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The purpose of this RFA is to encourage studies on reproductive health, fertility and fertility preservation/treatment options in patients born with a serious chronic condition who can now expect to survive into adulthood healthy enough to consider their reproductive health and fertility options. The underlying pathophysiology of diseases such as sickle cell anemia, thalassemia, and cystic fibrosis, among others, and/or the cumulative effects of their treatment, can compromise reproductive health. This RFA encourages teams of scientists with expertise in the realm of the particular disease and in reproductive health and fertility to work together to understand the effects of the diseases and/or their treatments on parameters of reproductive health, and to identify ways to preserve, protect, or treat and reproductive deficits in these patients.

The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications from the scientific community to support outstanding research related to the role of the gut microbiome in regulating metabolism and reproduction, and its impact on the fertility status. The overarching goal is to gain fundamental insight into the possible role of the gut microbiome in regulating reproduction through HPG, HPA, and HPT axes in the brain. The results of the study could lead to development of diagnostic markers (signature microbiomes) for reproductive and metabolic failure. The project is pertinent to multiple portfolios in the Fertility and Infertility Branch, e.g., basic ovarian biology, fertility preservation, assisted reproductive technology, spermatogenesis and sperm function, and therapeutic interventions to infertility. The emphasis on the gut microbiome and its impact on reproduction through its effects on HPG, HPA, and HPT axes leading to obesity, metabolic syndrome, stress disorders, infection and anxiety is also of interest to the Maternal and Pediatric infectious disease Branch, Pediatric Growth and Nutrition Branch and IDDB.

The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications from the scientific community to support outstanding research related to the role of the gut microbiome in regulating metabolism and reproduction, and its impact on the fertility status. The overarching goal is to gain fundamental insight into the possible role of the gut microbiome in regulating reproduction through HPG, HPA, and HPT axes in the brain. The results of the study could lead to development of diagnostic markers (signature microbiomes) for reproductive and metabolic failure. The project is pertinent to multiple portfolios in the Fertility and Infertility Branch, e.g., basic ovarian biology, fertility preservation, assisted reproductive technology, spermatogenesis and sperm function, and therapeutic interventions to infertility. The emphasis on the gut microbiome and its impact on reproduction through its effects on HPG, HPA, and HPT axes leading to obesity, metabolic syndrome, stress disorders, infection and anxiety is also of interest to the Maternal and Pediatric infectious disease Branch, Pediatric Growth and Nutrition Branch and IDDB.

This Funding Opportunity Announcement (FOA) invites research applications addressing cellular and molecular mechanisms that regulate aging of the reproductive tissues, including the niche, in gonads, reproductive accessory organs, and the reproductive neuroendocrine system. This FOA will accept basic mechanistic studies in human subjects and vertebrate animals. Research supported by this initiative should enhance knowledge of mechanisms that regulate aging of the reproductive system.

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), through the Fertility and Infertility (FI) Branch, provides funding for a limited number of research centers in the reproductive sciences.  These centers provide an arena for multidisciplinary interactions among basic and clinical scientists interested in establishing high quality translational research programs in this scientific area.  The centers also serve as national resources for the training and career development of young scientists electing to pursue biomedical research careers in reproduction and infertility.  Finally, center investigators develop and participate in community outreach and education efforts to increase awareness and convey the importance and implications of their research activities to the general public.  Accordingly, the purpose of this FOA is to announce the re-competition of the National Centers for Translational Research in Reproduction and Infertility (NCTRI).  The NCTRI will be administered through the Specialized Research Center (P50) award mechanism.  These centers will form a national network that facilitates and accelerates bidirectional knowledge transfer between the laboratory and clinic with the goal of improving human reproductive health through research excellence and innovation.

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), through the Fertility and Infertility (FI) Branch, provides funding for a limited number of research centers in the reproductive sciences. These centers provide an arena for multidisciplinary interactions among basic and clinical scientists interested in establishing high quality translational research programs in this scientific area. The centers also serve as national resources for the training and career development of junior scientists electing to pursue biomedical research careers in reproduction and infertility. Finally, center investigators develop and participate in community outreach and education efforts to increase awareness and convey the importance and implications of their research activities to the general public. The purpose of this FOA is to announce the re-competition of the National Centers for Translational Research in Reproduction and Infertility (NCTRI). The NCTRI will be administered through the Specialized Research Center (P50) award mechanism. These centers will form a national network that facilitates and accelerates bidirectional knowledge transfer between the laboratory and clinic with the ultimate goal of improving human reproductive health through research excellence and innovation.

