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Shell is a leading oil and gas producer in the deepwater Gulf of Mexico, a recognized pioneer in oil and gas exploration and production technology and one of America's leading oil and natural gas producers, gasoline and natural gas marketers and petrochemical manufacturers. Focus on energy awareness with special publics, increasing interest in technical careers among students and professional development in science and math among educators. We support K-12 programs that boost math and science skills, as well as university programs that aid engineering and geoscience students and departments. Shell funds projects at vocational and technical schools where chemical and refinery operators and technicians are trained. We are especially interested in supporting educational outreach in math, science and technology to women/minority students and academic institutions with ethnically diverse enrollments. Focus on biodiversity initiatives with support to programs that restore critical ecosystems, address water, air quality research, preserve wetlands and sponsor wetlands initiatives. As part of our commitment to environmental stewardship, we support projects that restore and protect critical ecosystems. In addition to restoration and preservation efforts, we fund research projects for threatened wildlife and/or habitats.

The goal of the Particulate and Multiphase Processes (PMP) program is to support fundamental research on physico-chemical phenomena that govern particulate and multiphase systems, including flow of suspensions, drops and bubbles, granular and granular-fluid flows, behavior of micro- and nanostructured fluids, and self-assembly/directed-assembly processes that involve particulates. The program encourages transformative research to improve our basic understanding of particulate and multiphase processes with emphasis on research that demonstrates how particle-scale phenomena affect the behavior and dynamics of larger-scale systems. Although proposed research should focus on fundamentals, a clear vision is required that anticipates how results could benefit important applications in advanced manufacturing, energy harvesting, transport in biological systems, biotechnology, or environmental sustainability. Collaborative and interdisciplinary proposals are encouraged, especially those that involve a combination of experiment with theory or modeling.

The MoM program supports fundamental research in interdisciplinary solid mechanics.  Emphasis is placed on fundamental understanding that i) advances theory, experimental, and/or computational methods in MoM, and/or ii) uses contemporary MoM methods to address modern challenges in material and device mechanics and physics. Proposed research can focus on existing or emerging material systems across time and length scales; especially of interest are contemporary materials including complex solids, phononic/elastic metamaterials, soft materials, and active materials.  Research is welcome in emerging areas of multiscale methods, nanomechanics, manufacturing mechanics, and areas that incorporate fundamental understanding of physics and chemistry into the continuum-level understanding of solids.

Fundamental research topics of interest in SusChEM include the replacement of rare, expensive, and/or toxic chemicals/materials with earth-abundant, inexpensive, and benign chemicals/materials; recycling of chemicals/materials that cannot be replaced; development of non-petroleum based sources of important raw materials; the elimination of waste products and enhancement in efficiencies of chemical reactions and processes; discovery of new separation science that will facilitate recycling and production of valuable chemicals/materials; and development and characterization of low cost, sustainable and scalable-manufactured materials with improved properties.

NineSigma, representing a Global Manufacturer, invites proposals for materials, coatings, chemicals or additives that will clearly identify where a surface has been in contact with or otherwise disrupted by external sources.

Examples of fundamental research topics of interest in SusChEM include the replacement of rare, expensive, and/or toxic chemicals/materials with earth-abundant, inexpensive, and benign chemicals/materials; recycling of chemicals/materials that cannot be replaced; development of non-petroleum based sources of important raw materials; chemicals/materials for food and/or water sustainability; the elimination of waste products and enhancement in efficiencies of chemical reactions and processes; discovery of new separation science that will facilitate recycling and production of valuable chemicals/materials; and development and characterization of low cost, sustainable and scalable-manufactured materials with improved properties.

