This program will investigate the base of the Selawik River basin aquatic food web, and link it to the anticipated increase in terrestrial inputs of carbon and nitrogen to the aquatic ecosystem as a result of climate change. The main objectives are: 1) assess the quality and quantity of terrestrial dissolved organic carbon (DOC), organic and inorganic nitrogen, and phosphorus released with increased soil thaw depth during spring and early summer, and its entry to the aquatic ecosystem; 2) quantify change in aquatic microbial, mainly bacterial, respiration and production rates with change in DOC quality and quantity; and 3) examine how change in terrestrial DOC and nitrogen inputs to the aquatic ecosystem might alter the rate of phytoplankton primary production, the community composition, and energy (lipid) content.
Cell-based therapies, especially immune cells, have the potential to revolutionize human healthcare in various different contexts, including cancer and personalized medicine. For example, CAR (Chimeric antigen receptor) T-cell therapy for cancer requires modification, in vitro culture and expansion of human T-cells. Manufacturing of therapeutic cells as the end product presents major engineering challenges. New therapies and cell-based products depend critically on the development of robust, reliable and reproducible biomanufacturing technologies.
GSK is seeking rapid, point of care analytical tests for gene therapy products that can go from sample to result within 2 hours
Tests should work with human cells at a concentration of 1x106 - 1x108 cells per mL in growth media. They should characterize / quantify the populations of cell immunophenotypes in the sample.
Lab tests are welcome. GSK would be especially interested in analytical techniques that could be carried out at or close to the patient's bedside.
Stora Enso, a leading manufacturer of renewable products, is seeking approaches that enable the regeneration of periodate from iodate, consumed in one of their production processes.
OBJECTIVE: This is an AF Special Topic partnership, please see the above AF Special Topic instructions for further details. A Phase I award will be completed over 3 months with a maximum award of $25K and a Phase II may be awarded for a maximum period of 12 months
DESCRIPTION: Academia is producing disruptive science and technology innovations at an increasingly rapid pace. Hence, rather than utilizing a pre-defined requirements approach, this topic is intended to be an open call for ideas and technologies that may not be currently listed (i.e. the unknown-unknown) under STTR topics, but nonetheless still fit within broad interest areas of the Air Force basic research level. These broad areas (Engineering and Complex Systems, Information and Networks, Physical Sciences, and Chemistry/Biological Sciences) are covered in greater detail at wpafb.af.mil/Welcome/Fact-Sheets/Display/Article/842026.
To be eligible, offeror(s) must be teams that have formed companies and partnered with a university (e.g. university entrepreneurship centers, university technology transfer offices).
The offeror should demonstrate their technical capability by demonstrating a credible and high-potential minimum viable product (MVP) along with a credible plan for developing the prototype to a commercially available solution. This topic is not looking for fully formed products, and it is acceptable if the solutions are earlier stage.
A large amount of the research and development of post-combustion carbon capture technology focuses on three main technologies: adsorption, absorption and membranes. Each of these technologies have energy and techno-economic advantages and disadvantages. However, an optimal process may involve the integration of multiple technologies into a single, hybrid, transformative process that is more economical and energy efficient. The challenge of developing this type of process is the integration of rigorous process sub-models into a single framework, where hybrid designs can be evaluated and optimized. The National Energy Technology Laboratory (NETL) has significant expertise in the development of rigorous process models and modeling for the advancement and acceleration of the commercialization of carbon capture process systems. A large part of the effort is the Carbon Capture Simulation Initiative (CCSI). The computational tools and multi-scale modeling techniques comprising the CCSI Toolset can be broadly applied for the development of a wide variety of technologies well beyond carbon capture including chemicals production, petroleum refining, natural gas processing and biofuel production.
Background A large amount of the research and development of post-combustion carbon capture technology focuses on three main technologies: adsorption, absorption and membranes. Each of these technologies have energy and techno-economic advantages and disadvantages. However, an optimal process may involve the integration of multiple technologies into a single, hybrid, transformative process that is more economical and energy efficient. The challenge of developing this type of process is the integration of rigorous process sub-models into a single framework, where hybrid designs can be evaluated and optimized. The National Energy Technology Laboratory (NETL) has significant expertise in the development of rigorous process models and modeling for the advancement and acceleration of the commercialization of carbon capture process systems. A large part of the effort is the Carbon Capture Simulation Initiative (CCSI) [Reference 1]. The computational tools and multi-scale modeling techniques comprising the CCSI Toolset can be broadly applied for the development of a wide variety of technologies well beyond carbon capture including chemicals production, petroleum refining, natural gas processing and biofuel production.
