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Ambika Kilaparthi

Placebos Are Getting More Effective. Drugmakers Are Desperate to Know Why. - 0 views

  • response to placebo was considered a psychological trait related to neurosis and gullibility rather than a physiological phenomenon that could be scrutinized in the lab and manipulated for therapeutic benefit. But then Benedetti came across a study, done years earlier, that suggested the placebo effect had a neurological foundation. US scientists had found that a drug called naloxone blocks the pain-relieving power of placebo treatments. The brain produces its own analgesic compounds called opioids, released under conditions of stress, and naloxone blocks the action of these natural painkillers and their synthetic analogs.
  • Placebo-activated opioids, for example, not only relieve pain; they also modulate heart rate and respiration. The neurotransmitter dopamine, when released by placebo treatment, helps improve motor function in Parkinson's patients. Mechanisms like these can elevate mood, sharpen cognitive ability, alleviate digestive disorders, relieve insomnia, and limit the secretion of stress-related hormones like insulin and cortisol.
  • Alzheimer's patients with impaired cognitive function get less pain relief from analgesic drugs than normal volunteers do. Using advanced methods of EEG analysis, he discovered that the connections between the patients' prefrontal lobes and their opioid systems had been damaged. Healthy volunteers feel the benefit of medication plus a placebo boost. Patients who are unable to formulate ideas about the future because of cortical deficits, however, feel only the effect of the drug itself. The experiment suggests that because Alzheimer's patients don't get the benefits of anticipating the treatment, they require higher doses of painkillers to experience normal levels of relief.
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  • placebo response has limits. It can ease the discomfort of chemotherapy, but it won't stop the growth of tumors. It also works in reverse to produce the placebo's evil twin, the nocebo effect. For example, men taking a commonly prescribed prostate drug who were informed that the medication may cause sexual dysfunction were twice as likely to become impotent.
  • placebo aids recovery is by hacking the mind's ability to predict the future. We are constantly parsing the reactions of those around us—such as the tone a doctor uses to deliver a diagnosis—to generate more-accurate estimations of our fate. One of the most powerful placebogenic triggers is watching someone else experience the benefits of an alleged drug. Researchers call these social aspects of medicine the therapeutic ritual.
  • What turns a dummy pill into a catalyst for relieving pain, anxiety, depression, sexual dysfunction, or the tremors of Parkinson's disease? The brain's own healing mechanisms, unleashed by the belief that a phony medication is the real thing. The most important ingredient in any placebo is the doctor's bedside manner, but according to research, the color of a tablet can boost the effectiveness even of genuine meds—or help convince a patient that a placebo is a potent remedy.
  • Red pills can give you a more stimulating kick
  • green reduces anxiety
  • White tablets—particularly those labeled "antacid"—are superior for soothing ulcers
  • More is better,scientists say. Placebos taken four times a day deliver greater
  • Branding matters. Placebos stamped or packaged with widely recognized trademarks are more effective than "generic"
  • Clever names
  • volunteers in this high-interaction group got as much relief as did people taking the two leading prescription drugs for IBS. And the benefits of their bogus treatment persisted for weeks afterward, contrary to the belief—widespread in the pharmaceutical industry—that the placebo response is short-lived.
  • hybrid treatment strategies that exploit the placebo effect to make real drugs safer and more effective. Cancer patients undergoing rounds of chemotherapy often suffer from debilitating nocebo effects—such as anticipatory nausea—conditioned by their past experiences with the drugs. A team of German researchers has shown that these associations can be unlearned through the administration of placebo, making chemo easier to bear.
  • body's response to certain types of medication is in constant flux, affected by expectations of treatment, conditioning, beliefs, and social cues.
  • Big Pharma have moved aggressively into Africa, India, China, and the former Soviet Union. In these places, however, cultural dynamics can boost the placebo response in other ways. Doctors in these countries are paid to fill up trial rosters quickly, which may motivate them to recruit patients with milder forms of illness that yield more readily to placebo treatment. Furthermore, a patient's hope of getting better and expectation of expert care—the primary placebo triggers in the brain—are particularly acute in societies where volunteers are clamoring to gain access to the most basic forms of medicine. "The quality of care that placebo patients get in trials is far superior to the best insurance you get in America
  • The HAM-D was created nearly 50 years ago based on a study of major depressive disorder in patients confined to asylums. Few trial volunteers now suffer from that level of illness. In fact, many experts are starting to wonder if what drug companies now call depression is even the same disease that the HAM-D was designed to diagnose.
  • What all of these disorders have in common, however, is that they engage the higher cortical centers that generate beliefs and expectations, interpret social cues, and anticipate rewards. So do chronic pain, sexual dysfunction, Parkinson's
  • In standard trials, the act of taking a pill or receiving an injection activates the placebo response. In open/hidden trials, drugs and placebos are given to some test subjects in the usual way and to others at random intervals through an IV line controlled by a concealed computer. Drugs that work only when the patient knows they're being administered are placebos themselves.
  • Ironically, Big Pharma's attempt to dominate the central nervous system has ended up revealing how powerful the brain really is. The placebo response doesn't care if the catalyst for healing is a triumph of pharmacology, a compassionate therapist, or a syringe of salt water. All it requires is a reasonable expectation of getting better. That's potent medicine.
anonymous

