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Naval Surface Warfare Center (NSWC) Crane and the Office of the Undersecretary of Defense for Research and Engineering (OUSD(R&E))'s Joint Hypersonic Transition Office (JHTO) are interested in receiving research proposals in the following areas. Each will have a Period of Performance (PoP) of 12 months. a. Systems-level design of high-temperature composite materials and structures research utilization of fiber architectures and matrix compositions b. Novel position, navigation, and timing and adaptive flight controls c. Design-oriented models to optimize scramjet and multi-mode engines d. Simulation Methods for the Rapid Prediction of Hypersonic Environments e. Addressing the flow path processes that occur in rectangular or curved inlets and isolators including the destabilization that may occur due to junction flows or off-nominal flight conditions f. The development of methods and models including validation experiments and instrumentation to provide high quality data on multiphase blast properties and structural responses to structures g. Improving the understanding of rotating detonation rocket engine (RDRE) physics and developing design solutions for their inherent technical challenges h. Hypersonic Workforce Curricula Development

The goal of the Ohio Third Frontier Technology Validation and Start-up Fund (TVSF) is to create greater economic growth in Ohio based on start-up companies that commercialize technologies developed by Ohio institutions of higher education and other Ohio not-for-profit research institutions. The Technology Validation and Start-Up Fund has been designed to: 1. Support protected technologies developed at Ohio research institutions that need known validation/proof that will directly impact and enhance both their commercial viability and ability to support a start-up company, and 2. Support Ohio start-up and Ohio young companies that license these validated/proven technologies from these Ohio research institutions.

The purpose of this award is to support outstanding basic and/or clinical researchers with the vision and expertise to translate research discoveries into medications for the treatment of Substance Use Disorders (SUDs) stemming from tobacco, cannabis, cocaine, methamphetamine, heroin, or prescription opiate use.Eligible applicants must demonstrate the ability to develop molecules with the potential to treat SUDs and advance them in the drug development continuum. The ultimate goal of this FOA is to bring molecules closer to FDA approval.

The purpose of this funding opportunity announcement (FOA) is to support studies on the very early development of the immune system and the humoral and cellular communication that exists between the mother and fetus that may shape or impact immune system development and maturation.

This Funding Opportunity Announcement (FOA) solicits R01 grant applications to develop novel technologies that will enable no less than one order of magnitude improvement in DNA sequencing, and practical methods for direct RNA sequencing. Advances in genomics and more broadly in biomedical research have been greatly facilitated by significant and sustained DNA sequencing throughput increases and cost decreases. The goal now is to improve the quality and efficiency of DNA sequencing and enable direct RNA sequencing (e.g., longer read lengths, faster turn-around time, greater accuracy, and higher-throughput etc.) at reasonable costs with the anticipation that significant advances in any of these and related areas would make significant contributions to the mission of NHGRI and the field of genomics, including to many of NHGRI's other technology development goals. Also listed under R21

This funding opportunity announcement (FOA) supports the development of PET radioligands that identify proteinopathies or pathological processes associated with the human biology of Alzheimer's disease related dementias (ADRDs). Activities supported under this FOA include, but are not limited to the in vitro screening of existing ligands against human ADRD brain tissue, medicinal chemistry support for development of new compounds and improvement of existing ligand specificity and selectivity, initial screening of ligands in appropriate animal models, and radioligand formulation and first-in-human testing. The Center without Walls should encompass research that will move promising ligands through in vitro and in vivo optimization to first-in-human studies. Applications must include an administrative core, a medicinal chemistry core, a clinical core, a scientific governance structure, and a minimum of two research projects with milestone plans that address workflows for screening of existing and newly derived ligands against human ADRD tissue and appropriate animal models. Synergy must be evident among Center research projects and cores, such that successful completion of the aims could not be accomplished without the Center structure.

This Funding Opportunity Announcement (FOA) solicits R21 grant applications to develop novel technologies that will enable substantive (no less than one order of magnitude) improvement in synthetic nucleic acids. The goal is to improve the quality, capabilities and efficiency of nucleic acid synthesis and synthetic constructs at reasonable and decreased costs. Applicants may propose to develop novel complete synthesis and/or synthetic constructs systems, investigate challenges underlying key novel system components, or propose substantive improvements of at least an order of magnitude improvement to existing systems. Exploration of methods other than those currently in use is highly encouraged. High-risk/high-payoff applications are appropriate to achieve the goals of this FOA.

