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The purpose of the Mentored Quantitative Research Career Development Award (K25) is to attract to NIH-relevant research those investigators whose quantitative science and engineering research has thus far not been focused primarily on questions of health and disease. The K25 award will provide support and "protected time" for a period of supervised study and research for productive professionals with quantitative (e.g., mathematics, statistics, economics, computer science, imaging science, informatics, physics, chemistry) and engineering backgrounds to integrate their expertise with NIH-relevant research. This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing to lead basic science experimental studies involving humans, referred to in NOT-OD-18-212 as prospective basic science studies involving human participants. These studies fall within the NIH definition of a clinical trial and also meet the definition of basic research. Types of studies that should submit under this FOA include studies that prospectively assign human participants to conditions (i.e., experimentally manipulate independent variables) and that assess biomedical or behavioral outcomes in humans for the purpose of understanding the fundamental aspects of phenomena without specific application towards processes or products in mind. Studies conducted with specific applications toward processes or products in mind should submit under the companion PA-18-395.

This FOA relates to one of the initiatives of the SPARC (Stimulating Peripheral Activity to Relieve Conditions) Common Fund program titled: Use of Existing Market-Approved Technology for New Market Indications. By establishing effective public-private partnerships, this SPARC initiative allows supported investigators to have access to existing neuromodulation technology to explore new indications. A number of device manufacturers have entered into partnership agreements with the NIH to make their neuromodulation technology, consisting of implantable devices with recording and/or stimulation capabilities, available to SPARC's supported clinical investigators (see Device Portal for a list of companies and available technologies). The specific goal of this FOA is to promote the pre-clinical development of these technologies, in support of a new market indication, towards enabling an Investigational Device Exemption (IDE) submission for a future pilot clinical study. Awarded projects of this FOA that fully reach their pre-clinical testing milestones will be eligible for further support, subject to a subsequent FOA, to conduct a pilot clinical study. The expectation is that these pilot clinical studies will provide the initial proof-of-principle demonstrations in humans that will motivate the additional studies needed in pursuing FDA approval as a labeled indication.

This FOA relates to one of the initiatives of the SPARC (Stimulating Peripheral Activity to Relieve Conditions) Common Fund program titled: Use of Existing Market-Approved Technology for New Market Indications. By establishing effective public-private partnerships, this SPARC initiative allows supported investigators to have access to existing neuromodulation technology to explore new indications. A number of device manufacturers have entered into partnership agreements with the NIH to make their neuromodulation technology, consisting of implantable devices with recording and/or stimulation capabilities, available to SPARC's supported clinical investigators (see Device Portal for a list of companies and available technologies). The specific goal of this FOA is to promote the pre-clinical development of these technologies, in support of a new market indication, towards enabling an Investigational Device Exemption (IDE) submission for a future pilot clinical study. Awarded projects of this FOA that fully reach their pre-clinical testing milestones will be eligible for further support, subject to a subsequent FOA, to conduct a pilot clinical study. The expectation is that these pilot clinical studies will provide the initial proof-of-principle demonstrations in humans that will motivate the additional studies needed in pursuing FDA approval as a labeled indication.

The purpose of this FOA is to solicit an application for the next 5-year cycle of the Midlife in the United States (MIDUS) Study, a National Longitudinal Study of Health and Well-being. The goals of this next phase are to complete the third wave of longitudinal data collection and enhance content in the area of daily stress; complete the second wave of data collection of clinical biomarkers and affective neuroscience assessments; continue innovative sub-studies such as how psychosocial influences affect gene expression and novel methods to track and reinstate non-responders; connect these content areas through innovative analyses to data on health, functioning, personality, cognitive status, affective functioning, economic well-being, social relationships, and well-being; and maintain and enhance data distribution and user support. A central goal of the MIDUS study is to support data dissemination, user support of public use files, and encourage data use broadly by the scientific community.

The NIH Blueprint for Neuroscience Research is a collaborative framework through which 14 NIH Institutes, Centers and Offices jointly support neuroscience-related research, with the aim of accelerating discoveries and reducing the burden of nervous system disorders. This Funding Opportunity Announcement (FOA) will solicit research projects focused on the development of new technology and tools, or novel mechanistic studies, or a combination of mechanistic and technology development studies specific to central nervous system (CNS, which includes retina) small blood and lymphatic vessels in health and disease, across the life span. The program aims at facilitating the development of tools and technology to image, profile and map CNS small blood and lymphatic vessels. Additional goals are to elucidate the mechanisms underlying CNS small blood and lymphatic vessels structural and functional heterogeneity, differential susceptibility to injury, role in disease and repair processes, and their responses to therapies. Preclinical studies using in vitro and/or animal models specific to CNS small blood and lymphatic vessels alone or in combination with pilot human studies are appropriate for this FOA.

