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Effect of glucosamine sulfate with or without omega-3 fatty acids in patients with osteoarthritis. Gruenwald J, Petzold E, Busch R, Petzold HP, Graubaum HJ. Adv Ther. 2009 Sep 4. [Epub ahead of print] PMID: 19756416 DOI: 10.1007/s12325-009-0060-3

"In the September 2009 issue of the journal Advances in Therapy, German researchers report that the addition of omega-3 polyunsaturated fatty acids to the over-the-counter arthritis treatment glucosamine sulfate resulted in improved alleviation of symptoms compared to glucosamine alone. The trial is the first, to the authors' knowledge, to test the combination in patients with osteoarthritis. In their introduction to the article, Joerg Gruenwald and his coauthors explain that a chronic imbalance between the synthesis and degradation of cartilage matrix leads to the loss of joint tissue that occurs in osteoarthritis. Glucosamine and omega-3 fatty acids appear to be successful in adjusting this imbalance in the direction of new cartilage synthesis"