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NineSigma, representing Sumitomo Dainippon Pharma Co., Ltd. (https://www.ds-pharma.com/) ("Client"), seeks a drug modality for novel anti-cancer drugs that target immunosuppressive cells and interfere with immune functions, or an evaluation system for creating a drug modality. In recent years, the emergence of immune checkpoint inhibitors has been gradually revealing that the local immunosuppressive environment in tumor affects cancer treatment. This attracts interest in the development of novel antitumor drugs for improving the immune state of the tumor microenvironment. In particular, we look for compounds that target host cells contributing to the formation of the immunosuppressive environment and interfering with these functions.

NineSigma, representing Sumitomo Dainippon Pharma Co., Ltd. (https://www.ds-pharma.com/) ("Client"), seeks a drug modality for novel anti-cancer drugs that target immunosuppressive cells and interfere with immune functions, or an evaluation system for creating a drug modality. In recent years, the emergence of immune checkpoint inhibitors has been gradually revealing that the local immunosuppressive environment in tumor affects cancer treatment. This attracts interest in the development of novel antitumor drugs for improving the immune state of the tumor microenvironment. In particular, we look for compounds that target host cells contributing to the formation of the immunosuppressive environment and interfering with these functions. Focusing on cancer as its key area and considering the development of novel unique products to be its basic strategy, the Client decided to seek a partner with whom it can provide novel drugs to the market as soon as possible based on the above concept.

The overarching goal of the Breast Cancer and the Environment Research Program (BCERP) is to support integrated scientific research to enhance our understanding of environmental and genetic factors underlying breast cancer risk. This funding opportunity will support a Coordinating Center, which together with a group of individual transdisciplinary projects investigating the influence of environmental exposures during specific time windows on breast cancer risk, will form the BCERP Consortium. The BCERP Coordinating Center will provide intellectual leadership as well as logistic support for the BCERP Consortium. A primary role of the BCERP Coordinating Center will be to identify opportunities for cross-BCERP collaborations and extend the transdisciplinary activities of the BCERP Consortium. The Coordinating Center will also assist in disseminating BCERP research findings and facilitating an internal evaluation of the Consortium.

This Funding Opportunity Announcement (FOA) solicits research projects focused on the process of effective communication of research findings about breast cancer and the environment. A central objective of this new initiative is to ensure effective translation of findings that result in risk messaging that is understood by targeted audiences.  The ultimate goal is to provide the scientific evidence for developing communication-based prevention efforts to reduce the risk for breast cancer from environmental factors.  

This Funding Opportunity Announcement encourages research projects focused on the process of effective communication of research findings about breast cancer and the environment. A central objective of this new initiative is to ensure that risk messaging is designed for dissemination and effectively implemented, and leads to individual behavior change or policy change.The ultimate goal is to provide the development, dissemination, and implementation communication-based prevention efforts to reduce the risk for breast cancer from environmental factors.

The OCRP Ovarian Cancer Academy, which was initially created in FY09, is intended to be a unique, interactive virtual academy providing intensive mentoring, national networking, and a peer group for junior faculty. The overarching goal of the Ovarian Cancer Academy is to develop successful, highly productive ovarian cancer researchers in a collaborative research training environment. The current Ovarian Cancer Academy is a virtual career development and research training platform consisting of nine Early-Career Investigator/Designated Mentor pairs from different institutions and one Academy Dean. The Academy Dean serves as a resource for the Early-Career Investigators and Mentors, assesses the progress of the Early-Career Investigators, and facilitates communication and collaboration among all of the Early-Career Investigators and Mentors.

BCAN's Young Investigator Awards seek to fund those researchers who may be working in basic, translational, clinical, epidemiologic, bioengineering or any other scientific or research field, but are also working in a research environment capable of supporting transformational bladder cancer research.

The National Cancer Institute supports the development of cancer-relevant technologies that would be suitable for global health environments with limited resources. NCI is announcing its intent to reissue a Funding Opportunity Announcement (FOA) soliciting applications for the development of new technologies/devices and/or adaptation of existing technologies/devices for cancer detection/diagnosis and treatment to be tested and ultimately implemented in low- and low-middle-income countries (LMICs), as listed by World Bank

The NIH encourages institutions that seek to engage undergraduate students in innovative mentored research training programs to submit applications for cooperative agreement awards through the NIH Building Infrastructure Leading to Diversity (BUILD) initiative, one of three new Common Fund initiatives that together aim to enhance diversity in the biomedical, behavioral, clinical, and social sciences research workforce. Addressing a major leakage point in the research workforce pipeline, BUILD awards are intended to support the design and implementation of innovative programs, strategies and approaches to transform undergraduate research training and mentorship. BUILD awards will also support institutional and faculty development to further strengthen undergraduate research training environments.

The overarching goal of the Breast Cancer and the Environment Research Program (BCERP) is to support integrated scientific research to enhance our knowledge of environmental and genetic factors underlying breast cancer risk. This funding opportunity will support transdisciplinary research projects to investigate the influence of environmental exposures during specific time windows of susceptibility on breast cancer risk. Applicants must propose transdisciplinary research project that addresses one or more potential windows of susceptibility and facilitates the integration of experimental model and human studies to accelerate understanding of the contribution of environmental factors to breast cancer risk, the underlying mechanisms, and potential prevention strategies. Applications must also include community-academic partnerships with defined community engagement activities.

