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A decade ago, an international research team completed an ambitious effort to read the 3 billion letters of genetic information found in every human cell. The program, known as the Human Genome Project, provided the blueprint for human life, an achievement that has been compared to landing a man on the moon.

Project Noah is a tool to explore and document wildlife and a platform to harness the power of citizen scientists everywhere.

The data comes from the open Tree of Life Project, a collaboration among biologists and other scientists around the world. It contains decades' worth of work in phylogeny, evolutionary history of and relationships among groups of organisms. The project is about a year away from a complete tree of all life, Rosindell said. He wanted a system in place that could visualize it as soon as it's ready. Right now, OneZoom only contains mammals, but that's still more than 5,000 species, all correlated with each other and color-coded according to their threat levels. Rosindell has big plans for the rest, and he even wants to build a searchable app for smartphones, showcasing the history and relationships between all life on Earth.

The National Park Service Air Resources Division in an effort to increase the public's awareness of air quality issues has developed a series of five activities for elementary and secondary schools. The activities are for grades six through eight and help teach students about Acid Rain. The lesson plan was prepared as a part of The Uplands Field Research Laboratory, Volunteer in Parks, and Interpretation of Science Project. Funding was provided by the Great Smoky Mountains Natural History Association.

In a unique twist on human genomics studies that seek to identify genetic variants linked to human disease, researchers have combined whole-exome sequencing of 50,726 adults with the individuals' long-term electronic health record (EHR) data. The effort, by researchers at the Geisinger Health System in Pennsylvania and Regeneron Genetics Center, a subsidiary of New York-based Regeneron Pharmaceuticals, has yielded novel disease-linked variants, including loss-of-function alleles. The team behind the project, called DiscovEHR, has also found that about one in 30 of the individuals harbors a deleterious genetic variant for which a screen or treatment already exists. The group's analysis is described in two papers published today (December 22) in Science.

Text and interactives on human evolution and genetic structure

Australian outfit Bridge 8, who have the admirable mission of devising "creative strategies for science and society," and animator James Hutson have created six fantastic two-minute animations on various aspects of critical thinking, aimed at school ages 8 to 10, or kids between the ages of 13 and 15, but also designed to resonate with grown-ups. Inspired by the animation style of the 1950s, most recognizably Saul Bass, the films are designed to promote a set of educational resources on critical thinking by TechNYou, an emerging technologies public information project funded by the Australian government.

The Rare Disease Foundation is focussed on linking basic science and clinical practice to increase the efficiency of rare disease research. This model is called Translational Care. This model drives patient based, treatment focussed research projects from disease characterization to treatment with greater efficiency. By incorporating research, astute clinician observation and parental knowledge into the various stages of rare disease research we impact the speed of discovery and the way rare conditions are managed.

The following six lessons enable students to use different features of the site to explore trends in population, the environment, and human well-being over the past 2,000 years, as well as projections of future growth. The lessons are designed for high school science and social studies classrooms and address current national and state standards, as well as content for several Advanced Placement (AP) courses. Links to standards and AP course outlines are available in a searchable database.

Protein folding and trafficking is essential for normal cell function, and when it goes awry it can lead to various chronic conditions, including fatty liver disease, diabetes, and Parkinson's. The narrative of this case study follows two undergraduate students engaged in a summer research project evaluating the effects of cell stress on cell function and health in the model organism Caenorhabditis elegans (C. elegans).  During the case study, students review animal cell organelle function and then learn about endoplasmic stress and unfolded protein response. Prior knowledge needed for the case is basic animal cell organelles and their functions and use of model organisms in research. The case was designed for a flipped classroom in which students prepare in advance by taking a quiz and watching two videos; a PowerPoint animation is also included.

"Thus far, the lineages of wolves that likely gave rise to dogs have not yet been discovered and it's possible that these puppies could be on that lineage, which would be very exciting," said evolutionary biologist Greger Larson, of the University of Oxford, one of the scientists behind a collaborative project aimed at finding out when and where dogs became the first domesticated animals.