The Small Business Innovation Research (SBIR) Program stimulates technological innovation in the private sector by strengthening the role of small business concerns in meeting Federal research and development needs, increasing the commercial application of federally supported research results, and fostering and encouraging participation by socially and economically disadvantaged and women-owned small businesses. The topics, listed below, are detailed on the SBIR/STTR topics homepage: Educational Technologies and Applications (EA) Information and Communication Technologies (IC) Semiconductors (S) and Photonic (PH) Devices and Materials Electronic Hardware, Robotics and Wireless Technologies (EW) Advanced Manufacturing and Nanotechnology (MN) Advanced Materials and Instrumentation (MI) Chemical and Environmental Technologies (CT) Biological Technologies (BT) Smart Health (SH) and Biomedical (BM) Technologies

To continue making safe and effective topical semisolid drug products available to the American public, it is essential that FDA's regulatory science, as well as best practices in the pharmaceutical industry, are informed by the most current understanding of the product quality attributes that are potentially critical to the therapeutic performance of topical semisolid dosage forms. The scope of this project is to characterize all measurable physical/chemical qualities of different dosage forms of semisolid topical drug products, identify appropriate methodologies for measuring each of these quality attributes, characterize formulation and manufacturing parameters that alter the arrangement of matter in the dosage form as measured by specific quality attributes, and utilize in vitro and/or in vivo measures of product performance to correlate variations in critical quality attributes with a failure mode for a drug product.  

Cell-based therapies, especially immune cells, have the potential to revolutionize human healthcare in various different contexts, including cancer and personalized medicine. For example, CAR (Chimeric antigen receptor) T-cell therapy for cancer requires modification, in vitro culture and expansion of human T-cells.   Manufacturing of therapeutic cells as the end product presents major engineering challenges.  New therapies and cell-based products depend critically on the development of robust, reliable and reproducible biomanufacturing technologies.

NineSigma, representing a major material manufacturer, seeks partners to develop a switchable dimming film that changes from a natural black (dark gray) color to transparency. We particularly expect technologies that enable the active modulation of black color and transparency. An elemental technology or film formation technology are also welcomed.

NineSigma, representing a global chemical manufacturer, is seeking Thermoplastic elastomer highly miscible with Nylon6 for excellent low temperature durability. The anticipated application of the elastomer is mixed into Nylon6 and realize film yielding excellent durability at low temperature.

A global automobile parts manufacturer, a client of NineSigma, believes credible air cleaning technology is key to comfortable automobile experience; particularly deodorization and sterilization technology will become increasingly important. The Client has promoted research and development on their own, however they now face a challenge to find a suitable solution to ensure both deodorization/sterilization and safety in a short time. Given that technological development of such air cleaning is done globally, the Client decided to find a partner to further accelerate the development speed, which lead to this offering.

This Funding Opportunity Announcement (FOA) encourages applications for Countermeasures Against Chemical Threats (CounterACT) Cooperative Agreement (U01) Research Projects for research on the optimization of small molecule or biologic compounds that are excellent candidates for therapeutic development. The mission of the CounterACT Program is to foster and support research and development of new and improved therapeutics for chemical threats. Chemical threats are toxic chemicals that could be used in a terrorist attack or accidentally released from industrial production, storage or shipping. They include traditional chemical warfare agents, toxic industrial chemicals, pharmaceutical-based agents, and pesticides. A previously identified lead compound is required to be eligible for this funding opportunity. In this regard, lead compounds are defined as biologically active compounds or hits where affinity, potency, target selectivity, and preliminary safety have been established. The scope of research supported by this FOA includes development of appropriate human-relevant animal models and generation of in vivo efficacy data consistent with the intended use of the product in humans. It also includes bioanalytical assay development and validation, laboratory-scale and scaleable manufacturing of the product, and non-GLP toxicity and pharmacology studies. The scope of this FOA encompasses Technical Readiness Levels (TRLs) 4-5 - see TRLs. Each project must include annual milestones that create discrete go or no-go decision points in a progressive translational study plan.

Predictive Science is potentially applicable to a variety of fields, including nuclear weapons, efficient manufacturing, biological systems, nanoscale material science, organic chemical processes, climate modeling, etc. Success in these simulations requires both software and algorithmic frameworks for integrating multiple disciplines into a single application and adding significant disciplinary strength and depth to make that integration effective. Applications should conduct computer science research in areas that will contribute to the advancement of Exascale computing technologies and demonstrate the results in the context of the chosen application. The FOA contains topics that are of particular interest to the NNSA National Laboratories as they move towards Exascale computing. Other topics that will enable the advancements in Exascale computing are encouraged as well. More details are contained in the FOA.

