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Too many carbs, not fats, may be the culprit in raising risk of premature death, according to a study published online Aug. 29 in the The Lancet to coincide with the European Society of Cardiology Congress 2017, held from Aug. 26 to 30 in Barcelona, Spain. Mahshid Dehghan, Ph.D., an investigator with the Population Health Research Institute at McMaster University in Hamilton, Canada, and colleagues tracked the diet and health of 135,335 people, aged 35 to 70, from 18 countries around the world, to gain a global perspective on the health effects of diet. Participants provided detailed information on their social and economic status, lifestyle, medical history, and current health. They also completed a questionnaire on their regular diet, which researchers used to calculate their average daily calories from fats, carbohydrates, and proteins. The research team then tracked the participants' health for about seven years on average, with follow-up visits at least every three years. The investigators found that high-carbohydrate diets are common, with more than half of the people deriving 70 percent of their daily calories from carbs. People with a high fat intake -- about 35 percent of their daily diet -- had a 23 percent lower risk of early death and 18 percent lower risk of stroke compared to people who ate less fat. The researchers also noted that a very low intake of saturated fats (below 3 percent of daily diet) was associated with a higher risk of death in the study, compared to diets containing up to 13 percent daily. At the same time, high-carb diets -- containing an average 77 percent carbohydrates -- were associated with a 28 percent increased risk of death versus low-carb diets. "The study showed that contrary to popular belief, increased consumption of dietary fats is associated with a lower risk of death," Dehghan told HealthDay. "We found no evidence that below 10 percent of energy by saturated fat is beneficial, and going below 7 percent may even be har

It was not a big problem in order to improve and support my health during the winter. Due to the problems with health, I am trying to maintain my condition.

Unfortunately, there are diseases that are relevant at any time of the year and can affect people with any immunity and at any age. For example https://easystd.com/gonorrhea Of course a lot depends on us in this case, but I agree that to suffer from something like this is extremely unpleasant and treatment may also cost a lot of money.

For patients undergoing right heart catheterization (RHC), borderline pulmonary hypertension (PH) is associated with increased risk of mortality, according to a study published online Oct. 25 in JAMA Cardiology. Tufik R. Assad, M.D., from Vanderbilt University School of Medicine in Nashville, Tennessee, and colleagues conducted a retrospective cohort study involving patients undergoing routine RHC for clinical indication. Patients were classified according to mean pulmonary arterial pressure (mPAP) values as reference, borderline PH, and PH (mPAP values of ≤18, 19 to 24, and ≥25 mmHg, respectively). The researchers found that the prevalence of PH and borderline PH was 62 and 18 percent, respectively, among 4,343 patients. Independent associations were seen for advanced age, features of the metabolic syndrome, and chronic heart and lung disease with increased likelihood of borderline PH versus reference patients. Borderline PH was correlated with increased mortality compared with reference patients after adjustment for 34 variables (hazard ratio, 1.31). With higher mPAP there was an incremental increase in the risk of death, without an observed threshold. Sixty-one percent of the 70 patients with borderline PH who underwent repeated RHC had developed overt PH, with a 5 mmHg median increase in mPAP (interquartile range, -1 to 11 mmHg; P < 0.001).

For young patients with type 1 diabetes, insulin pump therapy is associated with lower risks of severe hypoglycemia and diabetic ketoacidosis and better glycemic control than insulin injection therapy, according to a study published online Oct. 10 in the Journal of the American Medical Association. Beate Karges, M.D., from RWTH Aachen University in Germany, and colleagues conducted a population-based cohort study in 446 diabetes centers. They identified patients with type 1 diabetes who were younger than 20 years and had diabetes duration of more than one year. The researchers found that 14,119 patients used pump therapy and 16,460 used insulin injections. A total of 9,814 patients using pump therapy were matched with 9,814 using injection therapy. Compared with injection therapy, pump therapy was correlated with lower rates of severe hypoglycemia (9.55 versus 13.97 per 100 patient-years) and diabetic ketoacidosis (3.64 versus 4.26 per 100 patient-years). Lower levels of glycated hemoglobin were seen with pump versus injection therapy (8.04 versus 8.22 percent). Compared with injection therapy, pump therapy was associated with lower total daily insulin doses (0.84 versus 0.98 U/kg). No significant difference in body mass index was seen between the treatment regimens

