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This mechanism supports basic research to increase knowledge/understanding through discovery and hypothesis generation, and should focus on providing basic fundamental knowledge that will inform and enable the future development of novel autonomous and/or robotic medical systems to care for wounded soldiers/patients through breakthrough, exploratory research. The objective is focused on addressing the following 1. Autonomous and Unmanned Medical Capability - Identify novel ideas, approaches and research towards the conceptualization of autonomous and unmanned technologies for next-generation, high-quality medical capabilities with limited or absent medical care personnel, or personnel with limited skills. Research novel concepts, plausible approaches and advanced concept designs using biologically inspired cognitive computing models, machine learning, artificial intelligence, soft robotic semi-autonomous/autonomous resuscitation concepts and advanced applications of information sciences among other innovative, exploratory research towards advancing the state-of-the-art in delivery of forward resuscitative care at the point of injury. 2. Medical Robotics Research - Identify novel ideas, approaches and research towards the conceptualization of medical robotics and real-time tele-presence capabilities exploring the limits of machine perception for tele-robotic semi-autonomous and autonomous trauma care within remote and dispersed geographic settings. This could include exploratory research in semi-autonomous robotic surgery to improve the safety profile and efficacy of tele-surgical procedures and outcomes using hard robotics in challenging situations (e.g., combat casualties on the multi-domain battlefield or mass casualty situations) and remote or austere geographic locations, among other innovative, exploratory research aims and novel concepts.

The LEAP HI program challenges the engineering research community to take a leadership role in addressing demanding, urgent, and consequential challenges for advancing America’s prosperity, health and infrastructure. LEAP HI proposals confront engineering problems that are too complex to yield to the efforts of a single investigator --- problems that require sustained and coordinated effort from interdisciplinary research teams, with goals that are not achievable through a series of smaller, short-term projects. LEAP HI projects perform fundamental research that may lead to disruptive technologies and methods, lay the foundation for new and strengthened industries, enable notable improvements in quality of life, or reimagine and revitalize the built environment. LEAP HI supports fundamental research projects involving collaborating investigators, of duration up to five years, with total budget between $1 million and $2 million. LEAP HI proposals must articulate a fundamental research problem with compelling intellectual challenge and significant societal impact, particularly on economic competitiveness, quality of life, public health, or essential infrastructure. One or more CMMI core topics must lie at the heart of the proposal, and integration of disciplinary expertise not typically engaged in CMMI-funded projects is encouraged. LEAP HI proposals must highlight engineering research in a leadership role. LEAP HI proposals must demonstrate the need for a sustained research effort by an integrated, interdisciplinary team, and should include aresearch integrationplan and timeline for research activities, with convincing mechanisms for frequent and effective communication.

This Funding Opportunity Announcement (FOA) is associated with the Beau Biden Cancer MoonshotSM Initiative that is intended to accelerate cancer research. The purpose of this FOA is to establish Centers of collaborating investigators with the goal of identifying and advancing research opportunities for translating immunotherapy concepts for children and adolescents with cancer toward clinical applications. Specifically, this FOA targets the following area designated as a scientific priority by the Blue Ribbon Panel (BRP): Recommendation (B) that calls for the establishment of a pediatric immunotherapy translational science network. The network was envisioned by the BRP as focusing on identifying new targets for immunotherapies, developing new pediatric immunotherapy treatment approaches (e.g., cancer vaccines, cellular therapy, combinations of immunotherapy agents, and others), and defining the biological mechanisms by which pediatric tumors evade the immune system. The Pediatric Immunotherapy Discovery and Development Network (PI-DDN) Centers will address and implement these BRP recommendations.

Research supported by the Division of Materials Research (DMR) focuses on advancing fundamental understanding of materials, materials discovery, design, synthesis, characterization, properties, and materials-related phenomena. DMR awards enable understanding of the electronic, atomic, and molecular structures, mechanisms, and processes that govern nanoscale to macroscale morphology and properties; manipulation and control of these properties; discovery of emerging phenomena of matter

The Science of Learning program supports potentially transformative basic research to advance the science of learning. The goals of the SL Program are to develop basic theoretical insights and fundamental knowledge about learning principles, processes and constraints. Projects that are integrative and/or interdisciplinary may be especially valuable in moving basic understanding of learning forward but research with a single discipline or methodology is also appropriate if it addresses basic scientific questions in learning. The possibility of developing connections between proposed research and specific scientific, technological, educational, and workforce challenges will be considered as valuable broader impacts, but are not necessarily central to the intellectual merit of proposed research. The program will support research addressing learning in a wide range of domains at one or more levels of analysis including: molecular/cellular mechanisms; brain systems; cognitive affective, and behavioral processes; and social/cultural influences. The program supports a variety of methods including: experiments, field studies, surveys, secondary-data analyses, and modeling.

