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You might not think about your bones very often unless you break one. When you break a bone, the bone heals itself and begins to regrow. But, what if your muscles, tendons and ligaments turned to bone? What if you formed a second skeleton on top of the one you already have? That's what happens with Fibrodysplasia Ossificans Progressiva, or FOP.

Can you grow a human bone outside the human body? The answer may soon be yes. Nina Tandon explores the possibility by examining how bones naturally grow inside the body, and illuminating how scientists are hoping to replicate that process in a lab.

BodyMaps is an interactive visual search tool that allows users to explore the human body in 3-D. With easy-to-use navigation, users can search multiple layers of the human anatomy, view systems and organs down to their smallest parts, and understand in detail how the human body works. Using detailed 3-D models of body parts-including muscles, veins, bones, and organs-BodyMaps offers a new way to visualize and manage your health. See how the coronary artery delivers blood to the heart, and learn how plaque build-up on artery walls leads to heart disease. Locate the exact location of a pulled muscle or broken bone, and find information on how to prevent injuries. View a cross-section of the human brain, and learn which areas control certain emotions and body functions. By offering rich, detailed anatomical images alongside links to relevant and useful health information, BodyMaps allows you to leam about your body and your health in a personalized and revolutionary new way.

What an incredible transformation. A protein used to help bones mend can also force pancreatic cells into producing insulin. The discovery could help people with type 1 diabetes produce their own insulin without having to take daily injections. In type 1 diabetes, beta cells in the pancreas that make insulin - the hormone that keeps our blood glucose levels at a safe concentration - are destroyed by the immune system. As a result, people with the disease have to inject themselves daily with insulin. Now, researchers have discovered that non-beta cells in the pancreas can be transformed into insulin-producing cells, merely by exposing them to a growth factor called BMP-7.

" The typical naked mole rat lives 25 to 30 years, during which it shows little decline in activity, bone health, reproductive capacity and cognitive ability. What is the secret to this East African rodent's long, healthy life?"

2 minute animation, (includes full body animation rendition of Australopithicus) A recent study of fossil shoulder bones from a human ancestor reveals that this ancient relative was still well adapted to living in trees, even after the evolution of bipedalism. Studying features like these helps scientists to better understand when modern humans moved away from a partly arboreal lifestyle and transitioned to living exclusively on the ground.

This interrupted case study examines molecular genetic evidence reported in scientific literature to determine the fate of Louis-Charles, son of Louis XVI and Marie-Antoinette of France. Controversy and rumors surrounding the death of Louis-Charles suggested that either he died as a young boy while being held in captivity by the French revolutionaries or he escaped and was replaced by a substitute who died in his place. One individual claiming to be Louis-Charles was Karl Naundorff. Students begin the case by preparing pedigrees for the descendants of Maria Theresa and Francis I, the Holy Roman Emperor, parents of Marie-Antoinette. The pedigrees can be used to introduce the concepts of alleles identical-by-descent and cytoplasmic inheritance patterns. Students then compare mitochondrial DNA sequences and XY chromosome sequences from hair, bone, heart, and blood samples taken from descendants of Marie Theresa, Karl Naundorff and the heart of the boy who died in captivity to determine if the latter was truly Louis-Charles. An optional PowerPoint presentation with clicker questions is available to help guide the classroom activities.

In this interactive activity adapted from the HHMI Outreach Program at Harvard University, learn about the ways in which stem cells can be used to treat and help cure diseases in humans. The activity explains what stem cells are and how they're produced, and provides details on their existing or potential therapeutic role in diseases related to the pancreas, liver, lungs, and bone marrow.

Researchers have designed a nanoparticle-based therapy that is effective in treating mice with multiple myeloma, a cancer of immune cells in the bone marrow.

Through this method, the researchers were able to identify that the frizzled-6 gene was expressed around eight times more in tumor-forming cell lines. The specific cascade initiated by frizzled-6 and how it affects the development of cancerous cells has yet to be determined. The overexpression of frizzled-6 suggests that the protein either forms tumor cells directly or is an indirect result of other mutated pathways.

4:43video, Vitamins are the building blocks that keep our bodies running; they help build muscle and bone, capture energy, heal wounds and more. But if our body doesn't create vitamins, how do they get into our system? Ginnie Trinh Nguyen describes what vitamins are, how they get into our bodies -- and why they are so crucial.

Computed tomography (CT) is an excellent noninvasive technique to investigate bones and soft tissue structures in a patient. Unfortunately, sometimes imaging can be difficult, as any movement from the patient can result in images that are unclear and need to be redone. This is especially difficult when dealing with patients who are young children, mentally impaired, suffering from motor disease, or are in pain. To ensure these images are clear, these challenging patients may require sedation, which is not desirable. General Electronics sought to facilitate treatment of these patients and improve the imaging process in general with the development of the Revolution CT.

When it comes to charting the tree of life, the most important difference between humans and sharks isn't limbs versus fins or even lungs versus gills. It all comes down to our skeletons. Sharks' skeletons are made of cartilage, placing them along with rays and skates in a group of jawed vertebrates called cartilaginous fish. Humans-along with most other living vertebrates-belong to the same group as bony fish, whose skeletons are made of bone. Scientists knew that these groups diverged more than 420 million years ago, but what the last common ancestor looked like remained a mystery. Now, new discoveries inside the head of a small fossil fish from Siberia may provide some clues.

To look at the evolution of modern bird feathers, we must start a long time ago, with the dinosaurs from whence they came. We see early incarnations of feathers on dinosaur fossils, and remnants of dinosaurs in a bird's wish bone. Carl Zimmer explores the stages of evolution and how even the reasons for feathers have evolved over millions of years.

Story of Aiden's Law, new genetic disorder that newborns in NY will be screened for.

Unexpected discoveries in the quest to cure an extraordinary skeletal condition show how medically relevant rare diseases can be.