The USAFA is seeking unclassified research white papers and proposals (if requested) that do not contain proprietary information. If proprietary information is submitted it is the offerors responsibility to mark the relevant portions of their proposal as specified in USAFA-PASCC-BAA-2016 Amendment 0001. The United States Air Force's Institute for National Security Studies (INSS), in partnership with PASCC, invites white papers and proposals (if requested) for studies in many broad areas related to countering the threat posed by weapons of mass destruction (WMD). The Defense Threat Reduction Agency (DTRA) has requested that USAF INSS/PASCC issue a call for papers soliciting white papers outlining studies or strategic dialogues (also referred to as Track 2 dialogues). WMD are defined as chemical, biological, radiological, and nuclear weapons. With this Fiscal Year 2019 (FY19) call for papers, USAF INSS announces to academia, research institutions, and non-profit organizations it is soliciting white paper for studies and strategic dialogues that will help enable the DoD and the USG to ensure nuclear deterrence and to prepare for and combat WMD and improvised threats. The white papers should propose rigorous, innovative projects that: 1. Facilitate critical engagement between U.S. and foreign subject-matter experts (SMEs) on key WMD, CWMD, or nuclear deterrence issues; 2. Address current and emerging challenges facing CCMDs and DoD; or 3. Expand knowledge or develop new concepts relevant to the national security missions and requirements of DoD and the Armed Services.

The U.S. Department of Energy, National Nuclear Security Administration (DOE/NNSA), Defense Nuclear Nonproliferation (DNN), Office of Nonproliferation and Arms Control (DNN NPAC) is soliciting applications for the program studies, training and outreach needs described herein. The mission of DNN NPAC is to prevent proliferation, ensure peaceful nuclear uses, and enable verifiable nuclear reductions. DNN NPAC provides a comprehensive approach to strengthen nonproliferation and arms control regimes, achieving its mission through four subprograms: International Nuclear Safeguards; Nuclear Export Controls; Nuclear Verification; and, Nonproliferation Policy in order to fulfill this responsibility. Among its many activities, DNN NPAC sponsors program studies, domestic and international training, and outreach addressing International Nuclear Safeguards; domestic and international training, outreach, and program studies addressing Nuclear Controls; and, program studies addressing Nuclear Verification and Nonproliferation Policy. To meet its mission, DNN NPAC applies the broad base of U.S. technical expertise including that of other government agencies, the DOE/NNSA National Laboratories, academia, nongovernmental organizations, and industry. This Funding Opportunity Announcement (FOA) solicits grant applications for full and open competition.

AFOSR is seeking proposals to provide independent, objective analysis of scientific and technical topics of relevance to the Air Force and national defense. The activity would include refining areas of interest provided by the Air Force into organized, rigorous studies concerning, for many scientific and technical fields, determining the state of the art, projecting trends, utilizing science and technologies for national defense purposes, and identifying promising or necessary areas of additional study. This announcement solicits proposals for up to five (5) years of performance and up to $25M of funding, dependent on the needs of the Air Force and the availability of funding. All proposals must be unclassified, but work under any award may be classified.

AFOSR is seeking proposals to provide independent, objective analysis of scientific and technical topics of relevance to the Air Force and national defense. The activity would include refining areas of interest provided by the Air Force into organized, rigorous studies concerning, for many scientific and technical fields, determining the state of the art, projecting trends, utilizing science and technologies for national defense purposes, and identifying promising or necessary areas of additional study. This announcement solicits proposals for up to five (5) years of performance and up to $25M of funding, dependent on the needs of the Air Force and the availability of funding. All proposals must be unclassified, but work under any award may be classified.

Founded in 1996, the Marsha Rivkin Center for Ovarian Cancer Research provides funding for multiple efforts, including funding for innovative research pilot studies, scholar grants to up-and-coming investigators to encourage careers in ovarian cancer research, conducting public early detection screening for ovarian cancer, and producing nationally and internationally attended research symposia on ovarian cancer. To that end, the center is accepting applications for pilot study projects in ovarian cancer research. Through the center's Pilot Study Program, approximately ten one-year $75,000 grants will be awarded to support investigator-initiated projects in all areas of ovarian cancer research. Projects designed to analyze data from already funded clinical trials also will be considered. Priority will be given to proposals that are innovative, multidisciplinary, likely to lead to submission of grant applications for independently funded investigations, and have translational research potential.

The Geophysics Program supports basic research in the physics of the solid earth to explore its composition, structure, and processes from the Earth's surface to its' deepest interior. Laboratory, field, theoretical, and computational studies are supported. Topics include (but are not limited to) seismicity, seismic wave propagation, and the nature and occurrence of geophysical hazards; the Earth's magnetic, gravity, and electrical fields; the Earth's thermal structure; and geodynamics. Supported research also includes geophysical studies of active deformation, including geodesy, and theoretical and experimental studies of the properties and behavior of Earth materials.

