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The purpose of this program is to develop next generation health care solutions and encourage existing and new research communities to focus on breakthrough ideas in a variety of areas of value to health, such as sensor technology, networking, information and machine learning technology, decision support systems, modeling of behavioral and cognitive processes, as well as system and process modeling. Effective solutions must satisfy a multitude of constraints arising from clinical/medical needs, social interactions, cognitive limitations, barriers to behavioral change, heterogeneity of data, semantic mismatch and limitations of current cyberphysical systems. Such solutions demand multidisciplinary teams ready to address technical, behavioral and clinical issues ranging from fundamental science to clinical practice.

The purpose of this program is to develop next generation health care solutions and encourage existing and new research communities to focus on breakthrough ideas in a variety of areas of value to health, such as sensor technology, networking, information and machine learning technology, decision support systems, modeling of behavioral and cognitive processes, as well as system and process modeling. Effective solutions must satisfy a multitude of constraints arising from clinical/medical needs, social interactions, cognitive limitations, barriers to behavioral change, heterogeneity of data, semantic mismatch and limitations of current cyberphysical systems. Such solutions demand multidisciplinary teams ready to address technical, behavioral and clinical issues ranging from fundamental science to clinical practice.

Cyber-physical systems (CPS) are engineered systems that are built from, and depend upon, the seamless integration of computational algorithms and physical components. Advances in CPS will enable capability, adaptability, scalability, resiliency, safety, security, and usability that will far exceed the simple embedded systems of today. CPS technology will transform the way people interact with engineered systems -- just as the Internet has transformed the way people interact with information. New smart CPS will drive innovation and competition in sectors such as agriculture, energy, transportation, building design and automation, healthcare, and manufacturing. The December 2010 report of the President's Council of Advisors on Science and Technology (PCAST) titled Designing a Digital Future: Federally Funded Research and Development in Networking and Information Technologycalls for continued investment in CPS research because of its scientific and technological importance as well as its potential impact on grand challenges in a number of sectors critical to U.S. security and competitiveness such as the ones noted above. These challenges and technology gaps are further described in aCPS Vision Statementpublished in 2012 by the federal Networking and Information Technology Research and Development (NITRD) CPS Senior Steering Group. Tremendous progress has been made in advancing CPS technology over the last five-plus years. We have explored foundational technologies that have spanned an ever-growing set of application domains, enabling breakthrough achievements in many of these fields. At the same time, the demand for innovation in these domains continues to grow, and is driving the need to accelerate fundamental research to

The Dynamics, Control and Systems Diagnostics (DCSD) program supports fundamental research on the analysis, measurement, monitoring and control of dynamic systems. The program promotes innovation in the following areas: -Modeling: creation of new mathematical frameworks to apply tools of dynamics to physical systems -Analysis: discovery and exploration of structure in dynamic behavior -Diagnostics: dynamic methods that infer system properties from observations -Control: methods that produce desired dynamic behavior

The Dynamics, Control and Systems Diagnostics (DCSD) program supports fundamental research on the analysis, measurement, monitoring and control of dynamic systems. The program promotes innovation in the following areas: -Modeling: creation of new mathematical frameworks to apply tools of dynamics to physical systems -Analysis: discovery and exploration of structure in dynamic behavior -Diagnostics: dynamic methods that infer system properties from observations -Control: methods that produce desired dynamic behavior

The Dynamics, Control and Systems Diagnostics (DCSD) program supports fundamental research on the analysis, measurement, monitoring and control of dynamic systems. The program promotes innovation in the following areas: Modeling: creation of new mathematical frameworks to apply tools of dynamics to physical systems Analysis: discovery and exploration of structure in dynamic behavior Diagnostics: dynamic methods that infer system properties from observations Control: methods that produce desired dynamic behavior

The Design of Engineering Material Systems (DEMS) program supports fundamental research intended to lead to new paradigms of design, development, and insertion of advanced engineering material systems. Fundamental research that develops and creatively integrates theory, processing/manufacturing, data/informatics, experimental, and/or computational approaches with rigorous engineering design principles, approaches, and tools to enable the accelerated design and development of materials is welcome. Research proposals are sought that strive to develop systematic scientific methodologies to tailor the behavior of material systems in ways that are driven by performance metrics and incorporate processing/manufacturing. While an emphasis on a specific material system may be appropriate to provide the necessary project focus, techniques developed should transcend materials systems. Ultimately it is expected that research outcomes will be methodologies to enable the discovery of materials systems with new properties and behavior, and enable their rapid insertion into engineering systems.Proposals that focus on modeling, simulation, and prediction of material performance (even when research is coupled with experiments for validation or guidance) without an intellectual emphasis on design are not appropriate for this program and should be submitted to other disciplinary programs.