The incidence of lower urinary tract injuries is 0.33 percent for patients undergoing gynecologic laparoscopy for benign indications, according to a review published online Dec. 4 in Obstetrics & Gynecology. Jacqueline M.K. Wong, M.D., from the Northwestern University Feinberg School of Medicine in Chicago, and colleagues conducted a systematic review of studies to examine the incidence, location, etiology, timing, management, and long-term sequelae of urinary tract injury in gynecologic laparoscopy for benign indication. Ninety studies met the inclusion criteria, representing 140,444 surgeries. The researchers identified 458 lower urinary tract injuries with an incidence of 0.33 percent. Bladder injury occurred three times more often than ureteral injury (0.24 versus 0.08 percent). The highest rates of injury were seen for laparoscopic hysterectomy not otherwise specified and laparoscopically assisted vaginal hysterectomy (1.8 and 1.0 percent, respectively). Most ureteral and bladder injuries resulted from electrosurgery (33.3 percent) and lysis of adhesions (23.3 percent), respectively. Ureteral injuries were most often recognized postoperatively (60 percent) and repaired by open ureteral anastomosis (47.4 percent), while most bladder injuries were recognized intraoperatively (85 percent) and repaired by laparoscopic suturing (34.9 percent).

Intensive blood pressure lowering may similarly decrease cardiovascular events in both patients with and patients without type 2 diabetes mellitus, according to a study published online Dec. 6 in Diabetes Care. Tom F. Brouwer, M.D., from the University of Amsterdam, and colleagues assessed the effect of both type 2 diabetes and baseline cardiovascular disease risk on the treatment effect of intensive blood pressure lowering based on data and pooled analysis from two randomized trials (ACCORD-BP [Action to Control Cardiovascular Risk in Diabetes Blood Pressure]and SPRINT [Systolic Blood Pressure Intervention Trial] studies; total of 14,094 patients). The researchers found that the mean baseline systolic blood pressure was 139.5 mm Hg for the cohort and just over one-third (33.6 percent) had type 2 diabetes. The hazard ratio for the primary composite end point of unstable angina, myocardial infarction, acute heart failure, stroke, and cardiovascular death was 0.82 (P = 0.0017). There was a nonsignificant interaction between intensive blood pressure lowering and type 2 diabetes (P = 0.13). While the 10-year cardiovascular risk was higher in patients with type 2 diabetes, there was no interaction between the risk and treatment effect (P = 0.84).

A new screening tool can adequately detect risk of diabetic retinopathy in adults with diabetes in low-income communities in Mexico, according to a study published in the October issue of Preventing Chronic Disease. Kenny Mendoza-Herrera, from the National Institute of Public Health in Mexico, and colleagues analyzed biochemical, clinical, anthropometric, and sociodemographic information from 1,000 adults with diabetes in low-income communities in Mexico in order to develop a screening tool based on a predictive model for early detection of diabetic retinopathy. Time since diabetes diagnosis, high blood glucose levels, systolic hypertension, and physical inactivity were risk factors included in the screening tool. The researchers found that the model had a mean area under the receiver operating characteristic curve (AUC ROC) of 0.78 in the validation data set. Using the optimized cut point that best represented the study population, the model had a sensitivity of 82.9 percent and a specificity of 61.9 percent. "We developed a low-cost and easy-to-apply screening tool to detect people at high risk of diabetic retinopathy in Mexico," the authors write. "Although classification performance of our tool was acceptable (AUC ROC > 0.75), error rates (precision) depend on false-negative and false-positive rates. Therefore, confirmatory assessment of all cases in mandatory."

