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The nasal mucosa offers an effective target for inhaled drugs that either treat localized nasal conditions or quickly deliver drugs to the systemic circulation [1-3]. While nasal spray drug product designs can vary considerably between innovators, most sprays are formulated as either a homogeneous solution or a heterogeneous suspension; in the latter case, solid drug particles are dispersed within a carrier liquid [4]. Despite the many advancements in nasal drug delivery, effectively administering drugs via this route still poses many challenges. One of the main challenges relates to mucociliary motion, which tends to transport and clear drug particles from the nasal cavity after deposition, limiting the available time for drug absorption at the intended site of action [5-8].Many previous nasal spray models have considered solution formulations, where the active drug is already dissolved into a carrier liquid [9-11]

The program is focused on multidisciplinary research efforts where more than one traditional discipline interacts to provide rapid advances in scientific areas of interest to the DoD. As defined in the DoD Financial Management Regulation: Basic research is systematic study directed toward greater knowledge or understanding of the fundamental aspects of phenomena and of observable facts without specific applications towards processes or products in mind. It includes all scientific study and experimentation directed toward increasing fundamental knowledge and understanding in those fields of the physical, engineering, environmental, and life sciences related to long-term national security needs.

The purpose of this funding opportunity announcement (FOA) is to support non-commercial lab-to-user dissemination of novel, reliable imaging and bioengineering technologies, including devices, software, methods, chemical agents, etc. Proposed technologies should have been prototyped, validated, and are potentially highly impactful to the research community. However, their beyond-the-lab dissemination via commercialization or industry partnership is not anticipated. Projects should focus on transforming functioning prototypes to usable tools and delivering them to end users for high-quality research in a reliable manner. Related activities may include, but are not limited to, quality control, scale-up production, user training, and technical improvements that are within the scope of the prototyped technology and limited to applying proven techniques or existing resources. Projects that involve clinical trials, commercialization, academic-industry partnership, or service using existing equipment are not responsive to this FOA.

The illicit sale of fentanyl, fentanyl analogues, and other synthetic drugs is incredibly profitable, and their high potency in small quantities presents a low risk to traffickers. To respond to this challenge, the U.S. government's understanding of the production, transit, and sale of these drugs and their precursor chemicals must continually increase. We will support a data analytics provider that can produce reliable information to inform our future capacity building programming efforts to combat transnational organized crime. The combination of technology and investigative research on transnational criminal organizations has various potential applications, such as building partner capacity by giving countries leads on various transnational criminal networks, identifying target cells before problems infiltrate neighboring areas, using network overviews for strategy information, and providing training on a limited basis.

This Funding Opportunity Announcement (FOA) supports the research and development of key early-stage technical challenges for fuel cells and for hydrogen fuel production, delivery and storage, and will leverage the private sector to address institutional barriers that impact progress in the field. The goal of this research activity is to provide affordable, clean, safe, and reliable energy from diverse domestic resources, providing the benefits of increased energy security and reduced emissions through early-stage research and development. The global fuel cell market increased its growth 40% in 2016, with revenues of over $1.6 billion in 2016 and over 20,000 fuel cell units for material handling equipment purchased in the U.S. alone since 2009. Light duty vehicles are an emerging application for fuel cells that has earned substantial commercial and government interest worldwide due to the superior efficiencies, reductions in petroleum consumption, and reductions in criteria pollutants fuel cells make possible.

Analytic investigations are studies that increase DTRA's knowledge or understanding of emerging WMD threats and how DTRA might anticipate and counter them. The WMD threat spectrum includes: nuclear, radiological, biological, chemical and high-yield explosive (HE) weapons (including improvised threats); their up-stream acquisition, RDT&E and production; their storage, deployment and final disposition; strategic and tactical delivery systems, command and control; and their weapon effects if used.

Field corn production makes incredible contributions to human nutrition as a primary source of feed for cattle, hogs, and poultry; to cleaner air and reduced greenhouse gases as the source of ethanol fuel; and to the economy.

The Chemical Oceanography Program supports research into the chemical components, reaction mechanisms, and geochemical pathways within the ocean and at its interfaces with the solid earth and the atmosphere. Major emphases include:  studies of material inputs to and outputs from marine waters; orthochemical and biological production and transformation of chemical compounds and phases within the marine system; and the determination of reaction rates and study of equilibria. The Program encourages research into the chemistry, distribution, and fate of inorganic and organic substances introduced into or produced within marine environments including those from estuarine waters to the deep sea.

The mission of the Alternatives Research & Development Foundation is to fund and promote the development, validation, and adoption of non-animal methods in biomedical research, product testing, and education. To advance this mission, the foundation is soliciting proposals for its Annual Open Grant Program, which supports research projects aimed at developing methods to replace or reduce the use of animals in science. Expert reviewers will evaluate proposals based on scientific merit and feasibility, as well as the potential to reduce or replace the use of animals in science in the near future. Proposals are considered in the areas of research, testing, and/or education.

