NIMH seeks applications for pilot effectiveness projects to evaluate the preliminary effectiveness of therapeutic and service delivery interventions for the post-acute management of mental health conditions that are matched to the stage of illness in terms of both their focus (e.g., consolidating and maintaining gains from initial treatment, managing residual symptoms/impairment, preventing relapse, promoting adherence and appropriate service use) and intensity/burden. In this pilot phase of effectiveness research, the trial should be designed to evaluate the feasibility, tolerability, acceptability, safety, and potential effectiveness of the approach; to address whether the intervention engages the target(s)/mechanisms(s) that is/are presumed to underlie the intervention effects; and to obtain preliminary data needed as a pre-requisite to a larger-scale effectiveness trial (e.g., comparative effectiveness study, practical trial) designed to definitely test the effectiveness of interventions to improve post-acute outcomes.
NIMH seeks applications for research projects to evaluate the effectiveness of therapeutic and service delivery interventions for the post-acute management of mental health conditions affecting youth, adults, and older adults. This FOA encourages clinical trials to establish the effectiveness and test hypotheses regarding moderators, mediators, and mechanisms of action of post-acute phase therapeutic and services interventions that are matched to the stage of illness in terms of both their focus (e.g., consolidating and maintaining gains from initial treatment, managing residual symptoms/impairment, preventing relapse, promoting adherence and appropriate service use) and intensity/burden for promoting optimal longer-term outcomes.
The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications to continue the Cooperative Centers on Human Immunology (CCHI) program to support studies that will advance understanding of the mechanisms regulating human immune responses. The immediate objective of CCHI is to support mechanistic and hypothesis-testing studies to understand human immunity applicable to the biodefense effort; i.e. innate, adaptive and mucosal immune responses to infection, vaccination and adjuvants. Studies on immune-mediated diseases (e.g. airway allergy, food allergy, autoimmunity, organ transplant rejection) are also of interest, as these data will provide a more comprehensive understanding of the human immune system. The program will also support the centralized infrastructure needed to promote and coordinate multi-disciplinary research in human immunology. Additional objectives are to promote public access to CCHI-supported data and metadata through public portals such as ImmPort, and to develop new technologies to support human immunology research.
This Funding Opportunity Announcement (FOA) solicits behavioral, social, and implementation science research designed to
(a) identify gaps in the HIV pre-exposure prophylaxis (PrEP) care continuum and associated determinants;
(b) develop and test interventions to strengthen PrEP delivery, use, and outcomes; and
(c) reduce racial/ethnic and age-related disparities in PrEP uptake and use
This FOA uses the R01 grant mechanism while corresponding FOA PA-18-271 uses the R21 mechanism. High risk/high payoff projects that lack preliminary data are appropriate for the R21 mechanism, while applicants with preliminary data who propose longitudinal analyses and/or large scale projects may consider the R01 mechanism.
This FOA encourages applications at the intersection of HIV and aging by addressing two overarching objectives:
1) to improve understanding of biological, clinical, and socio-behavioral aspects of aging through the lens of HIV infection and its treatment; and
2) to improve approaches for testing, prevention, and treatment of HIV infection, and management of HIV-related comorbidities, co-infections, and complications in different populations and cultural settings by applying our current understanding of aging science
Applications appropriate to this FOA should be consistent with the scientific priorities outlined by the NIH Office of AIDS Research (OAR) as described in NOT-OD-15-137.
As part of the Collaborative Research on Addiction at NIH (CRAN) initiative, NIDA, NIAAA, and NCI join to issue this FOA. The purpose of this FOA is to support the development and testing of interventions, models, and/or frameworks that examine system-level implementation of evidence-based interventions, guidelines, or principles to improve the delivery, uptake, quality, and sustainability of substance use prevention and treatment interventions and services.
The purpose of this Funding Opportunity Announcement (FOA) is to provide support for innovative and promising intervention research designed to improve smoking cessation outcomes among socioeconomically disadvantaged populations. Specifically, this FOA is intended to stimulate research efforts aimed at the development of smoking cessation interventions that:
1) are targeted to socioeconomically disadvantaged populations, and
2) could be made scalable for broad population impact
Applicants may propose projects that develop and test novel cessation interventions with the potential to be scaled up, as well as projects that focus on enhancing the effectiveness, quality, accessibility, utilization, and cost-effectiveness of currently scaled smoking cessation interventions. This FOA provides funding for up to 2 years for protocol development and early phase, pilot, or exploratory projects.