The Civil Infrastructure Systems (CIS) program supports research leading to the engineering of infrastructure systems for resilience and sustainability without excluding other key performance issues.  Areas of interest include intra- and inter-physical, information and behavioral dependencies of infrastructure systems, infrastructure management, construction engineering, and transportation systems.  Special emphasis is on the design, construction, operation, and improvement of infrastructure networks with a focus on systems engineering and design, performance management, risk analysis, life-cycle analysis, modeling and simulation, behavioral and social considerations not excluding other methodological areas or the integration of methods. This program does not encourage research proposals primarily focused on structural engineering, materials or sensors that support infrastructure system design, extreme event modeling, hydrological engineering, and climate modeling, since they do not fall within the scope of the CIS program.

The SaTC program welcomes proposals that address cybersecurity and privacy, and draw on expertise in one or more of these areas: computing, communication and information sciences; engineering; economics; education; mathematics; statistics; and social and behavioral sciences. Proposals that advance the field of cybersecurity and privacy within a single discipline or interdisciplinary efforts that span multiple disciplines are both encouraged.

The goal of the Process Systems, Reaction Engineering and Molecular Thermodynamics (PRM) program is to advance fundamental engineering research on the rates and mechanisms of important classes of catalyzed and uncatalyzed chemical reactions as they relate to the design, production, and application of catalysts, chemical processes, biochemical processes, and specialized materials that have important impacts on society.  The program seeks to advance electrochemical and photochemical processes of engineering significance or with commercial potential, design and optimization of complex chemical and biochemical processes, thermodynamic modeling and experiments that relate molecular dynamics to macroscopic properties and behavior, dynamic modeling and control of process systems and individual process units, reactive processing of polymers/ceramics/thin films, and interactions between chemical reactions and transport processes in reactive systems, for the integration of this information into the design of complex chemical and biochemical reactors.  A substantial focus of the PRM program is to impact the chemical manufacturing enterprise by funding projects aimed at zero emissions and environmentally-friendly, smart manufacturing using sustainable materials.  Areas that focus on reactors of all types (fuel cells, batteries, microreactors, biochemical reactors, etc.), reactor design in general, and design and control of all systems associated with energy from renewable sources have a high priority for funding

The goal of the Process Systems, Reaction Engineering and Molecular Thermodynamics (PRM) program is to advance fundamental engineering research on the rates and mechanisms of important classes of catalyzed and uncatalyzed chemical reactions as they relate to the design, production, and application of catalysts, chemical processes, biochemical processes, and specialized materials that have important impacts on society.  The program seeks to advance electrochemical and photochemical processes of engineering significance or with commercial potential, design and optimization of complex chemical and biochemical processes, thermodynamic modeling and experiments that relate molecular dynamics to macroscopic properties and behavior, dynamic modeling and control of process systems and individual process units, reactive processing of polymers/ceramics/thin films, and interactions between chemical reactions and transport processes in reactive systems, for the integration of this information into the design of complex chemical and biochemical reactors.  A substantial focus of the PRM program is to impact the chemical manufacturing enterprise by funding projects aimed at zero emissions and environmentally-friendly, smart manufacturing using sustainable materials.  Areas that focus on reactors of all types (fuel cells, batteries, microreactors, biochemical reactors, etc.), reactor design in general, and design and control of all systems associated with energy from renewable sources have a high priority for funding