The centers also serve as national resources for the training and career development of junior scientists electing to pursue biomedical research careers in reproduction and infertility.  Finally, center investigators develop and participate in community outreach and education efforts to increase awareness and convey the importance and implications of their research activities to the general public.  The purpose of this FOA is to announce the re-competition of the National Centers for Translational Research in Reproduction and Infertility (NCTRI).  The NCTRI will be administered through the Specialized Research Center (P50) award mechanism.  These centers will form a national network that facilitates and accelerates bidirectional knowledge transfer between the laboratory and clinic with the ultimate goal of improving human reproductive health through research excellence and innovation.

The awards are open to researchers based at both national and international accredited academic and nonprofit research institutions. Funding mechanisms include: Senior Faculty Awards ($400,000 per year) - to support established investigators who are thought leaders in their fields and are recognized for substantial contributions of creative and productive research. We will seek to complement other major funders of research by placing emphasis on projects that may not be supported by traditional sources because of their perceived novelty or high risk, or because the investigator is moving into female reproductive aging from a different research area. Junior Faculty Awards ($250,000 per year) - to support newly independent investigators with outstanding promise when they are establishing their own labs and are malleable in the direction of their research. These awards will allow bright young scientists to pursue bold ideas when they are at their most scientifically creative. Pilot Awards ($100,000 per year) - to foster innovative collaborative or novel research projects that have the potential for high impact and high reward at an accelerated rate. These awards will allow collection of preliminary data to apply for larger grants. Postdoctoral Fellowships ($100,000 per year) - to increase the number of imaginative, well-trained junior scientists who will form the next generation of reproductive aging researchers. These awards will facilitate our efforts to build the field and provide both training and networking opportunities for trainees.

The United States Agency for International Development (USAID) is seeking concept papers from qualified U.S. non profit non-Governmental Organizations (NGOs) for a program titled "Family Planning and Reproductive Health Methods to Address Unmet Need" for funding of Cooperative Agreements.The purpose of this APS is to support the research, development, and introduction of technologies and approaches that better meet the needs of women and girls as their sexual and reproductive health concerns change over time. The General Objectives of the APS are to:1. Refine existing FP methods to address method-related reasons for non-use.2. Respond to product-related issues about currently available FP methods that arise at purchase and/or from the field, and that may affect provider/user perceptions and/or the supply chain.3. Develop new FP methods that address method-related reasons for non-use, and/or fill gaps in the existing method mix. 4. Conduct research to foster the introduction and uptake of new and/or underutilized woman-initiated methods, particularly non-hormonal barriers, contraceptive vaginal rings, and fertility awareness methods based on knowledge and monitoring of the menstrual cycle. 5. Develop multipurpose prevention technologies (MPTs) that address the simultaneous risks of unintended pregnancy, HIV, and other sexually transmitted infections (STIs) - particularly Herpes Simplex Virus (HSV) and Human Papillomavirus (HPV).

The NICHD invites applications from investigators to develop a multi-site project designed to conduct clinical trials to investigate problems in reproductive medicine, female and male infertility, and gynecologic and male reproductive system diseases and disorders that impact fertility. This funding opportunity announcement (FOA) is intended to support multi-site clinical research consortia devoted to evaluating safety and efficacy of new medications, treatments and technologies addressing questions in infertility.  The objective of this program is to advance scientific research that facilitates diagnostic and therapeutic solutions to infertility by using common protocols in large scale human trials to obtain answers more rapidly than individual sites acting alone.

The purpose of this FOA is to announce the re-competition of the National Centers for Translational Research in Reproduction and Infertility (NCTRI). The NCTRI will be administered through the Specialized Research Center (P50) award mechanism. These centers will form a national network that facilitates and accelerates bidirectional knowledge transfer between the laboratory and clinic with the ultimate goal of improving human reproductive and gynecological health through research excellence and innovation.

The purpose of this FOA is to encourage small businesses to collaborate with scientists and clinicians in the fields of female and male reproductive health, infertility, andrology, and/or gynecology to adapt discoveries in omics technologies such as genomics, epigenomics and metabolomics, as well as identification of disease biomarkers to the development of new devices, assays, digital apps, or technologies to improve the specificity of diagnosis and clinical care of infertility and to advance the application of precision medicine to reproductive health.

The program supports organizations that offer comprehensive, innovative, and unbiased sexual and reproductive health education to young women. The foundation is particularly interested in programs serving young women who are disadvantaged by poverty, discrimination, geographic isolation, lack of comprehensive sex education, hostile public policy, or other factors with potential to lead to inadequate sexual and reproductive health.

