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Weiye Loh

Rationally Speaking: Response to Jonathan Haidt's response, on the academy's liberal bias - 0 views

rationallyspeaking.blogspot.com/...nathan-haidts-response-on.html

Science Politics Diversity Divergent Thinking

shared by Weiye Loh on 14 Feb 11 - No Cached
  • Dear Prof. Haidt,You understandably got upset by my harsh criticism of your recent claims about the mechanisms behind the alleged anti-conservative bias that apparently so permeates the modern academy. I find it amusing that you simply assumed I had not looked at your talk and was therefore speaking without reason. Yet, I have indeed looked at it (it is currently published at Edge, a non-peer reviewed webzine), and found that it simply doesn’t add much to the substance (such as it is) of Tierney’s summary.
  • Yes, you do acknowledge that there may be multiple reasons for the imbalance between the number of conservative and liberal leaning academics, but then you go on to characterize the academy, at least in your field, as a tribe having a serious identity issue, with no data whatsoever to back up your preferred subset of causal explanations for the purported problem.
  • your talk is simply an extended op-ed piece, which starts out with a summary of your findings about the different moral outlooks of conservatives and liberals (which I have criticized elsewhere on this blog), and then proceeds to build a flimsy case based on a couple of anecdotes and some badly flawed data.
  • ...4 more annotations...
  • For instance, slide 23 shows a Google search for “liberal social psychologist,” highlighting the fact that one gets a whopping 2,740 results (which, actually, by Google standards is puny; a search under my own name yields 145,000, and I ain’t no Lady Gaga). You then compared this search to one for “conservative social psychologist” and get only three entries.
  • First of all, if Google searches are the main tool of social psychology these days, I fear for the entire field. Second, I actually re-did your searches — at the prompting of one of my readers — and came up with quite different results. As the photo here shows, if you actually bother to scroll through the initial Google search for “liberal social psychologist” you will find that there are in fact only 24 results, to be compared to 10 (not 3) if you search for “conservative social psychologist.” Oops. From this scant data I would simply conclude that political orientation isn’t a big deal in social psychology.
  • Your talk continues with some pretty vigorous hand-waving: “We rely on our peers to find flaws in our arguments, but when there is essentially nobody out there to challenge liberal assumptions and interpretations of experimental findings, the peer review process breaks down, at least for work that is related to those sacred values.” Right, except that I would like to see a systematic survey of exactly how the lack of conservative peer review has affected the quality of academic publications. Oh, wait, it hasn’t, at least according to what you yourself say in the next sentence: “The great majority of work in social psychology is excellent, and is unaffected by these problems.” I wonder how you know this, and why — if true — you then think that there is a problem. Philosophers call this an inherent contradiction, it’s a common example of bad argument.
  • Finally, let me get to your outrage at the fact that I have allegedly accused you of academic misconduct and lying. I have done no such thing, and you really ought (in the ethical sense) to be careful when throwing those words around. I have simply raised the logical possibility that you (and Tierney) have an agenda, a possibility based on reading several of the things both you and Tierney have written of late. As a psychologist, I’m sure you are aware that biases can be unconscious, and therefore need not imply that the person in question is lying or engaging in any form of purposeful misconduct. Or were you implying in your own talk that your colleagues’ bias was conscious? Because if so, you have just accused an entire profession of misconduct.
Weiye Loh

Haidt Requests Apology from Pigliucci « YourMorals.Org Moral Psychology Blog - 0 views

www.yourmorals.org/...equests-apology-from-pigliucci

Science Politics Diversity Divergent Thinking

shared by Weiye Loh on 14 Feb 11 - No Cached
  • Here is my response to Pigliucci, which I posted as a comment on his blog. (Well, I submitted it as a comment on Feb 13 at 4pm EST, but he has not approved it yet, so it doesn’t show yet over there.)
  • Massimo Pigliucci, the chair of the philosophy department at CUNY-Lehman, wrote a critique of me on his blog, Rationally Speaking, in which he accused me of professional misconduct.
  • Dear Prof. Pigliucci: Let me be certain that I have understood you. You did not watch my talk, even though a link to it was embedded in the Tierney article. Instead, you picked out one piece of my argument (that the near-total absence of conservatives in social psychology is evidence of discrimination) and you made the standard response, the one that most bloggers have made: underrepresentation of any group is not, by itself, evidence of discrimination. That’s a good point; I made it myself quite explicitly in my talk: Of course there are many reasons why conservatives would be underrepresented in social psychology, and most of them have nothing to do with discrimination or hostile climate. Research on personality consistently shows that liberals are higher on openness to experience. They’re more interested in novel ideas, and in trying to use science to improve society. So of course our field is and always will be mostly liberal. I don’t think we should ever strive for exact proportional representation.
  • ...6 more annotations...
  • I made it clear that I’m not concerned about simple underrepresentation. I did not even make the moral argument that we need ideological diversity to right an injustice. Rather, I focused on what happens when a scientific community shares sacred values. A tribal moral community arises, one that actively suppresses ideas that are sacrilegious, and that discourages non-believers from entering. I argued that my field has become a tribal moral community, and the absence of conservatives (not just their underrepresentation) has serious consequences for the quality of our science. We rely on our peers to find flaws in our arguments, but when there is essentially nobody out there to challenge liberal assumptions and interpretations of experimental findings, the peer review process breaks down, at least for work that is related to those sacred values. (
  • The fact that you criticized me without making an effort to understand me is not surprising.
  • Rather, what sets you apart from all other bloggers who are members of the academy is what you did next. You accused me of professional misconduct—lying, essentially–and you speculated as to my true motive: I suspect that Haidt is either an incompetent psychologist (not likely) or is disingenuously saying the sort of things controversial enough to get him in the New York Times (more likely).
  • As far as I can tell your evidence for these accusations is that my argument was so bad that I couldn’t have believed it myself. Here is how you justified your accusations: A serious social scientist doesn’t go around crying out discrimination just on the basis of unequal numbers. If that were the case, the NBA would be sued for discriminating against short people, dance companies against people without spatial coordination, and newspapers against dyslexics
  • Accusations of professional misconduct are sensibly made only if one has a reasonable and detailed understanding of the facts of the case, and can bring forth evidence of misconduct. Pigliucci has made no effort to acquire such an understanding, nor has he presented any evidence to support his accusation. He simply took one claim from the Tierney article and then ran wild with speculation about Haidt’s motives. It was pretty silly of him, and down right irresponsible of Pigliucci to publish that garbage without even knowing what Haidt said.
  • I challenge you to watch the video of my talk (click here) and then either 1) Retract your blog post and apologize publicly for calling me a liar or 2) State on your blog that you stand by your original post. If you do stand by your post, even after hearing my argument, then the world can decide for itself which of us is right, and which of us best models the ideals of science, philosophy, and the Enlightenment which you claim for yourself in the header of your blog, “Rationally Speaking.” Jonathan Haidt
Weiye Loh

Roger Pielke Jr.'s Blog: Ideological Diversity in Academia - 0 views

rogerpielkejr.blogspot.com/...cal-diversity-in-academia.html

Academia Diversity Politics

shared by Weiye Loh on 12 Feb 11 - No Cached
  • Jonathan Haidt's talk (above) at the annual meeting of the Society for Personality and Social Psychology was written up last week in a column by John Tierney in the NY Times.  This was soon followed by a dismissal of the work by Paul Krugman.  The entire sequence is interesting, but for me the best part, and the one that gets to the nub of the issue, is Haight's response to Krugman: My research, like so much research in social psychology, demonstrates that we humans are experts at using reasoning to find evidence for whatever conclusions we want to reach. We are terrible at searching for contradictory evidence. Science works because our peers are so darn good at finding that contradictory evidence for us. Social science — at least my corner of it — is broken because there is nobody to look for contradictory evidence regarding sacralized issues, particularly those related to race, gender, and class. I urged my colleagues to increase our ideological diversity not for any moral reason, but because it will make us better scientists. You do not have that problem in economics where the majority is liberal but there is a substantial and vocal minority of libertarians and conservatives. Your field is healthy, mine is not. Do you think I was wrong to call for my professional organization to seek out a modicum of ideological diversity?
  • On a related note, the IMF review of why the institution failed to warn of the global financial crisis identified a lack of intellectual diversity as being among the factors responsible (PDF): Several cognitive biases seem to have played an important role. Groupthink refers to the tendency among homogeneous, cohesive groups to consider issues only within a certain paradigm and not challenge its basic premises (Janis, 1982). The prevailing view among IMF staff—a cohesive group of macroeconomists—was that market discipline and self-regulation would be sufficient to stave off serious problems in financial institutions. They also believed that crises were unlikely to happen in advanced economies, where “sophisticated” financial markets could thrive safely with minimal regulation of a large and growing portion of the financial system.Everyyone in academia has seen similar dynamics at work.
Weiye Loh

