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The Environmental Chemical Sciences (ECS) Program supports basic research in chemistry that promotes the understanding of natural and anthropogenic chemical processes in our environment.  Projects supported by this program enable fundamentally new avenues of basic research and transformative technologies. The program is particularly interested in studying molecular phenomena on surfaces and interfaces in order to understand the inherently complex and heterogeneous environment.  Projects utilize advanced experimental, modeling and computational approaches, as well as developing new approaches.  Topics include studies of environmental surfaces and interfaces under laboratory conditions, the fundamental properties of water and water solutions important in environmental processes, dissolution, composition, origin and behavior of molecular scale systems under a variety of naturally occurring environmental conditions, chemical reactivity of synthetic nanoparticles and their molecular level interactions with the environment, and application of theoretical models and computational approaches to discover and predict environmental phenomena at the molecular scale.

The Environmental Chemical Sciences (ECS) Program supports basic research in chemistry that promotes the understanding of natural and anthropogenic chemical processes in our environment.  Projects supported by this program enable fundamentally new avenues of basic research and transformative technologies. The program is particularly interested in studying molecular phenomena on surfaces and interfaces in order to understand the inherently complex and heterogeneous environment.  Projects utilize advanced experimental, modeling and computational approaches, as well as developing new approaches.  Topics include studies of environmental surfaces and interfaces under laboratory conditions, the fundamental properties of water and water solutions important in environmental processes, dissolution, composition, origin and behavior of molecular scale systems under a variety of naturally occurring environmental conditions, chemical reactivity of synthetic nanoparticles and their molecular level interactions with the environment, and application of theoretical models and computational approaches to discover and predict environmental phenomena at the molecular scale.

The Biotechnology, Biochemical, and Biomass Engineering (BBBE) program supports fundamental engineering research that advances the understanding of cellular and biomolecular processes (in vivo, in vitro, and/or ex vivo) and eventually leads to the development of enabling technology and/or applications in support of the biopharmaceutical, biotechnology, and bioenergy industries, or with applications in health or the environment.  Quantitative assessments of bioprocesses are considered vital to successful research projects in the BBBE program.  Fundamental to many research projects in this area is the understanding of how biomolecules and cells interact in their environment, and how those molecular level interactions lead to changes in structure, function, phenotype, and/or behavior.  The program encourages proposals that address emerging research areas and technologies that effectively integrate knowledge and practices from different disciplines, and effectively incorporate ongoing research into educational activities. Research projects of particular interest in BBBE include, but are not limited to: Metabolic engineering and synthetic biology Quantitative systems biotechnology Tissue engineering and stem cell culture technologies Protein engineering/protein design Development of novel "omics" tools for biotechnology applications

The Fluid Dynamics program supports fundamental research and education on mechanisms and phenomena governing fluid flow. Proposed research should contribute to basic understanding; thus enabling the better design; predictability; efficiency; and control of systems that involve fluids. Encouraged are proposals that address innovative uses of fluids in materials development; manufacturing; biotechnology; nanotechnology; clinical diagnostics and drug delivery; sensor development and integration; energy and the environment. While the research should focus on fundamentals, a clear connection to potential application should be outlined.

The Fluid Dynamics program supports fundamental research and education on mechanisms and phenomena governing fluid flow.  Proposed research should contribute to basic understanding; thus enabling the better design; predictability; efficiency; and control of systems that involve fluids.  Encouraged are proposals that address innovative uses of fluids in materials development; manufacturing; biotechnology; nanotechnology; clinical diagnostics and drug delivery; sensor development and integration; energy and the environment. While the research should focus on fundamentals, a clear connection to potential application should be outlined.

The Fluid Dynamics program supports fundamental research on mechanisms and phenomena governing fluid flow from the molecular to the macroscopic scale.  Proposed research should contribute to basic understanding, thus enabling the better design, predictability, efficiency, and control of systems that involve fluids.  Encouraged are proposals that address behavior of new fluid materials and innovative uses of fluids in manufacturing, energy and the environment, materials development, biotechnology, nanotechnology, sensor development, clinical diagnostics and drug delivery. While the research should focus on fundamentals, a clear connection to potential applications with significant societal/technological impact should be outlined.

