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This Funding Opportunity Announcement (FOA) invites cooperative agreement applications that will contribute to a higher resolution understanding of the physical and functional organization of the human islet tissue environment by describing the composition (cellular and molecular) and function of important components of the pancreatic islet and peri-islet tissue architecture, the cell-cell relationships and means of communications used by cell types and cell subtypes within the pancreatic tissue ecosystem, and/or the contribution of adjacent (including acinar, ductal, lymphatic) and neighboring (intestinal, mesenteric and adipose) tissues to islet cell function and dysfunction. Successful projects will integrate the Human Pancreas Analysis Consortium (HPAC), that will consist of the research teams funded in response to this FOA with the Human Pancreas Analysis Program (HPAP), a resource-generation program that was funded in 2016 in response to RFA-DK-15-027. HPAC will become the fifth consortium of the Human Islet Research Network (HIRN, https://hirnetwork.org/ ). HIRN's overall mission is to support innovative and collaborative translational research to understand how human beta cells are lost in T1D, and to find innovative strategies to protect and replace functional beta cell mass in humans. This FOA will only support studies with a primary focus on increasing our understanding of human tissue structure and function, and human disease biology (as opposed to rodent or other animal models). This FOA is not intended to support the conduct of a clinical trial.

Miami faculty should notify Associate Provost Jim Oris of their interest in the following RFP. ---------- CGS invites doctoral-granting member institutions to apply to participate in Understanding PhD Career Pathways for Program Improvement, a multi-institution effort to collect and use data on PhD career pathways, funded by The Andrew W. Mellon Foundation and the National Science Foundation (NSF #1661272). This is an important opportunity to deepen your institution's understanding of the career goals and outcomes of its PhDs; communicate your support for the career diversity of PhDs; make evidence-based interventions that support the success of PhDs and the recruitment of future students; and access anonymized benchmarking data compiled from other project partners.   Awards: Option 1: Humanities Only. Provides awards of $30,000 each to support implementation of surveys of humanities PhD students and alumni over a period of twenty-four months. Supported by the Andrew W. Mellon Foundation; 15 awards available. Please indicate in your proposal why a humanities-only project aligns with your institutional mission.   Option 2: STEM Only. Provides awards of $50,000 to each to support implementation of surveys of STEM PhD students and alumni over a period of thirty-six months. Supported by the National Science Foundation; 15 awards available. Please indicate in your proposal why a STEM-only project aligns with your institutional mission.   Option 3: Combined Proposal. If an institution meets the eligibility requirements for both the Humanities and STEM awards, CGS strongly encourages the submission of a combined proposal. Institutions selected to participate in this category will receive a total award amount of $80,000.

The focus of this Funding Opportunity Announcement (FOA) is on in vivo human studies, and in vitro studies on human cells or tissues, aimed at potential identification of therapeutic targets or and/or testing of interventions for healthy aging. Potential therapeutic targets include FOXO3 itself and upstream and downstream regulators in pathways mediated by FOXO3. The range of research areas of interest in this FOA includes studies that: 1) examine in vivo phenotypic effects of human FOXO3 variants, and/or 2) elucidate effects of these variants on cellular functions and the pathways that mediate them, and/or 3) identify and evaluate candidate therapeutic targets (e.g., target validation studies, testing of candidate compounds) for potential interventions based on FOXO3 functional pathways. Projects involving whole genome sequencing of new or existing cohorts are outside the scope of this FOA. However, targeted resequencing on a limited sample set in an existing cohort could be supported by this FOA.

This Funding Opportunity Announcement (FOA) requests applications for the development of medium- to high-throughput "omics" technologies that can be used to explore human pancreatic tissues with single cell- or near single cell- resolution. Successful applicants will join the Consortium on Beta cell Death and Survival (CBDS), whose mission is to identify the mechanisms of beta cell stress and destruction central to the development of Type 1 Diabetes (T1D) in humans, with the long-term goal of protecting the residual beta cell mass in T1D patients as early as possible in the disease process, and preventing the progression towards autoimmunity. CBDS is part of the Human Islet Research Network (HIRN).

This Funding Opportunity Announcement (FOA) intends to support a group of Specialized Collaboratories that will adopt scalable technology platforms and streamlined workflows to accelerate progress towards establishing comprehensive molecular and anatomical reference cell atlases of human brain and/or non-human primate brains. A central goal of this FOA is to build a brain cell census resource that can be widely used throughout the research community.