Tom Morris - Catholicism and copyright - 0 views

blog.tommorris.org/...3405197609

Copyright Church Religion Scientology

shared by Weiye Loh on 20 Feb 11 - No Cached
  • One of the most amusing things about Scientology
  • is the fact that the scriptures of the church are copyright and some are kept very secret. The business model is simple: you have to pay to read more
  • The Bible isn’t copyright. The Qu’ran isn’t copyright. If you want to publish your own version of a huge range of religious texts, you can. Pop over to Wikisource and you can read copyright-free editions of the Bible, prayers, the Apocrypha and the Tao Te Ching among many thousands of other religious texts (and why not some atheist/humanist manifestos too?). This enables scholarship: theologians, historians and others can make their own commentaries building atop these scriptures. Critical scholarship of the sort Biblical commentators do is helped by not having the threat of a lawsuit hanging over one if one quotes a bit too much from the text.
  • ...4 more annotations...
  • What makes the Scientology situation so egregious is that no independent theological, philosophical or critical reflection can happen when the text is locked away. There seems to me to be a conflict here. If you believe you have access to a truth that has the ability to save people in the afterlife or to dramatically make their life better in this one, you have some kind of duty to share it. Or rather, if you are keeping your religious truths to yourself and not sharing them, people have very good reason to believe you might be a huckster.
  • But I found out today that Scientology is not alone in locking up their teachings behind the wall of copyright. The Catholic Church does too. All of the copyright in the papal writings of Pope Benedict XVI now belong to the Vatican publishing house, Libreria Editrice Vaticana.
  • The writings of the Pope will not go out of copyright until 70 years after his death.
  • What benefit is this to anyone? Did the lack of copyright protection for writings of Popes before the current copyright regime prevent the spread of Catholicism? If everything the Pope wrote was in public domain, would it prevent the development of the “useful Arts and Sciences”, as the U.S. Constitution puts it? The motivation of the Pope is really not the same as the motivation of the Walt Disney company. Without copyright protection, the Church will not fall to bits. Indeed, one interesting question is what the copyright status of the Catholic Catechism is. This is the basic doctrine of the Catholic faith. I would presume it is copyright in much the same way. If we criticise Scientology for locking it’s scriptures up behind copyright, surely the same could be said for the Catechism? For a body like the Catholic Church, it would seem totally reasonable and straight-forward to simply release all their materials completely as public domain.
Weiye Loh

Religion: Faith in science : Nature News - 0 views

www.nature.com/...470323a.html

Science Religion Faith Funding Academic Academic Research

shared by Weiye Loh on 18 Feb 11 - No Cached
  • The Templeton Foundation claims to be a friend of science. So why does it make so many researchers uneasy?
  • With a current endowment estimated at US$2.1 billion, the organization continues to pursue Templeton's goal of building bridges between science and religion. Each year, it doles out some $70 million in grants, more than $40 million of which goes to research in fields such as cosmology, evolutionary biology and psychology.
  • however, many scientists find it troubling — and some see it as a threat. Jerry Coyne, an evolutionary biologist at the University of Chicago, Illinois, calls the foundation "sneakier than the creationists". Through its grants to researchers, Coyne alleges, the foundation is trying to insinuate religious values into science. "It claims to be on the side of science, but wants to make faith a virtue," he says.
  • ...25 more annotations...
  • But other researchers, both with and without Templeton grants, say that they find the foundation remarkably open and non-dogmatic. "The Templeton Foundation has never in my experience pressured, suggested or hinted at any kind of ideological slant," says Michael Shermer, editor of Skeptic, a magazine that debunks pseudoscience, who was hired by the foundation to edit an essay series entitled 'Does science make belief in God obsolete?'
  • The debate highlights some of the challenges facing the Templeton Foundation after the death of its founder in July 2008, at the age of 95.
  • With the help of a $528-million bequest from Templeton, the foundation has been radically reframing its research programme. As part of that effort, it is reducing its emphasis on religion to make its programmes more palatable to the broader scientific community. Like many of his generation, Templeton was a great believer in progress, learning, initiative and the power of human imagination — not to mention the free-enterprise system that allowed him, a middle-class boy from Winchester, Tennessee, to earn billions of dollars on Wall Street. The foundation accordingly allocates 40% of its annual grants to programmes with names such as 'character development', 'freedom and free enterprise' and 'exceptional cognitive talent and genius'.
  • Unlike most of his peers, however, Templeton thought that the principles of progress should also apply to religion. He described himself as "an enthusiastic Christian" — but was also open to learning from Hinduism, Islam and other religious traditions. Why, he wondered, couldn't religious ideas be open to the type of constructive competition that had produced so many advances in science and the free market?
  • That question sparked Templeton's mission to make religion "just as progressive as medicine or astronomy".
  • Early Templeton prizes had nothing to do with science: the first went to the Catholic missionary Mother Theresa of Calcutta in 1973.
  • By the 1980s, however, Templeton had begun to realize that fields such as neuroscience, psychology and physics could advance understanding of topics that are usually considered spiritual matters — among them forgiveness, morality and even the nature of reality. So he started to appoint scientists to the prize panel, and in 1985 the award went to a research scientist for the first time: Alister Hardy, a marine biologist who also investigated religious experience. Since then, scientists have won with increasing frequency.
  • "There's a distinct feeling in the research community that Templeton just gives the award to the most senior scientist they can find who's willing to say something nice about religion," says Harold Kroto, a chemist at Florida State University in Tallahassee, who was co-recipient of the 1996 Nobel Prize in Chemistry and describes himself as a devout atheist.
  • Yet Templeton saw scientists as allies. They had what he called "the humble approach" to knowledge, as opposed to the dogmatic approach. "Almost every scientist will agree that they know so little and they need to learn," he once said.
  • Templeton wasn't interested in funding mainstream research, says Barnaby Marsh, the foundation's executive vice-president. Templeton wanted to explore areas — such as kindness and hatred — that were not well known and did not attract major funding agencies. Marsh says Templeton wondered, "Why is it that some conflicts go on for centuries, yet some groups are able to move on?"
  • Templeton's interests gave the resulting list of grants a certain New Age quality (See Table 1). For example, in 1999 the foundation gave $4.6 million for forgiveness research at the Virginia Commonwealth University in Richmond, and in 2001 it donated $8.2 million to create an Institute for Research on Unlimited Love (that is, altruism and compassion) at Case Western Reserve University in Cleveland, Ohio. "A lot of money wasted on nonsensical ideas," says Kroto. Worse, says Coyne, these projects are profoundly corrupting to science, because the money tempts researchers into wasting time and effort on topics that aren't worth it. If someone is willing to sell out for a million dollars, he says, "Templeton is there to oblige him".
  • At the same time, says Marsh, the 'dean of value investing', as Templeton was known on Wall Street, had no intention of wasting his money on junk science or unanswerables such as whether God exists. So before pursuing a scientific topic he would ask his staff to get an assessment from appropriate scholars — a practice that soon evolved into a peer-review process drawing on experts from across the scientific community.
  • Because Templeton didn't like bureaucracy, adds Marsh, the foundation outsourced much of its peer review and grant giving. In 1996, for example, it gave $5.3 million to the American Association for the Advancement of Science (AAAS) in Washington DC, to fund efforts that work with evangelical groups to find common ground on issues such as the environment, and to get more science into seminary curricula. In 2006, Templeton gave $8.8 million towards the creation of the Foundational Questions Institute (FQXi), which funds research on the origins of the Universe and other fundamental issues in physics, under the leadership of Anthony Aguirre, an astrophysicist at the University of California, Santa Cruz, and Max Tegmark, a cosmologist at the Massachusetts Institute of Technology in Cambridge.
  • But external peer review hasn't always kept the foundation out of trouble. In the 1990s, for example, Templeton-funded organizations gave book-writing grants to Guillermo Gonzalez, an astrophysicist now at Grove City College in Pennsylvania, and William Dembski, a philosopher now at the Southwestern Baptist Theological Seminary in Fort Worth, Texas. After obtaining the grants, both later joined the Discovery Institute — a think-tank based in Seattle, Washington, that promotes intelligent design. Other Templeton grants supported a number of college courses in which intelligent design was discussed. Then, in 1999, the foundation funded a conference at Concordia University in Mequon, Wisconsin, in which intelligent-design proponents confronted critics. Those awards became a major embarrassment in late 2005, during a highly publicized court fight over the teaching of intelligent design in schools in Dover, Pennsylvania. A number of media accounts of the intelligent design movement described the Templeton Foundation as a major supporter — a charge that Charles Harper, then senior vice-president, was at pains to deny.
  • Some foundation officials were initially intrigued by intelligent design, Harper told The New York Times. But disillusionment set in — and Templeton funding stopped — when it became clear that the theory was part of a political movement from the Christian right wing, not science. Today, the foundation website explicitly warns intelligent-design researchers not to bother submitting proposals: they will not be considered.
  • Avowedly antireligious scientists such as Coyne and Kroto see the intelligent-design imbroglio as a symptom of their fundamental complaint that religion and science should not mix at all. "Religion is based on dogma and belief, whereas science is based on doubt and questioning," says Coyne, echoing an argument made by many others. "In religion, faith is a virtue. In science, faith is a vice." The purpose of the Templeton Foundation is to break down that wall, he says — to reconcile the irreconcilable and give religion scholarly legitimacy.
  • Foundation officials insist that this is backwards: questioning is their reason for being. Religious dogma is what they are fighting. That does seem to be the experience of many scientists who have taken Templeton money. During the launch of FQXi, says Aguirre, "Max and I were very suspicious at first. So we said, 'We'll try this out, and the minute something smells, we'll cut and run.' It never happened. The grants we've given have not been connected with religion in any way, and they seem perfectly happy about that."
  • John Cacioppo, a psychologist at the University of Chicago, also had concerns when he started a Templeton-funded project in 2007. He had just published a paper with survey data showing that religious affiliation had a negative correlation with health among African-Americans — the opposite of what he assumed the foundation wanted to hear. He was bracing for a protest when someone told him to look at the foundation's website. They had displayed his finding on the front page. "That made me relax a bit," says Cacioppo.
  • Yet, even scientists who give the foundation high marks for openness often find it hard to shake their unease. Sean Carroll, a physicist at the California Institute of Technology in Pasadena, is willing to participate in Templeton-funded events — but worries about the foundation's emphasis on research into 'spiritual' matters. "The act of doing science means that you accept a purely material explanation of the Universe, that no spiritual dimension is required," he says.
  • It hasn't helped that Jack Templeton is much more politically and religiously conservative than his father was. The foundation shows no obvious rightwards trend in its grant-giving and other activities since John Templeton's death — and it is barred from supporting political activities by its legal status as a not-for-profit corporation. Still, many scientists find it hard to trust an organization whose president has used his personal fortune to support right-leaning candidates and causes such as the 2008 ballot initiative that outlawed gay marriage in California.
  • Scientists' discomfort with the foundation is probably inevitable in the current political climate, says Scott Atran, an anthropologist at the University of Michigan in Ann Arbor. The past 30 years have seen the growing power of the Christian religious right in the United States, the rise of radical Islam around the world, and religiously motivated terrorist attacks such as those in the United States on 11 September 2001. Given all that, says Atran, many scientists find it almost impossible to think of religion as anything but fundamentalism at war with reason.
  • the foundation has embraced the theme of 'science and the big questions' — an open-ended list that includes topics such as 'Does the Universe have a purpose?'
  • Towards the end of Templeton's life, says Marsh, he became increasingly concerned that this reaction was getting in the way of the foundation's mission: that the word 'religion' was alienating too many good scientists.
  • The peer-review and grant-making system has also been revamped: whereas in the past the foundation ran an informal mix of projects generated by Templeton and outside grant seekers, the system is now organized around an annual list of explicit funding priorities.
  • The foundation is still a work in progress, says Jack Templeton — and it always will be. "My father believed," he says, "we were all called to be part of an ongoing creative process. He was always trying to make people think differently." "And he always said, 'If you're still doing today what you tried to do two years ago, then you're not making progress.'" 
Weiye Loh