Partnerships for International Research and Education (PIRE) is an NSF-wide program that supports international activities across all NSF supported disciplines. The primary goal of PIRE is to support high quality projects in which advances in research and education could not occur without international collaboration. PIRE seeks to catalyze a higher level of international engagement in the U.S. science and engineering community. International partnerships are essential to addressing critical science and engineering problems. In the global context, U.S. researchers and educators must be able to operate effectively in teams with partners from different national environments and cultural backgrounds. PIRE promotes excellence in science and engineering through international collaboration and facilitates development of a diverse, globally-engaged, U.S. science and engineering workforce.

The Environmental Engineering program supports fundamental research and educational activities across the broad field of environmental engineering.  The goal of this program is to encourage transformative research which applies scientific and engineering principles to avoid or minimize solid, liquid, and gaseous discharges, resulting from human activity, into land, inland and coastal waters, and air, while promoting resource and energy conservation and recovery.  The program also fosters cutting-edge scientific research for identifying, evaluating, and monitoring the waste assimilative capacity of the natural environment and for removing or reducing contaminants from polluted air, water, and soils.

This Funding Opportunity Announcement (FOA) invites cooperative agreement applications that will contribute to a higher resolution understanding of the physical and functional organization of the human islet tissue environment by describing the composition (cellular and molecular) and function of important components of the pancreatic islet and peri-islet tissue architecture, the cell-cell relationships and means of communications used by cell types and cell subtypes within the pancreatic tissue ecosystem, and/or the contribution of adjacent (including acinar, ductal, lymphatic) and neighboring (intestinal, mesenteric and adipose) tissues to islet cell function and dysfunction. Successful projects will integrate the Human Pancreas Analysis Consortium (HPAC), that will consist of the research teams funded in response to this FOA with the Human Pancreas Analysis Program (HPAP), a resource-generation program that was funded in 2016 in response to RFA-DK-15-027. HPAC will become the fifth consortium of the Human Islet Research Network (HIRN, https://hirnetwork.org/ ). HIRN's overall mission is to support innovative and collaborative translational research to understand how human beta cells are lost in T1D, and to find innovative strategies to protect and replace functional beta cell mass in humans. This FOA will only support studies with a primary focus on increasing our understanding of human tissue structure and function, and human disease biology (as opposed to rodent or other animal models). This FOA is not intended to support the conduct of a clinical trial.

The Environmental Health and Safety of Nanotechnology (Nano EHS) program provides support to examine and mitigate the environmental effects of nanotechnologies. Fundamental research is sought to understand, evaluate, and lessen the impact of nanotechnology on the environment and biological systems. The program emphasizes engineering principles underlying the environmental health and safety impacts of nanotechnology. Innovative methods related to clean nanomaterials production processes, waste reduction, recycling, and industrial ecology of nanotechnology are also of interest.

he goal of the Interfacial Processes and Thermodynamics (IPT) program is to advance fundamental molecular engineering at interfaces, especially as applied to the nano-processing of soft materials.  The program views fundamental interfacial interactions, molecular transport at interfaces, and molecular thermodynamics as integral to developing new approaches for solving critical engineering needs that face society. Molecules at interfaces, with functional interfacial properties, are of special interest, as these molecules have potential use in important research areas, such as adhesion and advanced manufacturing/fabrication.  These interfacial molecules may also have biomolecular functions at the micro- and nano-scale, where the biomolecular functionalities may be re-directed toward engineering solutions. One new area of interest is the adhesion between unlike materials, or adhesion in adverse environments, with particular emphasis on applying strategies arising from nature.  Research supported in these fundamental areas should lead to more economical and environmentally benign processing, improved water quality, and novel functional materials for sensors, in industrial, environmental, and biomedical settings.  Nanotechnology plays a critical role in most of these new areas.