This Funding Opportunity Announcement (FOA) is to support studies that are essential, yet also sufficient, for investigators to make definitive decisions about the designs of important clinical trials within NHLBI's mission, the prevention and treatment of heart, lung, blood, and sleep disorders. This mechanism may be used to test the feasibility of novel and efficient (pragmatic) trial designs, as well as determine the feasibility of an intervention, intervention parameters, subject availability, or other information essential to complete the design of a trial. Applications should demonstrate that the proposed pilot studies are both necessary and sufficient to permit definitive decisions about the design of the subsequent clinical trial. Applicants who propose solely to write a protocol or manual of operations or to develop infrastructure for a clinical trial will not be considered appropriate for this announcement. The NHLBI anticipates that the R34 award period will yield robust investigator-initiated clinical trial grant applications for the evaluation of interventions for the treatment or prevention of heart, lung, blood, or sleep disorders.
The purpose of this Funding Opportunity Announcement (FOA) is to fund highly innovative and promising research that tests multi-level physical activity intervention programs acting on at least two levels of the socio-ecological model and designed to increase health-enhancing physical activity: 1) in persons or groups that can benefit from such activity; and 2) that could be made scalable and sustainable for broad use across the nation. This FOA provides support for up to 5 years for research planning, intervention delivery, and follow-up activities.
The United States Agency for International Development (USAID), Bureau for Food Security (BFS), Office of Strategic Planning and Program Management (SPPM), Monitoring and Evaluation Division (MEL), invites applications for funding from qualified U.S. and non-U.S., non-profit or for-profit non-governmental organizations (NGOs) and international organizations to carry out activities that develop, test or apply innovative methods for monitoring or evaluating Feed the Future/Global Food Security Strategy activities or programs. This Notice of Funding Opportunity serves as BFS's Monitoring and Evaluation team's Annual Program Statements (APS). An APS is issued when USAID intends to support a variety of creative approaches towards developing methodologies to assess and implement development objective activities. The purpose of this APS is to disseminate information to prospective applicants so that they may develop and submit applications for USAID funding. This APS: (a) describes the types of activities for which applications will be considered; (b) describes the funding available and the process and requirements for submitting Concept Papers and applications; (c) explains the criteria for evaluating Concept Papers and applications; and (d) refers prospective applicants to relevant documentation available on the internet.
A rich body of evidence suggests that optimal cognitive, affective, and social processes are associated with highly coordinated neural activity. These findings suggest that oscillatory rhythms, their co-modulation across frequency bands, spike-phase correlations, spike population dynamics, and other patterns might be useful drivers of therapeutic development for treatment of cognitive, social, or affective symptoms in neuropsychiatric disorders. This funding opportunity supports projects that test whether modifying electrophysiological patterns during behavior can improve cognitive, affective, or social processing. Also listed under R01.
The National Center for Advancing Translational Sciences mission is to catalyze the generation of innovative methods and technologies that will enhance the development, testing and implementation of diagnostics and therapeutics across a wide range of human diseases and conditions. Translation is the process of turning observations in the laboratory, clinic and community into interventions that improve the health of individuals and the public - from diagnostics and therapeutics to medical procedures and behavioral changes. NCATS focuses on research that impacts systemic change across the entire translational spectrum from basic research, pre-clinical research, clinical research, clinical implementation, and public health. NCATS encourages innovative approaches to systemic change and is disease and science domain agnostic.
The purpose of this funding opportunity announcement is to solicit research to develop, optimize and test mental health telehealth methods (i.e., without involving in-person interaction between a mental health clinician and the patient) to help evaluate and treat emergency department (ED) patients with suicide risk, compared to usual care of such patients in emergency departments without adequate on-site mental health specialty consultation. Primary research questions include if the use of telehealth methods affects the proportion of ED patients who are (1) considered at imminent risk for suicide, (2) boarded in the ED due to suicide risk, and (3) require hospitalization for suicide risk; (4) whether use of telehealth methods affects the rate of within-encounter provision of evidence-based suicide prevention interventions; and whether use of telehealth methods affects (5) the rates of suicide ideation, attempts and deaths, and (6) health care use and costs, in the year after an index ED visit in which a patient was identified with suicide risk. To inform future implementation of telehealth enabled suicide prevention practices in the ED, qualitative data on patient and provider views of telehealth provision of suicide prevention practices (feasibility and acceptability of clinical decision making; clinical workflows; ease of use of technology) are sought.
This Funding Oopportunity Aannouncement (FOA) invites pilot feasibility studies testing rapid-acting interventions to reduce severe suicide risk through clinical trials that are based in appropriate/specialized healthcare settings(e.g., emergency departments [ED], psychiatric inpatient units, other settings that meet Risk Evaluation and Mitigation Strategy approaches).