How Is Twitter Impacting Search and SEO? Here's the (Visual) Proof | MackCollier.com - Social Media Training and Consulting - 0 views

mackcollier.com/how-twitter-impacts-seo

Twitter Search Engine Optimization SEO Search Social Social Media Optimization Social Media

shared by Weiye Loh on 24 Feb 11 - No Cached
  • I picked a fairly specific term, in “Social Media Crisis Management”.  I checked prior to publishing yesterday’s post, and there were just a shade under 29,000 Google results for that term.  This is important because you need to pick the most specific term as possible, because this will result in less competition, and (if you’ve picked the right term for you) it means you will be more likely to get the ‘right’ kind of traffic.
  • Second, I made sure the term was in the title and mentioned a couple of times in the post.  I also made the term “Social Media Crisis Management” at the front of the post title, I originally had the title as “A No-Nonsense Guide to Social Media Crisis Management” but Amy wisely suggested that I flip it so the term I was targeting was at the front of the title.
  • when I published the post yesterday at 12:20pm, there were 28,900 Google results for the term “Social Media Crisis Management”.  I tweeted a link to it at that time.  Fifty minutes later at 1:10pm, the post was already showing up on the 3rd page for a Google search of #Social Media Crisis Management”:
  • ...5 more annotations...
  • I tweeted out another link to the post around 2pm, and then at 2:30pm, it moved a bit further up the results on the 3rd page:
  • The Latest results factors in real-time linking behavior, so it is picking up all the tweets where my post was being RTed, and as a result, the top half of the Latest results for the term “Social Media Crisis Management” were completely devoted to MY post.
  • That’s a perfect example of how Twitter and Facebook sharing is now impacting Google results.  And it’s also a wonderful illustration of the value of being active on Twitter.  I tweeted a link to that post several times yesterday and this morning, which was a big reason why it moved up the Google results so quickly, and a big reason why it dominated the Latest results for that term.
  • there are two things I want you to take away from this: 1 – This was very basic SEO stuff that any of you can do.  It was simply a case of targeting a specific phrase, and inserting it in the post.  Now as far as my having a large and engaged Twitter network and readership here (thanks guys!), that definitely played a big factor in the post moving up the results so quickly.  But at a basic level, everything I did from a SEO perspective is what you can do with every post.  And you should.
  • 2 – You can best learn by breaking stuff.  There are a gazillion ‘How to’ and ’10 Steps to…’ articles about using social media, and I have certainly written my fair share of these.  But the best way *I* learn is if you can show me the first 1 or 2 steps, then leave me alone and let me figure out the remaining 8 or 9 steps for myself.  Don’t just blindly follow my social media advice or anyone else’s.  Use the advice as a guide for how you can get started.  But there is no one RIGHT way to use social media.  Never forget that.  I can tell you what works for me and my clients, but you still need to tweak any advice so that it is perfect for you.  SEO geeks will no doubt see a ton of things that I could have done or altered in this experiment to get even better results.  And moving forward, I am going to continue to tweak and ‘break stuff’ in order to better figure out how all the moving parts work together.
Weiye Loh

Rationally Speaking: Studying folk morality: philosophy, psychology, or what? - 0 views

rationallyspeaking.blogspot.com/...-folk-morality-philosophy.html

Experiment Philosophy Inter-disciplinary Demarcation

shared by Weiye Loh on 28 Feb 11 - No Cached
  • in the magazine article Joshua mentions several studies of “folk morality,” i.e. of how ordinary people think about moral problems. The results are fascinating. It turns out that people’s views are correlated with personality traits, with subjects who score high on “openness to experience” being reliably more relativists than objectivists about morality (I am not using the latter term in the infamous Randyan meaning here, but as Knobe does, to indicate the idea that morality has objective bases).
  • Other studies show that people who are capable of considering multiple options in solving mathematical puzzles also tend to be moral relativists, and — in a study co-authored by Knobe himself — the very same situation (infanticide) was judged along a sliding scale from objectivism to relativism depending on whether the hypothetical scenario involved a fellow American (presumably sharing our same general moral values), the member of an imaginary Amazonian tribe (for which infanticide was acceptable), and an alien from the planet Pentar (belonging to a race whose only goal in life is to turn everything into equilateral pentagons, and killing individuals that might get in the way of that lofty objective is a duty). Oh, and related research also shows that young children tend to be objectivists, while young adults are usually relativists — but that later in life one’s primordial objectivism apparently experiences a comeback.
  • This is all very interesting social science, but is it philosophy? Granted, the differences between various disciplines are often not clear cut, and of course whenever people engage in truly inter-disciplinary work we should simply applaud the effort and encourage further work. But I do wonder in what sense, if any, the kinds of results that Joshua and his colleagues find have much to do with moral philosophy.
  • ...6 more annotations...
  • there seems to me the potential danger of confusing various categories of moral discourse. For instance, are the “folks” studied in these cases actually relativist, or perhaps adherents to one of several versions of moral anti-realism? The two are definitely not the same, but I doubt that the subjects in question could tell the difference (and I wouldn’t expect them to, after all they are not philosophers).
  • why do we expect philosophers to learn from “folk morality” when we do not expect, say, physicists to learn from folk physics (which tends to be Aristotelian in nature), or statisticians from people’s understanding of probability theory (which is generally remarkably poor, as casino owners know very well)? Or even, while I’m at it, why not ask literary critics to discuss Shakespeare in light of what common folks think about the bard (making sure, perhaps, that they have at least read his works, and not just watched the movies)?
  • Hence, my other examples of stat (i.e., math) and literary criticism. I conceive of philosophy in general, and moral philosophy in particular, as more akin to a (science-informed, to be sure) mix between logic and criticism. Some moral philosophy consists in engaging an “if ... then” sort of scenario, akin to logical-mathematical thinking, where one begins with certain axioms and attempts to derive the consequences of such axioms. In other respects, moral philosophers exercise reflective criticism concerning those consequences as they might be relevant to practical problems.
  • For instance, we may write philosophically about abortion, and begin our discussion from a comparison of different conceptions of “person.” We might conclude that “if” one adopts conception X of what a person is, “then” abortion is justifiable under such and such conditions; while “if” one adopts conception Y of a person, “then” abortion is justifiable under a different set of conditions, or not justifiable at all. We could, of course, back up even further and engage in a discussion of what “personhood” is, thus moving from moral philosophy to metaphysics.
  • Nowhere in the above are we going to ask “folks” what they think a person is, or how they think their implicit conception of personhood informs their views on abortion. Of course people’s actual views on abortion are crucial — especially for public policy — and they are intrinsically interesting to social scientists. But they don’t seem to me to make much more contact with philosophy than the above mentioned popular opinions on Shakespeare make contact with serious literary criticism. And please, let’s not play the cheap card of “elitism,” unless we are willing to apply the label to just about any intellectual endeavor, in any discipline.
  • There is one area in which experimental philosophy can potentially contribute to philosophy proper (as opposed to social science). Once we have a more empirically grounded understanding of what people’s moral reasoning actually is, then we can analyze the likely consequences of that reasoning for a variety of societal issues. But now we would be doing something more akin to political than moral philosophy.
  • Weiye Loh on 28 Feb 11
     
    My colleague Joshua Knobe at Yale University recently published an intriguing article in The Philosopher's Magazine about the experimental philosophy of moral decision making. Joshua and I have had a nice chat during a recent Rationally Speaking podcast dedicated to experimental philosophy, but I'm still not convinced about the whole enterprise.
Weiye Loh

Effective media reporting of sea level rise projections: 1989-2009 - 0 views

iopscience.iop.org/...014004

Journalism Climate Science Sea Level

shared by Weiye Loh on 26 Feb 11 - No Cached
  • Weiye Loh on 26 Feb 11
     
    In the mass media, sea level rise is commonly associated with the impacts of climate change due to increasing atmospheric greenhouse gases. As this issue garners ongoing international policy attention, segments of the scientific community have expressed unease about how this has been covered by mass media. Therefore, this study examines how sea level rise projections-in IPCC Assessment Reports and a sample of the scientific literature-have been represented in seven prominent United States (US) and United Kingdom (UK) newspapers over the past two decades. The research found that-with few exceptions-journalists have accurately portrayed scientific research on sea level rise projections to 2100. Moreover, while coverage has predictably increased in the past 20 years, journalists have paid particular attention to the issue in years when an IPCC report is released or when major international negotiations take place, rather than when direct research is completed and specific projections are published. We reason that the combination of these factors has contributed to a perceived problem in the sea level rise reporting by the scientific community, although systematic empirical research shows none. In this contemporary high-stakes, high-profile and highly politicized arena of climate science and policy interactions, such results mark a particular bright spot in media representations of climate change. These findings can also contribute to more measured considerations of climate impacts and policy action at a critical juncture of international negotiations and everyday decision-making associated with the causes and consequences of climate change.
Weiye Loh