The Cellular and Biochemical Engineering (CBE) program supports fundamental engineering research that advances the understanding of cellular and biomolecular processes in engineering biology and eventually leads to the development of enabling technology for advanced biomanufacturing in support of the therapeutic cells, biochemical, biopharmaceutical and biotechnology industries.  A quantitative treatment of biological and engineering problems of biological processes is considered vital to successful research projects in the CBE program.  Fundamental to many research projects in this area is the understanding of how biomolecules, cells and cell populations interact in the biomanufacturing environment, and how those molecular-level interactions lead to changes in structure, function, and behavior.  The program encourages highly innovative and potentially transformative engineering research leading to novel bioprocessing and biomanufacturing approaches, and proposals that address emerging research areas and technologies that effectively integrate knowledge and practices from different disciplines while incorporating ongoing research into educational activities.

The Environmental Health and Safety of Nanotechnology (Nano EHS) program provides support to examine and mitigate the environmental effects of nanotechnologies.  Fundamental research is sought to understand, evaluate, and lessen the impact of nanotechnology on the environment and biological systems.  The program emphasizes engineering principles underlying the environmental health and safety impacts of nanotechnology.  Innovative methods related to clean nanomaterials production processes, waste reduction, recycling, and industrial ecology of nanotechnology are also of interest.  

The NIH encourages institutions that seek to engage undergraduate students in innovative mentored research training programs to submit applications for cooperative agreement awards through the NIH Building Infrastructure Leading to Diversity (BUILD) initiative, one of three new Common Fund initiatives that together aim to enhance diversity in the biomedical, behavioral, clinical, and social sciences research workforce. Addressing a major leakage point in the research workforce pipeline, BUILD awards are intended to support the design and implementation of innovative programs, strategies and approaches to transform undergraduate research training and mentorship. BUILD awards will also support institutional and faculty development to further strengthen undergraduate research training environments.

he Metals and Metallic Nanostructures (MMN) Program supports fundamental research and education on the relationships between processing, structure and properties of metals and their alloys. The program focuses on experimental research while strongly encouraging the synergistic use of theory and computational materials science. Structure spanning atomic, nanometer, micrometer and larger length scales controls properties and connects these with processing.   The program emphasizes the role of structure across all these length scales, including structural imperfections such as vacancies, solutes, dislocations, boundaries and interfaces. Research should advance fundamental materials science that will enable the design and synthesis of metallic materials to optimize superior behaviors and enable the prediction of properties and performance. The program aims to advance the materials science of metals and alloys through transformative research on a diverse array of topics, including, but not limited to, phase transformations; equilibrium, non-equilibrium and far-from equilibrium structures; thermodynamics; kinetics; diffusion; interfaces; oxidation; performance in extreme environments; recyclability; magnetic behavior; thermal transport; plastic flow; and similar phenomena. Yield strength, flow stress, creep, fatigue and fracture are structural-materials examples. Magnetic energy density, shape-memory strain and thermoelectric efficiency are examples for functional materials.  Broader impacts are expected in education and other areas, such as workforce development, sustainability, environmental impact or critical infrastructure needs.  High-quality proposals that integrate research, education, and other broader impacts are invited.

Recognizing disciplinary differences and priorities, NSF's investment in research and development in undergraduate STEM education encompasses a range of approaches. These approaches include: experiential learning, assessment/metrics of learning and practice, scholarships, foundational education research, professional development/institutional change, formal and informal learning environments, and undergraduate disciplinary research. Both individually and integrated in a range of combinations, these approaches can lead to outcomes including: developing the STEM and STEM-related workforce, advancing science, broadening participation in STEM, educating a STEM-literate populace, improving K-12 STEM education, encouraging life-long learning, and building capacity in higher education.