The FY17 JPC-1/MSIS TRANSfeR Award Program Announcement/Funding Opportunity is seeking research to determine whether the medical skill learned on a simulation system has a downstream beneficial effect to patients and/or the MHS in the real clinical world. The Program Announcement/Funding Opportunity seeks applications for research to demonstrate that simulation-based medical training has a measurable outcome on patient care. Previous T1 studies have shown improvement in skills in the simulated environment when deliberate practice and mastery learning (a set of group-based, individualized, learning strategies based on the belief that students will achieve a high level of understanding in a given area when given enough time) occur as part of training. The next set of studies should measure whether these same techniques translate to patient care and affect systems of care such as return-to-duty rates and morbidity and mortality statistics. Such research will involve taking the lessons learned in the laboratory and measuring outcomes in the patients who are cared for either in an operational environment or medical treatment facility. Historical patient outcome data does exist for the way medical professionals are trained now, so the variable being introduced in new studies would be simulation-based training.

This Funding Opportunity Announcement (FOA) is intended to provide rapid support to revolutionary applied energy research (Studies) that may lead to new ARPA-E programs to develop transformational and disruptive energy technologies. Studies are defined as single-phase efforts of durations less than 12 months and cost less than $500,000. Awards will be issued through Grants.

This Funding Opportunity Announcement (FOA) is intended to provide rapid support to revolutionary applied energy research (Studies) that may lead to new ARPA-E programs to develop transformational and disruptive energy technologies. Studies are defined as single-phase efforts of durations less than 12 months and cost less than $500,000. Awards will be issued through Grants.

The Chemistry of Life Processes (CLP) Program supports fundamental studies of biomolecules or biological systems at the interface of chemistry and biology. The primary contributions and innovations of the proposed research focus on the chemical aspects of the project. The Program supports studies that investigate how molecular structure, dynamics and interactions, as well as reaction thermodynamics and mechanisms are integrated with the chemistry performed by, or intrinsic to, the biological systems.

The Chemistry of Life Processes (CLP) Program supports fundamental studies of biomolecules or biological systems at the interface of chemistry and biology. The primary contributions and innovations of the proposed research focus on the chemical aspects of the project. The Program supports studies that investigate how molecular structure, dynamics and interactions, as well as reaction thermodynamics and mechanisms are integrated with the chemistry performed by, or intrinsic to, the biological systems.

The Macromolecular, Supramolecular and Nanochemistry (MSN) Program focuses on basic research that addresses fundamental questions regarding the chemistry of macromolecular, supramolecular and nanoscopic species and other organized structures and that advances chemistry knowledge in these areas.  Research of interest to this program will explore novel chemistry concepts in the following topics: (1) The development of novel synthetic approaches to clusters, nanoparticles, polymers, and supramolecular architectures; innovative surface functionalization methodologies; surface monolayer chemistry; and template-directed synthesis.  (2) The study of molecular-scale interactions that give rise to macromolecular, supramolecular or nanoparticulate self-assembly into discrete structures; and the study of chemical forces and dynamics that are responsible for spatial organization in discrete organic, inorganic, or hybrid systems (excluding extended solids).  (3) Investigations that utilize advanced experimental or computational methods to understand or to predict the chemical structure, unique chemical and physicochemical properties, and chemical reactivities that result from the organized or nanoscopic structures.  Research in which theory advances experiment and experiment advances theory synergistically is of special interest.

The Macromolecular, Supramolecular and Nanochemistry (MSN) Program focuses on basic research that addresses fundamental questions regarding the chemistry of macromolecular, supramolecular and nanoscopic species and other organized structures and that advances chemistry knowledge in these areas.  Research of interest to this program will explore novel chemistry concepts in the following topics: (1) The development of novel synthetic approaches to clusters, nanoparticles, polymers, and supramolecular architectures; innovative surface functionalization methodologies; surface monolayer chemistry; and template-directed synthesis.  (2) The study of molecular-scale interactions that give rise to macromolecular, supramolecular or nanoparticulate self-assembly into discrete structures; and the study of chemical forces and dynamics that are responsible for spatial organization in discrete organic, inorganic, or hybrid systems (excluding extended solids).  (3) Investigations that utilize advanced experimental or computational methods to understand or to predict the chemical structure, unique chemical and physicochemical properties, and chemical reactivities that result from the organized or nanoscopic structures.  Research in which theory advances experiment and experiment advances theory synergistically is of special interest.