Skepticblog » A Creationist Challenge - 0 views

skepticblog.org/...a-creationist-challenge

Creationism Evolution Logic

shared by Weiye Loh on 01 Mar 11 - No Cached
  • The commenter starts with some ad hominems, asserting that my post is biased and emotional. They provide no evidence or argument to support this assertion. And of course they don’t even attempt to counter any of the arguments I laid out. They then follow up with an argument from authority – he can link to a PhD creationist – so there.
  • The article that the commenter links to is by Henry M. Morris, founder for the Institute for Creation Research (ICR) – a young-earth creationist organization. Morris was (he died in 2006 following a stroke) a PhD – in civil engineering. This point is irrelevant to his actual arguments. I bring it up only to put the commenter’s argument from authority into perspective. No disrespect to engineers – but they are not biologists. They have no expertise relevant to the question of evolution – no more than my MD. So let’s stick to the arguments themselves.
  • The article by Morris is an overview of so-called Creation Science, of which Morris was a major architect. The arguments he presents are all old creationist canards, long deconstructed by scientists. In fact I address many of them in my original refutation. Creationists generally are not very original – they recycle old arguments endlessly, regardless of how many times they have been destroyed.
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  • Morris also makes heavy use of the “taking a quote out of context” strategy favored by creationists. His quotes are often from secondary sources and are incomplete.
  • A more scholarly (i.e. intellectually honest) approach would be to cite actual evidence to support a point. If you are going to cite an authority, then make sure the quote is relevant, in context, and complete.
  • And even better, cite a number of sources to show that the opinion is representative. Rather we get single, partial, and often outdated quotes without context.
  • (nature is not, it turns out, cleanly divided into “kinds”, which have no operational definition). He also repeats this canard: Such variation is often called microevolution, and these minor horizontal (or downward) changes occur fairly often, but such changes are not true “vertical” evolution. This is the microevolution/macroevolution false dichotomy. It is only “often called” this by creationists – not by actual evolutionary scientists. There is no theoretical or empirical division between macro and micro evolution. There is just evolution, which can result in the full spectrum of change from minor tweaks to major changes.
  • Morris wonders why there are no “dats” – dog-cat transitional species. He misses the hierarchical nature of evolution. As evolution proceeds, and creatures develop a greater and greater evolutionary history behind them, they increasingly are committed to their body plan. This results in a nestled hierarchy of groups – which is reflected in taxonomy (the naming scheme of living things).
  • once our distant ancestors developed the basic body plan of chordates, they were committed to that body plan. Subsequent evolution resulted in variations on that plan, each of which then developed further variations, etc. But evolution cannot go backward, undo evolutionary changes and then proceed down a different path. Once an evolutionary line has developed into a dog, evolution can produce variations on the dog, but it cannot go backwards and produce a cat.
  • Stephen J. Gould described this distinction as the difference between disparity and diversity. Disparity (the degree of morphological difference) actually decreases over evolutionary time, as lineages go extinct and the surviving lineages are committed to fewer and fewer basic body plans. Meanwhile, diversity (the number of variations on a body plan) within groups tends to increase over time.
  • the kind of evolutionary changes that were happening in the past, when species were relatively undifferentiated (compared to contemporary species) is indeed not happening today. Modern multi-cellular life has 600 million years of evolutionary history constraining their future evolution – which was not true of species at the base of the evolutionary tree. But modern species are indeed still evolving.
  • Here is a list of research documenting observed instances of speciation. The list is from 1995, and there are more recent examples to add to the list. Here are some more. And here is a good list with references of more recent cases.
  • Next Morris tries to convince the reader that there is no evidence for evolution in the past, focusing on the fossil record. He repeats the false claim (again, which I already dealt with) that there are no transitional fossils: Even those who believe in rapid evolution recognize that a considerable number of generations would be required for one distinct “kind” to evolve into another more complex kind. There ought, therefore, to be a considerable number of true transitional structures preserved in the fossils — after all, there are billions of non-transitional structures there! But (with the exception of a few very doubtful creatures such as the controversial feathered dinosaurs and the alleged walking whales), they are not there.
  • I deal with this question at length here, pointing out that there are numerous transitional fossils for the evolution of terrestrial vertebrates, mammals, whales, birds, turtles, and yes – humans from ape ancestors. There are many more examples, these are just some of my favorites.
  • Much of what follows (as you can see it takes far more space to correct the lies and distortions of Morris than it did to create them) is classic denialism – misinterpreting the state of the science, and confusing lack of information about the details of evolution with lack of confidence in the fact of evolution. Here are some examples – he quotes Niles Eldridge: “It is a simple ineluctable truth that virtually all members of a biota remain basically stable, with minor fluctuations, throughout their durations. . . .“ So how do evolutionists arrive at their evolutionary trees from fossils of organisms which didn’t change during their durations? Beware the “….” – that means that meaningful parts of the quote are being omitted. I happen to have the book (The Pattern of Evolution) from which Morris mined that particular quote. Here’s the rest of it: (Remember, by “biota” we mean the commonly preserved plants and animals of a particular geological interval, which occupy regions often as large as Roger Tory Peterson’s “eastern” region of North American birds.) And when these systems change – when the older species disappear, and new ones take their place – the change happens relatively abruptly and in lockstep fashion.”
  • Eldridge was one of the authors (with Gould) of punctuated equilibrium theory. This states that, if you look at the fossil record, what we see are species emerging, persisting with little change for a while, and then disappearing from the fossil record. They theorize that most species most of the time are at equilibrium with their environment, and so do not change much. But these periods of equilibrium are punctuated by disequilibrium – periods of change when species will have to migrate, evolve, or go extinct.
  • This does not mean that speciation does not take place. And if you look at the fossil record we see a pattern of descendant species emerging from ancestor species over time – in a nice evolutionary pattern. Morris gives a complete misrepresentation of Eldridge’s point – once again we see intellectual dishonesty in his methods of an astounding degree.
  • Regarding the atheism = religion comment, it reminds me of a great analogy that I first heard on twitter from Evil Eye. (paraphrase) “those that say atheism is a religion, is like saying ‘not collecting stamps’ is a hobby too.”
  • Morris next tackles the genetic evidence, writing: More often is the argument used that similar DNA structures in two different organisms proves common evolutionary ancestry. Neither argument is valid. There is no reason whatever why the Creator could not or would not use the same type of genetic code based on DNA for all His created life forms. This is evidence for intelligent design and creation, not evolution.
  • Here is an excellent summary of the multiple lines of molecular evidence for evolution. Basically, if we look at the sequence of DNA, the variations in trinucleotide codes for amino acids, and amino acids for proteins, and transposons within DNA we see a pattern that can only be explained by evolution (or a mischievous god who chose, for some reason, to make life look exactly as if it had evolved – a non-falsifiable notion).
  • The genetic code is essentially comprised of four letters (ACGT for DNA), and every triplet of three letters equates to a specific amino acid. There are 64 (4^3) possible three letter combinations, and 20 amino acids. A few combinations are used for housekeeping, like a code to indicate where a gene stops, but the rest code for amino acids. There are more combinations than amino acids, so most amino acids are coded for by multiple combinations. This means that a mutation that results in a one-letter change might alter from one code for a particular amino acid to another code for the same amino acid. This is called a silent mutation because it does not result in any change in the resulting protein.
  • It also means that there are very many possible codes for any individual protein. The question is – which codes out of the gazillions of possible codes do we find for each type of protein in different species. If each “kind” were created separately there would not need to be any relationship. Each kind could have it’s own variation, or they could all be identical if they were essentially copied (plus any mutations accruing since creation, which would be minimal). But if life evolved then we would expect that the exact sequence of DNA code would be similar in related species, but progressively different (through silent mutations) over evolutionary time.
  • This is precisely what we find – in every protein we have examined. This pattern is necessary if evolution were true. It cannot be explained by random chance (the probability is absurdly tiny – essentially zero). And it makes no sense from a creationist perspective. This same pattern (a branching hierarchy) emerges when we look at amino acid substitutions in proteins and other aspects of the genetic code.
  • Morris goes for the second law of thermodynamics again – in the exact way that I already addressed. He responds to scientists correctly pointing out that the Earth is an open system, by writing: This naive response to the entropy law is typical of evolutionary dissimulation. While it is true that local order can increase in an open system if certain conditions are met, the fact is that evolution does not meet those conditions. Simply saying that the earth is open to the energy from the sun says nothing about how that raw solar heat is converted into increased complexity in any system, open or closed. The fact is that the best known and most fundamental equation of thermodynamics says that the influx of heat into an open system will increase the entropy of that system, not decrease it. All known cases of decreased entropy (or increased organization) in open systems involve a guiding program of some sort and one or more energy conversion mechanisms.
  • Energy has to be transformed into a usable form in order to do the work necessary to decrease entropy. That’s right. That work is done by life. Plants take solar energy (again – I’m not sure what “raw solar heat” means) and convert it into food. That food fuels the processes of life, which include development and reproduction. Evolution emerges from those processes- therefore the conditions that Morris speaks of are met.
  • But Morris next makes a very confused argument: Evolution has neither of these. Mutations are not “organizing” mechanisms, but disorganizing (in accord with the second law). They are commonly harmful, sometimes neutral, but never beneficial (at least as far as observed mutations are concerned). Natural selection cannot generate order, but can only “sieve out” the disorganizing mutations presented to it, thereby conserving the existing order, but never generating new order.
  • The notion that evolution (as if it’s a thing) needs to use energy is hopelessly confused. Evolution is a process that emerges from the system of life – and life certainly can use solar energy to decrease its entropy, and by extension the entropy of the biosphere. Morris slips into what is often presented as an information argument.  (Yet again – already dealt with. The pattern here is that we are seeing a shuffling around of the same tired creationists arguments.) It is first not true that most mutations are harmful. Many are silent, and many of those that are not silent are not harmful. They may be neutral, they may be a mixed blessing, and their relative benefit vs harm is likely to be situational. They may be fatal. And they also may be simply beneficial.
  • Morris finishes with a long rambling argument that evolution is religion. Evolution is promoted by its practitioners as more than mere science. Evolution is promulgated as an ideology, a secular religion — a full-fledged alternative to Christianity, with meaning and morality . . . . Evolution is a religion. This was true of evolution in the beginning, and it is true of evolution still today. Morris ties evolution to atheism, which, he argues, makes it a religion. This assumes, of course, that atheism is a religion. That depends on how you define atheism and how you define religion – but it is mostly wrong. Atheism is a lack of belief in one particular supernatural claim – that does not qualify it as a religion.
  • But mutations are not “disorganizing” – that does not even make sense. It seems to be based on a purely creationist notion that species are in some privileged perfect state, and any mutation can only take them farther from that perfection. For those who actually understand biology, life is a kluge of compromises and variation. Mutations are mostly lateral moves from one chaotic state to another. They are not directional. But they do provide raw material, variation, for natural selection. Natural selection cannot generate variation, but it can select among that variation to provide differential survival. This is an old game played by creationists – mutations are not selective, and natural selection is not creative (does not increase variation). These are true but irrelevant, because mutations increase variation and information, and selection is a creative force that results in the differential survival of better adapted variation.
  • Weiye Loh on 01 Mar 11
     