The Landon Foundation-AACR INNOVATOR Award for Research in Tumor Microenvironment was established to recognize the outstanding achievement of a junior faculty-level scientist working in the tumor microenvironment field, and support his or her research that, if successful, will have potential to advance knowledge on the tumor microenvironment. The goal of the grant program is to encourage junior faculty who are in the first five years of a faculty appointment (at the start of the grant term) to pursue novel tumor microenvironment research. Travel support is included to help foster interactions and collaborations among cancer scientists studying various aspects of cancer biology and to disseminate scientific knowledge about tumor microenvironment research within the field. Proposed projects may be basic, translational, clinical, or epidemiological in nature and must focus on the study of various aspects of the tumor microenvironment; including, but not limited to, the role of stroma and extracellular matrix in tumor development, angiogenesis, immunity and inflammation in the tumor microenvironment, as well as approaches to therapeutically target the tumor environment. The grant provides $100,000 over two years ($50,000 per year) for expenses related to the research project, which may include salary and benefits of the grant recipient, postdoctoral or clinical research fellows, graduate students, and/or research assistants, research/laboratory supplies, equipment, publication charges for manuscripts that pertain directly to the funded project, other research expenses, and for attendance at an AACR annual meeting, any AACR tumor microenvironment-related conference, or other AACR meeting for the purpose of participating in scholarly exchange about the funded research.

This year, PCAN has partnered with the Celgene Corporation to accelerate the development of novel therapies by establishing strong relationships between academia and industry through research grants. Funded projects will benefit from industry input and insight, leading to an accelerated translation to a therapeutic product. Projects should aim to identify novel targets and approaches to the treatment of pancreatic cancer or understand and circumvent treatment resistance. Of particular interest are projects that fall into at least one of these three areas of research: a) immune context and tumor micro-environment interactions; (b) regulators of pathogenesis, progression, and metabolism, with particular interest in epigenetic mechanisms; and (c) transcriptional networks essential for viability and maintenance of malignant phenotype.

The OCRP Ovarian Cancer Academy Award mechanism, which was initially created in FY09, is a unique, interactive virtual academy providing intensive mentoring, national networking, collaborations, and a peer group for junior faculty. The overarching goal of the Ovarian Cancer Academy (OCA) is to develop successful, highly productive ovarian cancer researchers in a collaborative research and career development environment. The OCA is a virtual career development and research training platform that currently consists of 13 Early-Career Investigator (ECI)/Designated Mentor pairs from different institutions, and one Academy Dean and one Assistant Dean. Three ECIs will be graduating in the fall of FY19 and three FY18 OCA-ECI/Designated Mentor awards will be made by September 2019. In addition, eight have Academy graduates continue to participate in the annual Academy meetings. Information about the Academy is available in the FY17 Ovarian Cancer Program Booklet at http://cdmrp.army.mil/ocrp/pbks/ocrppbk2017.pdf. The Academy Dean and Assistant Dean catalyze the growth and professional development of the ECIs in collaboration with their Designated Mentors, assess the progress of the ECIs, and facilitate communication and collaboration among all of the Academy members.

The OCRP Ovarian Cancer Academy Award mechanism, which was initially created in FY09, is a unique, interactive virtual academy providing intensive mentoring, national networking, collaborations, and a peer group for junior faculty. The overarching goal of the Ovarian Cancer Academy (OCA) is to develop successful, highly productive ovarian cancer researchers in a collaborative research and career development environment. The OCA is a virtual career development and research training platform that consists of Early-Career Investigators (ECIs) and their Designated Mentors from different institutions, and an Academy Dean and Assistant Dean. The OCRP Ovarian Cancer Academy - Early-Career Investigator Award is not a traditional career development award; the ECI is expected to participate in monthly webinars and annual workshops and to communicate and collaborate with other members of the Academy (other ECIs, Mentors, Dean, Assistant Dean) as well as with the advocacy community. Since the inception of the Academy, the Academy's ECIs have presented at and chaired sessions for ovarian cancer-specific symposia and served on symposia review committees. They have also served as peer reviewers for the Department of Defense (DoD) OCRP and other funding agencies.

This Funding Opportunity Announcement (FOA) encourages research projects focused on adducts to cellular macromolecules as indicators of exposures to cancer risk factors relevant to human populations. The priority is on projects that will focus on adductomic approaches, i.e., address some aspects of the totality of adducts. These projects should explore the basic aspects of adducts/adductomics that may have a potential utility in cancer detection, cancer prevention, and/or assessing cancer risks. The projects should be relevant to adducts in humans and human populations but may be conducted using various model systems (e.g., cultured cells, animals, etc.). The use of human biospecimens is encouraged and expected if appropriate but not required. In well-justified cases, innovative studies using the adductomic approaches in the context of cancer etiology and/or gene-environment interaction research may also be appropriate. For projects intended for NIEHS support, the focus may be on innovative technology and method development.