This FOA invites applications for the Microphysiological Systems (MPS) for Disease Modeling and Efficacy Testing Program to develop highly reproducible and translatable in vitro models for preclinical efficacy studies through discovery and validation of translatable biomarkers, development of standardized methods for preclinical efficacy testing and definitive efficacy testing of candidate therapeutics using best practices and rigorous study design. An essential feature will be a multidisciplinary approach that brings together experts in bioengineering, microfluidics, material science, "omic" sciences, computational biology, disease biology, pathology, electrophysiology, pharmacology, biostatistics and clinical science.

This FOA invites applications for the Microphysiological Systems (MPS) for Disease Modeling and Efficacy Testing Program to develop highly reproducible and translatable in vitro models for preclinical efficacy studies through discovery and validation of translatable biomarkers, development of standardized methods for preclinical efficacy testing and definitive efficacy testing of candidate therapeutics using best practices and rigorous study design. An essential feature will be a multidisciplinary approach that brings together experts in bioengineering, microfluidics, material science, "omic" sciences, computational biology, disease biology, pathology, electrophysiology, pharmacology, biostatistics and clinical science.

Founded in 1996, the Marsha Rivkin Center for Ovarian Cancer Research supports public early detection screening for ovarian cancer, produces nationally and internationally attended research symposia, and provides funding for innovative ovarian cancer research and scholar grants to up-and-coming investigators. The center is accepting applications for pilot study projects in ovarian cancer research. Through the center's Pilot Study Program, approximately ten one-year grants of $75,000 will be awarded to support investigator-initiated projects in all areas of ovarian cancer research. Projects designed to analyze data from already funded clinical trials also will be considered. Priority will be given to proposals that are innovative, multi-disciplinary, and likely to lead to the submission of grant applications for independently funded investigations. Investigators at all levels are encouraged to apply.

 Current product-specific bioequivalence (BE) guidance published by the Office of Generic Drugs for dry powder inhalers (DPIs) include in vitro testing recommendations for single actuation content and aerodynamic particle size distribution, as well as recommendations for a pharmacokinetic study and a pharmacodynamic or clinical endpoint study.  Given the extensive nature of current DPI BE guidance, it is desirable that current in vitro testing for DPIs be more reflective of in vivo performance.  Computational fluid dynamics (CFD) and discrete element modeling (DEM) have been used to predict dry powder aerosol behavior, including the effects of agglomeration and deagglomeration.  The purpose of the study will be to develop a CFD-DEM model which can be used to evaluate the impact of various physicochemical properties and device performance properties on regional deposition, to identify potentially biorelevant ranges for these properties that may be useful for future BE recommendations.   

The PRMRP Investigator-Initiated Research Award (IIRA) is intended to support studies that will make an important contribution toward research and/or patient care for a disease or condition related to at least one of the FY19 PRMRP Topic Areas. The rationale for a research idea may be derived from a laboratory discovery, population-based studies, a clinician's first-hand knowledge of patients, or anecdotal data. Applications must include relevant data that support the rationale for the proposed study. These data may be unpublished or from the published literature

Mine Drainage Technology Initiative (MDTI) study provides a forum for collaboration and information exchange with the following goals: Mine Drainage Technology Initiative (MDTI) (formally known as the Acid Mine Drainage Initiative ) studies provide a forum for collaboration and information exchange with the following goals: (1) Develop an understanding of mine drainage (MD) so as to better predict, avoid, monitor, and remediate mine drainage; (2) Develop innovative solutions to MD water-quality problems; (3) Identify, evaluate, and develop "best science" practices to predict MD prior to mining; and (4) Identify successful remediation practices for existing sources of MD and describe the best technology for MD prevention. OSMRE is looking for MDTI studies that address the specific goals listed above that have the potential for improving the effectiveness of both the coal industry and the regulatory authority to conducts surface coal mining and reclamation activities and regulate coal mining activities, respectively, by gaining a better understanding of mine drainage effects on the environment.

The purpose of this FOA is to invite applications that investigate aspects of lymphatic vessel physiology, development and pathophysiology related to health and diseases of the digestive system. Studies to understand the factors that control local lymphatic vessel functional anatomy and physiology and development during health or disease in this system and its organs, and the mechanisms by which alterations of lymphatic vessel function affect organ function, are of interest. However, studies with the major focus on immune mechanisms, role of lymphatics in cancer metastasis and study of lymphatic vessels in organs other than those from the digestive system will not be considered responsive.

This announcement solicits applications for two (2) separate competitions, HRSA-17-013 Autism Field-Initiated Innovative Research Studies and HRSA-17-014 Autism Longitudinal Data Project.  The purpose of the Autism Field-Initiated Innovative Research Studies and the Autism Longitudinal Data Project competitions are to support the conduct of empirical research that advances the evidence base on interventions to improve the health and wellbeing of children and adolescents with autism spectrum disorders (ASD), with a special focus on addressing the needs of underserved populations.  These competitions will address the critical need that exists for research on the barriers to screening, diagnosis, and receipt of evidence-based interventions.