    One of my earlier posts on SkepticBlog was Ten Major Flaws in Evolution: A Refutation, published two years ago. Occasionally a creationist shows up to snipe at the post, like this one:i read this and found it funny. It supposedly gives a scientific refutation, but it is full of more bias than fox news, and a lot of emotion as well.here's a scientific case by an actual scientists, you know, one with a ph. D, and he uses statements by some of your favorite evolutionary scientists to insist evolution doesn't exist.i challenge you to write a refutation on this one.http://www.icr.org/home/resources/resources_tracts_scientificcaseagainstevolution/Challenge accepted.
Weiye Loh

Do Fights Over Climate Communication Reflect the End of 'Scientism'? - NYTimes.com - 0 views

dotearth.blogs.nytimes.com/...n-reflect-the-end-of-scientism

Climate Science Journalism Communication Scientism Politics Policy

shared by Weiye Loh on 28 Feb 11 - No Cached
  • climate (mis)communication. Two sessions explored a focal point of this blog, the interface of climate science and policy, and the roles of scientists and the media in fostering productive discourse. Both discussions homed in on an uncomfortable reality — the erosion of a longstanding presumption that scientific information, if communicated more effectively, will end up framing policy choices.
  • First I sat in on a symposium on the  future of climate communication in a world where traditional science journalism is a shrinking wedge of a growing pie of communication options. The discussion didn’t really provide many answers, but did reveal the persistent frustrations of some scientists with the way the media cover their field.
  • Sparks flew between Kerry Emanuel, a climatologist long focused on hurricanes and warming, and Seth Borenstein, who covers climate and other science for the Associated Press. Borenstein spoke highly of a Boston Globe dual profile of Emanuel and his colleague at the Massachusetts Institute of Technology,  Richard Lindzen. To Emanuel, the piece was a great example of what he described as “he said, he said” coverage of science. Borenstein replied that this particular piece was not centered on the science, but on the men — in the context of their relationship, research and worldviews. (It’s worth noting that Emanuel, whom I’ve been interviewing on hurricanes and climate since 1988, describes himself as  a conservative and, mainly, Republican voter.)
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  • Keith Kloor, blogging on the session  at Collide-a-Scape, included a sobering assessment of the scientist-journalist tensions over global warming from Tom Rosensteil, a panelist and long-time journalist who now heads up Pew’s Project for Excellence in Journalism: If you’re waiting for the press to persuade the public, you’re going to lose. The press doesn’t see that as its job.
  • scientists have  a great opportunity, and responsibility, to tell their own story more directly, as some are doing occasionally through Dot Earth “ Post Cards” and The Times’ Scientist at Work blog.
  • Naomi Oreskes, a political scientist at the University of California, San Diego, and co-author of “Merchants of Doubt“: Of Mavericks and Mules Gavin Schmidt of NASA’s Goddard Institute for Space Studies and Realclimate.org: Between Sound Bites and the Scientific Paper: Communicating in the Hinterland Thomas Lessl, a scholar at the University of Georgia focused on the cultural history of science: Reforming Scientific Communication About Anthropogenic Climate Change
  • I focused on two words in the title of the session — diversity and denial. The diversity of lines of inquiry in climate science has a two-pronged impact. It helps build a robust overall picture of a growing human influence on a complex system. But for many of the most important  pixel points in that picture, there is robust, durable and un-manufactured debate. That debate can then be exploited by naysayers eager to cast doubt on the enterprise, when in fact — as I’ve written here before — it’s simply the (sometimes ugly) way that science progresses.
  • My denial, I said, lay in my longstanding presumption, like that of many scientists and journalists, that better communication of information will tend to change people’s perceptions, priorities and behavior. This attitude, in my view, crested for climate scientists in the wake of the 2007 report from the Intergovernmental Panel on Climate Change.
  • In his talk, Thomas Lessl said much of this attitude is rooted in what he and some other social science scholars call “scientism,” the idea — rooted in the 19th century — that scientific inquiry is a “distinctive mode of inquiry that promises to bring clarity to all human endeavors.” [5:45 p.m. | Updated Chris Mooney sent an e-mail noting how the discussion below resonates with "Do Scientists Understand the Public," a report he wrote last year for the American Academy of Arts and Sciences and explored here.]
  • Scientism, though it is good at promoting the recognition that scientific knowledge is the only kind of knowledge, also promotes communication behavior that is bad for the scientific ethos. By this I mean that it turns such communication into combat. By presuming that scientific understanding is the only criterion that matters, scientism inclines public actors to treat resistant audiences as an enemy: If the public doesn’t get the science, shame on the public. If the public rejects a scientific claim, it is either because they don’t get it or because they operate upon some sinister motive.
  • Scientific knowledge cannot take the place of prudence in public affairs.
  • Prudence, according to Robert Harriman, “is the mode of reasoning about contingent matters in order to select the best course of action. Contingent events cannot be known with certainty, and actions are intelligible only with regard to some idea of what is good.”
  • Scientism tends to suppose a one-size-fits-all notion of truth telling. But in the public sphere, people don’t think that way. They bring to the table a variety of truth standards: moral judgment, common-sense judgment, a variety of metaphysical perspectives, and ideological frameworks. The scientists who communicate about climate change may regard these standards as wrong-headed or at best irrelevant, but scientists don’t get to decide this in a democratic debate. When scientists become public actors, they have stepped outside of science, and they are obliged to honor the rules of communication and thought that govern the rest of the world. This might be different, if climate change was just about determining the causes of climate change, but it never is. Getting from the acceptance of ACC to acceptance of the kinds of emissions-reducing policies that are being advocated takes us from one domain of knowing into another.
  • One might object by saying that the formation of public policy depends upon first establishing the scientific bases of ACC, and that the first question can be considered independently of the second. Of course that is right, but that is an abstract academic distinction that does not hold in public debates. In public debates a different set of norms and assumptions apply: motive is not to be casually set aside as a nonfactor. Just because scientists customarily bracket off scientific topics from their policy implications does not mean that lay people do this—or even that they should be compelled to do so. When scientists talk about one thing, they seem to imply the other. But which is the motive force? Are they advocating for ACC because they subscribe to a political worldview that supports legal curtailments upon free enterprise? Or do they support such a political worldview because they are convinced of ACC? The fact that they speak as scientists may mean to other scientists that they reason from evidence alone. But the public does not necessarily share this assumption. If scientists don’t respect this fact about their audiences, they are bound to get in trouble. [Read the rest.]
Weiye Loh

Roger Pielke Jr.'s Blog: What's a Science Advisor For? - 0 views

rogerpielkejr.blogspot.com/...whats-science-advisor-for.html

Science Politics Policy

shared by Weiye Loh on 24 Feb 11 - No Cached
  • The first Chief Scientist for Australia, Penny Sackett, resigned this week halfway into her five-year term, citing personal and professional reasons.  The Australian media has reported that during her tenure Professor Sackett met with Kevin Rudd once and has never briefed Julia Gillard. In a Senate hearing yesterday, Professor Sackett downplayed any conflict.
  • Even so, the distance from top level policy making is at distinct odds with how the position of Chief Scientist is officially described (PDF): The Chief Scientist for Australia, Professor Penny D Sackett, provides high-level independent advice to the Prime Minister and other Ministers on matters relating to science, technology and innovation. . . While responsive to requests from Government for advice generated as a result of emerging issues, Professor Sackett also provides proactive advice to the Prime Minister on issues she deems important in securing Australia’s wellbeing into the future.
  • Nature reports the views of a few leading Australian scientists on the role of Chief Scientist: “I don’t think the chief scientist’s role is very highly regarded by Australian governments,” said Peter Doherty, a Nobel prize-winning immunologist from the University of Melbourne. Doherty said Sackett was a victim of the new political landscape in Australia that evolveed while she was in office, largely shaped by the fact that the government is now in a minority. “I think new appointee would have to be pretty naïve going into this parliament if they thought they were going to make much of a difference, except on something the government is already looking to do, such as putting a price on carbon.” “I suspect that Penny Sackett probably signed up for a job that was different to the one that she ended up having to do,” agreed materials scientist Cathy Foley, president of the Federation of Australian Scientific and Technological Societies, who served with Sackett on the Prime Minister’s Science, Engineering and Innovation Council. “I think when it comes to policy development, science has been the loser for the sake of political concerns.”
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  • From 2005-2007 I conducted interviews of 7 former science advisors to the US president, who had served presidents from Lyndon Johnson to George W. Bush.  What we learned from them suggests that we should not be too surprised by what has happened in Australia. Our analysis of those interviews concludes as follows (PDF): The position of science advisor has evolved and changed over the past half-century, as has both science and government. The experiences of the science advisors that we were fortunate to visit with chronicle those changes. Underneath the anecdotes and stories that describe presidents over the past half-century is a deeper story, one of the long-term decline of the influence of the president’s science advisor while at the same time, the importance of expertise to government has increased tremendously. The decline of the science advisor, juxtaposed against the rise of government expertise, provides ample reason to reconsider the future role of the presidential science advisor, and to set our expectations for that role accordingly.
  • Professor Sackett's departing advice is well worth heeding: When quizzed about what improvements could be made to the role of chief scientist, Professor Sackett said it was the Government's responsibility to clarify what role the chief scientist should play. "I think the responsibility rests firmly with the Government to make it, to decide how the role of chief scientist for Australia will fit into the variety of advice that it receives on matters of science"
  • R. A. Pielke, Jr. and R. Klein (2009). The Rise and Fall of the Science Advisor to the President of the United States. Minerva 47 (1) 7-29, doi: 10.1007/s11024-009-9117-3.
Weiye Loh