The aim of this RFP is to develop biomarkers for which there is a clear clinical need in Alzheimer's disease and related dementias. Specifically, this RFP focuses on: - developing novel PET ligands for clinical use - supporting novel CSF biomarkers - validating established MRI approaches in larger cohorts Novel biomarkers of neuroinflammation and synaptic integrity are considered high priority. Other target areas of interest include: - Neuronal loss - Vascular injury and blood-brain barrier integrity - Mitochondria and metabolic function - Protein misfolding/proteostasis - Oxidative stress - White matter changes - Other novel targets supported by compelling biological rationale and connection to disease The ADDF has limited interest in CSF measures of amyloid and tau.

The Major Research Instrumentation (MRI) Program serves to increase access to multi-user scientific and engineering instrumentation for research and research training in our Nation's institutions of higher education and not-for-profit scientific/engineering research organizations. An MRI award supports the acquisition or development of a multi-user research instrument that is, in general, too costly and/or not appropriate for support through other NSF programs.

The goals of the Network for Computational Nanotechnology (NCN) are to: 1) accelerate the transformation of nanoscience to nanotechnology through the integration of simulation with experimentation; 2) engage an ever-larger and more diverse cyber community sharing novel, high-quality nanoscale computation and simulation research and educational resources; 3) develop open-access, open-source software to stimulate data sharing; and 4) inspire and educate the next-generation workforce. The NCN consists of a stand-alone Cyber Platform, which provides computation, simulation, and education services to over 330,000 researchers, educators, students, and industry members of the nanoscience and engineering community annually worldwide; and Nodes, which develop compelling new computational and simulation tools to disseminate through Cyber Platform (nanoHUB.org) and cultivate communities of users in emerging areas of nanoscale science and engineering.

The Industry-University Cooperative Research Centers (IUCRC) program develops long-term partnerships among industry, academe, and government. The Centers are catalyzed by an investment from the National Science Foundation (NSF) and are primarily supported by industry Center members, with NSF taking a supporting role in the development and evolution of the Center. Each Center is established to conduct research that is of interest to both the industry members and the Center faculty. An IUCRC contributes to the nation's research infrastructure base and enhances the intellectual capacity of the engineering and science workforce through the integration of research and education. As appropriate, an IUCRC uses international collaborations to advance these goals within the global context.

The NSF Research Traineeship (NRT) program is designed to encourage the development and implementation of bold, new, and potentially transformative models for STEM graduate education training. The NRT program seeks proposals that ensure that graduate students in research-based master's and doctoral degree programs develop the skills, knowledge, and competencies needed to pursue a range of STEM careers. The NRT program includes two tracks: the Traineeship Track and the Innovations in Graduate Education (IGE) Track.

This program supports fundamental scientific research in ceramics (e.g., oxides, carbides, nitrides and borides), glass-ceramics, inorganic glasses, ceramic-based composites and inorganic carbon-based materials. Projects should be centered on experiments; inclusion of computational and theory components are encouraged. The objective of the program is to increase fundamental understanding and to develop predictive capabilities for relating synthesis, processing, and microstructure of these materials to their properties and ultimate performance in various environments and applications. Research to enhance or enable the discovery or creation of new ceramic materials is welcome. Development of new experimental techniques or novel approaches to carry out projects is encouraged. Topics supported include basic processes and mechanisms associated with nucleation and growth of thin films; bulk crystal growth; phase transformations and equilibria; morphology; surface modification; corrosion, interfaces and grain boundary structure; and defects. Additional Information Eligibility rules apply for submissions; please see the Program Description section of the CER solicitation for details. PIs are encouraged to include all anticipated broader impact activities in their initial proposals, rather than planning on supplemental requests. Most projects include: (1) the anticipated significance on science, engineering and/or technology including possible benefits to society, (2) plans for the dissemination, and (3) broadening participation of underrepresented groups and/or excellence in training, mentoring, and/or teaching. Many successful proposals include one additional broader impact activity.

