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Scientists and healthcare professionals initially exhibited little concern over the Zika virus even after evidence of human infection was first identified in 1952; Zika appeared to be both rare and unassociated with morbidity or mortality. Around 2015 all of this changed as journalists, scientists, public health officials, and laypeople scrambled to learn about its varied modes of transmission and devastating consequences (e.g., birth defects and autoimmune disorders). Although research continues to rapidly evolve, this case study directs students to reliable scientific sources (e.g., Centers for Disease Control and World Health Organization) that will likely continue to provide the most current information in order to explore questions such as: Where did the virus come from? How does it spread? What can we do to prevent it? Students will also consider the public health challenges and possible solutions associated with emerging infectious diseases. The case was originally written for an upper-level biology or public health course in which students already have some basic background knowledge regarding viruses, vaccines, and infectious disease.

This interdisciplinary case study uses the format of a progressive disclosure to explore certain advances in biotechnology and evaluate them within the framework of societal needs, concerns and pressures.  When faced with a heart valve transplant, a high school student and her mother must decide between multiple approaches, some current and others emergent. Highlighted in this case study are the topics of xenotransplantation, 3D bioprinting and the mature minor rule. The case includes a role-playing, public hearing activity that can be used to explore many aspects at the interface of technology and culture: religious rights, parental rights, public health care policy and safety, animal rights, economic issues of organ marketing, and psychological issues of body image.  This case study was originally designed for first year collegiate classes (introduction to biology, introduction to psychology) but is also applicable to AP high school. The flexible nature of the case also allows for expansion of several aspects for advanced classes across multiple disciplines.

Human populations have adapted to varying intensities of sunlight with varying tones of skin coloration. The balanced interplay between melanin content and UV absorption allowed populations to successfully migrate from sub-Saharan Africa by influencing levels of two key vitamins: vitamin D and folic acid. This case study explores the evolutionary advantage of different skin tones for the human race; it also emphasizes the absence of scientific evidence for the correlation of abilities, talents, and other complex traits to skin color, and exposes certain social misconceptions linking skin color to specific traits. Although the discussion of race is not always a comfortable fit for science and biology courses, this case study uses the topic as an inherently interesting and important subject for applying basic biological concepts of DNA, the central dogma, and mutations to real world questions of physical difference and skin color. This case has been used in biology courses for non-science majors but would also be appropriate for advanced high school students.

In this case study, a college student named "Blake" winds up in the emergency room after he experiences a panic attack brought on by drinking a mixture of beverages containing caffeine and alcohol. His panic attack results in a severe episode of hyperventilation. The alcohol he has consumed has the added effect of making the situation worse by impairing Blake's perception and judgement. Through this case study, students learn about acid/base chemistry as they explore hyperventilation, the Bohr effect, the Haldane effect, and how alcohol and stimulants such as caffeine can affect the acid-base balance in the body. This case was originally designed for a flipped classroom, and the associated videos, including one developed by the author, contain foundational information to lead students through basic chemistry and help them connect daily activities to homeostasis and the Bohr effect. Originally written for a general biology course in which general chemistry concepts are discussed, the case could easily be modified for use in an anatomy and physiology course.

In this interrupted case study, students meet a pair of fictional newlyweds on their way to Australia for their honeymoon. Initially eager to enjoy the sun, sand, and sights, Tanya and Julien Brahim end up more intimately acquainted with the local wildlife than they had planned. Tanya is bitten by a venomous arachnid and Julien has a run-in with a dangerous cnidarian. This case study was created to help students solidify their knowledge about cardiac myocytes, particularly ion movements associated with action potential generation in autorhythmic and contractile cells. As students work through the case, they will complete fill-in-the-blank paragraphs describing the heart, diagram membrane potentials and ion movements, and compare and contrast action potentials from different cell types. Written for a course in human physiology, the case requires some prior knowledge of membrane potentials, equilibrium potentials, ion gradients, neuronal action potentials, and skeletal muscle action potentials. An optional pre-case assignment (included in the teaching notes) can be used to make sure that students are familiar with the necessary concepts.