Random Thoughts Of A Free Thinker: The TCM vs. Western medicine debate -- a philosophical and political debate? - 0 views

searchingforenlightenment.blogspot.com/...s-western-medicine-debate.html

TCM Alternative Medicine Health Science Epistemology Politics Post-Colonialism

shared by Weiye Loh on 19 Feb 11 - No Cached
  • there is a sub-field within the study of philosophy that looks at what should qualify as valid or certain knowledge. And one main divide in this sub-field would perhaps be the divide between empiricism and rationalism. Proponents of the former generally argue that only what can be observed by the senses should qualify as valid knowledge while proponents of the latter are more sceptical about sensory data since such data can be "false" (for example, optical illusions) and instead argue that valid knowledge should be knowledge that is congruent with reason.
  • Another significant divide in this sub-field would be the divide between positivism/scientism and non-positivism/scientism. Essentially, proponents of the former argue that only knowledge that is congruent with scientific reasoning or that can be scientifically proven should qualify as valid knowledge. In contrast, the proponents of non-positivism/scientism is of the stance that although scientific knowledge may indeed be a form of valid knowledge, it is not the only form of valid knowledge; knowledge derived from other sources or methods may be just as valid.
  • Evidently, the latter divide is relevant with regards to this debate over the validity of TCM, or alternative medicine in general, as a form of medical treatment vis-a-vis Western medicine, in that the general impression perhaps that while Western medicine is scientifically proven, the former is however not as scientifically proven. And thus, to those who abide by the stance of positivism/scientism, this will imply that TCM, or alternative medicine in general, is not as valid or reliable a form of medical treatment as Western medicine. On the other hand, as can be seen from the letters written in to the ST Forum to defend TCM, there are those who will argue that although TCM may not be as scientifically proven, this does not however imply that it is not a valid or reliable form of medical treatment.
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  • Of course, while there are similarities between the positions adopted in the "positivism/scientism versus non-positivism/scientism" and "Western medicine versus alternative medicine" debates, I suppose that one main difference is however that the latter is not just a theoretical debate but involves people's health and lives.
  • As was mentioned earlier, the general impression is perhaps that while Western medicine, which generally has its roots in Western societies, is scientifically proven, TCM, or alternative medicine, is however not as scientifically proven. The former is thus regarded as the dominant mainstream model of medical treatment while non-Western medical knowledge or treatment is regarded as "alternative medicine".
  • The process by which the above impression was created was, according to the postcolonial theorists, a highly political one. Essentially, it may be argued that along with their political colonisation of non-European territories in the past, the European/Western colonialists also colonised the minds of those living in those territories. This means that along with colonisation, traditional forms of knowledge, including medical knowledge, and cultures in the colonised terrorities were relegated to a non-dominant, if not inferior, position vis-a-vis Western knowledge and culture. And as postcolonial theorists may argue, the legacy and aftermath of this process is still felt today and efforts should be made to reverse it.
  • In light of the above, the increased push to have non-Western forms of medical treatment be recognised as an equally valid model of medical treatment besides that of Western medicine may be seen as part of the effort to reverse the dominance of Western knowledge and culture set in place during the colonial period. Of course, this push to reverse Western dominance is especially relevant in recent times, in light of the economic and political rise of non-Western powers such as China and India (interestingly enough, to the best of my knowledge, when talking about "alternative medicine", people are usually referring to traditional Indian or Chinese medical treatments and not really traditional African medical treatment).
  • Here, it is worthwhile to pause and think for a while: if it is recognised that Western and non-Western medicine are different but equally valid models of medical treatment, would they be complimentary or competing models? Or would they be just different models?
  • Moving on, so far it would seem that , for at least the foreseeable future, Western medicine will retain its dominant "mainstream" position but who knows what the future may hold?
Weiye Loh

Leong Sze Hian stands corrected? | The Online Citizen - 0 views

theonlinecitizen.com/...eong-sze-hian-stands-corrected

Statistics Interpretation Singapore Education

shared by Weiye Loh on 26 Mar 11 - No Cached
  • In your article, you make the argument that “Straits Times Forum Editor, was merely amending his (my) letter to cite the correct statistics. “For example, the Education Minister said “How children from the bottom one-third by socio-economic background fare: One in two scores in the top two-thirds at PSLE” - But, Mr Samuel Wee wrote “His statement is backed up with the statistic that 50% of children from the bottom third of the socio-economic ladder score in the bottom third of the Primary School Leaving Examination”.” Kind sir, the statistics state that 1 in 2 are in the top 66.6% (Which, incidentally, includes the top fifth of the bottom 50%!) Does it not stand to reason, then, that if 50% are in the top 66.6%, the remaining 50% are in the bottom 33.3%, as I stated in my letter?
  • Also, perhaps you were not aware of the existence of this resource, but here is a graph from the Straits Times illustrating the fact that only 10% of children from one-to-three room flats make it to university–which is to say, 90% of them don’t. http://www.straitstimes.com/STI/STIMEDIA/pdf/20110308/a10.pdf I look forward to your reply, Mr Leong. Thank you for taking the time to read this message.
  • we should, wherever possible, try to agree to disagree, as it is healthy to have and to encourage different viewpoints.
    • Weiye Loh
      Weiye Loh on 26 Mar 11
       
      Does that mean that every viewpoint can and should be accepted as correct to encourage differences? 
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  • If I say I think it is fair in Singapore, because half of the bottom one-third of the people make it to the top two-thirds, it does not mean that someone can quote me and say that I said what I said because half the bottom one-third of people did not make it. I think it is alright to say that I do not agree entirely with what was said, because does it also mean on the flip side that half of the bottom one-third of the people did not make it? This is what I mean by quoting one out of context, by using statistics that I did not say, and implying that I did, or by innuendo.
  • Moreover, depending on the methodology, definition, sampling, etc, half of the  bottom one-third of the people making it, does not necessary mean that half did not make it, because some may not be in the population because of various reasons, like emigration, not turning up, transfer, whether adjustments are made  for the mobility of people up or down the social strata over time, etc. If I did not use a particular statistic to state my case, for example, I don’t think it is appropriate to quote me and say that you agree with me by citing statistics from a third party source, like the MOE chart in the Straits Times article, instead of quoting the statistics that I said.
  • I cannot find anything in any of the media reports to say with certainty that the Minister backed up his remarks with direct reference to the MOE chart. There is also nothing in the narrative that only 10 per cent  of children from one-to-three room flats make it to university – which is to say, 90 per cent  of them don’t. The ’90 per cent’ cannot be attributed to what the minister said, as at best it is the writer’s interpretation of the MOE chart.
  • Interesting exchange of letters. Samuel’s interpretation of the statistics provided by Ng Eng Hen and ST is correct. There is little doubt about it. While I can see where Leong Sze Hian is coming from, I don’t totally agree with him. Specifically, Samuel’s first statement (only ~10% of students living in 1-3 room flat make it to university) is directed at ST’s report that education is a good social leveller but not at Ng. It is therefore a valid point to make.
Weiye Loh

CultureLab: Thoughts within thoughts make us human - 0 views

www.newscientist.com/...in-thoughts-make-us-human.html

Language Thinking Technology

shared by Weiye Loh on 05 Jun 11 - No Cached
  • Corballis reckons instead that the thought processes that made language possible were non-linguistic, but had recursive properties to which language adapted: "Where Chomsky views thought through the lens of language, I prefer to view language though the lens of thought." From this, says Corballis, follows a better understanding of how humans actually think - and a very different perspective on language and its evolution.
  • So how did recursion help ancient humans pull themselves up by their cognitive bootstraps? It allowed us to engage in mental time travel, says Corballis, the recursive operation whereby we recall past episodes into present consciousness and imagine future ones, and sometimes even insert fictions into reality.
  • theory of mind is uniquely highly developed in humans: I may know not only what you are thinking, says Corballis, but also that you know what I am thinking. Most - but not all - language depends on this capability.
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  • Corballis's theories also help make sense of apparent anomalies such as linguist and anthropologist Daniel's Everett's work on the Pirahã, an Amazonian people who hit the headlines because of debates over whether their language has any words for colours, and, crucially, numbers. Corballis now thinks that the Pirahã language may not be that unusual, and cites the example of other languages from oral cultures, such as the Iatmul language of New Guinea, which is also said to lack recursion.
  • The emerging point is that recursion developed in the mind and need not be expressed in a language. But, as Corballis is at pains to point out, although recursion was critical to the evolution of the human mind, it is not one of those "modules" much beloved of evolutionary psychologists, many of which are said to have evolved in the Pleistocene. Nor did it depend on some genetic mutation or the emergence of some new neuron or brain structure. Instead, he suggests it came of progressive increases in short-term memory and capacity for hierarchical organisation - all dependent in turn on incremental increases in brain size.
  • But as Corballis admits, this brain size increase was especially rapid in the Pleistocene. These incremental changes can lead to sudden more substantial jumps - think water boiling or balloons popping. In mathematics these shifts are called catastrophes. So, notes Corballis, wryly, "we may perhaps conclude that the emergence of the human mind was catastrophic". Let's hope that's not too prescient.
  • Weiye Loh on 05 Jun 11
     