Recent advances in communications, computation, and sensing technologies offer unprecedented opportunities for the design of cyber-physical systems with increased responsiveness, interconnectivity and automation. To meet new challenges and societal needs, the Energy, Power, Control and Networks (EPCN) Program invests in systems and control methods for analysis and design of cyber-physical systems to ensure stability, performance, robustness, and security. Topics of interest include modeling, optimization, learning, and control of networked multi-agent systems, higher-level decision making, and dynamic resource allocation as well as risk management in the presence of uncertainty, sub-system failures and stochastic disturbances. EPCN also invests in adaptive dynamic programing, brain-like networked architectures performing real-time learning, and neuromorphic engineering. EPCN supports innovative proposals dealing with systems research in such areas as energy, transportation, and nanotechnology. EPCN places emphasis on electric power systems, including generation, transmission, storage, and integration of renewables; power electronics and drives; battery management systems; hybrid and electric vehicles; and understanding of the interplay of power systems with associated regulatory and economic structures and with consumer behavior. Also of interest are interdependencies of power and energy systems with other critical infrastructures. Topics of interest also include systems analysis and design for energy scavenging and alternate energy technologies such as solar, wind, and hydrokinetic. The program also supports innovative tools and test beds, as well as curriculum development integrating research and education. In addition to single investigator projects, EPCN encourages cross-disciplinary proposals that benefit from active collaboration of researchers with complementary skills.

Recent advances in communications, computation, and sensing technologies offer unprecedented opportunities for the design of cyber-physical systems with increased responsiveness, interconnectivity and automation. To meet new challenges and societal needs, the Energy, Power, Control and Networks (EPCN) Program invests in systems and control methods for analysis and design of cyber-physical systems to ensure stability, performance, robustness, and security. Topics of interest include modeling, optimization, learning, and control of networked multi-agent systems, higher-level decision making, and dynamic resource allocation as well as risk management in the presence of uncertainty, sub-system failures and stochastic disturbances. EPCN also invests in adaptive dynamic programing, brain-like networked architectures performing real-time learning, and neuromorphic engineering. EPCN supports innovative proposals dealing with systems research in such areas as energy, transportation, and nanotechnology. EPCN places emphasis on electric power systems, including generation, transmission, storage, and integration of renewables; power electronics and drives; battery management systems; hybrid and electric vehicles; and understanding of the interplay of power systems with associated regulatory and economic structures and with consumer behavior. Also of interest are interdependencies of power and energy systems with other critical infrastructures. Topics of interest also include systems analysis and design for energy scavenging and alternate energy technologies such as solar, wind, and hydrokinetic. The program also supports innovative tools and test beds, as well as curriculum development integrating research and education. In addition to single investigator projects, EPCN encourages cross-disciplinary proposals that benefit from active collaboration of researchers with complementary skills.

The goal of the Smart and Connected Health (SCH) Program is to accelerate the development and use of innovative approaches that would support the much needed transformation of healthcare from reactive and hospital-centered to preventive, proactive, evidence-based, person-centered and focused on well-being rather than disease. Approaches that partner technology-based solutions with biobehavioral health research are supported by multiple agencies of the federal government including the National Science Foundation (NSF) and the National Institutes of Health (NIH). The purpose of this program is to develop next generation health care solutions and encourage existing and new research communities to focus on breakthrough ideas in a variety of areas of value to health, such as sensor technology, networking, information and machine learning technology, decision support systems, modeling of behavioral and cognitive processes, as well as system and process modeling.

The Dynamics, Control and Systems Diagnostics (DCSD) program supports fundamental research on the analysis, measurement, monitoring and control of dynamic systems, including development of new analytical, computational and experimental tools, and novel applications to engineered and natural systems. Dynamics is the science of systems that change in time. Control concerns the use of external influences to produce desired dynamic behaviors. Systems diagnostics concerns the use of observation to infer information about a dynamic system. Objectives of the DCSD program are the discovery of new phenomena and the investigation of innovative methods and applications in dynamics, control and diagnostics. The intellectual merit of proposals submitted to the DCSD program will be evaluated on the basis of fundamental innovation in foundational areas of dynamics and control, and on the potential for transformative impact within and across disciplinary boundaries.