"This modular case study tells the story of Dan and Annie, a married couple of Acadian ancestry who have a genetic form of deafblindness called Usher syndrome. They live in Southwest Louisiana, home of the largest population of DeafBlind citizens in the United States. Acadian Usher syndrome is caused by an allele of the USH1C gene that came to Louisiana with the first Acadian settlers from Canada who founded today's Cajun population. This allele's single nucleotide substitution creates an erroneous splice site that produces a defective cytoskeletal protein (harmonin) of the cochlear and vestibular hair cells and retinal photoreceptors. This splice site is the target of a promising gene therapy. The case study applies and connects Mendelian inheritance, chromosomes, cell division, vision and hearing, DNA sequences, gene expression, gene therapy and population genetics to a specific gene and its movement through generations of Dan and Annie's families.  After the introduction, each of the remaining sections can be used independently either for in-class team activities or out-of-class extensions or assignments over an entire year of introductory undergraduate biology. "

"This case study introduces students to Duchenne muscular dystrophy (DMD) and its underlying genetics, cell biology, and some of the associated biochemical pathways.  DMD is an X-linked disorder characterized by progressive muscle weakness and wasting due to the absence of a protein called dystrophin, which in turn causes degeneration of skeletal and cardiac muscle. There is currently no established cure for this disease.  The case follows the progress of "Casey," an undergraduate student who has just declared her biology major and is interested in expanding her scientific understanding of the different fields of biology. The case is organized in three parts: genetics, cell biology, and biochemistry, each exploring DMD through its unique lens. Throughout the case, Casey is presented with multiple outlets of information, including class lectures, direct e-mail interaction with a professor, scientific journals and websites, from which she (and any student engaged with the case) gathers knowledge about DMD."

Squirrels are frequent and beloved residents of college campuses throughout the United States, but oftentimes less welcomed by campus maintenance officials who report squirrels nesting in buildings, interfering with airflow from heating and cooling units, and destroying gutters. In this laboratory case, students act as members of a fictitious "squirrel task force" appointed by their campus administrators to provide recommendations for how to manage their school's squirrel population.  Students work in groups to assess the habitat suitability of their campus for squirrels by identifying and measuring trees that provide seasonal food for squirrels, and by identifying desirable hunting perches for common squirrel predators.  Students conduct squirrel surveys in designated campus zones to calculate the number of squirrels per acre on their campus and compare it with mean squirrel densities reported in forested areas and at a rival institution.  Students then compile and synthesize class data to provide management recommendations for university maintenance officials for either increasing or decreasing campus squirrel populations. Originally developed for an undergraduate wildlife biology course, the case could also be used in a lower-division biology or environmental studies course.

n this interrupted case study, students learn about the influence of early fetal nutritional conditions on the expression of genes related to metabolism and growth. Beginning with the true event of a food and fuel embargo that led to famine in the western Netherlands toward the end of World War II, students learn about the historical background of the Dutch Hunger Winter and its social impact. Using real data from the study conducted by Heijmans and coauthors (2008), students then compare the methylation level of a specific gene between individuals conceived during the famine and their unaffected siblings, and how changes in the expression of this metabolically important gene may impact the risk of developing type 2 diabetes. Supported by other studies on mice and in humans, students conclude that in utero events may impact the health of individuals later in life through epigenetic mechanisms. The case is ideally suited for a molecular or cell biology course, but is also appropriate for an introductory biology course in which students have an understanding of descriptive statistics, interpretation of statistical test results, eukaryotic gene structure, and regulation of gene expression.