    His new book, The Recursive Mind: The origins of human language, thought, and civilization, is a fascinating and well-grounded exposition of the nature and power of recursion. In its ultra-reasonable way, this is quite a revolutionary book because it attacks key notions about language and thought. Most notably, it disputes the idea, argued especially by linguist Noam Chomsky, that thought is fundamentally linguistic - in other words, you need language before you can have thoughts.
Weiye Loh

The Failure of Liberal Bioethics - NYTimes.com - 1 views

douthat.blogs.nytimes.com/...e-failure-of-liberal-bioethics

Bioethics

shared by Weiye Loh on 20 Aug 11 - No Cached
  • There are three broad camps in contemporary debates over bioethics. In the name of human rights and human dignity, “bio-conservatives” tend to support restricting, regulating and stigmatizing the technologies that allow us to create, manipulate and destroy embryonic life. In the name of scientific progress and human freedom, “bio-libertarians” tend to oppose any restrictions on what individuals, doctors and researchers are allowed to do. Then somewhere in between are the anguished liberals, who are uncomfortable with what they see as the absolutism of both sides, and who tend to argue that society needs to decide where to draw its bioethical lines not based on some general ideal (like “life” or “choice”), but rather case by case by case — accepting this kind of abortion but not that kind; this use of embryos but not that use; existing developments in genetic engineering but not, perhaps, the developments that await us in the future.
  • at least in the United States, the liberal effort to (as the Goodman of 1980 put it) “monitor” and “debate” and “control” the development of reproductive technologies has been extraordinarily ineffectual. From embryo experimentation to selective reduction to the eugenic uses of abortion, liberals always promise to draw lines and then never actually manage to draw them. Like Dr. Evans, they find reasons to embrace each new technological leap while promising to resist the next one — and then time passes, science marches on, and they find reasons why the next moral compromise, too, must be accepted for the greater good, or at least tolerated in the name of privacy and choice. You can always count on them to worry, often perceptively, about hypothetical evils, potential slips down the bioethical slope. But they’re either ineffectual or accommodating once an evil actually arrives. Tomorrow, they always say — tomorrow, we’ll draw the line. But tomorrow never comes.
  • Weiye Loh on 20 Aug 11
     
    The Failure of Liberal Bioethics; http://t.co/6QrUPkl
yongernn teo

Ethics and Values Case Study- Mercy Killing, Euthanasia - 8 views

www.brainmass.com/...86151

Euthanasia

shared by yongernn teo on 21 Oct 09 - Cached
  • yongernn teo on 21 Oct 09
     
    THE ETHICAL PROBLEM: Allowing someone to die, mercy death, and mercy killing, Euthanasia: A 24-year-old man named Robert who has a wife and child is paralyzed from the neck down in a motorcycle accident. He has always been very active and hates the idea of being paralyzed. He also is in a great deal of pain, an he has asked his doctors and other members of his family to "put him out of his misery." After several days of such pleading, his brother comes into Robert's hospital ward and asks him if he is sure he still wants to be put out of his misery. Robert says yes and pleads with his brother to kill him. The brother kisses and blesses Robert, then takes out a gun and shoots him, killing him instantly. The brother later is tried for murder and acquitted by reason of temporary insanity. Was what Robert's brother did moral? Do you think he should have been brought to trial at all? Do you think he should have been acquitted? Would you do the same for a loved one if you were asked? THE DISCUSSION: In my opinion, the most dubious part about the case would be the part on Robert pleading with his brother, asking his brother to kill him. This could be his brother's own account of the incident and could/could not have been a plea by Robert. 1) With assumption that Robert indeed pleaded with his brother to kill him, an ethical analysis as such could be derived: That Robert's brother was only respecting Robert's choice and killed him because he wanted to relieve him from his misery. This could be argued to be ethical using a teleoloigical framework where the focus is on the end-result and the consequences that entails the action. Here, although the act of killing per se may be wrong and illegal, Robert was able to relieved of his pain and suffering. 2) With an assumption that Robert did not plea with his brother to kill him and that it was his brother's own decision to relieve Robert of all-suffering: In this case, the b
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  • Elaine Ong on 22 Oct 09
     
    I find euthanasia to be a very interesting ethical dilemma. Even I myself am caught in the middle. Euthanasia has been termed as 'mercy killing' and even 'happy death'. Others may simply just term it as being 'evil'. Is it right to end someone's life even when he or she pleads you to do so? In the first place, is it even right to commit suicide? Once someone pulls off the main support that's keeping the person alive, such as the feeding tube, there is no turning back. Hmm..Come to think of it, technology is kind of unethical by being made available, for in the past, when someone is dying, they had the right to die naturally. Now, scientific technology is 'forcing' us to stay alive and cling on to a life that may be deemed being worthless if we were standing outside our bodies looking at our comatose selves. Then again, this may just be MY personal standpoint. But I have to argue, who gave technology the right to make me a worthless vegetable!(and here I am, attaching a value/judgement onto an immobile human being..) Hence, being incompetent in making decisions for my unconscious self (or perhaps even brain dead), who should take responsibility for my life, for my existence? And on what basis are they allowed to help me out? Taking the other side of the argument, against euthanasia, we can say that the act of ending someone else's life is the act of destroying societal respect for life. Based on the utilitarian perspective, we are not thinking of the overall beneficence for society and disregarding the moral considerations encompassed within the state's interest to preserve the sanctity of all life. It has been said that life in itself takes priority over all other values. We should let the person live so as to give him/her a chance to wake up or hope for recovery (think comatose patients). But then again we can also argue that life is not the top of the hierarchy! A life without rights is as if not living a life at all? By removing the patient
  • juliet huang on 28 Oct 09
     
    as a human being, you supposedly have a right to live, whether you are mobile or immobile. however, i think that, in the case of euthanasia, you 'give up' your rights when you "show" that you are no longer able to serve the pre-requisites of having the right. for example, if "living" rights are equate to you being able to talk, walk, etc etc, then, obviously the opposite means you no longer are able to perform up to the expectations of that right. then again, it is very subjective as to who gets to make that criteria!
  • Magdaleine on 02 Nov 09
     
    hmm interesting.. however, a question i have is who and when can this "right" be "given up"? when i am a victim in a car accident, and i lost the ability to breathe, walk and may need months to recover. i am unconscious and the doctor is unable to determine when am i gonna regain consciousness. when should my parents decide i can no longer be able to have any living rights? and taking elaine's point into consideration, is committing suicide even 'right'? if it is legally not right, when i ask someone to take my life and wrote a letter that it was cus i wanted to die, does that make it committing suicide only in the hands of others?
  • Low Yunying on 04 Nov 09
     
    Similarly, I question the 'rights' that you have to 'give up' when you no longer 'serve the pre-requisites of having the right'. If the living rights means being able to talk and walk, then where does it leave infants? Where does it leave people who may be handicapped? Have their lost their rights to living?
Weiye Loh

AP IMPACT: Framed for child porn - by a PC virus by AP: Yahoo! Tech - 0 views

tech.yahoo.com/...us_tec_a_virus_framed_me

Privacy Child Pornography Virus

shared by Weiye Loh on 14 Nov 09 - Cached
  • Pedophiles can exploit virus-infected PCs to remotely store and view their stash without fear they'll get caught. Pranksters or someone trying to frame you can tap viruses to make it appear that you surf illegal Web sites.
  • Whatever the motivation, you get child porn on your computer — and might not realize it until police knock at your door.
  • In 2007, Fiola's bosses became suspicious after the Internet bill for his state-issued laptop showed that he used 4 1/2 times more data than his colleagues. A technician found child porn in the PC folder that stores images viewed online. Fiola was fired and charged with possession of child pornography, which carries up to five years in prison. He endured death threats, his car tires were slashed and he was shunned by friends. Fiola and his wife fought the case, spending $250,000 on legal fees. They liquidated their savings, took a second mortgage and sold their car. An inspection for his defense revealed the laptop was severely infected. It was programmed to visit as many as 40 child porn sites per minute — an inhuman feat. While Fiola and his wife were out to dinner one night, someone logged on to the computer and porn flowed in for an hour and a half. Prosecutors performed another test and confirmed the defense findings. The charge was dropped — 11 months after it was filed.
    • Weiye Loh
      Weiye Loh on 14 Nov 09
       
      The law is reason beyond passion. Yet, reasons may be flawed, bounded, or limited by our in irrationality. Who are we to blame if we are victims of such false accusation? Is it right then to carry on with these proceedings just so those who are truly guilty won't get away scot-free? 
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  • The Fiolas say they have health problems from the stress of the case. They say they've talked to dozens of lawyers but can't get one to sue the state, because of a cap on the amount they can recover. "It ruined my life, my wife's life and my family's life," he says. The Massachusetts attorney general's office, which charged Fiola, declined interview requests.
Weiye Loh

