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USAID is seeking to enhance our malaria vaccine investments through a collaborative design process. The goal of USAID's Malaria Vaccine Development Program (MVDP) is to demonstrate the proof of concept of a vaccine to reduce morbidity and mortality due to malaria caused by infection with Plasmodium falciparum. Target malaria vaccine end characteristics will include at least 75% efficacy and evidence of affordability. USAID intends to support efforts towards vaccines that have the potential to directly protect recipients against disease caused by P. falciparum such as vaccines that target the pre-erythrocytic (sporozoite and liver stage) and erythrocytic stages of the life cycle. The purpose of this Addendum is to solicit Expressions of Interest (EOI) for novel and innovative approaches to malaria vaccine development that would encompass preclinical development through proof of principle clinical studies to motivate advanced development of a deployable, effective malaria vaccine.

The purpose of the Tanzania Malaria Surveillance and Monitoring (TMSM) Cooperative Agreement is to support the Government of Tanzania to reduce the burden of malaria and to move towards the long-term goal of malaria elimination.

The purpose of this initiative is to stimulate basic research, discovery, and early translational research to enable and accelerate the generation of highly efficacious pre-erythrocytic stage malaria vaccines, including sporozoite-based vaccines    . Cross-fertilization and collaboration among investigators from malaria vaccine research and other basic research areas such as parasite biology, parasite genomics, pathogenesis, and host immunology are highly encouraged. The goal is to generate one or more promising vaccine candidates against human malaria that exhibit performance superior to currently available sporozoite-based vaccines and are suitable for further downstream process development and future clinical evaluation.

The purpose of this FOA is to solicit multiple-Program Director/Principal Investigator (PD/PI) applications that propose collaborative studies to address the role of vascular activation and dysfunction in the pathogenesis of severe malaria. Multidisciplinary teams of investigators are needed to identify pathways and regulatory mechanisms by which vascular factors contribute to the complex etiology of severe malaria.

The overarching goal of the ICEMR program is to establish research centers in malaria-endemic settings that will provide the necessary knowledge, tools, and evidence-based strategies for use by government organizations and health care institutions to control and treat malaria. This program is not intended to support research which can be conducted primarily in U.S. institutions.

The purpose of this Funding Opportunity Announcement (FOA) is to support early phase translational research that will generate new malaria vaccine candidates suitable for further downstream development and clinical evaluation. This research opportunity encourages studies that will lead to discovery of new vaccine candidates that prevent infection, ameliorate disease, and/or interrupt transmission caused by human malaria parasites, especially P. falciparum and P. vivax.

Infectious diseases have negatively impacted U.S. military operations dating as far back as the Revolutionary War. Recent outbreaks of Ebola, Chikungunya and Zika combined with the ongoing threats posed by malaria, infectious diarrhea and multi-drug resistant bacteria in regions where U.S. military personnel operate underscore the need for preventive measures to mitigate against the impact that infectious diseases have on the operational forces of the U. S. The goal of this Cooperative Agreement is to engage in a collaborative research and development (R&D) effort for protective vaccines and other countermeasures targeting the causative agents of malaria, travelers' diarrhea, rickettsial pathogens, multi-drug resistant bacteria, and emerging viral diseases.

This notice solicits applications for the Resilient and Responsive Health Systems (RRHS) Initiative - South Sudan, a multi-year program to strengthen human resources for health (HRH) to address public health challenges like HIV/AIDS, tuberculosis (TB) and malaria in South Sudan. This initiative also seeks to achieve health system resiliency by addressing fundamental health systems constraints that impede the availability of and access to quality health services by supporting the implementation of national health strategies and recovery plans to respond to emerging epidemics, prevent, manage and control HIV/AIDS, TB, malaria, and other communicable and non-communicable diseases, and improve population health outcomes.

he AFPMB is soliciting pre-proposals for original, innovative research designed to develop new interventions for protection of deployed military personnel from diseases caused by arthropod-borne pathogens and to improve control of filth flies. Diseases of significant concern include malaria, dengue fever, chikungunya fever, and other arboviruses. 

The goal of the Vaccine Action Program (VAP) is to support collaborative vaccine-related research projects that ultimately reduce the burden of infectious diseases of importance in India, the U.S., the South Asian region and globally. Applications are encouraged from organizations/institutions that propose to conduct vaccine-related research through collaborations with Indian investigators on the following: dengue, influenza (including avian influenza), malaria, enteric diseases, HIV/AIDS, and tuberculosis.  Basic, translational, clinical, or epidemiological vaccine research may be proposed (no clinical trials will be supported under this FOA).

USAID/Cambodia seeks to make a five-year award focused on the goal of improving the quality of public and private health services in Cambodia in a sustainable manner through technical assistance to national and sub-national health systems. The activity will achieve this goal through four objectives: 1) improved policies, guidelines and standards for streamlined quality assurance; 2) increased efficiency and effectiveness of service delivery; 3) strengthened regulatory framework, implementation, and enforcement; and 4) strengthened pre-service public health training. Under these objectives, the award will support the Ministry of Health, Provincial Health Departments, Operational District Offices and Referral Hospital Management to improve the quality of health services through targeted technical assistance and limited introduction of new techniques, approaches, and technologies that improve quality of health services in both the public and private sector. The award will build upon existing, effective quality assurance systems and ensure that they incorporate a focus on USAID/Cambodia's technical priorities (maternal and child health, family planning, nutrition, tuberculosis, HIV and malaria). In addition, a major focus of the award will be ensuring quality of health services provided in the private sector. This will include, but is not limited to, strengthening licensing and regulation of service providers and monitoring of service quality in the private sector toward the development of an accreditation system for both public and private providers.

Infectious diseases have negatively impacted U.S. military operations dating as far back as the Revolutionary War. Recent conflicts and outbreaks involving infectious agents such as Ebola, Chikungunya and Zika underscore the need for preventive measures to mitigate the effects on operational forces of the U. S. The goal of this Cooperative Agreement is to engage in a collaborative research and development (R&D) effort to devise protective vaccines and other countermeasures targeting the causative agents of malaria, travelers' diarrhea, rickettsial pathogens and emerging viral diseases. Research will also focus on developing novel countermeasures targeting multi-drug resistant bacteria that are associated with combat related wound infections.

This funding opportunity announcement will supportprojectsto enhance the availability and delivery of safe blood to be used for transfusion in patients from low or lower-middle income countries (LLMICs) in Sub-Saharan Africa (SSA). For example, ensuring that children with malaria or sickle cell disease and pregnant women who suffer from obstetric hemorrhage have access to safe transfusion therapies is of high programmatic interest. BLOODSAFE will support projects that develop and test feasible, effective and sustainable strategies to increase the number of safe blood donors, to improve quality and safety of blood supplies, and to enhance blood delivery to patients in need, especially in remote settings.