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This CRISP 2.0 solicitation responds both to national needs on the resilience of critical infrastructures and to increasing NSF emphasis on transdisciplinary research. In this context, the solicitation is one element of the NSF-wide Risk and Resilience activity, with the overarching goal of advancing knowledge in support of improvement of the nation's infrastructure resilience. The devastating effects of recent disasters such as Hurricanes Harvey, Irma and Maria have underscored that a great deal remains to be done. In addition, CRISP 2.0 is aligned with the NSF-wide frontier thinking on convergence, characterized as "deep integration of knowledge, techniques, and expertise from multiple fields to form new and expanded frameworks for addressing scientific and societal challenges and opportunities".

The Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET) is conducting a Re-entry to Active Research (RARE) program to reengage, retrain, and broaden participation within the academic workforce. The primary objective of the RARE program is to catalyze the advancement along the academic tenure-track of highly meritorious individuals who are returning from a hiatus from active research. By providing re-entry points to active academic research, the RARE program will reinvest in the nation's most highly trained scientists and engineers, while broadening participation and increasing diversity of experience. A RARE research proposal must describe potentially transformative research that falls within the scope of participating CBET programs.

The Biological and Environmental Research (BER) of the SC, U.S. Department of Energy (DOE) hereby announces its interest in receiving applications to support fundamental research towards enabling new bioimaging capabilities for the study of plant and microbial systems relevant to bioenergy research. New imaging instrumentation is needed to observe and characterize multiple metabolic processes occurring within the living plant and microbial systems relevant to bioenergy and bioproduct production from renewable biomass. These processes include, but are not limited to real-time dynamic imaging of metabolic pathways, the transport of materials within and among cellular organelles including plant-root and organismal interactions, enzyme function and cellular structures. Of interest is the development of multimodal imaging devices constructed by merging new, innovative and/or transformational improvements to existing capabilities which will enable simultaneous observations in synergistic combination with correlated structural and/or chemical imaging to interpret biological function in and among whole microbial or plant cells.