Roger Pielke Jr.'s Blog: Blind Spots in Australian Flood Policies - 0 views

rogerpielkejr.blogspot.com/...spots-in-australian-flood.html

Flood Disaster Climate Science Data

shared by Weiye Loh on 14 Apr 11 - No Cached
  • better management of flood risks in Australia will depend up better data on flood risk.  However, collecting such data has proven problematic
  • As many Queenslanders affected by January’s floods are realising, riverine flood damage is commonly excluded from household insurance policies. And this is unlikely to change until councils – especially in Queensland – stop dragging their feet and actively assist in developing comprehensive data insurance companies can use.
  • ? Because there is often little available information that would allow an insurer to adequately price this flood risk. Without this, there is little economic incentive for insurers to accept this risk. It would be irresponsible for insurers to cover riverine flood without quantifying and pricing the risk accordingly.
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  • The first step in establishing risk-adjusted premiums is to know the likelihood of the depth of flooding at each address. This information has to be address-specific because the severity of flooding can vary widely over small distances, for example, from one side of a road to the other.
  • A litany of reasons is given for withholding data. At times it seems that refusal stems from a view that insurance is innately evil. This is ironic in view of the gratuitous advice sometimes offered by politicians and commentators in the aftermath of extreme events, exhorting insurers to pay claims even when no legal liability exists and riverine flood is explicitly excluded from policies.
  • Risk Frontiers is involved in jointly developing the National Flood Information Database (NFID) for the Insurance Council of Australia with Willis Re, a reinsurance broking intermediary. NFID is a five year project aiming to integrate flood information from all city councils in a consistent insurance-relevant form. The aim of NFID is to help insurers understand and quantify their risk. Unfortunately, obtaining the base data for NFID from some local councils is difficult and sometimes impossible despite the support of all state governments for the development of NFID. Councils have an obligation to assess their flood risk and to establish rules for safe land development. However, many are antipathetic to the idea of insurance. Some states and councils have been very supportive – in New South Wales and Victoria, particularly. Some states have a central repository – a library of all flood studies and digital terrain models (digital elevation data). Council reluctance to release data is most prevalent in Queensland, where, unfortunately, no central repository exists.
  • Second, models of flood risk are sometimes misused:
  • many councils only undertake flood modelling in order to create a single design flood level, usually the so-called one-in-100 year flood. (For reasons given later, a better term is the flood with an 1% annual likelihood of being exceeded.)
  • Inundation maps showing the extent of the flood with a 1% annual likelihood of exceedance are increasingly common on council websites, even in Queensland. Unfortunately these maps say little about the depth of water at an address or, importantly, how depth varies for less probable floods. Insurance claims usually begin when the ground is flooded and increase rapidly as water rises above the floor level. At Windsor in NSW, for example, the difference in the water depth between the flood with a 1% annual chance of exceedance and the maximum possible flood is nine metres. In other catchments this difference may be as small as ten centimetres. The risk of damage is quite different in both cases and an insurer needs this information if they are to provide coverage in these areas.
  • The ‘one-in-100 year flood’ term is misleading. To many it is something that happens regularly once every 100 years — with the reliability of a bus timetable. It is still possible, though unlikely, that a flood of similar magnitude or even greater flood could happen twice in one year or three times in successive years.
  • The calculations underpinning this are not straightforward but the probability that an address exposed to a 1-in-100 year flood will experience such an event or greater over the lifetime of the house – 50 years say – is around 40%. Over the lifetime of a typical home mortgage – 25 years – the probability of occurrence is 22%. These are not good odds.
  • Weiye Loh on 14 Apr 11
     
    John McAneney of Risk Frontiers at Macquarie University in Sydney identifies some opportunities for better flood policies in Australia.
Weiye Loh

A Brief Primer on Criminal Statistics « Canada « Skeptic North - 0 views

www.skepticnorth.com/...-primer-on-criminal-statistics

Crime Statistics

shared by Weiye Loh on 20 Apr 11 - No Cached
  • Occurrences of crime are properly expressed as the number of incidences per 100,000 people. Total numbers are not informative on their own and it is very easy to manipulate an argument by cherry picking between a total number and a rate.  Beware of claims about crime that use raw incidence numbers. When a change in whole incidence numbers is observed, this might not have any bearing on crime levels at all, because levels of crime are dependent on population.
  • Whole Numbers versus Rates
  • Reliability Not every criminal statistic is equally reliable. Even though we have measures of incidences of crimes across types and subtypes, not every one of these statistics samples the actual incidence of these crimes in the same way. Indeed, very few measure the total incidences very reliably at all. The crime rates that you are most likely to encounter capture only crimes known and substantiated by police. These numbers are vulnerable to variances in how crimes become known and verified by police in the first place. Crimes very often go unreported or undiscovered. Some crimes are more likely to go unreported than others (such as sexual assaults and drug possession), and some crimes are more difficult to substantiate as having occurred than others.
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  • Complicating matters further is the fact that these reporting patterns vary over time and are reflected in observed trends.   So, when a change in the police reported crime rate is observed from year to year or across a span of time we may be observing a “real” change, we may be observing a change in how these crimes come to the attention of police, or we may be seeing a mixture of both.
  • Generally, the most reliable criminal statistic is the homicide rate – it’s very difficult, though not impossible, to miss a dead body. In fact, homicides in Canada are counted in the year that they become known to police and not in the year that they occurred.  Our most reliable number is very, very close, but not infallible.
  • Crimes known to the police nearly always under measure the true incidence of crime, so other measures are needed to better complete our understanding. The reported crimes measure is reported every year to Statistics Canada from data that makes up the Uniform Crime Reporting Survey. This is a very rich data set that measures police data very accurately but tells us nothing about unreported crime.
  • We do have some data on unreported crime available. Victims are interviewed (after self-identifying) via the General Social Survey. The survey is conducted every five years
  • This measure captures information in eight crime categories both reported, and not reported to police. It has its own set of interpretation problems and pathways to misuse. The survey relies on self-reporting, so the accuracy of the information will be open to errors due to faulty memories, willingness to report, recording errors etc.
  • From the last data set available, self-identified victims did not report 69% of violent victimizations (sexual assault, robbery and physical assault), 62% of household victimizations (break and enter, motor vehicle/parts theft, household property theft and vandalism), and 71% of personal property theft victimizations.
  • while people generally understand that crimes go unreported and unknown to police, they tend to be surprised and perhaps even shocked at the actual amounts that get unreported. These numbers sound scary. However, the most common reasons reported by victims of violent and household crime for not reporting were: believing the incident was not important enough (68%) believing the police couldn’t do anything about the incident (59%), and stating that the incident was dealt with in another way (42%).
  • Also, note that the survey indicated that 82% of violent incidents did not result in injuries to the victims. Do claims that we should do something about all this hidden crime make sense in light of what this crime looks like in the limited way we can understand it? How could you be reasonably certain that whatever intervention proposed would in fact reduce the actual amount of crime and not just reduce the amount that goes unreported?
  • Data is collected at all levels of the crime continuum with differing levels of accuracy and applicability. This is nicely reflected in the concept of “the crime funnel”. All criminal incidents that are ever committed are at the opening of the funnel. There is “loss” all along the way to the bottom where only a small sample of incidences become known with charges laid, prosecuted successfully and responded to by the justice system.  What goes into the top levels of the funnel affects what we can know at any other point later.
Weiye Loh

Alzheimer's Studies Find New Genetic Links - NYTimes.com - 0 views

www.nytimes.com/...04alzheimer.html

Genetic Alzheimer Data

shared by Weiye Loh on 04 Apr 11 - No Cached
  • The two largest studies of Alzheimer’s disease have led to the discovery of no fewer than five genes that provide intriguing new clues to why the disease strikes and how it progresses.
  • For years, there have been unproven but persistent hints that cholesterol and inflammation are part of the disease process. People with high cholesterol are more likely to get the disease. Strokes and head injuries, which make Alzheimer’s more likely, also cause brain inflammation. Now, some of the newly discovered genes appear to bolster this line of thought, because some are involved with cholesterol and others are linked to inflammation or the transport of molecules inside cells.
  • By themselves, the genes are not nearly as important a factor as APOE, a gene discovered in 1995 that greatly increases risk for the disease: by 400 percent if a person inherits a copy from one parent, by 1,000 percent if from both parents.
  • ...7 more annotations...
  • In contrast, each of the new genes increases risk by no more than 10 to 15 percent; for that reason, they will not be used to decide if a person is likely to develop Alzheimer’s. APOE, which is involved in metabolizing cholesterol, “is in a class of its own,” said Dr. Rudolph Tanzi, a neurology professor at Harvard Medical School and an author of one of the papers.
  • But researchers say that even a slight increase in risk helps them in understanding the disease and developing new therapies. And like APOE, some of the newly discovered genes appear to be involved with cholesterol.
  • The other paper is by researchers in Britain, France and other European countries with contributions from the United States. They confirmed the genes found by the American researchers and added one more gene.
  • The American study got started about three years ago when Gerard D. Schellenberg, a pathology professor at the University of Pennsylvania, went to the National Institutes of Health with a complaint and a proposal. Individual research groups had been doing their own genome studies but not having much success, because no one center had enough subjects. In an interview, Dr. Schellenberg said that he had told Dr. Richard J. Hodes, director of the National Institute on Aging, the small genomic studies had to stop, and that Dr. Hodes had agreed. These days, Dr. Hodes said, “the old model in which researchers jealously guarded their data is no longer applicable.”
  • So Dr. Schellenberg set out to gather all the data he could on Alzheimer’s patients and on healthy people of the same ages. The idea was to compare one million positions on each person’s genome to determine whether some genes were more common in those who had Alzheimer’s. “I spent a lot of time being nice to people on the phone,” Dr. Schellenberg said. He got what he wanted: nearly every Alzheimer’s center and Alzheimer’s geneticist in the country cooperated. Dr. Schellenberg and his colleagues used the mass of genetic data to do an analysis and find the genes and then, using two different populations, to confirm that the same genes were conferring the risk. That helped assure the investigators that they were not looking at a chance association. It was a huge effort, Dr. Mayeux said. Many medical centers had Alzheimer’s patients’ tissue sitting in freezers. They had to extract the DNA and do genome scans.
  • “One of my jobs was to make sure the Alzheimer’s cases really were cases — that they had used some reasonable criteria” for diagnosis, Dr. Mayeux said. “And I had to be sure that people who were unaffected really were unaffected.”
  • Meanwhile, the European group, led by Dr. Julie Williams of the School of Medicine at Cardiff University, was engaged in a similar effort. Dr. Schellenberg said the two groups compared their results and were reassured that they were largely finding the same genes. “If there were mistakes, we wouldn’t see the same things,” he added. Now the European and American groups are pooling their data to do an enormous study, looking for genes in the combined samples. “We are upping the sample size,” Dr. Schellenberg said. “We are pretty sure more stuff will pop out.”
  • Weiye Loh on 04 Apr 11
     
    Gene Study Yields
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