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AARP Foundation Issues RFP for Food Security, Social Connectedness Programs | RFPs | PND - 0 views

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    The foundation has established key objectives for increasing the number of people it serves and achieving specific outcomes by 2020, including working to improve food security for 770,000 older, low-income adults as measured by the USDA Adult Food Security Survey, and sustained improvement in social connectedness over twelve months for 55 percent of 500,000 low-income 50+ older adults as measured by the Duke Social Support Index.

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Prevention Research in Mid-Life Adults (R01 Clinical Trial Optional) - 0 views

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    This Funding Opportunity Announcement (FOA) seeks to stimulate research on mid-life adults (those 50 to 64 years of age) that can inform efforts to optimize health and wellness as individuals age and prevent illness and disability in later years. Also listed under R21.
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RFA-AG-19-019: The National Health and Aging Trends Study (U01 Clinical Trial Not Allowed) - 0 views

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    This funding opportunity announcement (FOA) invites applications for the next five-year cycle of the National Health and Aging Trends Study (NHATS), the leading nationally representative, longitudinal data resource in the US for research on trends, dynamics, and disparities in late-life disability, and for studies of the social and economic consequences of late-life disability for individuals, families and society, including caregiving and end-of-life issues. NHATS has conducted seven annual rounds of data collection to date (an eighth round is in process) and is linked to the separately funded National Study of Caregiving (NSOC). The goals of the next cycle are to: 1) Continue the current structure and design elements of NHATS; 2) Permit studies of long-term trends in disability prevalence; 3) Enrich measurement of cognitive capacity; 4) Enhance measurement of physical activity and sedentary behavior; 5) Continue linkages with administrative records; and 6) Augment data dissemination and user support.

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RFA-DC-19-001: NIDCD Hearing Healthcare for Adults: Improving Access and Affordability ... - 0 views

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    This funding opportunity announcement (FOA) encourages Exploratory/Developmental Phased Innovation (R21/R33) grant applications to support research and/or infrastructure needs in emerging scientific areas leading to more accessible and affordable hearing health care for adults with mild to moderate hearing loss. The proposed research aims should be milestone-driven and lead to better hearing healthcare, targeting enhanced access and affordability, in an effort to improve outcomes for adults with hearing loss. The total project period for an application submitted in response to this FOA may not exceed five years. This FOA provides support for up to two years (R21 phase) for preliminary/developmental studies, followed by possible transition of up to four years of expanded research and development support (R33), although the total duration of the award may not exceed five years. This FOA requires measurable R21 milestones.
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RFA-AG-19-009: NIA AD/ADRD Health Care Systems Research Collaboratory (U54 - Clinical T... - 0 views

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    The purpose of this FOA is to solicit applications for the AD/ADRD Health Care Systems Research Collaboratory ("Collaboratory", henceforth) to improve care for persons with dementia (PWD) and their caregivers through health systems. Health and long-term systems for this FOA are defined broadly and include organizations providing care across settings to include primary and specialty outpatient care, acute inpatient care, skilled nursing and other rehabilitation facilities, residential long-term care, and home and community-based services. Organizations may be traditional health care systems (e.g., health maintenance organizations, or HMOs), health insurance companies, managed care plans, home health care providers, memory clinics, nursing homes, assisted living facilities, outpatient clinics, federally-designated health centers, hospitals, and other providers of acute and long-term care.
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RFA-AG-19-011: Integrative Omics to Enhance Therapeutics Development for Healthy Aging ... - 0 views

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    This Funding Opportunity Announcement (FOA) is a phased innovation initiative to facilitate multi-omics/integrative approaches to identify omics profiles associated with protection against multiple aging conditions, with exceptional health span, and to refine strategies for utilizing these profiles for therapeutics development. Specifically, a phased innovation cooperative agreement mechanism (UH2/UH3) involving an interdisciplinary research team will be used to support a single project that will conduct integrative analysis of person-specific multiple omics measurements (e.g., transcriptomics, proteomics, metabolomics) generated across multiple tissues; the multi-omic profiling should be conducted on individuals from extensively phenotyped cohorts with substantial numbers of long-lived individuals with characteristics of exceptionally healthy aging and appropriate controls.
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RFA-AG-19-015: High-Priority Behavioral and Social Research Networks (R24 Clinical Tria... - 0 views