In this case study, students follow "Mr. Okoro" as he makes the long journey with his sick daughter "Ada" to seek medical attention at the nearest clinic in Enugu, Nigeria. It is the rainy season, and "Dr. Fabian" from the Division of Parasitic Diseases and Malaria has been called in to investigate a suspected outbreak of malaria. Students learn about the circumstances in Ada's background that may have led to her illness, and then adopt the perspective of Dr. Fabian as she investigates the outbreak. They consider the epidemiological triangle, the different stages of the Plasmodium parasite lifecycle and how it leads to malaria, and evaluate the broader societal factors and future implications of malaria in Sub-Saharan Africa. The case was designed for upper-level global health, public health, and human biology courses, but could also be adapted for general biology, health studies, infectious disease, and epidemiology courses.

The external environment's effects upon genes can influence disease, and some of these effects can be inherited in humans. Studies investigating how environmental factors impact the genetics of an individual's offspring are difficult to design. However, in certain parts of the world in which social systems are highly centralized, environmental information that might have influenced families can be obtained. For example, Swedish scientists recently conducted investigations examining whether nutrition affected the death rate associated with cardiovascular disease and diabetes and whether these effects were passed from parents to their children and grandchildren (Kaati et al., 2002). These researchers estimated how much access individuals had to food by examining records of annual harvests and food prices in Sweden across three generations of families, starting as far back as the 1890s. These researchers found that if a father did not have enough food available to him during a critical period in his development just before puberty, his sons were less likely to die from cardiovascular disease. Remarkably, death related to diabetes increased for children if food was plentiful during this critical period for the paternal grandfather, but it decreased when excess food was available to the father. These findings suggest that diet can cause changes to genes that are passed down though generations by the males in a family, and that these alterations can affect susceptibility to certain diseases. But what are these changes, and how are they remembered? The answers to questions such as these lie in the concept of epigenetics.

The NISE Network offers a variety of programs and activities designed for small and large groups in different settings. Educational programs are a great way to introduce audiences to nanoscale science, engineering, and technology. Presenters can choose a format and topic that is appropriate for their audience. Facilitated experiences foster visitor conversation and interaction, and allow educators to adjust the science content, pace, and delivery style to suit their audience.

This flipped case study is suited for general education undergraduate level biology. Students prepare ahead of time for class by viewing a video created by the authors that reviews the basics of nutrition and digestion; in class, students then engage in three activities to further explore aspects of the video's content using specific and concrete examples of diverse foods. During the first part of the case study, students learn information about balanced diets, nutrition and the digestive system. Students apply their knowledge on how food passes through the digestive tract, and how absorption and breakdown of nutrients occur by explaining and presenting the process based on assigned food items. Students are then asked to further apply their knowledge when presented with two scenarios ("mini-cases"), one involving gastric bypass surgery and the other the effects of cholera.

TeachEngineering.org is a collaborative project between faculty, students and teachers associated with five universities and the American Society for Engineering Education, with NSF National Science Digital Library funding. TeachEngineering.org is a searchable, web-based digital library collection populated with standards-based engineering curricula for use by K-12 teachers and engineering faculty to make applied science and math (engineering) come alive in K-12 settings. The TeachEngineering collection provides educators with *free* access to a growing curricular resource of multi-week units, lessons, activities and living labs. Initiated by the merging of K-12 engineering curricula created by four universities, the collection continues to grow and evolve over time with new additions from other universities, and input from teachers who use the curricula in their classrooms.

This interrupted case study tells the story of Michael, a Harvard law graduate with a stressful job and a seemingly heavy drinking problem. Students are provided with background information, medical history, and lab results in order to guide them towards determining what is wrong with Michael. This study highlights cirrhosis and the effects of alcohol abuse on the liver. Before beginning the case study, students should have a background in the physiological role of the liver and the breakdown of hemoglobin. Students are asked to use the information provided for them in the case study to gather more information about liver cells and their functions, alcohol, and alcoholic liver damage. Ultimately, using multiple blood tests, the Maddrey's discriminant function (DF) score, and results from a magnetic resonance elastography (MRE), they will diagnose Michael with alcoholic cirrhosis. This case was developed for use in a non-majors physiology course, but could easily be used for a majors class.

