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This Notice is to inform the community that NIH has revised its approach to resuming operations after the government shutdown.

This Notice supersedes NOT-OD-15-024 about the NIH and AHRQ requirement for use of a new biosketch format and provides some latitude in the transition for those who have already been compiling biosketches for their large grant applications with deadlines in early in 2015. NIH and AHRQ encourages applicants to use the newly published biosketch format for all grant and cooperative agreement applications submitted for due dates on or after January 25, 2015, and will require use of the new format for applications submitted for due dates on or after May 25, 2015. Applicants may submit using the new biosketch format for due dates before January 25, 2015, if they wish.

The purpose of this Notice is to inform new NIH applicants, their mentors, and grant administrators at their institution about two upcoming webinars the NIH Center for Scientific Review (CSR) is hosting in November 2015.  These webinars are designed to give participants useful insights into our application submission and peer review processes.  CSR is the portal for NIH grant applications and their review for scientific and technical merit.

NOTICE:  Applications are submitted to the American Heart Association via Grants@Heart, a Web-based application system.  Grants@Heart is scheduled to open on May 15, 2013.  In the meantime, please review the program listings, instructions and information in preparation for your application. 

In September, Miami received notice from the government that our new F&A rates are: 44.5% for On Campus Organized Research 44.0% On Campus Sponsored Instruction 39.0% On Campus Other Sponsored Activities 26.0% Off Campus All Programs These rates are effective beginning September 1, 2014. Awards received beginning in September and all proposal submissions going forward will be required to use the new rates.

The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is aimed at revolutionizing neuroscience through development and application of innovative technologies to map neural circuits, monitor and modulate their activity, and understand how they contribute to thoughts, sensations, emotions and behavior. NIH has issued a variety of Funding Opportunity Announcements (FOAs) that will support projects that apply technologies to understand neural circuit function in the context of specific circuits, resulting in a diverse portfolio of research into the fundamental biology of nervous system function. The purpose of this announcement is to notify the research community that NIH welcomes BRAIN Initiative applications targeting central nervous system nociceptive and pain circuits, as appropriate to the goals and requirements of specific BRAIN Initiative FOAs. Pain conditions represent an important public health problem and NIH continues to support research into pain pathologies through normal Institute and Center appropriations. However, pain and nociception are also components of normal nervous system function, and the BRAIN Initiative is committed to understanding pain circuits along with brain circuits underlying other sensory, motor, cognitive and emotional functions. It is expected that the unique opportunities of the BRAIN Initiative will enable production of detailed maps of pain circuits, and the adoption of powerful new tools for monitoring and modulating pain circuit activity, leading to significant advances in the understanding of pain and nociception. For a list of past and open BRAIN Initiative FOAs, see https://braininitiative.nih.gov/funding/.

The purpose of this Funding Opportunity Announcement (FOA) is to invite applications proposing research on current topics in Alzheimer's disease and its related dementias. Further information on the high priority topics of interest will be announced through a series of notices published in late January and early February of 2018.

The NINDS, with other NIH Institutes and Centers participating in the BRAIN Initiative, intends to publish "BRAIN Initiative Advanced Postdoctoral Career Transition Award to Promote Diversity (K99/R00)." The program is designed to increase biomedical research workforce diversity and foster a strong cohort of new, highly skilled and well trained, NIH-supported, independent investigators from underrepresented groups working in research areas supported by the BRAIN Initiative, as highlighted in BRAIN 2025: A Scientific Vision. It is designed to facilitate a timely transition of outstanding postdoctoral researchers with a research and/or clinical doctorate degree from mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions. This Notice is being provided to allow potential applicants sufficient time to develop meaningful mentoring teams and responsive projects. The FOA is expected to be published in April 2018 with an expected application due date in June 2018. This FOA will utilize the K99/R00 funding activity. Details of the planned FOA are provided below. Research Initiative Details The BRAIN Initiative K99/R00 award is intended for women and members of underrepresented groups who are working in research areas supported by the BRAIN Initiative, who have no more than five years of postdoctoral research experience, and who require at least 12 months of mentored research training and career development (K99 phase) before transitioning to the independent research (R00) phase of the program.

Repeated exposure to drugs of abuse can cause changes in neuronal structure and function that contribute to and sustain drug use. Research has largely focused on the interactions of drugs with specific neuronal targets, and on the consequences of drug exposure on neuronal function, excitability, neuroplasticity, and neurochemistry. However, emerging evidence shows that neuroimmune factors, released from both glia or neurons, can modulate neuronal structure and function, either by affecting neuron-glia interactions or through direct effects on neurons. Yet the role of neuroimmune signaling in the modulation of neuronal function as it affects the expression of substance use behaviors is poorly understood. Research has shown that drugs of abuse, including methamphetamine, morphine, cocaine and nicotine, can elicit neuroinflammatory responses. Stress, an important contributor to relapse, can also elicit neuroimmune responses. Consequently, neuroimmune signaling may be integral to mechanisms underlying drug misuse, addiction, and other consequences of repeated drug use. Further, because the molecular targets and receptors for abused substances differ, the complement of neuroimmune factors affected by exposure to a particular drug may be drug-specific. Research to identify the commonalities between specific drugs of abuse, the neuroimmune factors released by drug use, and the neuroanatomical specificity of the responses is needed. It is expected that the contributing actions of neuroimmune signaling to addictive behaviors are most likely due not to obvious brain damage and overt pathology, but to the consequences of such signaling in altering specific molecular and cellular processes within glia, neurons, and neural circuits.