This funding opportunity announcement (FOA) invites applications for P50 Research Center Grants for Specialized Programs of Research Excellence (SPOREs). The program will fund P50 SPORE grants to support state-of-the-art investigator-initiated translational research that will contribute to improved prevention, early detection, diagnosis, and treatment of an organ-specific cancer or a related group of cancers. For the purpose of this FOA, cancers derived from the same organ system (i.e., a group of organs that perform a common function) are considered related. Examples of such organ systems include gastrointestinal, endocrine and other biological systems. Other programmatically appropriate groups of cancers may include those centered around a common biological mechanism critical for promoting tumorigenesis and/or cancer progression in organ sites that belong to different organ systems. For example, a SPORE may focus on cancers caused by the same infectious agent or cancers sustained and promoted by dysregulation of a common signaling pathway. In addition, a SPORE may focus on cross-cutting themes such as pediatric cancers or cancer health disparities. The research supported through this program must be translational and must stem from research on human biology using cellular, molecular, structural, biochemical, and/or genetic experimental approaches. SPORE projects must have the goal of reaching a translational human endpoint within the project period of the grant.

The Engineering Design and Systems Engineering (EDSE) program supports fundamental research into the basic processes and phenomena of engineering design and systems engineering. The program seeks proposals leading to improved understanding about how processes, organizational structure, social interactions, strategic decision making, and other factors impact success in the planning and execution of engineering design and systems engineering projects. It also supports advances pertaining to engineering design and systems engineering in areas that include, but are not limited to, decision making under uncertainty, including preference and demand modeling; problem decomposition and decision delegation; applications of reverse game theory (mechanism design); computer-aided design; design representation; system performance modeling and prediction; design optimization; uncertainty quantification; domain- or concern-specific design methods; and advanced computational techniques for supporting effective human cognition, decision making, and collaboration. Competitive proposals for novel methods will include a plan to evaluate rigorously the effectiveness and performance of the proposed approach.

The Department of Defense (DoD) seeks innovative applications on mechanisms to implement Science, Technology, Engineering, and Mathematics (STEM) education, outreach, and/or workforce initiative programs, here onto will be referred as STEM activities. The Department intends to award multiple grants, subject to the availability of funds. Each individual award will be up to a maximum of $3,000,000, for a period of up to three (3) years. Applications for larger amounts may be considered on a case-by-case basis.

The COVID-19 pandemic has highlighted the need for improved environmental sensing of pathogens. Sensing SARS-CoV-2 virus in the air with high sensitivity and specificity could provide a new mechanism for public health monitoring, enabling safer conditions for a wide range of basic activities including work, travel, and school. SenSARS aims to identify SARS-CoV-2 signatures suitable for rapid indoor air monitoring and use these signatures to develop and demonstrate a technology readiness level (TRL) 4 prototype sensor.

Our goal is to bend the Keeling Curve. To that end, our team is looking for projects with a proven track record of taking greenhouse gases out of the atmosphere. We've developed five categories, each one addressing a specific sector of climate innovation. We award $25,000 to two projects in each category annually. Capture & Utilization -- Projects in this category are advancing technological and nature-based strategies for capturing and/or utilizing heat-trapping gases from the air or oceans. Energy -- Projects in this category decarbonize energy, support zero-carbon energy innovations, and lead the way in improving the supply, distribution, and access of low or zero-emissions energy systems worldwide. Finance -- Projects in this category are making financial mechanisms and economics work for greenhouse gas reduction and/or reversal ventures. Social & Cultural Pathways -- Projects in this category are changing the way people consider, understand, and act concerning human impacts on planet Earth. They are trying to answer the question: what does it take, socially and culturally, to develop beyond fossil fuels? Transport & Mobility -- Projects that apply in this category are reimagining and reinventing all types of vehicles, fuels, and mobility options for both people and products. These projects will confront the carbon footprint of the vehicles themselves and the routes traveled.

The NIAID Radiation/Nuclear Countermeasures Development Program supports extramural research to develop safe and effective radiological/nuclear medical countermeasures for clinical use under emergency situations. This program spans basic through applied research. The role of the endovascular network in radiation injury pathogenesis is not well understood; however, the importance of this biological system in the observed multi-organ dysfunction and failure that occurs following radiation exposure has recently been established. The purpose of the Funding Opportunity Announcement (FOA) is to provide an opportunity for academic, industry and government laboratory researchers to address gaps in the understanding of the pathophysiology of radiation injury in the vasculature, and how this damage contributes to overall mortality following radiation exposure. This funding will also advance the development of post-exposure treatment approaches targeting the vascular endothelium, with the ultimate goal of licensure of candidate medical countermeasures by the Food and Drug Administration (FDA) for the radiation/nuclear public health emergency indication.