The Dynamics, Control and Systems Diagnostics (DCSD) program supports fundamental research on the analysis, measurement, monitoring and control of dynamic systems, including development of new analytical, computational and experimental tools, and novel applications to engineered and natural systems. Dynamics is the science of systems that change in time. Control concerns the use of external influences to produce desired dynamic behaviors. Systems diagnostics concerns the use of observation to infer information about a dynamic system. Objectives of the DCSD program are the discovery of new phenomena and the investigation of innovative methods and applications in dynamics, control and diagnostics. The intellectual merit of proposals submitted to the DCSD program will be evaluated on the basis of fundamental innovation in foundational areas of dynamics and control, and on the potential for transformative impact within and across disciplinary boundaries. Proposals submitted to the DCSD program should be aligned with the disciplinary thrusts of the CMMI division. For example, innovative research that primarily concerns electromagnetic or chemical phenomena should be directed to the ECCS or CBET divisions. To ensure that a project is appropriate for the DCSD program, PIs are very strongly encouraged to email a project summary of approximately 250 words to the DCSD Program Directors prior to the full submission. The DCSD Program does not fund fundamental research relating to sensing modalities or sensor development. Proposals offering fundamental research on sensing modalities should be submitted to the Communications, Circuits and Sensing Systems (CCSS) program or the Electronics, Photonics, and Magnetic Devices (EPMD) program in the ECCS Division.

The goal of the CPS program is to develop the core system science needed to engineer complex cyber-physical systems that people can use or interact with and depend upon. Some of these may require high-confidence or provable behaviors. The program aims to foster a research community committed to advancing research and education in CPS and to transitioning CPS science and technology into engineering practice. By abstracting from the particulars of specific systems and application domains, the CPS program seeks to reveal cross-cutting fundamental scientific and engineering principles that underpin the integration of cyber and physical elements across all application sectors. To expedite and accelerate the realization of cyber-physical systems in a wide range of applications, the CPS program also supports the development of methods, tools, and hardware and software components based upon these cross-cutting principles, along with validation of the principles via prototypes and testbeds. We have also seen a convergence of CPS technologies and research thrusts that underpin Smart & Connected Communities (S&CC) and the Internet of Things (IoT). These domains offer new and exciting challenges for foundational research and provide opportunities for maturation at multiple time horizons.

The Division of Integrative Organismal Systems (IOS) supports research aimed at understanding why organisms are structured the way they are and function as they do. Proposals should focus on organisms as a fundamental unit of biological organization. Principal Investigators (PIs) are encouraged to apply systems approaches that will lead to conceptual and theoretical insights and predictions about emergent organismal properties. Areas of inquiry include, but are not limited to, developmental biology and the evolution of developmental processes, nervous system development, structure, and function, physiological processes, functional morphology, symbioses, interactions of organisms with biotic and abiotic environments, and animal behavior. Proposals are welcomed in all areas of science supported by the Division of Integrative Organismal Systems. All investigator-initiated proposals to the core programs in the Division of Integrative Organismal Systems must now be invited based on merit review of preliminary proposals. 

The Particulate and Multiphase Processes program supports fundamental and applied research on phenomena governing particulate and multiphase processes, including flows of suspensions of particles, drops or bubbles, granular and granular-fluid flows, flow behavior of micro or nano-structured fluids, aerosol science and technology, and self- and directed-assembly processes involving particulates. Innovative research is sought that contributes to improving the basic understanding, design, predictability, efficiency, and control of particulate and multiphase processes with particular emphasis on: novel manufacturing techniques, multiphase systems of relevance to energy harvesting, multiphase transport in biological systems or biotechnology, and environmental sustainability.

The Systems Science (SYS) program supports fundamental research leading to a theoretical foundation for design and systems engineering.   In particular, the Systems Science program seeks intellectual advances in which underlying theories (such as probability theory, decision theory, game theory, organizational sociology, behavioral economics or cognitive psychology) are integrated and abstracted to develop explanatory models for design and systems engineering in a general, domain-independent fashion.  Ideally, the explanatory models, derived from the underlying theoretical foundations will lead to testable hypotheses.  Based on collected evidence supporting or falsifying the hypotheses, new insights are gained allowing the explanatory models to be refined or updated.

