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This Funding Opportunity Announcement (FOA) invites cooperative agreement applications that will contribute to a higher resolution understanding of the physical and functional organization of the human islet tissue environment by describing the composition (cellular and molecular) and function of important components of the pancreatic islet and peri-islet tissue architecture, the cell-cell relationships and means of communications used by cell types and cell subtypes within the pancreatic tissue ecosystem, and/or the contribution of adjacent (including acinar, ductal, lymphatic) and neighboring (intestinal, mesenteric and adipose) tissues to islet cell function and dysfunction. Successful projects will integrate the Human Pancreas Analysis Consortium (HPAC), that will consist of the research teams funded in response to this FOA with the Human Pancreas Analysis Program (HPAP), a resource-generation program that was funded in 2016 in response to RFA-DK-15-027. HPAC will become the fifth consortium of the Human Islet Research Network (HIRN, https://hirnetwork.org/ ). HIRN's overall mission is to support innovative and collaborative translational research to understand how human beta cells are lost in T1D, and to find innovative strategies to protect and replace functional beta cell mass in humans. This FOA will only support studies with a primary focus on increasing our understanding of human tissue structure and function, and human disease biology (as opposed to rodent or other animal models). This FOA is not intended to support the conduct of a clinical trial.

This Funding Opportunity Announcement (FOA) requests applications for the development of medium- to high-throughput "omics" technologies that can be used to explore human pancreatic tissues with single cell- or near single cell- resolution. Successful applicants will join the Consortium on Beta cell Death and Survival (CBDS), whose mission is to identify the mechanisms of beta cell stress and destruction central to the development of Type 1 Diabetes (T1D) in humans, with the long-term goal of protecting the residual beta cell mass in T1D patients as early as possible in the disease process, and preventing the progression towards autoimmunity. CBDS is part of the Human Islet Research Network (HIRN).

This Funding Opportunity Announcement (FOA) requests applications for the development of medium- to high-throughput "omics" technologies that can be used to explore human pancreatic tissues with single cell- or near single cell- resolution. Successful applicants will join the Consortium on Beta cell Death and Survival (CBDS), whose mission is to identify the mechanisms of beta cell stress and destruction central to the development of Type 1 Diabetes (T1D) in humans, with the long-term goal of protecting the residual beta cell mass in T1D patients as early as possible in the disease process, and preventing the progression towards autoimmunity. 

This Funding Opportunity Announcement (FOA) intends to support a group of Specialized Collaboratories that will adopt scalable technology platforms and streamlined workflows to accelerate progress towards establishing comprehensive molecular and anatomical reference cell atlases of human brain and/or non-human primate brains. A central goal of this FOA is to build a brain cell census resource that can be widely used throughout the research community.

The Cellular and Biochemical Engineering (CBE) program supports fundamental engineering research that advances the understanding of cellular and biomolecular processes in engineering biology and eventually leads to the development of enabling technology for advanced biomanufacturing in support of the therapeutic cells, biochemical, biopharmaceutical and biotechnology industries.  A quantitative treatment of biological and engineering problems of biological processes is considered vital to successful research projects in the CBE program.  Fundamental to many research projects in this area is the understanding of how biomolecules, cells and cell populations interact in the biomanufacturing environment, and how those molecular-level interactions lead to changes in structure, function, and behavior.  The program encourages highly innovative and potentially transformative engineering research leading to novel bioprocessing and biomanufacturing approaches, and proposals that address emerging research areas and technologies that effectively integrate knowledge and practices from different disciplines while incorporating ongoing research into educational activities.