The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications to pursue invasive neural recording studies focused on mental health-relevant questions. Invasive neural recordings provide an unparalleled window into the human brain to explore the neural circuitry and neural dynamics underlying complex moods, emotions, cognitive functions, and behaviors with high spatial and temporal resolution. Additionally, the ability to stimulate, via the same electrodes, allows for direct causal tests by modulating network dynamics. This funding opportunity aims to target a gap in the scientific knowledge of neural circuit function related to mental health disorders. Researchers should target specific questions suited to invasive recording modalities that have high translational potential. Development of new technologies and therapies is outside the scope of this FOA.
Substantial progress has been made in the development and testing of efficacious theory-based developmentally focused prevention interventions designed to address modifiable proximal risk and protective factors with the goal of having an impact on distal mental health outcomes, including suicide behaviors and the occurrence of serious mental illness. Pediatric-serving primary care (including obstetrics/gynecological for pregnancy and post-partum, pediatric care, family practice, adolescent medicine) is a health care setting that holds potential for the implementation of mental health prevention interventions because it offers broad access and is non-stigmatizing. In addition, there is the potential for prevention interventions found to be efficacious in the primary care setting to be endorsed by the United States Preventive Services Task Force (USPSTF) and covered under insurance.
Because pediatric primary care offers broad access and is non-stigmatizing, it may be an appropriate setting for reaching populations who experience mental health disparities, including racial/ethnic minority groups, sexual and gender minorities, individuals living in rural areas, socioeconomically disadvantaged persons, or any other subgroup with documented disparities in prevalence of mental illnesses, mental illness trajectories, access to prevention services, and quality and outcomes of mental health care. Accordingly, this Funding Opportunity Announcement (FOA) encourages studies that involve diverse populations, including groups that might experience health disparities, and as appropriate, it encourages examination of whether prevention services in primary care can potentially reduce or eliminate disparities.
Substantial progress has been made in the development and testing of efficacious theory-based developmentally focused prevention interventions designed to address modifiable proximal risk and protective factors with the goal of having an impact on distal mental health outcomes, including suicide behaviors and the occurrence of serious mental illness. Pediatric-serving primary care (including obstetrics/gynecological for pregnancy and post-partum, pediatric care, family practice, adolescent medicine) is a health care setting that holds potential for the implementation of mental health prevention interventions because it offers broad access and is non-stigmatizing. In addition, there is the potential for prevention interventions found to be efficacious in the primary care setting to be endorsed by the United States Prevention Services Task Force (USPSTF) and covered under insurance.
Because pediatric primary care offers broad access and is non-stigmatizing, it may be an appropriate setting for reaching populations who experience mental health disparities, including racial/ethnic minority groups, sexual and gender minorities, individuals living in rural areas, socioeconomically disadvantaged persons, or any other subgroup with documented disparities in prevalence of mental illnesses, mental illness trajectories, access to prevention services, and quality and outcomes of mental health care. Accordingly, this Funding Opportunity Announcement (FOA) encourages studies that involve diverse populations, including groups that might experience health disparities, and as appropriate, it encourages examination of whether prevention services in primary care can potentially reduce or eliminate disparities.
The purpose of this Funding Opportunity Announcement (FOA) is to invite applications to produce health services research that will rigorously test promising interventions aimed at improving communication and coordination during care transitions.
Purpose
This Funding Opportunity Announcement (FOA) invites R01 grant applications for funding health services research that improves the quality of care and patient outcomes during transitions of care. The purpose of this FOA is to support large-scale research projects that rigorously test promising interventions aimed at improving communication and coordination during care transitions.
Background
Transitions of care are the movements of patients between providers or clinical settings which typically occur when primary care providers refer patients to specialty care, or when patients are discharged from the hospital to subsequent care settings. During care transitions, critical information aimed to improve the patient's condition and health outcomes needs to be accurately communicated and coordinated between health professionals, the patient, and the family to ensure that safe, high-quality care is provided and care continuity is maintained.
This Funding Opportunity Announcement (FOA) supports pilot work in support of subsequent studies testing the effectiveness of strategies to deliver evidence-based mental health services, treatment interventions, and/or preventive interventions (EBPs) in low-resource mental health specialty and non- specialty settings within the United States. The FOA targets settings where EBPs are not currently delivered or delivered with fidelity, such that there are disparities in mental health and related functional outcomes (e.g., employment, educational attainment, stable housing, integration in the community, treatment of co-morbid substance use disorders, etc.) for the population(s) served. Implementation strategies should identify and use innovative approaches to remediate barriers to provision, receipt, and/or benefit from EBPs and generate new information about factors integral to achieving equity in mental health outcomes for under-served populations. Research generating new information about factors causing/reducing disparities is strongly encouraged, including due consideration for the needs of individuals across the life span.
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