The protagonist of this two-day flipped case study, "Maria," has two problems. She doesn't like it when the apple slices in her lunch turn brown, and she needs to find a project for her biology class that includes molecular biology, preferably one that incorporates plants. Students are enlisted to help Maria understand Arctic Apples™, which don't turn brown because they have been genetically modified to suppress the expression of polyphenol oxidase via RNAi. The case also explores the health, environmental, and safety aspects of growing and eating plants that have been genetically modified to use RNAi. The case applies the central dogma of biology to the creation of genetically modified foods and RNAi and includes a discussion of whether genetically modified foods should be labeled. Several videos are included with the case, including one created by the author specifically for the case. The case is appropriate for use in an introductory level biology or survey level biochemistry course.

Although rabies still causes thousands of deaths globally every year, it has essentially been eradicated from most industrialized countries. Part of the success story is due to an unusual project undertaken by the Swiss prompted by a series of large outbreaks in the 1970s: the large-scale vaccination of wild foxes to stop the epidemic. In this directed case study, students use an easily accessible MS Excel-based model to understand key epidemiological parameters of rabies outbreaks in wild foxes. The simple model allows students also to predict what proportion of foxes needs to be vaccinated to eradicate the virus from the population. The case fits into both ecological and microbiological (epidemiological) courses and offers opportunities to explore zoonotic diseases and "One Health" questions. The mathematical basis of the differential equations in the models is explained, although prior knowledge of calculus is not essential. A key learning outcome is the critical understanding of both the power and limitations of simple epidemiological models. This case was written for an online course but could also be used as a face-to-face activity if students have access to computers in class.

Your genome, every human's genome, consists of a unique DNA sequence of A's, T's, C's and G's that tell your cells how to operate. Thanks to technological advances, scientists are now able to know the sequence of letters that makes up an individual genome relatively quickly and inexpensively. Mark J. Kiel takes an in-depth look at the science behind the sequence.

The Underrepresentation Curriculum (URC) is a free, flexible curriculum for STEM instructors to teach about injustice and change the culture of STEM. Using tools such as data analysis, hypothesis creation, and investigation, students look critically at science through the lenses of equity and inclusion. By comparing the general population to similar data describing scientists, students can explore issues of social justice in STEM.

Inthis lesson students will enter the world of the genome, learning about humanhistory and evolution by examining information about human, Neanderthal, andchimpanzee DNA. Using web interactives and videosfrom The Human Spark, studentswill be introduced to the ambitious Human Genome Project, learn about thegenetic similarities and differences between human beings and our hominidancestors, explore how specific genes manifest themselves in differentorganisms, and discover how genetic information can help us trace a path ofhuman migration all the way back to our earliest ancestors.

This case study follows two beginning undergraduate researchers on a quest for a summer research project related to food web ecology. While writing their research proposal, the students receive feedback indicating that they have neglected an entire group of organisms from their food web-parasites, which leads them to a scientific research paper discussing how these organisms have been overlooked by scientists studying food webs, the challenges involved with including parasites in food webs, and the contributions parasites ultimately make to food webs. An integrated activity in which students visualize the food web using images of organisms and answer questions about species interactions provides opportunities to examine key concepts such as omnivory, ontogenetic diet changes, trophic levels, complex life cycles, and taxonomic aggregation. This case study was originally written for an undergraduate general ecology course, but could easily be adapted to undergraduate general biology courses covering community ecology or specific courses in invertebrate zoology, parasitology, or disease ecology. The teaching notes also discuss how the included code for R statistical computing software can be used to extend the case study in a more quantitative direction if desired.

Variety of Biology resources from teacher site. Includes PBL and IB resources.

With that in mind, we formed the first storylining working group, which is open to anyone to join at any time. The group is led by Dr. Jason Crean and Mrs. Kristin Rademaker and meets once a month to maintain that open collaboration.  We are able to offer Professional Development Credits to participants with an open-door policy.    We began this project with 3 goals in mind: Train educators in three-dimensional learning, teaching, and coherent curricular design through sustained collaborative work and by both experiencing and doing it themselves;  Create coherent storylines, including embedded three-dimensional assessment pieces that will evolve over time through continuous feedback from pilot teachers; and most of all Share our work- for teachers, by teachers, for free-  with any stakeholders interested in making the fundamental shift towards a three-dimensional classroom.