This Funding Opportunity Announcement (FOA) requests applications for the development of medium- to high-throughput "omics" technologies that can be used to explore human pancreatic tissues with single cell- or near single cell- resolution. Successful applicants will join the Consortium on Beta cell Death and Survival (CBDS), whose mission is to identify the mechanisms of beta cell stress and destruction central to the development of Type 1 Diabetes (T1D) in humans, with the long-term goal of protecting the residual beta cell mass in T1D patients as early as possible in the disease process, and preventing the progression towards autoimmunity. 

The Nano-Bio Manufacturing Consortium is expected to grow the US-centric innovation ecosystem that will risk reduce material supply (including nanomaterials & biomaterials), processing techniques, and flexible/stretchable device concepts by demonstrating component- and system-level functionality relevant to human-integrated technologies, such as airman-performance monitoring (APM) and augmentation (APA) systems. This public-private partnership should build upon the foundation of research & development excellence that has been established within NBMC since its 2013 inception. It is envisioned that technology development will require teaming between academia and industry in partnership with government researchers as well as with appropriate members of the regulatory and operational DoD communities. A balance between enabling component- and systems-level prototype development is expected to be realized through end-technologies between TRL 3 and TRL 6. It is expected that during the completion of certain NBMC projects, lab and/or field demonstrations will be conducted in partnership with relevant DoD partners to ensure that members of military human performance and/or aeromedical communities can assess the utility of developments and provide iterative feedback with respect to critical path issues.

A. Noam Chomsky Global Connections Awards celebrate the power of human connections. The awards recognize distinguished service to the global mission of the STAR Scholars Network. Several individuals with a deep impact on advancing global, social mobility are recognized every year. We live in a time when innovation and creativity in support of humanity are of great importance. The Star Scholars Network recognizes the commitment of concerned people able and willing to make a difference in the lives of others. Nominations for this award are solicited from around the world. The nominee can be from any field. Beginning in 2020, the Star Scholars Network is committed to promoting transnational research, or collaborative research between scholars of two or more countries (e.g., joint publications, research partnerships, etc.). The Global Connections Awards recognize STAR Scholars for their achievements and distinctive contributions to translational research that demonstrates the very best of scholarly collaboration among scholars around the world. In December 2020, the Star Scholars Network will provide awards in three categories: North Star Medal of Lifetime Achievement, Shining Star Achievement in Research Award, Rising Star Emerging Scholar Certificate

The third joint transnational call of the ERA-NET SIINN is open for the submission of innovative transnational research proposals focused on manufactured nanomaterials (MNMs) in the four topics listed below: Exposure assessment Toxicity mechanisms Effects of MNMs on human health Environmental impacts of MNMs Please read carefully the following call documents:

The Nano-Biosensing program is part of the Engineering Biology and Health cluster, which includes also 1) Cellular and Biochemical Engineering; 2) Engineering of Biomedical Systems; 3) Biophotonics; and 4) Disability and Rehabilitation Engineering. The Nano-Biosensing program supports fundamental engineering research on devices and methods for measurement and quantification of biological analytes. Proposals that incorporate emerging nanotechnology methods are especially encouraged. Areas of interest include: -Multi-purpose sensor platforms that exceed the performance of current state-of-the-art devices. -Novel transduction principles, mechanisms and sensor designs suitable for measurement in practical matrix and sample-preparation-free approaches. These include error-free detection of pathogens and toxins in food matrices, waterborne pathogens, parasites, toxins, biomarkers in body fluids, and others that improve human condition. -Nano-biosensors that enable measurement of biomolecular interactions in their native states, transmembrane transport, intracellular transport and reactions, and other biological phenomena. -Studies that examine intracellular measurements must include discussion on the significance of the measurement. 

Two $60,000 pilot grants are available for Lymphangioleiomyomatosis (LAM) research. Focus is on translational proposals with strong likelihood of future federal funding, that use LAM samples, models or patient data, and which have the potential to favorably impact human health will be given priority. Examples of desirable topic areas include identification of molecular targets, biomarker development, and biomarker driven small pilot trials

The purpose of this Funding Opportunity Announcement (FOA)is to encourage research into dental, oral, and craniofacial diseases and disorders for which there is evidence for genetic heritability but for which we do not have a strong understanding of the genetics/genomics of the disease or disorder. Applicable areas of investigation include identification of promising areas of the genome, and characterization and elucidation of the function(s) of genetic variants that affect disease risk in humans. The ultimate goal of these studies will be to drive development of effective diagnostic, therapeutic, and preventive approaches.