Biophotonics applies photonics technology to the fields of medicine, biology and biotechnology.  Basic research and innovation in photonics that is very fundamental in science and engineering is needed to lay the foundation for new technologies beyond those that are mature and ready for application in medical diagnostics and therapies.  Advances are needed in nanophotonics, optogenetics, contrast and targeting agents, ultra-thin probes, wide field imaging, and rapid biomarker screening.  Low cost and minimally invasive medical diagnostics and therapies are key goals. Examples of topics are: Macromolecule Markers - Innovative methods for labeling of macromolecules, new compositions of matter/methods of fabrication of multi-color probes such as might be used for marking and detection of specific pathological cells and push the envelope of optical sensing to the limits of detection, resolution, and identification Low Coherence Sensing at the Nanoscale - Low coherence enhanced backscattering (LEBS), n-dimensional elastic light scattering, and angle-resolved low coherence interferometry for early cancer detection (dysplasia) Neurophotonics - Studies of photon activation of neurons at the interface of nanomaterials attached to cells.  Development and application of biocompatible photonic tools such as parallel interfaces and interconnects for communicating and control of neural networks Micro- and Nano-photonic - Development and application of nanoparticle fluorescent quantum-dots; sensitive, multiplexed, high-throughput characterization of macromolecular properties of cells; nanomaterials and nanodevices for biomedicine Optogenetics - Employing light-activated channels and enzymes for manipulation of neural activity with temporal precision. 

Biophotonics applies photonics technology to the fields of medicine, biology and biotechnology.  Basic research and innovation in photonics that is very fundamental in science and engineering is needed to lay the foundation for new technologies beyond those that are mature and ready for application in medical diagnostics and therapies.  Advances are needed in nanophotonics, optogenetics, contrast and targeting agents, ultra-thin probes, wide field imaging, and rapid biomarker screening.  Low cost and minimally invasive medical diagnostics and therapies are key goals. Examples of topics are: Macromolecule Markers - Innovative methods for labeling of macromolecules, new compositions of matter/methods of fabrication of multi-color probes such as might be used for marking and detection of specific pathological cells and push the envelope of optical sensing to the limits of detection, resolution, and identification Low Coherence Sensing at the Nanoscale - Low coherence enhanced backscattering (LEBS), n-dimensional elastic light scattering, and angle-resolved low coherence interferometry for early cancer detection (dysplasia) Neurophotonics - Studies of photon activation of neurons at the interface of nanomaterials attached to cells.  Development and application of biocompatible photonic tools such as parallel interfaces and interconnects for communicating and control of neural networks Micro- and Nano-photonic - Development and application of nanoparticle fluorescent quantum-dots; sensitive, multiplexed, high-throughput characterization of macromolecular properties of cells; nanomaterials and nanodevices for biomedicine Optogenetics - Employing light-activated channels and enzymes for manipulation of neural activity with temporal precision. 

Alliance for Cancer Gene Therapy, Inc. (ACGT) funds research aimed at furthering the development of cell and gene therapy approaches to the treatment of cancer. To this end, ACGT offers awards in Clinical Translation of Cell and Gene Therapy for Cancer, to qualified scientists at the assistant professor level and above. This award is specifically for those conducting Cell and Gene Therapy Research for sarcoma and is entitled, The Wendy Walk/ACGT Sarcoma Research Grant.

Papers can be submitted in the following categories of nanomedicine research: Bioimaging & Drug Delivery Biosensing & Biophotonics Biophysics Modeling Instrumentation Regenerative Medicine Rehabilitative Engineering Tissue Engineering Biomaterials Biomechanics & Mechanobiology Biofuels & Bioenergy Molecular Cell Engineering Synthetic Biology Quantitative Systems Biology Stem Cells Bioengineering Education Education Start-up Companies Any research area of interest at the intersection of nanotechnology and medicine. The conference will be held on the campus of Northeastern University in Boston, MA, USA. The conference will include plenary speakers, oral and poster presentations, and numerous activities specifically for undergraduate and graduate students. As the focus of the conference is to highlight translational nanomedicine research, we will also focus on highlighting start-up companies and well-established companies in the nanomedicine sectors.

The Biotechnology, Biochemical, and Biomass Engineering (BBBE) program supports fundamental engineering research that advances the understanding of cellular and biomolecular processes (in vivo, in vitro, and/or ex vivo) and eventually leads to the development of enabling technology and/or applications in support of the biopharmaceutical, biotechnology, and bioenergy industries, or with applications in health or the environment.  Quantitative assessments of bioprocesses are considered vital to successful research projects in the BBBE program.  Fundamental to many research projects in this area is the understanding of how biomolecules and cells interact in their environment, and how those molecular level interactions lead to changes in structure, function, phenotype, and/or behavior.  The program encourages proposals that address emerging research areas and technologies that effectively integrate knowledge and practices from different disciplines, and effectively incorporate ongoing research into educational activities. Research projects of particular interest in BBBE include, but are not limited to: Metabolic engineering and synthetic biology Quantitative systems biotechnology Tissue engineering and stem cell culture technologies Protein engineering/protein design Development of novel "omics" tools for biotechnology applications