1. Lithium-ion Battery Safety. Safety concerns continue to hamper full adoption of lithium-ion batteries for defense systems, despite significant research investments by the government and the private sector. This Defense initiative will advance promising lithium-ion battery safety technologies at university research laboratories into early laboratory prototypes and potentially minimum viable products for adoption by the defense and commercial sectors via early startups, small businesses and non-traditional defense contractors. Specific technical areas of interest include, but are not limited to, the following: improved electrolytes; stable high-energy anodes and cathodes; cell components and structures that enhance safety and reliability (e.g. use of electrode coatings and electrolyte additives); safety optimization through battery and battery module design and packaging; and battery management and state of health techniques that prevent and/or mitigate catastrophic failure. 2. Electrical Grid Reliability, Resiliency and Security. Both the defense and commercial sectors recognize the ever-growing criticality to enhance electrical grid reliability, resiliency and security through innovation at the component and system levels. This Defense initiative will advance relevant electrical grid innovations at university research laboratories into early laboratory prototypes and potentially minimum viable products for adoption by the defense and commercial sectors via early startups, small businesses and non-traditional defense contractors. Specific technical areas of interest include, but are not limited to, the following: advanced electrical power generation, transmission and distribution hardware and software; physical cyber secured industrial controls hardware and software; effective control of microgrids supporting high-dynamic loads; electrical grid protocols and controls to maintain secured operations of critical infrastructure under adverse conditions; hardening of e
This Funding Opportunity Announcement (FOA) encourages Small Business Innovative Research (SBIR) grant applications from small business concerns (SBCs) to address problems associated with the methods of collection, bioassay, isolation, purification, de-replication, yield, and supply that hamper the full utilization of natural products.
This Funding Opportunity Announcement (FOA) encourages Small Business Technology Transfer (STTR) grant applications from small business concerns (SBCs) to address problems associated with the methods of collection, bioassay, isolation, purification, de-replication, yield, and supply that hamper the full utilization of natural products.
The goal of the Environmental Engineering program is to support transformative research which applies scientific and engineering principles to avoid or minimize solid, liquid, and gaseous discharges, resulting from human activities on land, inland and coastal waters, and air, while promoting resource and energy conservation and recovery. The program also fosters cutting-edge scientific research for identifying, evaluating, and monitoring the waste assimilative capacity of the natural environment and for removing or reducing contaminants from polluted air, water, and soils. Any proposal investigating sensors, materials or devices that does not integrate these products with an environmental engineering activity or area of research may be returned without review.
The goal of the Environmental Engineering program is to support transformative research which applies scientific and engineering principles to avoid or minimize solid, liquid, and gaseous discharges, resulting from human activities on land, inland and coastal waters, and air, while promoting resource and energy conservation and recovery. The program also fosters cutting-edge scientific research for identifying, evaluating, and monitoring the waste assimilative capacity of the natural environment and for removing or reducing contaminants from polluted air, water, and soils. Any proposal investigating sensors, materials or devices that does not integrate these products with an environmental engineering activity or area of research may be returned without review.
The Centers of Excellence in Genomic Science (CEGS) program establishes academic Centers for advanced genome research. Each CEGS grant supports a multi-investigator, interdisciplinary team to develop innovative genomic approaches to address a particular biomedical problem. A CEGS project will address a critical issue in genomic science or genomic medicine, proposing a solution that would be a very substantial advance. Thus, the research conducted at these Centers will entail substantial risk, balanced by outstanding scientific and management plans and very high potential payoff. A CEGS will focus on the development of novel technological or computational methods for the production or analysis of comprehensive data sets, or on a particular genome-scale biomedical problem, or on other ways to develop and use genomic approaches for understanding biological systems and/or significantly furthering the application of genomic knowledge, data and methods towards clinical applications. Exploiting its outstanding scientific plan and team, each CEGS will nurture genomic science at its institution by facilitating the interaction of investigators from different disciplines, and by providing training to new and experienced investigators, it will expand the pool of highly-qualified professional genomics scientists and engineers.
