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The Synergistic Population and Data Science Award mechanism supports multi-institutional partnerships that will leverage existing prostate cancer patient datasets or cohorts to answer questions that will make a significant impact in addressing the FY19 PCRP Overarching Challenges. Thus, applications must be responsive to at least one of the FY19 PCRP Overarching Challenges. The award is intended to support both the development of infrastructure to facilitate access to multiple datasets/cohorts by a team of investigators, as well as conducting hypothesis-based studies utilizing the multi-institutional datasets. To qualify for this mechanism, a minimum of three institutions and three well-annotated patient datasets/cohorts is required. Dataset Coordination: Central to the pursuit of the hypothesis proposed in the application is the development of the infrastructure to facilitate multi-institutional access to the identified datasets/cohorts. The application must describe the key elements that will need to be in place in order to facilitate the multi-institution collaboration, including: * Administrative and management plans for decision-making and allocation of resources * Description of the dataset logistics, including storage, how data will be shared among PIs/institutions, and plans for data harmonization * Description of key members and roles of the multi-institutional research team * Communication plans among the research team members to discuss research progress and results * Regulatory plan, including coordination of local Institutional Review Board (IRB) approvals * Data security and integrity measures * Intellectual property plan * Plan for disseminating information and distributing data to the prostate cancer research community

Cyber-physical systems (CPS) are engineered systems that are built from, and depend upon, the seamless integration of computational algorithms and physical components. Advances in CPS will enable capability, adaptability, scalability, resiliency, safety, security, and usability that will far exceed the simple embedded systems of today. CPS technology will transform the way people interact with engineered systems -- just as the Internet has transformed the way people interact with information. New smart CPS will drive innovation and competition in sectors such as agriculture, energy, transportation, building design and automation, healthcare, and manufacturing. The December 2010 report of the President's Council of Advisors on Science and Technology (PCAST) titled Designing a Digital Future: Federally Funded Research and Development in Networking and Information Technologycalls for continued investment in CPS research because of its scientific and technological importance as well as its potential impact on grand challenges in a number of sectors critical to U.S. security and competitiveness such as the ones noted above. These challenges and technology gaps are further described in aCPS Vision Statementpublished in 2012 by the federal Networking and Information Technology Research and Development (NITRD) CPS Senior Steering Group. Tremendous progress has been made in advancing CPS technology over the last five-plus years. We have explored foundational technologies that have spanned an ever-growing set of application domains, enabling breakthrough achievements in many of these fields. At the same time, the demand for innovation in these domains continues to grow, and is driving the need to accelerate fundamental research to

The following programs have due dates that fall between October 1 - 25, 2013, and these dates are being revised due to the Federal  government shutdown. These revised dates apply whether the proposal is being submitted via the NSF FastLane System or  Grants.gov. Due to compressed proposal deadlines resulting from the shutdown, proposers are advised that they may experience a  delay when contacting IT Help Central with technical support questions. Frequently asked questions regarding these date changes  are available on the Resumption of Operations page on the NSF website at: http://www.nsf.gov/bfa/dias/policy/postshutdown.jsp.