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NineSigma, representing a global consumer products multi-national invites proposals for chemical, biological or mechanical solutions to remove the waxy organic layers from plant materials.

NineSigma, representing a Fortune 500 Packaged Foods Company, seeks proposals for plant proteins and protein combinations that deliver on nutrition, clean taste, and functionality for beverage and baked snacks applications. The goal is to use plant proteins in new applications. The sponsor seeks to understand the protein chemistry and the contributing factors to negative sensory attributes (e.g., off flavors, bad aftertaste, texture) with the aim to improve overall product acceptability.

Hazards SEES seeks research projects that will productively cross the boundaries of the atmospheric and geospace, earth, and ocean sciences; computer and information science (including cyberinfrastructure); engineering; mathematics and statistics; and social, economic, and behavioral sciences. Successful proposals will integrate across multiple disciplines to promote research that advances new paradigms that contribute to creating a society resilient to hazards.

For Fiscal Year 2015, the Advanced Energy Systems (AES) Program will solicit proposals under this Funding Opportunity Announcement for support of the Gasification Systems technology area. There will be a total of two Areas of Interest. The AES Program is pursuing research and development to (1) accelerate in-situ bio-gasification of coal seams with a goal of creating methane at a lower cost than typical U.S. natural gas recovery systems; and (2) produce oxygen for use in coal gasification processes at a significantly lower cost than that of the commercial state of the art technology.

The Chemical Oceanography Program supports research into the chemical components, reaction mechanisms, and geochemical pathways within the ocean and at its interfaces with the solid earth and the atmosphere. Major emphases include:  studies of material inputs to and outputs from marine waters; orthochemical and biological production and transformation of chemical compounds and phases within the marine system; and the determination of reaction rates and study of equilibria. The Program encourages research into the chemistry, distribution, and fate of inorganic and organic substances introduced into or produced within marine environments including those from estuarine waters to the deep sea.

The purpose of the Mentored Quantitative Research Career Development Award (K25) is to attract to NIH-relevant research those investigators whose quantitative science and engineering research has thus far not been focused primarily on questions of health and disease. The K25 award will provide support and protected time for a period of supervised study and research for productive professionals with quantitative (e.g., mathematics, statistics, economics, computer science, imaging science, informatics, physics, chemistry) and engineering backgrounds to integrate their expertise with NIH-relevant research. 

The Chemical Oceanography Program supports research into the chemical components, reaction mechanisms, and geochemical pathways within the ocean and at its interfaces with the solid earth and the atmosphere. Major emphases include: studies of material inputs to and outputs from marine waters; orthochemical and biological production and transformation of chemical compounds and phases within the marine system; and the determination of reaction rates and study of equilibria. The Program encourages research into the chemistry, distribution, and fate of inorganic and organic substances introduced into or produced within marine environments including those from estuarine waters to the deep sea.

The National Science Foundation (NSF) seeks to develop and nurture a national innovation ecosystem that builds upon research to guide the output of scientific discoveries closer to the development of technologies, products and processes that benefit society.

The American Society for Radiation Oncology is accepting applications for its 2019 Minority Summer Fellowship Award. The annual program is designed to introduce medical students from backgrounds that are underrepresented in medicine to the discipline of radiation oncology early in their medical education. Although medical students in all years are encouraged to apply, preference will be given to first- and second-year students. In an effort to promote radiation oncology as a career choice, the fellowship will expose medical students to clinical, basic, and translational research questions in radiation oncology. The fellowship provides each student with a $4,500 package that includes a $3,500 stipend for the eight-week training program (exceptions can be made for a longer program but will need to be approved by ASTRO's Committee on Health Equity, Diversity and Inclusion, or "CHEDI") and $1,000 toward the cost of travel to the organization's 2019 annual meeting. To be eligible, applicants must be enrolled in a United States medical school and be able to identify a mentor with a successful record of research productivity. The mentor should be an ASTRO member. In addition, research must be undertaken at a North American institution during the summer of 2019.