Aspirin therapy is associated with a reduced risk of hepatitis B virus-related hepatocellular carcinoma (HCC), according to a study scheduled for presentation at The Liver Meeting, held by the American Association for the Study of Liver Diseases from Oct. 20 to 24 in Washington, D.C. Teng-Yu Lee, M.D., Ph.D., from Taichung Veterans General Hospital in Taiwan, and colleagues used data from Taiwan's National Health Insurance Research Database from 1998 to 2012. Patients with non-hepatitis B infections were excluded, as were those with HCC before the follow-up index dates. A total of 1,553 patients who continuously received daily aspirin ≥90 days were randomly matched (1-to-4 ratio) with 6,212 patients who never received anti-platelet therapy based on baseline characteristics, the index date, and nucelos(t)ide analogue (NA) use during follow-up. The researchers found that the cumulative incidence of HCC in the treated group was significantly lower than that in the untreated group in five years (2.86 percent versus 5.59 percent). Aspirin therapy was independently associated with a reduced HCC risk (hazard ratio [HR], 0.63) in a multivariable regression analysis. An increased HCC risk was independently associated with older age (HR, 1.03 per year), male gender (HR, 2.65), cirrhosis (HR, 1.89), and diabetes mellitus (HR, 1.51). NA (HR, 0.57) and statin (HR, 0.57) use were associated with a decreased HCC risk.

There's still a lot of confusion across the nation about whether or not marijuana is effective for cancer patients. Odds are you've heard something about it but weren't sure whether the information was reliable or definitive. So, in order to help clear things up,

Colorado teens are now rejecting smoking choosing weed edibles as an alternative, claims a new study. It argues that there is a rise in dabbing too.

CPC Exams and CPC Exam Study : Sedona Ultrasound Workshop is organized by Encore Symposiums and will be held on Nov 04, 2018 at Hilton Sedona Resort at Bell Rock, Sedona, Arizona, United States of America.

Higher dietary total fiber and fruit fiber is protective against bone loss at the femoral neck in men, according to a study published online Oct. 12 in the Journal of Bone and Mineral Research. Zhaoli Dai, Ph.D., from the Boston University School of Medicine, and colleagues examined the correlation between dietary fiber, assessed using the Willett food frequency questionnaire, and bone loss at the femoral neck, trochanter, and lumbar spine in older men and women. Bone mineral density was measured using dual-energy X-ray absorptiometry at baseline (1996 to 2011) and in 2001 to 2005 and 2005 to 2008 among 792 men and 1,065 women. The researchers found that in men, but not women, higher dietary total fiber and fruit fiber was protective against bone loss at the femoral neck (P = 0.003 and 0.008, respectively). Compared with men in quartile 1 of fiber intake, those in quartiles 2 to 4 had significantly less bone loss at the femoral neck (all P < 0.04). There were no associations with hip bone loss in women; fiber from vegetables seemed protective against spine bone loss in women but not men. No correlations were seen for cereal fiber or nut and legume fiber with bone loss in men or women.

Alzheimer disease (AD) is a chronic neuro-degenerative disease accounting for almost 70% of dementia cases. The most common symptom being short term memory loss, the disease leads to a decline in self management and behavior with impacts varying per individual. Though, AD is an age related disorder with people above 60 being most likely to be affected, individuals with a history of frequent head injuries, depression, hypertension may also carry a risk. Researchers and scientists are unsure about the cause of Alzheimers but studies have been conducted and they claim that 7 out of 10 cases are genetically caused (e4 allele of gene apolipoprotein E). Additionally, pathophysiological causes (Plaques and neurofibrillary tangles, neuronal death) cannot be ruled out in the disease pathology and progression. AD forms one of the most actively explored and researched areas in the field of medicine.