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    This Funding Opportunity Announcement (FOA) invites applications to provide infrastructure support for advancing development of specific high-priority areas of behavioral and social research of relevance to aging. The infrastructure support will facilitate research networks through meetings, conferences, small-scale pilots, short-term educational opportunities (such as intensive workshops, summer institutes, or visiting scholar programs), and dissemination to encourage growth and development of specified priority areas and build resources for advancing aging-relevant research in the field at large. Network applications are limited to the following areas: (1) Midlife Reversibility of Biobehavioral Risk Associated with Early Life Adversity, (2) Stress Measurement, (3) Reproducibility in the Social and Behavioral Sciences, (4) Life Course Health Disparities at Older Ages, (5) Genomics of Behavioral and Social Science, (6) Integrating Animal Models to Inform Behavioral and Social Research on Aging, and (7) Rural Aging.    

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DoD Peer Reviewed Alzheimer's Quality of Life Research Award - 0 views

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    FY18 PRARP QUAL Overarching Challenges: This FY18 PRARP QUAL funding opportunity requires applications to address one or more of the following FY18 PRARP QUAL Overarching Challenges:



    Paucity of Clinical Studies: The paucity of clinical studies to examine the interrelationship between TBI and subsequent AD/ADRD for the military, Veteran, and civilian communities. This includes research into risk factors that may predispose individuals to AD/ADRD subsequent to TBI.



    Quality of Life: The need for technologies, assessments, interventions, or devices to benefit individuals living with the common symptoms or deficits of TBI and AD/ADRD.



    Caregiver Support: The need for technologies, assessments, interventions, or devices with the goal of enhancing the lives of caregivers for individuals living with the common symptoms or deficits of TBI and AD/ADRD.



    Epidemiology: The paucity of epidemiological research to examine the interrelationship between TBI and subsequent AD/ADRD for the military, Veteran, and civilian communities. This includes research into risk factors that may predispose individuals to AD/ADRD subsequent to TBI.



    FY18 PRARP QUAL Focus Areas: In addition to addressing one or more of the specified FY18 PRARP QUAL Overarching Challenges, applications should address at least one of the following FY18 PRARP QUAL Focus Areas in support of the FY18 PRARP QUAL Overarching Challenges. An application that proposes research outside of the FY18 PRARP QUAL Focus Areas is acceptable, as long as the applicant provides a strong rationale.
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DoD Peer Reviewed Alzheimer's Convergence Science Research Award - 0 views

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    Paucity of Research Resources: The paucity of research resources to examine the interrelationship between TBI and subsequent AD/ADRD for the military, Veteran, and civilian communities.

    Paucity of Clinical Studies: The paucity of clinical studies to examine the interrelationship between TBI and subsequent AD/ADRD for the military, Veteran, and civilian communities. This includes research into risk factors that may predispose individuals to AD/ADRD subsequent to TBI.

    Diagnostic Technologies, Tests, Biomarkers, or Devices: The need for technologies, tests, or devices to detect or prognose the progression to AD/ADRD subsequent to TBI. This includes research into risk factors that may predispose individuals to AD/ADRD subsequent to TBI.

    Epidemiology: The paucity of epidemiological research to examine the interrelationship between TBI and subsequent AD/ADRD for the military, Veteran, and civilian communities. This includes research into risk factors that may predispose individuals to AD/ADRD subsequent to TBI.
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Promoting Aging In Place by Enhancing Access to Home Modifications - 0 views

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    Older adults overwhelmingly prefer to stay in their homes and communities as they age. But millions of older individuals live in homes that lack accessibility features that support the ability to live safely and independently. In fact, the Census Bureau reveals that 1 in 3 older adult has trouble using some feature of their home. Another major concern in the risk of falling among older adults. Most serious falls occur in and around the home, and can be life-changing. Home modifications and repairs can help older adults age in place and maintain their independence. In many cases home modifications can also help prevent falls and other accidents in the home. The Administration on Aging, an agency within the Administration for Community Living, intends to award one cooperative agreement designed to address barriers to optimal access to and use of home modifications that support aging in place. The project will be expected to provide technical assistance and serve as a repository for home modification best practices and innovations that can be replicated at the local level.
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Exploratory Analyses of Adherence Strategies and Data Sets from CALERIE to Investigate ... - 0 views