This directed case study follows two college roommates, Darrell and Anthony, who have just returned to school after winter vacation. They share that their ageing fathers are concerned about their declining faculties and are amused by their fathers' efforts to reverse the process.  Darrell's dad plays "brain games" on the computer while Anthony's father believes running will slow his memory decline. Intrigued, the roommates search through their biopsychology class notes to find out whether their fathers are correct. They review the topics of synaptic formation and plasticity, including axonal and dendritic development, and chemical factors in the brain that promote the survival and growth of neurons or stop the genetically programmed death of neurons. Based on research findings, students reading this case will decide whether Darrell and Anthony's fathers are correct in their assertions. The case is appropriate for a wide variety of courses including introductory anatomy or physiology, or for upper-division biopsychology, biology, or neuroscience courses.

This interrupted case is based on a genome wide association study (GWAS) that identified the genetic variation causing some inhabitants of the Solomon Islands to have blond hair. The case illustrates the connection between genotype and phenotype, and an application of Hardy-Weinberg equilibrium. The narrative focusses on John and his new roommate, Peter, from the Solomon Islands who happens to have dark skin and blond hair. Using thought-provoking questions students learn about the genetics and the biochemistry of the hair color trait and how a single genetic variation can influence phenotype. Is migration or mutation involved?  Upon completion of the activity students will know the source of the genetic variation that causes the blond hair phenomenon in the Solomon Islands and if it has any European origins. The case was written for an upper-level genetics course, but could also be adapted for introductory biology or for a genetics course for non-majors. An optional PowerPoint presentation with clicker questions is available for download from within the Answer Key.

Curriculum materials for the following topics: HeLa Cells & HPV Genes: Immortality & Cancer, which reviews basic cell biology, tissue culture, and human subjects research in the context of privacy, rights, and compensation. Link: http://www.stemcellcurriculum.org/hela-cells-hpv-genes-immortality-cancer.html · Eggs & Blood: Gifts & Commodities, which addresses the value placed on some bodily tissues/cells and not on others. Link: http://www.stemcellcurriculum.org/eggs-and-blood.html · Disease, Disability, & Immortality: Hope & Hype, which explores the natural physical and cognitive variability in the human population and questions the goal of a "cure" in biomedical research. Link: http://www.stemcellcurriculum.org/disease-disability-immortality-hope-hype.html · Stem Cells & Policy: Values & Religion, which analyzes how policy is shaped in pluralistic societies that require tolerance of different points of view. Link: http://www.stemcellcurriculum.org/stem-cells-policy-values-and-religion.html

This interrupted case study was inspired by and uses data from one of the largest commercial restaurant associated outbreaks of norovirus reported in the literature. It applies basic principles of epidemiology and outbreak investigation to a shellfish-linked norovirus outbreak at a Michelin star restaurant in the UK in 2009. The details of the case are taken directly from the report that was produced by the health protection agency and publications that followed. Students take on the role of an infection control team (ICT) that is responsible for identifying the extent and source of the outbreak. They are taken through different stages of the outbreak investigation and at each stage asked what their team would do in response to given pieces of information. Specifically, students uncover the scope and source of the outbreak using descriptive and basic analytical epidemiology methods. The case is suitable for first or second year introductory courses in microbiology, epidemiology, or other infectious disease related topics.

This case study was developed to teach the topic of human ABO blood type and genetic inheritance in biology courses at the lower undergraduate level or upper high school level. It is suitable for entry level biology, genetics, and physiology courses. The case narrative tells the story of Kevin, a teenager who is puzzled by the fact that neither of his parents can donate blood to him. He and his best friend ask their biology teacher for help, and she explains human ABO blood types at the molecular and genetic level to solve the mystery. The case consists of three sections, which can be used sequentially or separately. After completing the case study, students will understand the molecular basis of ABO blood types and how genes control the phenotype and genotype of an individual. They will also have a better understanding of how human ABO blood type is inherited from generation to generation.