The NIAID Radiation/Nuclear Countermeasures Development Program supports extramural research to develop safe and effective radiological/nuclear medical countermeasures for clinical use under emergency situations. This program spans basic through applied research. The role of the endovascular network in radiation injury pathogenesis is not well understood; however, the importance of this biological system in the observed multi-organ dysfunction and failure that occurs following radiation exposure has recently been established. The purpose of the Funding Opportunity Announcement (FOA) is to provide an opportunity for academic, industry and government laboratory researchers to address gaps in the understanding of the pathophysiology of radiation injury in the vasculature, and how this damage contributes to overall mortality following radiation exposure. This funding will also advance the development of post-exposure treatment approaches targeting the vascular endothelium, with the ultimate goal of licensure of candidate medical countermeasures by the Food and Drug Administration (FDA) for the radiation/nuclear public health emergency indication.

NineSigma, representing a major automotive manufacturer, seeks lightweight sound insulation, sound-absorbing, or vibration-damping material that is highly effective in the frequency band of 1,000 Hz or less. We welcome a wide range of proposals from academia to manufacturers which have development capabilities.

Every organization that intends to submit a proposal in response to ROSES-2018 must be registered with NSPIRES; organizations that intend to submit proposals via Grants.gov must be registered with Grants.gov, in addition to being registered with NSPIRES. Such registration must identify the authorized organizational representative(s) (AOR) who will submit the electronic proposal. All Principal Investigators (PIs) and other participants e.g., Co-Investigators (Co-Is) must be registered in NSPIRES regardless of the submission system. Potential proposers and proposing organizations are urged to access the system(s) well in advance of the proposal due date(s) of interest to familiarize themselves with its structure and to enter the requested information.

The NIH Blueprint for Neuroscience Research is a collaborative framework through which 14 NIH Institutes, Centers and Offices jointly support neuroscience-related research, with the aim of accelerating discoveries and reducing the burden of nervous system disorders. This Funding Opportunity Announcement (FOA) will solicit research projects to facilitate the development and translation of tools and technology for non-invasive imaging and profiling of human central nervous system (CNS, including retina) small blood and lymphatic vessels; to investigate their role in CNS physiology, disease, repair processes, and responses to therapy using novel approaches. Applications can be focused on the development of new technology and tools, novel target or biomarker identification and validation studies, or a combination of mechanistic and technology development studies specific to human CNS small blood and lymphatic vessels in health and disease, across the life span.

The Quantum Idea Incubator for Transformational Advances in Quantum Systems (QII - TAQS) program is designed to support interdisciplinary teams that will explore highly innovative, original, and potentially transformative ideas for developing and applying quantum science, quantum computing, and quantum engineering. Proposals with the potential to deliver new concepts, new platforms, and/or new approaches that will accelerate the science, computing, and engineering of quantum technologies are encouraged. Breakthroughs in quantum sensing, quantum communications, quantum simulations, or quantum computing systems are anticipated. This Quantum Idea Incubator solicitation aims to support the process of translating such ideas into reality. This solicitation calls for proposals focused on interdisciplinary research that includes elements from the following thrust areas: (i) fundamental science such as, but not limited to, physics, chemistry, materials science, mathematics, biology, or geoscience, as well as foundational concepts and techniques in quantum information science and engineering; (ii) communication, computation, and modeling; and (iii) devices and engineered systems. Proposals must articulate how the project leverages and/or promotes advances in knowledge in the selected thrust areas.

This FOA will support high-impact R&D for plastics by developing new plastics that are capable of efficient recyclability and improving recycling strategies that can break existing plastics into chemical building blocks that can be used to make higher-value products. DOE's Bioenergy Technologies Office (BETO) develops technologies that convert domestic biomass and waste resources into fuels, products, and power to enable affordable energy, economic growth, and innovation in renewable energy and chemicals production. DOE's Advanced Manufacturing Office (AMO) develops technologies that drive energy productivity improvements in the U.S. manufacturing sector, efficiently utilize abundant and available domestic energy resources, and support the manufacture of clean energy products with benefits extending across the economy. This Funding Opportunity Announcement (FOA) will support high-impact technology research and development (R&D) to enable the development of technologies that overcome the challenges associated with plastic waste. Topic Areas include: 1) Highly Recyclable or Biodegradable Plastics: develop new plastics that have improved performance attributes over a comparable existing plastic that can be cost-effectively recycled or biodegrade completely in the environment or in compost facilities. 2) Novel Methods for Deconstructing and Upcycling Existing Plastics: generate energy efficient recycling technologies (mechanical, chemical, or biological) that are capable of breaking plastic streams into intermediates which can be upgraded into higher value products. 3) BOTTLE Consortium Collaborations to Tackle Challenges in Plastic Waste: create collaborations with the Bio-Optimized Technologies to Keep Thermoplastics out of Landfills and the Environment (BOTTLE) Laboratory Consortium to further the long-term goals of the Consortium and the Plastics Innovation Challenge.