The Electronics, Photonics, and Magnetic Devices (EPMD) Program seeks to improve the fundamental understanding of devices and components based on the principles of micro- and nano-electronics, optics and photonics, optoelectronics, magnetics, electromechanics, electromagnetics, and related physical phenomena. The Electronics & Magnetic Devices component of EPMD enables discovery and innovation advancing the frontiers of nanoelectronics, spin electronics, molecular and organic electronics, bioelectronics, biomagnetics, non-silicon electronics, and flexible electronics. It also addresses advances in energy-efficient electronics, sensors, low-noise, power electronics, and mixed signal devices. The Optic & Photonic Devices component of EPMD supports research and engineering efforts leading to significant advances in novel optical sources and photodetectors, optical communication devices, photonic integrated circuits, single-photon quantum devices, and nanophotonics. It also addresses novel optical imaging and sensing applications and solar cell photovoltaics.

The Electronics, Photonics, and Magnetic Devices (EPMD) Program seeks to improve the fundamental understanding of devices and components based on the principles of micro- and nano-electronics, optics and photonics, optoelectronics, magnetics, electromechanics, electromagnetics, and related physical phenomena. The Electronics & Magnetic Devices component of EPMD enables discovery and innovation advancing the frontiers of nanoelectronics, spin electronics, molecular and organic electronics, bioelectronics, biomagnetics, non-silicon electronics, and flexible electronics. It also addresses advances in energy-efficient electronics, sensors, low-noise, power electronics, and mixed signal devices. The Optic & Photonic Devices component of EPMD supports research and engineering efforts leading to significant advances in novel optical sources and photodetectors, optical communication devices, photonic integrated circuits, single-photon quantum devices, and nanophotonics. It also addresses novel optical imaging and sensing applications and solar cell photovoltaics.

The Electronics, Photonics, and Magnetic Devices (EPMD) Program seeks to improve the fundamental understanding of devices and components based on the principles of micro- and nano-electronics, optics and photonics, optoelectronics, magnetics, electromechanics, electromagnetics, and related physical phenomena. The Electronics & Magnetic Devices component of EPMD enables discovery and innovation advancing the frontiers of nanoelectronics, spin electronics, molecular and organic electronics, bioelectronics, biomagnetics, non-silicon electronics, and flexible electronics. It also addresses advances in energy-efficient electronics, sensors, low-noise, power electronics, and mixed signal devices. The Optic & Photonic Devicescomponent of EPMD supports research and engineering efforts leading to significant advances in novel optical sources and photodetectors, optical communication devices, photonic integrated circuits, single-photon quantum devices, and nanophotonics. It also addresses novel optical imaging and sensing applications and solar cell photovoltaics. EPMD further supports topics in quantum devices and novel electromagnetic materials-based device solutions from DC to high-frequency, millimeter-wave and THz, monolithic integrated circuits built with them, and electromagnetic effects, components needed for communications, telemedicine, and other wireless applications. Wide bandgap semiconductor devices, device design, processing and characterization, as well as metamaterial and plasmonic based devices are of interest. Novel electronic, photonic and magnetic devices with organic, inorganic or hybrid materials on conformable or transparent substrates are also of interest, as are carbon-based and emerging 2D atomic-layered materials for electronic, photonic, magnetic, energy harvesting and other related device application areas. Interest also extends to novel ideas for next generation memory devices. The program supports cooperative efforts with the semiconduc

The Office of Biological and Environmental Research (BER) of the Office of Science (SC), U.S. Department of Energy (DOE) hereby announces its interest in receiving research applications for novel imaging and measurement technologies for biological systems science. This Funding Opportunity Announcement (FOA) will consider applications for the development of novel imaging instrumentation and measurement technologies that support the integrative analysis of communication among subcellular compartments, between individual microbial cells and within multicellular communities/plant tissues. The goal is to develop in situ, dynamic and nondestructive approaches to enable multifunctional imaging, quantitative flux measurements, and multiscale integrative analysis of bioenergy-relevant plant and microbial systems. 