The Long Term Research in Environmental Biology (LTREB) Program supports the generation of extended time series of data to address important questions in evolutionary biology, ecology, and ecosystem science. Research areas include, but are not limited to, the effects of natural selection or other evolutionary processes on populations, communities, or ecosystems; the effects of interspecific interactions that vary over time and space; population or community dynamics for organisms that have extended life spans and long turnover times; feedbacks between ecological and evolutionary processes; pools of materials such as nutrients in soils that turn over at intermediate to longer time scales; and external forcing functions such as climatic cycles that operate over long return intervals. The Program intends to support decadal projects. Funding for an initial, 5-year period requires submission of a preliminary proposal and, if invited, submission of a full proposal that includes a 15-page project description. Proposals for the second five years of support (renewal proposals) are limited to an eight-page project description and do not require a preliminary proposal. Continuation of an LTREB project beyond an initial ten year award will require submission of a new preliminary proposal that presents a new decadal research plan.?? Successful LTREB proposals address three essential components: A Decadal Research Plan that clearly articulates important questions that cannot be addressed with data that have already been collected, but could be answered if ten additional years of data were collected. This plan is not a research timeline or management plan. It is a concise justification for ten additional years of support in order to advance understanding of key concepts, questions, or theories in environmental biology.Core Data: LTREB proposals require that the author has studied a particular phenomenon or process for at least six years up to the present or for long enough to gene

This Funding Opportunity Announcement (FOA) is intended to support research projects to enhance our understanding of the nature, extent, distribution, etiology, comorbidities, and consequences of drug use, abuse, and addiction across individuals, families, communities, and diverse population groups. This FOA strongly encourages applications that reflect the breadth of epidemiology research by addressing multiple levels of risk, resilience, and causation across scientific disciplines; by applying novel methods to advance knowledge of the interplay among genetic, environmental, and developmental factors and between social environments and associated health and disease outcomes; and by building on the research investments of NIH and sister HHS agencies to harness existing data on the epidemiology and etiology of drug abuse to improve public health prevention and treatment programs.

The purpose of the BRAG program is to support the generation of new information that will assist Federal regulatory agencies in making science-based decisions about the effects of introducing into the environment genetically engineered organisms (GE), including plants, microorganisms (including fungi, bacteria, and viruses), arthropods, fish, birds, mammals and other animals excluding humans.

The CZI Neurodegeneration Challenge Network has three goals: (1) to make fundamental advances toward understanding neurodegeneration; (2) to bring new ideas and talent to the field of neurodegeneration; and (3) to encourage a new type of interdisciplinary collaborative research involving scientists, clinicians and engineers. We invite applications to join the Neurodegeneration Challenge Network through two RFA mechanisms: CZI Ben Barres Early Career Acceleration Awards: five-year investigator grants for early career academic investigators, with an emphasis on those who are new to the field of neurodegeneration. We seek to empower investigators to pursue bold ideas and to take risks within a supportive and collaborative environment. Awardees will benefit from mentorship support, as well as professional development, training and network opportunities, and practical career guidance to help them navigate this early stage of their careers. It is with great pleasure that we name this Award in memory of Dr. Ben Barres. Through his research career and his life and humanity, Ben embodied both the spirit and the scientific aims of this Award and the Challenge Network approach. CZI Collaborative Science Awards: three-year grants for small group interdisciplinary collaborations. At least one member of the collaboration should be a physician with active clinical engagement in an area relevant to the proposal. These grants are aimed to support innovative, bold, high risk/high impact projects at the interface of basic and disease biology. The scope of these collaborations should focus on foundational science (as opposed to translation and clinical application), aligned with clinical context.

National Science Foundation's Major Research Instrumentation Program (MRI) assists in the acquisition or development of major research instrumentation. This program seeks to improve the quality and expand the scope of research and research training in science and engineering, and to foster the integration of research and education by providing instrumentation for research-intensive learning environments. The MRI program also encourages the shared inter- and/or intra-organizational use of the acquired research instrumentation. For more information, please consult the program's guidelines. Miami University may submit up to three MRI proposals (up to two that request between $100,000 and $1 million and no more than one that requests between $1 million and $4 million) on which Miami is either the lead or a partner institution. To facilitate the selection of our submissions to NSF, we have set a deadline of October 28, 2019 to receive preliminary MRI proposals for internal review. You are required to provide a preliminary proposal regardless of whether you were selected as an institutional submission in previous years.