A central goal of the BRAIN Initiative is to understand how electrical and chemical signals code information in neural circuits and give rise to sensations, thoughts, emotions and actions. While currently available technologies can provide some understanding, they may not be sufficient to accomplish this goal. For example, non-invasive technologies are low resolution and/or provide indirect measures such as blood flow, which are imprecise; invasive technologies can provide information at the level of single neurons producing the fundamental biophysical signals, but they can only be applied to tens or hundreds of neurons, out of a total number in the human brain estimated at 85 billion. Other BRAIN FOAs seek to develop novel technology (RFA-NS-16-006) or to optimize existing technology ready for in-vivo proof-of-concept testing and collection of preliminary data (RFA-NS-16-007) for recording or manipulating neural activity on a scale that is beyond what is currently possible. This FOA seeks applications for unique and innovative technologies that are in an even earlier stage of development than that sought in other FOAs, including new and untested ideas that are in the initial stages of conceptualization.

The Office of Nuclear Physics (NP), Office of Science (SC), U.S. Department of Energy (DOE), hereby announces its interest in receiving applications for research and development that will allow existing technology candidates to demonstrate down-selection criteria for the next generation of neutrinoless double beta decay measurements.

The Office of Nuclear Physics (NP), Office of Science (SC), U.S. Department of Energy (DOE), hereby announces its interest in receiving applications for research and development that will allow existing technology candidates to demonstrate down-selection criteria for the next generation of neutrinoless double beta decay measurements.

The Industry-University Cooperative Research Centers (IUCRC) program develops long-term partnerships among industry, academe, and government. The Centers are catalyzed by an investment from the National Science Foundation (NSF) and are primarily supported by industry Center members, with NSF taking a supporting role in the development and evolution of the Center. Each Center is established to conduct research that is of interest to both the industry members and the Center faculty. An IUCRC contributes to the nation's research infrastructure base and enhances the intellectual capacity of the engineering and science workforce through the integration of research and education. As appropriate, an IUCRC uses international collaborations to advance these goals within the global context.

The U.S. Environmental Protection Agency (EPA) - as part of its People, Prosperity and the Planet (P3) Award Program - is seeking applications proposing to research, develop, and design solutions to real world challenges involving sustainability. The P3 competition highlights the use of scientific principles in creating innovative projects focused on sustainability. The P3 Award Program was developed to foster progress toward sustainability by achieving the mutual goals of improved quality of life, economic prosperity and protection of the planet-people, prosperity, and the planet-the three pillars of sustainability. The EPA offers the P3 competition in order to respond to the technical needs of the world while moving towards the goal of sustainability. Please see the People, Prosperity and the Planet (P3) Student Design Competition website for more details about this program.

The U.S. Environmental Protection Agency (EPA) - as part of its People, Prosperity and the Planet (P3) Award Program - is seeking applications proposing to research, develop, and design solutions to real world challenges involving sustainability. The P3 competition highlights the use of scientific principles in creating innovative projects focused on sustainability. The P3 Award Program was developed to foster progress toward sustainability by achieving the mutual goals of improved quality of life, economic prosperity and protection of the planet-people, prosperity, and the planet-the three pillars of sustainability. The EPA offers the P3 competition in order to respond to the technical needs of the world while moving towards the goal of sustainability. Please see the People, Prosperity and the Planet (P3) Student Design Competition website for more details about this program.

The Fiscal Year 2017 Air Force Young Investigator Research Program (YIP) intends support for scientists and engineers who have received Ph.D. or equivalent degrees 1 April 2011 or later that show exceptional ability and promise for conducting basic research. The program objective is to foster creative basic research in science and engineering; enhance early career development of outstanding young investigators; and increase opportunities for the young investigator to recognize the Air Force mission and related challenges in science and engineering. Individual awards are made to U.S. institutions of higher education, industrial laboratories, or non-profit research organizations where the principal investigator is employed on a full-time basis and holds a regular position. YIP primary investigators must be a U.S. citizen, national, or permanent resident. Researchers working at a Federally Funded Research and Development Center or DoD Laboratory are not eligible for this competition.

This FOA encourages Research Conference Grant (R13) applications from institutions and organizations that propose to develop interdisciplinary research teams. Teams must include investigators from the social and/or behavioral sciences, and may include the life and/or physical sciences.  The goal is to broaden the scope of investigation into scientific problems, yield fresh and possibly unexpected insights, and increase the sophistication of theoretical, methodological, and analytical approaches by integrating the analytical strengths of two or more disparate scientific disciplines while addressing gaps in terminology, approach, and methodology.  This program will allow investigators from multiple disciplines to hold meetings in order to provide the foundation for developing interdisciplinary research projects.