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The CZI Neurodegeneration Challenge Network has three goals: (1) to make fundamental advances toward understanding neurodegeneration; (2) to bring new ideas and talent to the field of neurodegeneration; and (3) to encourage a new type of interdisciplinary collaborative research involving scientists, clinicians and engineers. We invite applications to join the Neurodegeneration Challenge Network through two RFA mechanisms: CZI Ben Barres Early Career Acceleration Awards: five-year investigator grants for early career academic investigators, with an emphasis on those who are new to the field of neurodegeneration. We seek to empower investigators to pursue bold ideas and to take risks within a supportive and collaborative environment. Awardees will benefit from mentorship support, as well as professional development, training and network opportunities, and practical career guidance to help them navigate this early stage of their careers. It is with great pleasure that we name this Award in memory of Dr. Ben Barres. Through his research career and his life and humanity, Ben embodied both the spirit and the scientific aims of this Award and the Challenge Network approach. CZI Collaborative Science Awards: three-year grants for small group interdisciplinary collaborations. At least one member of the collaboration should be a physician with active clinical engagement in an area relevant to the proposal. These grants are aimed to support innovative, bold, high risk/high impact projects at the interface of basic and disease biology. The scope of these collaborations should focus on foundational science (as opposed to translation and clinical application), aligned with clinical context.