This Funding Opportunity Announcement (FOA) encourages applications for Countermeasures Against Chemical Threats (CounterACT) Cooperative Agreement (U01) Research Projects for research on the identification of small molecule or biologic lead compounds that are excellent candidates for therapeutic development. The mission of the CounterACT program is to foster and support research and development of new and improved therapeutics for chemical threats. Chemical threats are toxic chemicals that could be used in a terrorist attack or accidentally released from industrial production, storage or shipping. They include traditional chemical warfare agents, toxic industrial chemicals, pharmaceutical-based agents, and pesticides. The scope of research supported by this FOA includes confirmation of molecular targets for therapeutic development, demonstration of in vitro activity of candidate therapeutics, preliminary in vivo proof-of-concept efficacy data, preliminary adsorption, distribution, metabolism, excretion, and toxicity (ADME/Tox) evaluations and pharmacokinetics/pharmacodynamics (PK/PD) data. These studies should result in the identification of at least one lead compound ready for optimization. Lead compounds are biologically active and synthetically feasible compounds where specificity, affinity, potency, target selectivity, efficacy, and safety have been established. Lead compounds should be ready for more advanced development under possible support from other programs such as the one described in the companion FOA "CounterACT Optimization of Therapeutic Lead Compound (U01)" (PAR-18-NNN). The scope of this FOA encompasses Technical Readiness Level (TRL) 1-3 - see TRLs. Each project must include annual milestones that create discrete go or no-go decision points in a progressive translational study plan.

As defined by the DoD, basic research is "systematic study directed toward greater knowledge or understanding of the fundamental aspects of phenomena and of observable facts without specific applications towards processes or products in mind. It includes all scientific study and experimentation directed toward increasing fundamental knowledge and understanding in those fields of the physical, engineering, environmental, and life sciences related to long-term national security needs. It is farsighted high payoff research that provides the basis for technological progress." (DoD 7000.14-R, vol. 2B, chap. 5, para. 050105.B) The DoD's basic research program invests broadly in many scientific fields to ensure that it has early cognizance of new scientific knowledge.

The objective of this Funding Opportunity Announcement (FOA) is to support the development of new and innovative multipurpose prevention technologies (MPT) with rheological/biophysical properties and product user perceptions compatible with current long-acting reversible contraceptive (LARC) strategies (look, feel, effectiveness, safety and duration of action) for the dual purpose of preventing pregnancy and HIV infection in women. MPTs proposed for development must be dual indication and prevent pregnancy and HIV infection and have drug delivery systems (DDS) capable with sustained/extended release of both drugs. MPTs proposed for development must use a licensed contraceptive. This FOA requires an industry partner, milestones linked to Go/No Go decisions and year 5 funding requires submission of a pre-IND application to the FDA.

The Epilepsy Foundation has announced its seventh annual epilepsy "Shark Tank" competition for the most innovative ideas in epilepsy and seizure treatment and care. Selected finalists will receive international recognition and compete for grants totaling $150,000 to support the development and commercialization of important new products, technologies, or therapeutic concepts. As many as six finalists will be selected to present at the 2018 Epilepsy Pipeline Conference (San Francisco, February 22-23, 2018). Each presenter will have five minutes to present the concept, followed by five minutes of questioning. The event will feature live voting among audience members and a panel of judges (Sharks) representative of industry, advocacy, investors, and the research and medical communities. The winning project(s) deemed to be the most innovative will be announced at the conclusion of the competition. To be eligible, applicants must demonstrate an ability to move the proposed plan to completion, showing how the prize can accelerate any step along the path to market. Inventors who submitted ideas in previous Shark Tank competitions are encouraged to re-submit their ideas if substantial progress has been made.

The When Everyone Survives Foundation was founded to advance cures and treatment for leukemia through support for innovative research. To that end, the foundation has issued its 2018 Request for Proposals for leukemia research. One-year grants of up to $50,000 will be awarded in support of innovative laboratory, translational, or clinical research related to acute leukemia. Renewal of initial research support may be considered for one or more additional years based on productivity. New and established investigators are eligible to apply.

This Funding Opportunity Announcement invites applications to establish NINR P30 Center of Excellence. The purpose of the NINR P30 Centers of Excellence is to support shared resources and facilities for categorical research by a number of scientists who focus on a common research problem. The core grant is integrated with the center's component projects or program projects, though funded independently from them. This support, by providing more accessible resources, is expected to assure a greater productivity than from the separate projects and program projects.