The purpose of this Funding Opportunity Announcement (FOA) is to establish a Model Organisms Screening Center for evaluating the pathogenicity and function of approximately 200 gene variants per year identified through the Undiagnosed Diseases Network (UDN). Responsive applications will propose to establish a screening platform involving at a minimum Drosophila and zebrafish models; the screening pipeline may include additional small animal models or cell-based assays, as appropriate, to analyze the function of UDN gene variants in the context of the respective UDN patient's disease phenotype. This initiative is funded through the NIH Common Fund which supports cross-cutting programs that are expected to have exceptionally high impact.

The goal of this Funding Opportunity Announcement (FOA) is to support novel basic and translational research projects that focus on the biology of residual oral reservoirs for HIV and opportunistic oral pathogens.These studies will advance our understanding of the immunologic, pathogenic, molecular and cellular mechanisms important for eliminating latently persistent, reactivation competent HIV and other opportunistic pathogens from residual oral reservoirs.Specifically, this FOA encourages studies on: 1) purging and abolishing these pathogens after using Highly Active Anti-Retroviral Therapy (HAART) to induce cytopathic killing and immunoclearance; or 2) developing alternative strategies that directly eliminate latently infected cells in which HAART resistant HIV and opportunistic pathogens persist in oral reservoirs.

The Energy, Power, and Adaptive Systems (EPAS) program invests in the design and analysis of intelligent and adaptive engineering networks, including sensing, imaging, controls, and computational technologies for a variety of application domains. EPAS places emphasis on electric power networks and grids, including generation, transmission and integration of renewable, sustainable and distributed energy systems; high power electronics and drives; and understanding of associated regulatory and economic structures. Topics of interest include alternate energy sources, the Smart Grid, and interdependencies of critical infrastructure in power and communications. The program also places emphasis on energy scavenging and alternative energy technologies, including solar cells, ocean waves, wind, and low-head hydro. In addition, the program supports innovative test beds, and laboratory and curriculum development to integrate research and education.  EPAS invests in adaptive dynamic programming, brain-like networked architectures performing real-time learning, neuromorphic engineering, telerobotics, and systems theory. The program supports distributed control of multi-agent systems with embedded computation for sensor and adaptive networks. EPAS provides additional emphasis on emerging areas, such as quantum systems engineering, quantum and molecular modeling and simulation of devices and systems.

The purpose of this FOA is to solicit applications that will accelerate the development and validation of imaging technologies for visualizing the structural and functional organization of the mammalian genome and its spatiotemporal dynamics. Projects must propose innovative, high resolution, high throughput, quantitative technologies that can be used to study a statistically significant number of single cells to address critical unmet needs in our understanding of nuclear organization.

The purpose of this Funding Opportunity Announcement (FOA) is to establish a Model Organisms Screening Center for evaluating the pathogenicity and function of approximately 200 gene variants per year identified through the Undiagnosed Diseases Network (UDN). Responsive applications will propose to establish a screening platform involving at a minimum Drosophila and zebrafish models; the screening pipeline may include additional small animal models or cell-based assays, as appropriate, to analyze the function of UDN gene variants in the context of the respective UDN patient's disease phenotype. This initiative is funded through the NIH Common Fund which supports cross-cutting programs that are expected to have exceptionally high impact.

Supports research on algebraic topology, including homotopy theory, ordinary and extraordinary homology and cohomology, cobordism theory, and K-theory; topological manifolds and cell complexes, fiberings, knots, and links; differential topology and actions of groups of transformations; geometric group theory; and general topology and continua theory.

This challenge focuses on innovations in vaccine manufacturing platforms designed to lower production cost for vaccines that target diseases of great global burden and that are among the most costly to produce with current technologies. The vaccines should target one of the following diseases: human papillomavirus vaccine; inactivated poliovirus vaccine; measles-rubella vaccine; pentavalent vaccine (diphtheria, tetanus, whole-cell pertussis, hepatitis B, Hib); pneumococcal vaccine; or rotavirus vaccine. The target production cost of ≤ $0.15 per dose should represent the fully-loaded cost, which ensures that all relevant costs are accounted for.