The Centers of Excellence in Genomic Science (CEGS) program establishes academic Centers for advanced genome research. Each CEGS grant supports a multi-investigator, interdisciplinary team to develop innovative genomic approaches to address a particular biomedical problem. A CEGS project will address a critical issue in genomic science or genomic medicine, proposing a solution that would be a very substantial advance. Thus, the research conducted at these Centers will entail substantial risk, balanced by outstanding scientific and management plans and very high potential payoff. A CEGS will focus on the development of novel technological or computational methods for the production or analysis of comprehensive data sets, or on a particular genome-scale biomedical problem, or on other ways to develop and use genomic approaches for understanding biological systems and/or significantly furthering the application of genomic knowledge, data and methods towards clinical applications. Exploiting its outstanding scientific plan and team, each CEGS will nurture genomic science at its institution by facilitating the interaction of investigators from different disciplines, and by providing training to new and experienced investigators, it will expand the pool of highly-qualified professional genomics scientists and engineers.
The goal of the Process Systems, Reaction Engineering and Molecular Thermodynamics (PRM) program is to advance fundamental engineering research on the rates and mechanisms of important classes of catalyzed and uncatalyzed chemical reactions as they relate to the design, production, and application of catalysts, chemical processes, biochemical processes, and specialized materials that have important impacts on society. The program seeks to advance electrochemical and photochemical processes of engineering significance or with commercial potential, design and optimization of complex chemical and biochemical processes, thermodynamic modeling and experiments that relate molecular dynamics to macroscopic properties and behavior, dynamic modeling and control of process systems and individual process units, reactive processing of polymers/ceramics/thin films, and interactions between chemical reactions and transport processes in reactive systems, for the integration of this information into the design of complex chemical and biochemical reactors. A substantial focus of the PRM program is to impact the chemical manufacturing enterprise by funding projects aimed at zero emissions and environmentally-friendly, smart manufacturing using sustainable materials. Areas that focus on reactors of all types (fuel cells, batteries, microreactors, biochemical reactors, etc.), reactor design in general, and design and control of all systems associated with energy from renewable sources have a high priority for funding
The goal of the Process Systems, Reaction Engineering and Molecular Thermodynamics (PRM) program is to advance fundamental engineering research on the rates and mechanisms of important classes of catalyzed and uncatalyzed chemical reactions as they relate to the design, production, and application of catalysts, chemical processes, biochemical processes, and specialized materials that have important impacts on society. The program seeks to advance electrochemical and photochemical processes of engineering significance or with commercial potential, design and optimization of complex chemical and biochemical processes, thermodynamic modeling and experiments that relate molecular dynamics to macroscopic properties and behavior, dynamic modeling and control of process systems and individual process units, reactive processing of polymers/ceramics/thin films, and interactions between chemical reactions and transport processes in reactive systems, for the integration of this information into the design of complex chemical and biochemical reactors. A substantial focus of the PRM program is to impact the chemical manufacturing enterprise by funding projects aimed at zero emissions and environmentally-friendly, smart manufacturing using sustainable materials. Areas that focus on reactors of all types (fuel cells, batteries, microreactors, biochemical reactors, etc.), reactor design in general, and design and control of all systems associated with energy from renewable sources have a high priority for funding
The goal of the Process Systems, Reaction Engineering and Molecular Thermodynamics (PRM) program is to advance fundamental engineering research on the rates and mechanisms of important classes of catalyzed and uncatalyzed chemical reactions as they relate to the design, production, and application of catalysts, chemical processes, biochemical processes, and specialized materials that have important impacts on society. The program seeks to advance electrochemical and photochemical processes of engineering significance or with commercial potential, design and optimization of complex chemical and biochemical processes, thermodynamic modeling and experiments that relate molecular dynamics to macroscopic properties and behavior, dynamic modeling and control of process systems and individual process units, reactive processing of polymers/ceramics/thin films, and interactions between chemical reactions and transport processes in reactive systems, for the integration of this information into the design of complex chemical and biochemical reactors. A substantial focus of the PRM program is to impact the chemical manufacturing enterprise by funding projects aimed at zero emissions and environmentally-friendly, smart manufacturing using sustainable materials. Areas that focus on reactors of all types (fuel cells, batteries, microreactors, biochemical reactors, etc.), reactor design in general, and design and control of all systems associated with energy from renewable sources have a high priority for funding.
