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This FOA will provide support for assays (and associated data analysis) of repository-held samples for studies focused on an NIDDK relevant disease.  The review of applications to this FOA will consider both access to repository-held samples and funding for assays using the samples.  These studies are expected to generate scientific discoveries on disease mechanisms, disease pathogenic processes, disease progression, or clinical responses.  Projects that make good use of the associated data from the clinical trials and studies, the original intent of the clinical study and/or trial are highly encouraged.  Exploratory studies and discovery research are encouraged especially when samples are not severely limited, the work is justified, and the goal is consistent with the original intent of the clinical research.

This Funding Opportunity Announcement (FOA) invites Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) for funding to perform research leading to the development of innovative technologies that may advance progress toward integrated long term glucose regulated insulin/pancreatic hormones delivery systems (artificial pancreas).

This Funding Opportunity Announcement (FOA) encourages applications from institutions/organizations proposing clinical studies of the use of current and emerging technologies for monitoring of blood glucose and insulin administration in older adults with T1D.

The goal of this initiative is to support creative research projects that address major obstacles to development and testing of new therapeutic approaches for T1D complications.  This Funding Opportunity Announcement (FOA) solicits research focused on defining biomarkers that can be used to track the onset, progression, and extent of tissue damage that develops over time in people with T1D.  It also solicits research to develop approaches to regenerate damaged tissue. Proposed studies should be designed to address major unmet needs and/or compelling opportunities that have the potential to dramatically advance the field.

This Funding Opportunity Announcement (FOA) does not allow applicants to propose to lead an independent clinical trial, but does allow applicants to propose research experience in a clinical trial led by a sponsor or co-sponsor.

This Funding Opportunity Announcement (FOA) does not allow applicants to propose to lead an independent clinical trial, but does allow applicants to propose research experience in a clinical trial led by a sponsor or co-sponsor.