Cyberspace has transformed the daily lives of people. Society's overwhelming reliance on cyberspace, however, has exposed its fragility and vulnerabilities: corporations, agencies, national infrastructure and individuals continue to suffer cyber-attacks. Achieving a truly secure cyberspace requires addressing both challenging scientific and engineering problems involving many components of a system, and vulnerabilities that stem from human behaviors and choices. Examining the fundamentals of security and privacy as a multidisciplinary subject can lead to fundamentally new ways to design, build and operate cyber systems, protect existing infrastructure, and motivate and educate individuals about cybersecurity. The Cybersecurity Enhancement Act of 2014, as amended by the National Defense Authorization Act for FY 2018, authorizes the National Science Foundation, in coordination with the Office of Personnel Management and the Department of Homeland Security, to offer a scholarship program to recruit and train the next generation of information technology professionals, industry control system security professionals and security managers to meet the needs of the cybersecurity mission for federal, state, local, and tribal governments.

The Smart and Autonomous Systems (S&AS) program focuses on Intelligent Physical Systems (IPS) that are capable of robust, long-term autonomy requiring minimal or no human operator intervention in the face of uncertain, unanticipated, and dynamically changing situations. IPS are systems that combine perception, cognition, communication, and actuation to operate in the physical world. Examples include, but are not limited to, robotic platforms, self-driving vehicles, underwater exploration vehicles, and smart grids. Most current IPS operate in pre-programmed ways and in a limited variety of contexts. They are largely incapable of handling novel situations, or of even understanding when they are outside their areas of expertise. To achieve robust, long-term autonomy, however, future IPS need to be aware of their capabilities and limitations and to adapt their behaviors to compensate for limitations and/or changing conditions.

SoftwareInfrastructure for Sustained Innovation (SI2) is a long-term investment focused on realizing a portion of the Cyberinfrastructure Framework for 21st Century Science and Engineering (CIF21, http://www.nsf.gov/funding/pgm_summ.jsp?pims_id=504730) vision and catalyzing new thinking, paradigms and practices in science and engineering. CIF21 envisions a linked cyberinfrastructure architecture that integrates large-scale computing, high-speed networks, massive data archives, instruments and major facilities, observatories, experiments, and embedded sensors and actuators, across the nation and the world, and that enables research at unprecedented scales, complexity, resolution, and accuracy by integrating computation, data, and experiments in novel ways. Software is a primary modality through which CIF21 innovation and discovery will be realized. It permeates all aspects and layers of cyberinfrastructure (from application codes and frameworks, programming systems, libraries and system software, to middleware, operating systems, networking and the low-level drivers). The CIF21 software infrastructure must address the complexity of this cyberinfrastructure, accommodating: disruptive hardware trends; ever-increasing data volumes; data integrity, privacy, and confidentiality; security; complex application structures and behaviors; and emerging concerns such as fault-tolerance and energy efficiency. The programs must focus on building robust, reliable and sustainable software that will support and advance sustained scientific innovation and discovery.
 The Division of Advanced Cyberinfrastructure in the Computer & Information Science & Engineering Directorate (CISE/ACI) is partnering with Directorates and Offices across the NSF to support SI2, a long-term comprehensive program focused on realizing a sustained software infrastructure that is an integral part of CIF21.

Humanity depends upon the Earth's physical resources and natural systems for food, energy, and water (FEW). However, both the physical resources and the FEW systems are under increasing stress. It is becoming imperative that we determine how society can best integrate social, ecological, physical and built environments to provide for growing demand for food, energy and water in the short term while also maintaining appropriate ecosystem services for the future. Known stressors in FEW systems include governance challenges, population growth and migration, land use change, climate variability, and uneven resource distribution. The interconnections and interdependencies associated with the FEW Nexus pose research grand challenges. To meet these grand challenges, there is a critical need for research that enables new means of adapting societal use of FEW systems. The INFEWS program seeks to support research that conceptualizes FEW systems broadly and inclusively, incorporating social and behavioral processes (such as decision making and governance), physical processes (such as built infrastructure and new technologies for more efficient resource utilization), natural processes (such as biogeochemical and hydrologic cycles), biological processes (such as agroecosystem structure and productivity), and cyber-components (such as sensing, networking, computation and visualization for decision-making and assessment). Investigations of these complex systems may produce discoveries that cannot emerge from research on food or energy or water systems alone. It is the synergy among these components in the context of sustainability that will open innovative science and engineering pathways to produce new knowledge, novel technologies, and innovative predictive capabilities.