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Research Highlights Characterizing the Effects of Triclosan and Triclocarban on the Intestinal Epithelial Homeostasis Using Small Intestinal Organoids Assessment of TCS/TCC Toxicity on Intestinal Epithelium Using Organoid Models.

Pancreatic Organoids Research Highlights Pancreatic Cancer Tumor Organoids Exhibit Subtype-Specific Differences in Metabolic Profiles Organoid Models Uncover Subtype-Specific Therapeutic Avenues in PDAC Patient-derived Organoid Pharmacotyping as A Predictive Tool for Therapeutic Selection in Pancreatic Ductal Adenocarcinoma Advancing Pancreatic Cancer Therapies with Patient-Derived Organoid Pharmacotyping Wnt-Deficient and Hypoxic Environment Orchestrates Squamous Reprogramming of Human Pancreatic Ductal Adenocarcinoma Integrating Organoid Systems to Elucidate the Epigenetic Mechanisms of Pancreatic Tumorigenesis

Research Highlights Optimization of Culture Conditions to Generate Vascularized Multi-Lineage Liver Organoids with Structural Complexity and Functionalityv Vascularized Multi-Lineage Liver Organoids: A New Frontier in Disease Modeling Evaluating the Effects of Perinatal Exposures to BPSIP on Hepatic Cholesterol Metabolism in Female and Male Offspring ICR Mice Breaking Barriers: Utilizing Liver Organoids to Study BPSIP's Metabolic Impact HKDC1 Promotes Liver Cancer Stemness Under Hypoxia via Stabilizing β-Catenin Exploiting Hepatic Organoid Models to Uncover HKDC1's Role in Liver Cancer Metastasis m6A-Dependent ITIH1 Regulated by TGF-β Acts as a Target for Hepatocellular Carcinoma Progression Recombinant ITIH1 Protein Inhibits Hepatocellular Carcinoma Growth in 3D Organoid Cultures

Research Highlights Malignant Pleural Effusion Facilitates the Establishment and Maintenance of Tumor Organoid Biobank with Multiple Patient-Derived Lung Tumor Cell Sources Malignant Pleural Effusion Boosts Lung Cancer Organoid Establishment Modeling Lung Adenocarcinoma Metastases Using Patient-Derived Lung Organoids The Role of Organoid Models in Evaluating GOQD-PEI/S2.2/pLVSIN-iC9 Gene Therapy

Research Highlights KCNJ16-Depleted Kidney Organoids Recapitulate Tubulopathy and Lipid Recovery upon Statins Treatment Statin Treatment Reverses Lipid Accumulation in KCNJ16-Deficient Kidney Organoids T2+ T-regulatory Cells in Renal Inflammation and Fibrosis following Ischemic Kidney Injury Kidney Organoids Illuminate the Protective Role of ST2+ Tregs in Renal Inflammation and Fibrosis A perfusable, vascularized kidney organoid-on-chip model [Biofabrication] Microfluidic Kidney Organoid with Vascular Integration for Perfusion Studies. A Genetically Inducible Endothelial Niche Enables Vascularization of Human Kidney Organoids with Multilineage Maturation and Emergence of Renin Expressing Cells [Lab on a Chip] Brain Organoid sEVs Modulate Breast Cancer Invasion in Microphysiological Assays. Kidney Organoid Modeling of WT1 Mutations Reveals Key Regulatory Paths Underlying Podocyte Development [Advanced Science] WT1 Mutations in Kidney Organoids: Unveiling Regulatory Pathways.