Diabetes Intensive Training is organized by Mayo clinic and would be held during Jul 10 - Sep 29, 2017. The target audience for this medical event basically for Endocrinology, Metabolism and Diabetes, The CME conference has been approved with maximum of 32.00 AMA PRA Category 1 Credit. he Diabetes Intensive Training online course is a comprehensive web based graduate credit level professional enhancement course geared toward practicing professionals. Diabetes Intensive Training is an online self-paced 12 week course through Blackboard Learn. The course is offered on a quarterly basis. The curriculum includes a pretest, 16 modules for study, a post-test requiring an 80% passing score for continuing education credit, and a required evaluation of the course at completion. Currently the curriculum is offered to physicians, physician assistants, advanced nurse practitioners, registered nurses and pharmacists with a current license without restrictions. Target audience: This course is designed for Primary care providers - Family Medicine and General Internal Medicine MDs, Pharmacists, Dietitians, NPs, RNs and APRNs. Learning objectives: Upon conclusion of this program, participants should be able to: * Integrate the principles of theory and research of nursing and medicine into comprehensive health care plan for patients with diabetes including prevention, promotion and treatment * Demonstrate knowledge of evidence based and clinical guidelines in treatment of diabetes inpatient and outpatient management. * Develop and acquire skills for self- directed lifelong learning and staying current in diabetes management (prevention, promotion and treatment).

For patients with stage 4 or 5 chronic kidney disease and hepatitis C virus (HCV) infection, 12 weeks of treatment with glecaprevir and pibrentasvir results in a high rate of sustained virologic response, according to a study published online Oct. 11 in the New England Journal of Medicine. Edward Gane, M.D., from Auckland City Hospital in New Zealand, and colleagues conducted a multicenter trial to examine the efficacy and safety of combination treatment with the NS3/4A protease inhibitor glecaprevir and the NS5A inhibitor pibrentasvir for 12 weeks in adults with HCV infection and compensated liver disease with severe renal impairment, dependence on dialysis, or both. Participants had stage 4 or 5 chronic kidney disease. One hundred four patients were enrolled in the trial. The researchers found that the sustained virologic response rate was 98 percent. During treatment, none of the patients had virologic failure, and none had a virologic relapse after the end of treatment. Pruritus, fatigue, and nausea were reported in at least 10 percent of the patients. Twenty-four percent of the patients reported serious adverse events. Because of adverse events, four patients discontinued the trial treatment prematurely; three of these had sustained virologic response

Mayo Clinic Pulmonary Manifestations of Connective Tissue Disorders is organized by Mayo Clinic CME and would be held during Oct 20 - 21, 2017 at The Ritz Carlton, Amelia Island, Fernandina Beach, Florida, United States Of America. The target audience for this medical event for pulmonologists, rheumatologist, and primary care physicians and providers with an interest in pulmonary involvement of connective tissue disorders. This cme conference has been approved with a maximum of 11.75 AMA PRA Category 1 Credits. Course Description : This two-day course provides pulmonologists, rheumatologists, internists and general practitioners with an up-to-date focus on pulmonary manifestations of rheumatologic disorders. From this course, participants gain a better understanding of how to recognize and diagnose interstitial lung disease, pulmonary hypertension and other respiratory problems which are common in autoimmune rheumatologic disorders, and the latest information regarding pathogenic mechanisms, clinical trials and therapeutic modalities. The speakers will be nationally and internationally recognized specialists in the field. Residents and fellows will have the opportunity to participate by submitting original studies for poster presentations. Conference Objectives are : * Review basic clinical and therapeutic aspects of interstitial lung disease and pulmonary hypertension in patients with connective tissue diseases * Improve interpretation skills for laboratory and pulmonary testing pertaining to patients with interstitial lung disease and connective tissue diseases * Identify patients that need a multidisciplinary approach early in the course of the disease * Review up-to-date information about ongoing research in connective tissue disease with patients with autoimmune lung involvement

Most ophthalmologists write no more than 10 opioid prescriptions annually, with a mean supply per prescription of five days, according to a study published online Oct. 5 in JAMA Ophthalmology. Shriji Patel, M.D., and Paul Sternberg Jr., M.D., both from Vanderbilt Eye Institute in Nashville, Tennessee, analyzed physician and beneficiary measures using Medicare Part D Prescriber Data (2013 to 2015) to determine prescribing patterns for opioid drugs for participating ophthalmologists. The researchers found that, consistently, 88 to 89 percent of ophthalmologists wrote 10 opioid prescriptions or fewer annually. Only about 1 percent of ophthalmologists wrote more than 100 opioid prescriptions annually. On average, ophthalmologists wrote seven opioid prescriptions per year with a mean supply of five days. The six states with the highest volume of annual opioid prescriptions per ophthalmologist were in the South.