The goal of the Process Systems, Reaction Engineering and Molecular Thermodynamics (PRM) program is to advance fundamental engineering research on the rates and mechanisms of important classes of catalyzed and uncatalyzed chemical reactions as they relate to the design, production, and application of catalysts, chemical processes, biochemical processes, and specialized materials that have important impacts on society. The program seeks to advance electrochemical and photochemical processes of engineering significance or with commercial potential, design and optimization of complex chemical and biochemical processes, thermodynamic modeling and experiments that relate molecular dynamics to macroscopic properties and behavior, dynamic modeling and control of process systems and individual process units, reactive processing of polymers/ceramics/thin films, and interactions between chemical reactions and transport processes in reactive systems, for the integration of this information into the design of complex chemical and biochemical reactors. A substantial focus of the PRM program is to impact the chemical manufacturing enterprise by funding projects aimed at zero emissions and environmentally-friendly, smart manufacturing using sustainable materials. Areas that focus on reactors of all types (fuel cells, batteries, microreactors, biochemical reactors, etc.), reactor design in general, and design and control of all systems associated with energy from renewable sources have a high priority for funding.
The Common Fund Program - Accelerating Translation of Glycoscience: Integration and Accessibility - aims to develop accessible and affordable new tools and technologies for studying carbohydrates that will allow biomedical researchers to significantly advance our understanding of the roles of these complex molecules in health and disease. This program will enable investigators who might not otherwise conduct research in the glycosciences, to undertake the study of carbohydrate structure and function.
In support of these aims, this FOA seeks applications for a community-driven project to develop computational and informatics tools for the manipulation, analysis, interpretation, and integration of glycoscience data. The product of this research will be accessible resources for analysis of carbohydrate and glycoconjugate structural, analytical, and interaction data, and integration of that information within the context of comparable gene, protein, and lipid data and databases.
The Common Fund Program - Accelerating Translation of Glycoscience: Integration and Accessibility - aims to develop accessible and affordable new tools and technologies for studying carbohydrates that will allow biomedical researchers to significantly advance our understanding of the roles of these complex molecules in health and disease. This program will enable investigators who might not otherwise conduct research in the glycosciences, to undertake the study of carbohydrate structure and function.
In support of these aims, this FOA seeks applications for a community-driven project to develop computational and informatics tools for the manipulation, analysis, interpretation, and integration of glycoscience data. The product of this research will be accessible resources for analysis of carbohydrate and glycoconjugate structural, analytical, and interaction data, and integration of that information within the context of comparable gene, protein, and lipid data and databases.
The goal of the Process Systems, Reaction Engineering and Molecular Thermodynamics (PRM) program is to advance fundamental engineering research on the rates and mechanisms of important classes of catalyzed and uncatalyzed chemical reactions as they relate to the design, production, and application of catalysts, chemical processes, biochemical processes, and specialized materials that have important impacts on society. The program seeks to advance electrochemical and photochemical processes of engineering significance or with commercial potential, design and optimization of complex chemical and biochemical processes, thermodynamic modeling and experiments that relate molecular dynamics to macroscopic properties and behavior, dynamic modeling and control of process systems and individual process units, reactive processing of polymers/ceramics/thin films, and interactions between chemical reactions and transport processes in reactive systems, for the integration of this information into the design of complex chemical and biochemical reactors. A substantial focus of the PRM program is to impact the chemical manufacturing enterprise by funding projects aimed at zero emissions and environmentally-friendly, smart manufacturing using sustainable materials. Areas that focus on reactors of all types (fuel cells, batteries, microreactors, biochemical reactors, etc.), reactor design in general, and design and control of all systems associated with energy from renewable sources have a high priority for funding
The goal of the Process Systems, Reaction Engineering and Molecular Thermodynamics (PRM) program is to advance fundamental engineering research on the rates and mechanisms of important classes of catalyzed and uncatalyzed chemical reactions as they relate to the design, production, and application of catalysts, chemical processes, biochemical processes, and specialized materials that have important impacts on society. The program seeks to advance electrochemical and photochemical processes of engineering significance or with commercial potential, design and optimization of complex chemical and biochemical processes, thermodynamic modeling and experiments that relate molecular dynamics to macroscopic properties and behavior, dynamic modeling and control of process systems and individual process units, reactive processing of polymers/ceramics/thin films, and interactions between chemical reactions and transport processes in reactive systems, for the integration of this information into the design of complex chemical and biochemical reactors. A substantial focus of the PRM program is to impact the chemical manufacturing enterprise by funding projects aimed at zero emissions and environmentally-friendly, smart manufacturing using sustainable materials. Areas that focus on reactors of all types (fuel cells, batteries, microreactors, biochemical reactors, etc.), reactor design in general, and design and control of all systems associated with energy from renewable sources have a high priority for funding