The Environmental Engineering program supports fundamental research and educational activities across the broad field of environmental engineering.  The goal of this program is to encourage transformative research which applies scientific and engineering principles to avoid or minimize solid, liquid, and gaseous discharges, resulting from human activity, into land, inland and coastal waters, and air, while promoting resource and energy conservation and recovery.  The program also fosters cutting-edge scientific research for identifying, evaluating, and monitoring the waste assimilative capacity of the natural environment and for removing or reducing contaminants from polluted air, water, and soils.

This Administrative Supplement funding opportunity is part of the Common Fund Metabolomics Program created to increase and improve the nation's ability to undertake metabolomics analyses in translational and clinical research. Metabolomics has great potential to advance our understanding of human diseases, but requires specialized expertise in metabolomics study design, technology, and data analysis and interpretation.

The purpose of the BRAG program is to support the generation of new information that will assist Federal regulatory agencies in making science-based decisions about the effects of introducing into the environment genetically engineered organisms (GE), including plants, microorganisms (including fungi, bacteria, and viruses), arthropods, fish, birds, mammals and other animals excluding humans.

This challenge focuses on innovations in vaccine manufacturing platforms designed to lower production cost for vaccines that target diseases of great global burden and that are among the most costly to produce with current technologies. The vaccines should target one of the following diseases: human papillomavirus vaccine; inactivated poliovirus vaccine; measles-rubella vaccine; pentavalent vaccine (diphtheria, tetanus, whole-cell pertussis, hepatitis B, Hib); pneumococcal vaccine; or rotavirus vaccine. The target production cost of ≤ $0.15 per dose should represent the fully-loaded cost, which ensures that all relevant costs are accounted for.

The European Research Area (ERA-NET) is a coordination activity funded by the European Commission within the 7th Framework Program. The main objective of an ERA-NET is to provide a framework to network and mutually open national or regional research programs, leading to concrete cooperations, such as the development and implementation of joint transnational calls. The ERA-NET for Safe Implementation of Innovative Nanoscience and Nanotechnology (ERA-NET SIINN) is putting out a call to encourage joint U.S.-European collaborations focusing on the environmental and health effects of manufactured nanomaterial (MNMs) in 4 topic areas: * Topic 1. Exposure assessment * Topic 2. Fundamental aspects underlying toxicity mechanisms * Topic 3. Effects of MNM on human health * Topic 4. Environmental impacts of MNMs

This Funding Opportunity Announcement (FOA) solicits Phase I (R43) Small Business Innovative Research (SBIR) grant applications from small business concerns (SBCs) to develop and/or adapt novel technologies to enable the characterization of human exposures to engineered nanomaterials (ENMs) and to monitor or assess ENMs in diverse media ranging from biological samples to air and water.  

The CZI Neurodegeneration Challenge Network has three goals: (1) to make fundamental advances toward understanding neurodegeneration; (2) to bring new ideas and talent to the field of neurodegeneration; and (3) to encourage a new type of interdisciplinary collaborative research involving scientists, clinicians and engineers. We invite applications to join the Neurodegeneration Challenge Network through two RFA mechanisms: CZI Ben Barres Early Career Acceleration Awards: five-year investigator grants for early career academic investigators, with an emphasis on those who are new to the field of neurodegeneration. We seek to empower investigators to pursue bold ideas and to take risks within a supportive and collaborative environment. Awardees will benefit from mentorship support, as well as professional development, training and network opportunities, and practical career guidance to help them navigate this early stage of their careers. It is with great pleasure that we name this Award in memory of Dr. Ben Barres. Through his research career and his life and humanity, Ben embodied both the spirit and the scientific aims of this Award and the Challenge Network approach. CZI Collaborative Science Awards: three-year grants for small group interdisciplinary collaborations. At least one member of the collaboration should be a physician with active clinical engagement in an area relevant to the proposal. These grants are aimed to support innovative, bold, high risk/high impact projects at the interface of basic and disease biology. The scope of these collaborations should focus on foundational science (as opposed to translation and clinical application), aligned with clinical context.

The English Speaking Union of the United States each year sponsors a travel grant for study or research providing a stipend of up to $2,000. This competition is open to qualified under-graduate and post-graduate students, faculty, and others involved in academic pursuits that are in accord with the goal of the English Speaking Union of promoting education and understanding among the English speaking peoples of the world. The grant is designed to assist worthy individuals who are active in the fields of Business, the Humanities, Science and Engineering, Liberal, Fine or Applied Arts and who wish to study or conduct research either in the United States or in one of the countries of the British Commonwealth.