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    The National Institute on Aging (NIA) invites applications for new exploratory research projects (R21) involving secondary analyses of data in the Computerized Tracking System (CTS) database from the CALERIE (Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy) trial to explore behavioral and psychosocial aspects of sustained caloric restriction (CR) in humans, including the translation of the CR adherence strategies used in the trial to promote healthy behaviors, especially for the prevention of weight gain with age. CALERIE was the first trial in humans to specifically focus on the effects of sustained CR. It demonstrated feasibility of sustained human CR (for at least two years) and favorable effects on predictors of longevity, as well as on cardiometabolic risk factors. The sustained weight loss in CALERIE has not been previously attained in any clinical study in non-obese individuals.
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Paul B. Beeson Emerging Leaders Career Development Award in Aging (K76 Independent Clin... - 0 views

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    This Funding Opportunity Announcement (FOA) invites early-stage physician and other health professional investigators with a commitment to aging and/or aging-related diseases to apply for this award to advance their research and leadership skills in their specialty and in the broader field of aging and geriatrics research. The National Institute on Aging is pursuing this initiative to recruit new investigators who have begun to establish research programs and who, through this award, will be ready to assume leadership roles in their field of expertise and will be poised to change theory, practice and health outcomes related to the health of older individuals. Unlike other mentored K awards, candidates for this award must have received competitively awarded research support as a PD/PI at the faculty level or have otherwise leveraged faculty-level research support to develop an independent line of research. They must show evidence of leadership in the clinical or research domain. This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, or an ancillary study to a clinical trial. Applicants to this FOA are permitted to propose research experience in a clinical trial led by a mentor or co-mentor. Applicants proposing a clinical trial or an ancillary study to an ongoing clinical trial as lead investigator, should apply to the companion FOA (RFA-AG-19-018).
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RFA-AG-19-017: Paul B. Beeson Emerging Leaders Career Development Award in Aging (K76 I... - 0 views

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    The National Institute on Aging is pursuing this initiative to recruit early-stage investigators who have begun to establish research programs and who, through this award, will be ready to assume leadership roles in their field of expertise and will be poised to change theory, practice and health outcomes related to the health of older individuals. Unlike other mentored K awards, candidates for this award must have received competitively awarded research support as a PD/PI at the faculty level or have otherwise leveraged faculty-level research support to develop an independent line of research. They must show evidence of leadership in the clinical or research domain.    

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RFA-AG-19-008: Edward R. Roybal Coordinating Center (R24 - Clinical Trial Not Allowed) - 0 views

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    This FOA invites applications from qualified institutions to create a Roybal Center Coordinating Center (CC), serving the needs of the Roybal Centers for Translational Research on Aging program as well as the Roybal Centers for Translational Research on Dementia Care Provider Support program. The Roybal Coordinating Center will serve as a hub for the Roybal Center grant program. Roybal Center programs conduct translational research in the behavioral and social sciences of aging, structured in accordance with the NIH Stage Model. Roybal Center program resources are intended for pilot and preliminary translational, multi-directional research at Stages 0 through IV of the behavioral intervention development pipeline with the goal of creating principle-driven interventions that improve the lives of mid-life and older people and the capacity of institutions to adapt to societal aging. The Roybal Coordinating Center will facilitate and coordinate trans-Roybal activities. The Center will work closely with the NIA Program Officer and, in coordination with all Roybal sites, will be responsive to requests generated by key Roybal site personnel, NIA, NIH, the scientific community, and the general public.