NIJ is seeking investigator-initiated proposals to conduct research that examines criminal justice tools, protocols, and policies concerning drug trafficking, markets and use, and the effects of drug legalization and decriminalization on law enforcement, applicable to State, tribal and local jurisdictions. Proposals must address one of two criminal justice activities: drug intelligence and community surveillance, or criminal investigation and prosecution. In addition, NIJ has identified three drug research priorities: Marijuana and cannabis products; Heroin and other opioids (including diverted prescription drugs); and Novel psychoactive substances (also known as synthetic drugs).
NIJ is seeking investigator-initiated proposals to conduct research that examines criminal justice tools, protocols, and policies concerning drug trafficking, markets and use, and the effects of drug legalization and decriminalization on law enforcement, applicable to State, tribal and local jurisdictions. Proposals must address one of two criminal justice activities: drug intelligence and community surveillance, or criminal investigation and prosecution. In addition, NIJ has identified three drug research priorities: Marijuana and cannabis products; Heroin and other opioids (including diverted prescription drugs); and Novel psychoactive substances (also known as synthetic drugs).
The International Research Network Connections (IRNC) program supports high-performance network connectivity required by international science and engineering research and education collaborations involving the NSF research community. NSF expects to make 1-2 awards to link U.S. research networks with peer networks in Europe and Africa and leverage existing international network connectivity. High-performance network connections funded by this program are intended to support science and engineering research and education applications, and preference will be given to solutions that provide the best economy of scale and demonstrate the ability to support the largest communities of interest with the broadest services. Funded projects will assist the U.S. research and education community by enabling state-of-the-art international network services and access to increased collaboration and data services. Through extended international network connections, additional research and production network services will be enabled, complementing those currently offered or planned by domestic research networks.
The International Research Network Connections (IRNC) program supports high-performance network connectivity required by international science and engineering research and education collaborations involving the NSF research community. NSF expects to make 1-2 awards to link U.S. research networks with peer networks in Europe and Africa and leverage existing international network connectivity. High-performance network connections funded by this program are intended to support science and engineering research and education applications, and preference will be given to solutions that provide the best economy of scale and demonstrate the ability to support the largest communities of interest with the broadest services. Funded projects will assist the U.S. research and education community by enabling state-of-the-art international network services and access to increased collaboration and data services. Through extended international network connections, additional research and production network services will be enabled, complementing those currently offered or planned by domestic research networks.
The objectives of this research are to use simulated data from three or more national parks to econometrically estimate a production function where fuels and preparedness budgets are used to improve the value of the landscape. The landscape value is improved through fuel treatments aimed at hazardous fuel reductions and ecosystem improvement. It is also improved by preparedness through loss mitigation of fire affected values and by introducing fire in areas that promote ecosystem health. This research will, for the first time, quantify how the two programs (fuels and preparedness) interact to mutually improve the value of the landscape and associated natural and human resources. The second objective is to locate current programs on the econometrically derived value-added surface and to also identify how to manage increasing or declining budgets.
EPA's Office of Pesticide Programs (OPP), in coordination with the EPA Regional Offices, announces the availability of approximately $506,000 for FY13 to further, through research, development, monitoring, public education, training, demonstrations, or studies, the adoption of Integrated Pest Management (IPM) approaches to reduce pesticide risk in production agriculture settings in the United States. IPM is a sustainable approach to managing pests by combining biological, cultural, physical, and chemical tools in a way that minimizes economic, health, and environmental risks.
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