This funding opportunity aims to stimulate multi-disciplinary collaboration and secondary analyses of existing clinical research datasets, from two or more multi-site clinical research studies, for addressing scientific and / or clinically relevant hypotheses that have the potential to address knowledge gaps to inform future clinical trials and/or improve clinical care in research areas within the NINDS mission. For purposes of this RFA, "existing clinical research datasets" refers to datasets from clinical trials, natural history studies, and / or comparative effectiveness research studies but excludes "mechanistic clinical studies" and "basic experimental studies of humans" (for definitions see https://grants.nih.gov/grants/guide/notice-files/NOT-NS-18-011.html and https://grants.nih.gov/grants/glossary.htm#BasicExperimentalStudieswithHumans, respectively). This RFA will support the curation and analyses of datasets from two or more multi-site clinical research studies to conduct additional secondary analyses; it will not support the collection of new data.

The Agency for Toxic Substances and Disease Registry (ATSDR) is soliciting investigator initiated research that will further the understanding of potential risk factors for ALS, while supporting the ATSDR National ALS Registry's mission. The National ALS Registry's goals are to estimate the number of new ALS cases each year, estimate the number of people who have ALS at a specific point in time, better understand who gets ALS, and identify what contributing factors, including environmental, may affect ALS. ATSDR is seeking investigator-initiated research that will identify and evaluate risk factors contributing to ALS, with preferred focus in this Notice of Funding Opportunity on factors related to military service, contact sports, traumatic brain injury, neuroinflammation and infectious agents.

In 2013, a new NSF-funded petascale computing system, Blue Waters, was deployed at the University of Illinois.  The goal of this project and system is to open up new possibilities in science and engineering by providing computational capability that makes it possible for investigators to tackle much larger and more complex research challenges across a wide spectrum of domains.  The purpose of this solicitation is to invite research groups to submit requests for allocations of resources on the Blue Waters system. Proposers must show a compelling science or engineering challenge that will require petascale computing resources. Proposers must also be prepared to demonstrate that they have a science or engineering research problem that requires and can effectively exploit the petascale computing  capabilities offered by Blue Waters.  Proposals from or including junior researchers are encouraged, as one of the goals of this solicitation is to build a community capable of using petascale computing.

The National Institutes of Health (NIH) seeks input on the restructuring of the NIH grant application instructions. We invite comments from any interested parties. We encourage feedback from PD/PIs, Administrative Offices, Offices of Sponsored Programs, Systems Administrators, and any other parties that rely on our application submission information.

The following programs have due dates that fall between October 1 - 25, 2013, and these dates are being revised due to the Federal  government shutdown. These revised dates apply whether the proposal is being submitted via the NSF FastLane System or  Grants.gov. Due to compressed proposal deadlines resulting from the shutdown, proposers are advised that they may experience a  delay when contacting IT Help Central with technical support questions. Frequently asked questions regarding these date changes  are available on the Resumption of Operations page on the NSF website at: http://www.nsf.gov/bfa/dias/policy/postshutdown.jsp. 

We are pleased to announce that the new OARS website is up and running (although the new Research Compliance and Undergraduate Research sections are still in development).   If you haven't had a chance to check it out yet, we hope you will soon.  Once you've visited, we'd be grateful if you'd give us five minutes of your time to let us know how we're doing by completing a brief eight-question survey at https://miamioh.qualtrics.com/SE/?SID=SV_erhRsEFwwWVP6m1 Finally, don't forget to update any bookmarks you may have to material on our old website!

Mark your calendar for the 2015 NIH Regional Seminar on Program Funding and Grants Administration in Baltimore, Maryland - May 6-8, 2015. This two-day seminar, with an optional third day of pre-seminar workshops, is ideal for anyone in the extramural research community who is new to working with NIH grants, including administrators, new and early stage investigators, and grant writers. Registration will open in early 2015.

The Fiscal Year 2015 Department of Defense Appropriations Act provides research funding for the following peer reviewed programs managed by the Department of Defense office of Congressionally Directed Medical Research Programs (CDMRP): Alcohol and Substance Abuse Research Program - $4.0 million Amyotrophic Lateral Sclerosis Research Program - $7.5 million Autism Research Program - $6.0 million Bone Marrow Failure Research Program - $3.2 million Breast Cancer Research Program - $120.0 million Duchenne Muscular Dystrophy Research Program - $3.2 million Epilepsy Research Program - $7.5 million Gulf War Illness Research Program - $20.0 million Joint Warfighter Medical Research Program - $50.0 million Lung Cancer Research Program - $10.5 million Military Burn Research Program - $8.0 million Multiple Sclerosis Research Program - $5.0 million Neurofibromatosis Research Program - $15.0 million Neurotoxin Exposure Treatment Parkinson's Research Program - $16.0 million Orthotics and Prosthetics Outcomes - $10.0 million Ovarian Cancer Research Program - $20.0 million Peer Reviewed Alzheimer's Research Program - $12.0 million Peer Reviewed Cancer Research Program - $50.0 million Peer Reviewed Medical Research Program - $247.5 million Peer Reviewed Orthopaedic Research Program - $30.0 million Prostate Cancer Research Program - $80.0 million Spinal Cord Injury Research Program - $30.0 million Tuberous Sclerosis Complex Research Program - $6.0 million Vision Research Program - $10.0 million