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Roybal Centers for Translational Research on Dementia Care Provider Support (P30 - Clin... - 0 views

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    This Funding Opportunity Announcement (FOA) solicits Edward R. Roybal Centers for translational intervention development research for Alzheimers Disease and Alzheimers Disease related dementias care provider support. The purpose of the Roybal Centers is to develop behavioral interventions that improve the health, well-being and/or capacity of individuals and/or systems that provide care to persons with AD-ADRD. Roybal Centers will conduct Stage 0 through IV pilot studies in accordance with the multidirectional, translational NIH Stage Model, to produce potent and implementable principle-driven behavioral interventions.
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Edward R. Roybal Coordinating Center (R24 - Clinical Trial Not Allowed) - 0 views

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    This FOA invites applications from qualified institutions to create a Roybal Center Coordinating Center (CC), serving the needs of the Roybal Centers for Translational Research on Aging program as well as the Roybal Centers for Translational Research on Dementia Care Provider Support program. The Roybal Coordinating Center will serve as a hub for the Roybal Center grant program. Roybal Center programs conduct translational in the behavioral and social sciences of aging, structured in accordance with the NIH Stage Model. Roybal Center program resources are intended for pilot and preliminary translational, multi-directional research at Stages 0 through IV of the behavioral intervention development pipeline with the goal of creating principle-driven interventions that improve the lives of mid-life and older people and the capacity of institutions to adapt to societal aging. The Roybal Coordinating Center will facilitate and coordinate trans-Roybal activities. The Center will work closely with the NIA Program Officer and, in coordination with all Roybal sites, will be responsive to requests generated by key Roybal site personnel, NIA, NIH, the scientific community, and the general public.
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Alzheimer's Drug-Development Program (U01 Clinical Trial Optional) - 0 views

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    The goal of this Funding Opportunity Announcement (FOA) is to provide funding support for the pre-clinical and early stage clinical (Phase I) development of novel small-molecule and biologic therapeutic agents that prevent Alzheimer's disease (AD), slow its progression or treat its cognitive and behavioral symptoms. Participants in this program will receive funding for therapy development activities such as medicinal chemistry, pharmacokinetics (PK), Absorption, Distribution, Metabolism, Excretion, Toxicology (ADMET), efficacy in animal models, formulation development, chemical synthesis under Good Manufacturing Practices (GMP), Investigational New Drug (IND) enabling studies and initial Phase I clinical testing. This program does not support research on basic mechanisms of disease, mechanisms of drug action, development of biomarkers, devices, non-pharmacological interventions (e.g., exercise, diet, cognitive training), repurposed drugs and combinations therapies, or discovery activities such as high throughput screening and hit optimization.
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Roybal Centers for Translational Research on Aging (P30 - Clinical Trial Required) - 0 views

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    This Funding Opportunity Announcement (FOA) solicits Edward R. Roybal Centers for Translation Research in the Behavioral and Social Sciences of Aging. The purpose of the Roybal Centers is to develop behavioral interventions that improve the health and well-being of people as they are aging and the capacity of institutions to adapt to societal aging. Roybal Centers will conduct Stage 0 through IV pilot studies in accordance with the multidirectional, translational NIH Stage Model, to produce potent and implementable principle-driven behavioral interventions.
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Information and Planning: Understanding the Capacity of the Aging Network - 0 views

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    The Administration on Aging ACL intends to award one cooperative agreement designed to better understand and address the needs of the aging network through a comprehensive system of documenting and reporting on Area Agencies on Aging and Tribal Organization activities and expertise in health and the delivery of community-based services and supports.
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2018 Part the Cloud: Translational Research Funding for Alzheimer's Disease - 0 views

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    Applications will be accepted from academic investigators and small companies with lead candidate therapeutic agents that require early stage testing prior to Proof of Concept (POC) Phase 2 or 3 efficacy studies, or with lead therapeutic agents that have already established human safety data and require a small-scale pilot Proof of Mechanism (POM) study in humans to begin proving the scientific concept in humans. This award will support Phase 1 studies or pilot small- scale Phase 2a studies for repurposed drugs in normal individuals or individuals with preclinical or symptomatic Alzheimer's disease (i.e. early human studies to set the stage for efficacy studies), including single and multiple dose studies to establish safety, brain penetration and/or target engagement and POM in preparation for larger proof of concept trials. In addition, proposals may be considered that are POC to validate biological marker(s) of disease progression in a clinical trial environment. Any proposal must have a clear focus on Alzheimer's disease and related disorder and be translational in nature. All proposals should clearly and explicitly outline the measure to be investigated, the methods for study, and outcomes. Researchers from underrepresented groups are encouraged to apply.
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