The mission of BTO is to foster, demonstrate, and transition breakthrough fundamental research, discoveries, and applications that integrate biology, engineering, computer science, mathematics, and the physical sciences. BTO's investment portfolio goes far beyond life sciences applications in medicine to include areas of research such as human-machine interfaces, microbes as production platforms, and deep exploration of the impact of evolving ecologies and environments on U.S. readiness and capabilities. BTO's programs operate across a wide range of scales, from individual cells to the warfighter to global ecosystems. BTO responds to the urgent and long-term needs of the Department of Defense (DoD) and addresses national security priorities.

Request for Information - Upgrading Carbon Derived from Methane Pyrolysis This is a Request for Information (RFI) only. This RFI is not accepting application for financial assistance. The purpose of this RFI is solely to solicit input for ARPA-E consideration to inform the possible formulation of future programs. The Advanced Research Projects Agency -Energy (ARPA-E) in the US Department of Energy is seeking information concerning technologies to produce hydrogen and elemental carbon from the thermal decomposition of methane (also known as methane pyrolysis, methane cracking, or methane splitting). Recognizing that the value of the carbon product would be a key factor in the economic feasibility of such processes, ARPA-E seeks input from experts in the fields of materials science (including advanced carbon fiber synthesis), process engineering, methane pyrolysis, plasma chemistry, and chemical engineering regarding potential mechanisms for the bulk conversion of carbon materials, specifically from less valuable forms (e.g. amorphous carbon) or mixtures, to more valuable single allotropes or controlled mixtures of high-value carbon structures. Consistent with the agency's mission, ARPA-E is seeking insights on clearly disruptive, novel technologies for such conversions, early in the R&D cycle, and not integration strategies for existing technologies. The information you provide may be used by ARPA-E in support of program planning.

The Process Systems, Reaction Engineering and Molecular Thermodynamics program is part of the Chemical Process Systems cluster, which also includes: 1) the Catalysis program; 2) the Electrochemical Systems program; and 3) the Interfacial Engineering program. The goal of the Process Systems, Reaction Engineering and Molecular Thermodynamics program is to advance fundamental engineering research on the rates and mechanisms of chemical reactions, systems engineering and molecular thermodynamics as they relate to the design and optimization of chemical reactors and the production of specialized materials that have important impacts on society. The program supports the development of advanced optimization and control algorithms for chemical processes, molecular and multi-scale modeling of complex chemical systems, fundamental studies on molecular thermodynamics, and the integration of this information into the design of complex chemical reactors. An important area supported by the program focuses on the development of energy-efficient and environmentally-friendly chemical processes and materials. Proposals should focus on: · Chemical reaction engineering: This area encompasses the interaction of transport phenomena and kinetics in reactive systems and the use of this knowledge in the design of complex chemical reactors. Focus areas include novel reactor designs, such as catalytic and membrane reactors, micro-reactors, and atomic layer deposition systems; studies of reactions in supercritical fluids; novel activation techniques, such as plasmas, acoustics, and microwaves; design of multifunctional systems, such as "chemical-factory/lab-on-a-chip" concepts; and biomass conversion to fuels and chemicals. The program also supports new approaches that enable the design of modular chemical manufacturing systems.

The National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET), seeks proposals that elucidate mechanisms of, and develop strategies to, direct the differentiation of undifferentiated cells into mature, functional cells or organoids. Projects responsive to this solicitation must aim to establish a robust and reproducible set of differentiation design rules, predictive models, real-time sensing, control, and quality assurance methods, and integrate them into a workable differentiation strategy. They must develop a fundamental understanding of how cells develop, including mechanisms, molecular machinery, dynamics, and cell-cell interactions, and use this understanding to manipulate cells purposefully. Investigators can choose any undifferentiated cell type, from any animal species, as a starting point and choose any appropriate functional product (cell, organoid, etc.) with real-world relevance. This solicitation parallels NSF's investment in Understanding the Rules of Life (URoL): Predicting Phenotype, NSF's Big Idea focused on predicting the set of observable characteristics (phenotype) of an organism based on its genetic makeup and the nature of its environment and applies it to understanding and accomplishing the intentional and guided differentiation of an undifferentiated cell into cells, organoids or tissues with predetermined activities and functions.