The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications from the scientific community to support outstanding research in the area of spermatogenic stem cell (SSC) biology.The overarching goal is to increase the chances that couples may have biological offspring without using conventional assisted reproductive modalities (i.e., IVF, ICSI).A focal point of the initiative is on the development of new techniques to culture and expand these cells over an extended period of time.Another area of study includes methods to eliminate malignant cells from SSC cultures following chemotherapy/radiation treatment. Also, spermatogenic stem cells from human adults could have a major impact on drug development and toxicity testing as animal-based systems do not sufficiently mirror the situation in humans.

The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications from the scientific community to support outstanding research in the area of spermatogenic stem cell (SSC) biology.The overarching goal is to increase the chances that couples may have biological offspring without using conventional assisted reproductive modalities (i.e., IVF, ICSI).A focal point of the initiative is on the development of new techniques to culture and expand these cells over an extended period of time.Another area of study includes methods to eliminate malignant cells from SSC cultures following chemotherapy/radiation treatment. Also, spermatogenic stem cells from human adults could have a major impact on drug development and toxicity testing as animal-based systems do not sufficiently mirror the situation in humans.

The purpose of this funding opportunity announcement (FOA) is to invite applications to continue to support a national program of mentored institutional career development programs for junior faculty who have recently completed postgraduate clinical training in obstetrics and gynecology, and are committed to an independent research career in women's reproductive health. The supervised research training will assist junior faculty in their transition into productive, physician scientists in areas related to obstetrics and gynecology and its subspecialties.

This encompasses basic biological processes governing differentiation and development involving both human and animal model systems, genetics and genomics of these processes, clinical studies, reproductive health and environmental toxicology. Social and behavioral studies are encouraged concerning cognitive and behavioral risks that affect outcomes of pregnancy, the perinatal period, and subsequent child development. The latter may involve family units and those genes, toxicants and social determinants that adversely affect language or behavior.

This encompasses basic biological processes governing differentiation and development involving both human and animal model systems, genetics and genomics of these processes, clinical studies, reproductive health and environmental toxicology. Social and behavioral studies are encouraged concerning cognitive and behavioral risks that affect outcomes of pregnancy, the perinatal period, and subsequent child development. The latter may involve family units and those genes, toxicants and social determinants that adversely affect language or behavior.

The purpose of this FOA issued by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH is to announce the re-competition of the Reproductive Scientist Development Program (RSDP). This program constitutes a national network of mentors and scholars, in contrast to K12 programs that are based solely at a single applicant institution. The purpose of the RSDP is to provide career development support for obstetricians and gynecologists who have completed their clinical training, and who are committed to a career conducting basic science research in an academic setting. The overall goal of the Program is to strengthen the field of obstetrics and gynecology by encouraging the application of contemporary science advances to clinical practice and facilitating the transition to independence of physician-scientists in areas related to obstetrics and gynecology and its subspecialties.

This interagency Funding Opportunity Announcement (FOA) issued by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Institute of Food and Agriculture (USDA-NIFA) is to invite the submission of grant applications that utilize agriculturally important domestic animal species to improve human health through the advancement of basic and translational research deemed highly relevant to both agricultural and biomedical research. This initiative is designed to facilitate and encourage comparative medicine research studies through the careful selection and refinement of farm animal models that mimic human developmental, physiological and etiological processes to better understand disease origins and improve assisted reproduction efficiencies. The anticipated outcomes include both the elucidation of fundamental information relevant for the improvement of human health and an increase in food animal production and improvement in animal health and product quality. It is envisioned that each application will address mission-relevant areas of both agencies.

This funding opportunity announcement (FOA) issued by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH) invites innovative, multidisciplinary, interactive, and synergistic Program Project grant applications from institutions/organizations that propose to conduct research on reproductive, developmental, behavioral, social, and rehabilitative processes that determine the health or functioning of newborns, infants, children, adults, families, and populations. The purpose of the P01 activity code is to encourage investigation of complex problems relevant to NICHD's mission and to facilitate economy of effort, space, and equipment. Under appropriate circumstances, the collaborative research effort of a Program Project can accelerate the acquisition of knowledge more effectively than a simple aggregate of research projects without thematic integration.

MOD invites all qualified scientists with faculty appointments or the equivalent, at universities, hospitals and research institutions (not for profit or profit), to submit applications for research grants relevant to our mission. This encompasses basic biological processes governing differentiation and development, genetics and genomics of these processes, clinical studies, reproductive health and environmental toxicology, and social and behavioral studies concerning cognitive and behavioral risks that affect outcomes of pregnancy, the perinatal period, and subsequent child development. Applications will be directed to one of three committees whose respective foci are:    * Cell Lineage and Differentiation  * Gene Discovery and Translational Medicine  * Social and Behavioral Sciences. This involves family units and includes genes, toxicants, social  determinants that adversely affect language or behavior, especially if involving premature  infants or children with birth defects.