This Funding Opportunity Announcement (FOA), encourages research projects focused on adducts to cellular macromolecules as indicators of exposures to cancer risk factors relevant to human populations. The priority is on projects that will focus on adductomic approaches, i.e., address some aspects of the totality of adducts. These projects should explore the basic aspects of adducts/adductomics that may have a potential utility in cancer detection, cancer prevention, and/or assessing cancer risks. The projects should be relevant to adducts in humans and human populations but may be conducted using various model systems (e.g., cultured cells, animals, etc.). The use of human biospecimens is encouraged and expected if appropriate but not required. In well-justified cases, innovative studies using the adductomic approaches in the context of cancer etiology and/or gene-environment interaction research may also be appropriate. r NIEHS may support projects with a focus on innovative technology and method development. Also listed under R01

This Funding Opportunity Announcement (FOA) invites applications that seek to apply one or more innovative methodologies in communication research across the cancer control continuum, from prevention, early detection, diagnosis, treatment, and survivorship, to end of life. Applications to this FOA should utilize one or more of the following analytic approaches, methods, and data sources, including but not limited to social media data mining, Natural Language Processing (NLP) techniques, online social network analysis, crowdsourcing research tools (e.g., mTurk), online search data, Ecological Momentary Assessment, neuroscience and biobehavioral approaches to communication, and geographic information systems. Studies should assess outcomes related to cancer prevention and control (e.g., knowledge, attitudes, beliefs, perceived risk, decision making in screening and treatment, information inequalities, social support, shared decision making, persuasion, caregiving, behavioral intentions, preventive behaviors, and policy support, among others). Also listed under R21

The Virtual Cancer Center Director Award (VCCDA) mechanism is a unique, interactive virtual cancer center (VCC) focused on bringing together two established investigators (Director and Deputy Director) and up to nine early career investigators (Scholars) to interrogate the commonalities of cancer. Candidates for Scholars will apply to a separate funding opportunity (W81XWH-20-PRCRP-CDA). The Director and Deputy Director will catalyze the growth and professional development of the Scholars in collaboration with the Scholars' Career Guides, assess the progress of the Scholars, promote the cross pollination of different cancer disciplines, and facilitate communication and collaboration amongst all of the VCC members. The overarching goal of the VCC is to develop successful, highly productive Scholars in a collaborative research and career developmental environment. The VCC will provide intensive mentoring, national networking, collaborations, and a peer group for junior faculty. The VCC will give Scholars opportunities to operate in a collegial, highly dynamic, and cutting edge center to lead cancer research to a new frontier. It is the intention that through the VCC, collaborations will foster new growth in different cancers and spur an integrated cancer center to ensure the research advancements across different cancers.

This opportunity allows for young investigators to develop a research project, investigate a problem or question in prostate cancer research, and further their intellectual development as a prostate cancer researcher of the future. The postdoctoral investigator is considered the Principal Investigator (PI) of the application and must exhibit strong potential for, and commitment to, pursuing a career as an investigator at the forefront of prostate cancer research; however, the PI is not required to have previous prostate cancer research experience. Applications must include at least one Mentor, appropriate to the proposed research project, who has experience in prostate cancer research and mentoring as demonstrated by a record of active funding, recent publications, and successful mentorship. The primary Mentor can be a junior faculty member, in which case the PI is encouraged to include a secondary Mentor with a more robust track record in prostate cancer research and mentorship. The selected Mentor(s) should also demonstrate a clear commitment to the development of the PI toward independence as a prostate cancer researcher. The PI must outline an individualized, prostate cancer-focused researcher development plan. The researcher development plan should include a clearly articulated strategy for acquiring the necessary skills, competence, and expertise that will enable the PI to successfully complete the proposed research project and foster the PI's development as an independent prostate cancer researcher. An environment appropriate to the proposed mentoring and research project must be clearly described, although any deficiencies of resources and/or mentorship at the PI's institution can be mitigated through collaboration(s) with other institutions.

The purpose of the NLA Junior Faculty Research is to encourage scholarly advancement of Junior Faculty in the pursuit of a career related to hyperlipidemia and other lipid disorders in humans. The NLA will fund eligible institutions to provide $70,000 per year in salary support for those actively involved in clinical and/or basic science that provides promise of developing new information in fields of study that could advance the diagnosis and management of lipid disorders such as biochemistry, physiology, or genetics as well as interventions that improve therapy. The institutions eligible shall be nonprofit and offer an environment that would logically support a young faculty member with appropriate equipment, space and experienced faculty for proposed studies. The proposal will identify a specific candidate with training and strong signs of early success in an appropriate area of research and with a plan for developing appropriate experiments or clinical studies. To be eligible, an applicant is expected to hold or be eligible for a doctoral level degree (PhD, PharmD or MD) prior to the date of the scheduled award. There must be a record of accomplishment in a relevant research area as manifest by publications or a PhD thesis of high quality. The application for the Basic Science Award may focus on any aspect of lipid metabolism that has relevance to human disease. This may include experiments at the laboratory bench involving structural chemistry, biochemistry, physiology or genetics.