NineSigma, representing SEIKAGAKU CORPORATION (http://www.seikagaku.co.jp/english/index.html  ), seeks a potential partner to expand medical applications of fermented chondroitin (FCH) and chemically sulfated fermented chondroitin (s-FCH) manufactured by the client.

The Divisions of Chemical, Bioengineering and Environmental Transport (CBET) and Civil, Mechanical, and Manufacturing Infrastructure (CMMI) in the Engineering Directorate of the National Science Foundation (NSF) are partnering with The Center for the Advancement of Science in Space (CASIS) to solicit research projects in the general fields of tissue engineering and mechanobiology that can utilize the International Space Station (ISS) National Lab to conduct research that will benefit life on Earth. U.S. entities including academic investigators, non-profit independent research laboratories and academic-commercial teams are eligible to apply.

Although invention and proof-of-concept testing of new technologies are a key component of the BRAIN Initiative, to achieve their potential these technologies must also be optimized through feedback from end-users in the context of the intended experimental use. This seeks applications for the optimization of existing and emerging technologies and approaches that have potential to address major challenges associated with recording and manipulating neural activity, at or near cellular resolution, at multiple spatial and temporal scales, in any region and throughout the entire depth of the brain. This FOA is intended for the iterative refinement of emergent technologies and approaches that have already demonstrated their transformative potential through initial proof-of-concept testing, and are appropriate for accelerated development of hardware and software while scaling manufacturing techniques towards sustainable, broad dissemination and user-friendly incorporation into regular neuroscience practice. Proposed technologies should be compatible with experiments in behaving animals, and should include advancements that enable or reduce major barriers to hypothesis-driven experiments. Technologies may engage diverse types of signaling beyond neuronal electrical activity for large-scale analysis, and may utilize any modality such as optical, electrical, magnetic, acoustic or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. Applications are expected to integrate appropriate domains of expertise, including where appropriate biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.

Description: The Communications, Circuits, and Sensing-Systems (CCSS) Program supports innovative research in circuit and system hardware and signal processing techniques. CCSS also supports system and network architectures for communications and sensing to enable the next-generation cyber-physical systems (CPS) that leverage computation, communication, and sensing integrated with physical domains. CCSS invests in micro- and nano-electromechanical systems (MEMS/NEMS), physical, chemical, and biological sensing systems, neurotechnologies, and communication & sensing circuits and systems. The goal is to create new complex and hybrid systems ranging from nano- to macro-scale with innovative engineering principles and solutions for a variety of applications including but not limited to healthcare, medicine, environmental and biological monitoring, communications, disaster mitigation, homeland security, intelligent transportation, manufacturing, energy, and smart buildings. CCSS encourages research proposals based on emerging technologies and applications for communications and sensing such as high-speed communications of terabits per second and beyond, sensing and imaging covering microwave to terahertz frequencies, personalized health monitoring and assistance, secured wireless connectivity and sensing for the Internet of Things, and dynamic-data-enabled autonomous systems through real-time sensing and learning.

The purpose of this Request for Information is to seek information from power generation equipment manufacturers, utilities, power plant architect-engineers, and other stakeholders that can be used as input to a Department of Energy Fossil Energy Research and Development program that will culminate in the design, construction, and operation of a coal-based pilot-scale power plant by 2025. The coal-based pilot plant will be used as the basis for scaling up to a commercial offering that is highly efficient (40 percent or greater higher heating value), modular (unit sizes of approximately 50 to 350 MW), and economical for both international and domestic power generation. The pilot plant and commercial offering does not have to capture and store carbon dioxide, but must be carbon capture ready. This is solely a request for information and is not a Funding Opportunity Announcement. U.S. Department of Energy is not accepting applications to this Request for Information.

Stora Enso, a leading manufacturer of renewable products, is seeking approaches that enable the regeneration of periodate from iodate, consumed in one of their production processes.