Asstated intheStrategy for American Leadership in Advanced Manufacturing,worldwide competition in manufacturing has been dominated in recent decades by the maturation, commoditization, and widespread application of computation in production equipment and logistics, effectively leveling the global technological playing field and putting a premium on low wages and incremental technical improvements.[1] The next generation of technological competition in manufacturing will be dictated by inventions of new materials, chemicals, devices, systems, processes, machines, design and work methods, social structures and business practices. Fundamental research will be required in robotics, artificial intelligence, biotechnology, materials science, sustainability, education and public policy, and workforce development to take the lead in this global competition. The research supported under this solicitationwillenhance U.S. leadership in manufacturing far into the future by providing new capabilitiesfor established companies andentrepreneurs,improving ourhealth and quality of life,andreducingthe impact of manufacturing industries on the environment.

With this solicitation, NIJ seeks proposals for basic or applied research and development projects. An NIJ forensic science research and development grant supports a discrete, specified, circumscribed project that will: (1) increase the body of knowledge to guide and inform forensic science policy and practice, or (2) lead to the production of useful material(s), device(s), system(s), or method(s) that have the potential for forensic application. The intent of this program is to direct the findings of basic scientific research; research and development in broader scientific fields applicable to forensic science; and ongoing forensic science research toward the development of highly-discriminating, accurate, reliable, cost-effective, and rapid methods for the identification, analysis, and interpretation of physical evidence for criminal justice purposes. Projects should address the challenges and needs of the forensic science community. The operational needs discussed at NIJ's FY 2016 Forensic Science TWG meeting may be found on NIJ.gov. Additional research needs of the forensic science community can be found at the Organization of Scientific Area Committees website. While the goals and deliverables of proposed projects do not necessarily need to result in immediate solutions to the posted challenges or needs, they should speak to them and produce knowledge that adds to work towards eventual resolutions.

The National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET), seeks proposals that elucidate mechanisms of, and develop strategies to, direct the differentiation of undifferentiated cells into mature, functional cells or organoids. Projects responsive to this solicitation must aim to establish a robust and reproducible set of differentiation design rules, predictive models, real-time sensing, control, and quality assurance methods, and integrate them into a workable differentiation strategy. They must develop a fundamental understanding of how cells develop, including mechanisms, molecular machinery, dynamics, and cell-cell interactions, and use this understanding to manipulate cells purposefully. Investigators can choose any undifferentiated cell type, from any animal species, as a starting point and choose any appropriate functional product (cell, organoid, etc.) with real-world relevance.This solicitation parallels NSF's investment inUnderstanding the Rules of Life (URoL): Predicting Phenotype, NSF's Big Idea focused on predicting the set of observable characteristics (phenotype) of an organism based on its genetic makeup and the nature of its environment and applies it to understanding and accomplishing the intentional and guided differentiation of an undifferentiated cell into cells, organoids or tissues with predetermined activities and functions.

This Funding Opportunity Announcement (FOA) encourages Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to further the development of Advanced Technology Training (ATT) products for the health and safety training of hazardous materials (HAZMAT) workers; skilled support personnel; emergency responders in biosafety response, infectious disease training and cleanup; emergency responders in disasters and resiliency training; and for ATT tools to assist in research into the acute and long-term health effects of environmental disasters. ATT as defined by the Worker Training Program (WTP) includes, but is not limited to, online training, virtual reality, and serious gaming, which complement all aspects of training from development to evaluation including advance technologies that enhance, supplement, improve, and provide health and safety training for hazardous materials workers

Research Grants: Research grants are available to established scientists of all ages working at accredited institutions in the United States. Applications will be judged on the scientific merit and the innovative aspects of the proposal as well as on the competence of the applicant. Grants-in-Aid: The Grants-in-Aid program is designed for researchers at the assistant professor level who experience difficulty in competing for research funds because they have not yet become firmly established. Grants-in-Aid can also be made to senior scientists. All applications will be judged on the scientific merit and innovative aspects of the proposal, as well as on past performance and evidence of the applicant's continued productivity. Grants-in-Aid are awarded for a one-year period and do not exceed $30,000.

The Joint Program Executive Office for Chemical and Biological Defense (JPEO-CBD) is organized into five Joint Project Management Offices (JPMO), each responsible for specific commodity areas. General information on the JPEO-CBD and subordinate JPMOs can be obtained from the JPEO-CBD website at http://www.jpeocbd.osd.mil/. The medical CBRN countermeasures developed by the Joint Project Manager Medical Countermeasure Systems (JPM MCS) office directly support the current, near-term, and far-term challenges by providing the capability to prevent, diagnose and treat the effects of chemical, radiological and biological warfare agents. Mission areas and technical points of contact for the product management offices within the JPM MCS are shown in Section VII of this BAA. Proposals are sought from all eligible sources as specified herein, including educational institutions, nonprofit organizations, and private industry. This Broad Agency Announcement (BAA) provides general information, proposal preparation instructions, evaluation and selection criteria, and award administration.

NineSigma, representing a Top Global Personal Hygiene Company, invites proposals for technologies to reduce or neutralize odors caused by menses and/or blood in disposable personal care products.