Immediate access to opioid agonist treatment (OAT) for patients presenting with opioid use disorder may provide greater health benefits at less cost than observed standard of care, according to a study published online Nov. 21 in the Annals of Internal Medicine. Emanuel Krebs, from St. Paul's Hospital in Vancouver, Canada, and colleagues sought to determine the cost-effectiveness of OAT versus observed standard of care for patients presenting with opioid use disorder. Population-level administrative databases capturing treatment and criminal justice records for California were linked (2006 to 2010). Immediate access to OAT for all treatment recipients was found by the researchers to cost less (by $78,257), with patients accumulating more quality-adjusted life-years (by 0.42) versus the observed standard of care. Imagining a hypothetical scenario where all Californians starting treatment of opioid use disorder in 2014 had immediate access to OAT, the team found that total lifetime savings for this cohort could be as high as $3.8 billion.

For patients with unruptured intracranial aneurysms (UIAs) that are 3 mm or smaller, no preventive treatment or imaging follow-up is the most effective management strategy, according to a study published online Nov. 20 in JAMA Neurology. Ajay Malhotra, M.D., from the Yale School of Medicine in New Haven, Conn., and colleagues used inputs from the medical literature to conduct a decision-analytic model-based comparative effectiveness analysis. Five management strategies were assessed: annual magnetic resonance angiography (MRA) screening, biennial MRA screening, MRA screening every five years, aneurysm coiling and follow-up, and no treatment or preventive follow-up. In an analysis of 10,000 iterations simulating adult patients, the researchers found that the highest health benefit was seen for the management strategy of no treatment or preventive follow-up (mean quality-adjusted life-years, 19.40). MRA every five years was the best of the management strategies that incorporate follow-up imaging, with the next highest effectiveness (mean quality-adjusted life-years, 18.05). When the annual growth rate and risk of rupture of growing aneurysms are varied, no routine follow-up remains the optimal strategy. No follow-up is the optimal strategy when the annual risk of rupture of nongrowing UIAs is less than 1.7 percent; coiling should be performed directly if the annual risk of rupture is >1.7 percent.

Most physicians on Twitter with a financial conflict of interest (FCOI) and frequent tweets mention specific drugs for which they have a conflict, according to a study published in the September issue of The Lancet Haematology. Victoria Kaestner, from the Oregon Health & Science University in Portland, and colleagues examined whether conflicted physicians tweet about specific products for which they have a FCOI. A total of 156 physicians who tweeted a median of 584 times were included, with a 2014 median general payment totaling $13,600.

Conjugated linoleic acid (CLA) supplementation is associated with an increase in serum C-reactive protein (CRP) concentration, according to a review and meta-analysis published online May 29 in Cardiovascular Therapeutics. Mohsen Mazidi, Ph.D., from the Chinese Academy of Sciences in Beijing, and colleagues conducted a systematic review and meta-analysis to examine the impact of CLA supplementation on serum CRP. Data were included from 14 studies. The researchers found that following supplementation with CLAs there was a significant increase in serum CRP concentrations (weighted mean difference, 0.63 mg/dL; 95 percent confidence interval, 0.13 to 1.13; heterogeneity P = 0.026); these findings were robust in sensitivity analyses. The changes in serum CRP levels were found to be independent of CLA supplementation dosage (slope, −0.02; 95 percent confidence interval, −0.10 to 0.12; P = 0.889) or follow-up duration (slope, 0.271; 95 percent confidence interval, −0.05 to 0.59; P = 0.098). "This meta-analysis suggests that CLA supplementation is associated with an increase in plasma CRP concentrations and a reduction in serum adiponectin concentrations, which indicates that CLA supplements have a pro-inflammatory effect," the authors write.