The Air Force Office of Scientific Research "we, us, our, or AFOSR" manages the basic research investment for the U.S. Air Force. As a part of the Air Force Research Laboratory (AFRL), our technical experts discover, shape, and champion research within the Air Force Research Laboratory, universities, and industry laboratories to ensure the transition of research results to support U.S. Air Force needs. Using a carefully balanced research portfolio, our research managers seek to foster revolutionary scientific breakthroughs enabling the Air Force and U.S. industry to produce world-class, militarily significant, and commercially valuable products. Our focus is on research areas that offer significant and comprehensive benefits to our national warfighting and peacekeeping capabilities. These areas are organized and managed in two scientific Branches:  Engineering and Information Sciences (RTA) Physical and Biological Sciences (RTB)

The purpose of this Funding Opportunity Announcement (FOA) is to provide opportunities for eligible small business concerns (SBCs) to submit STTR grant applications to develop interactive digital media science, technology, engineering and mathematics (STEM) resources that address student career choice and health and medicine topics for: (1) pre-kindergarten to grade 12 (P-12) students and pre- and in-service teachers ("Teachers") or (2) Informal science education (ISE), i.e., outside the classroom, audiences. Interactive digital media (IDM) are defined as products and services on digital computer-based systems which respond to the user's actions by presenting content such as text, moving image, animation, video, audio, and video games. There is a large body of evidence that IDM technology has the potential to support learning in a variety of contexts from primary and secondary schools, to universities, adult education and workplace training. IDM is widely used to train, educate, and encourage behavioral changes in a virtual world format where progressive learning, feedback on success and user control are combined into an interactive and engaging experience. It is anticipated that this STTR FOA will facilitate the translation of new or existing health and medicine-based, P-12 STEM curricula and museum exhibits into educational Interactive Digital Media STEM (IDM STEM) resources that will provide a hands-on, inquiry-based and learning-by-doing experience for students, teachers and the community.

This Funding Opportunity Announcement (FOA) encourages applications for Countermeasures Against Chemical Threats (CounterACT) exploratory/developmental translational research (R21). The mission of the CounterACT program is to foster and support research and development of new and improved therapeutics to mitigate the health effects of chemical threats. Chemical threats are toxic chemicals that could be used in a terrorist attack or accidentally released from industrial production, storage or shipping. They include traditional chemical warfare agents, toxic industrial chemicals, pesticides, and pharmaceutical-based agents. The scope of the research includes basic toxicological research on the chemical threat for the purpose of target and therapeutic hit identification, hit validation, lead optimization, and demonstration of in vivo ADME/Tox and efficacy. Projects supported by this FOA are expected to generate preliminary data that would facilitate the development of competitive applications for more extensive support from the NIH CounterACT Cooperative Agreement programs or other related initiatives.

This Funding Opportunity Announcement (FOA) encourages applications for Countermeasures Against Chemical Threats (CounterACT) Research Centers of Excellence (U54s). The mission of the CounterACT program is to foster and support research and development of new and improved therapeutics for chemical threats. Chemical threats are toxic chemicals that could be used in a terrorist attack or accidentally released from industrial production, storage or shipping. They include traditional chemical warfare agents, toxic industrial chemicals, pharmaceutical-based agents, and pesticides. The scope of the research includes target and candidate identification and characterization, through candidate optimization and demonstration of in vivo efficacy consistent with the product's intended use in humans. For applicants submitting U54 renewal applications, research under this FOA should culminate in an optimized lead compound ready for advanced development. The Centers will contain at least three research projects supported by an administrative core, up to three optional scientific cores, and a research education core. Each research project must include milestones that create discrete go or no-go decision points in a progressive translational study plan.

This Funding Opportunity Announcement (FOA) encourages applications for Countermeasures against Chemical Threats (CounterACT) Research Centers of Excellence (U54s). The mission of the CounterACT program is to foster and support research and development of new and improved therapeutics for chemical threats. Chemical threats are toxic chemicals that could be used in a terrorist attack or accidentally released from industrial production, storage or shipping. They include traditional chemical warfare agents, toxic industrial chemicals, pharmaceutical-based agents, and pesticides. The scope of the research includes target and candidate identification and characterization, through candidate optimization and demonstration of in vivo efficacy consistent with the product's intended use in humans. For applicants submitting U54 renewal applications, research under this FOA should culminate in an optimized lead compound ready for advanced development. The Centers will contain at least three research projects supported by an administrative core, up to three optional scientific cores, and a research education core. Each research project must include milestones that create discrete go or no-go decision points in a progressive translational study plan.