease Control (CDC) keep constant watch over the most potentially dangerous diseases and the most likely threats to various world populations.

Before civilization began to impact the human life cycle approximately 10,000 years ago, human beings had high birth and death rates. Today the world is in the midst of a demographic transition - a transition to low birth and death rates - as the ability to control both disease and reproduction increases. Along the way, between these extremes, populations go through an intermediate period of continued high birth rates, combined with low death rates, resulting in a population explosion.

As you learned in Unit 4, ecosystems are a complex and delicate balancing game. The addition or removal of one species affects many other species with which it might compete for, or provide food. In this lab you will get a chance to "build your own" ecosystem, and explore the effects of these interrelationships.

Made possible through Toyota USA Foundation funding, the REMS curriculum options include nine online lesson plans and interactive activities themed to examine three pressing challenges in the US: preserving sustainable, competitive manufacturing; distributing products and services across the world; and developing and delivering efficient health care services. Each of the lesson plans provides age-appropriate math and science curriculum that tie to the Common Core Learning Standards for elementary, middle and high school students.

The PBL Clearinghouse contains problems from a wide variety of disciplines. As the problems and supporting materials are covered by the Creative Commons Attribution-NonCommercial 4.0 International License, you are welcome to borrow and adapt these problems for your classroom. Because these files are open sourced, your students may search and discover the teaching notes and solutions. We encourage you to make changes, adapt the problems to your specific goals and classroom contexts and thereby discourage your students from "borrowing" solutions or otherwise circumventing your instructional goals.