The Clinical Assessment of Substance Use Disorders - publication - MedEdPORTAL - 0 views

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    "To describe the essential components of the medical model of substance use disorders. To delineate the interviewing skills necessary to screen effectively for substance use and abuse. To understand the high rate of psychiatric and medical co-morbidity and more effectively screen patients for these disorders. To demonstrate skills for evaluating patients' stage of change, readiness to accept the diagnosis, and readiness to undertake behavior change. To clearly and supportively recommend treatment to patients with substance use disorders. To describe the skills required for addiction prevention counseling. To define the skills that help set respectful limits on patient requests for prescription medication. To demonstrate awareness of how physician/clinician attitudes toward patients with substance use disorders impact recognition, diagnosis, and treatment of patients. To demonstrate knowledge of substance use disorder treatment standards and the ability to recommend appropriate referrals."
Joseph Reynolds

Updated Treatment Guidelines for Malignant Pleural Mesothelioma Physicians - 0 views

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    The National Comprehensive Cancer Network (NCNN) has recently updated its treatment guidelines for malignant pleural mesothelioma for oncologists and other
anonymous

Perspective: A Culture of Respect, Part 1: The Nature and Causes of Disrespectful Beha... - 1 views

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    "The authors identify a broad range of disrespectful conduct, suggesting six categories for classifying disrespectful behavior in the health care setting: disruptive behavior; humiliating, demeaning treatment of nurses, residents, and students; passive-aggressive behavior; passive disrespect; dismissive treatment of patients; and systemic disrespect."
Andrea Owen

McGraw Hill's AccessEmergency Medicine | Home - 0 views

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    Quickly search AccessEmergency Medicine for diagnosis and treatment information plus technique-oriented videos for teaching, learning, and board review. Quickly search AccessEmergency Medicine for diagnosis and treatment information plus technique-oriented videos for teaching, learning, and board review.
mmgillis

Assessment of decision-making capacity in adults - 3 views

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    "WHAT TO DO WHEN A PATIENT LACKS CAPACITY - The degree and urgency with which to act on findings of impaired capacity depends on multiple factors, including the expected duration of impairment, the severity of the impairment, and the seriousness of the decision. Unless the urgency of a patient's medical condition requires that a substituted decision be made immediately, efforts should be made to identify and correct any reversible causes of the impairment [26]. This is particularly relevant in hospitalized patients with impaired capacity due to delirium. Treatment of the underlying causes of delirium may restore decision-making capacity. Patients with mild to moderate cognitive impairment that is not expected to fluctuate may benefit from more intensive efforts at education to improve understanding of the relevant facts, followed by reassessment of decision-making abilities. A randomized trial found that a memory and organizational aid given to patients with mild stage Alzheimer disease dementia (n = 80) improved performance on understanding, which in turn increased the likelihood of being judged capable of providing informed consent to enroll in a clinical trial [34]. This enhancement was also effective in a randomized trial with middle-aged and older adults with schizophrenia [35]. For patients whose impairments are severe enough that they are judged to lack the capacity to make a decision, there is a clear ethical obligation to seek out a substitute decision maker. Substitute or surrogate decision makers should ideally have been chosen by the patient in advance. In the absence of a designated surrogate, laws may vary in terms of which people can serve in this proxy role and their hierarchy; in general, the order is the spouse, adult children, parents, siblings, and other relatives. (See "Legal aspects in palliative and end of life care", section on 'Surrogate decision makers'.) When making a substituted decision, the proxy should take into consideration
anonymous

CDC - 2010 STD Treatment Guidelines iBook - 0 views

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    An iBook on STD treatment guidelines.
Dr.Ravichandra Karkal

WHO Issues Guidelines for Antiviral Treatment for H1N1 and Other Influenza - 1 views

  • WHO Issues Guidelines for Antiviral Treatment for H1N1 and Other Influenza
  • Recommendations for Antiviral Treatment of H1N1
anonymous

STATworkUP - Medical App Journal - 1 views

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    "STATworkUP™ has an immense amount of correlated data between symptoms, tests, diagnoses and treatments. While the app cannot be relied upon to thoroughly determine a differential diagnosis or provide an evidence-based summary of therapy, it can serve as an additional arrow in the clinicians quiver especially when wrestling with an uncommon diagnostic dilemma."
anonymous

CAMH: Collaborating with Families Affected by Concurrent Disorders Online Course - 0 views

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    Families are an immense resource in the care, treatment and recovery of individuals with co-occurring mental health and addiction problems. However, they often have limited access to the resources, information and help that they need to be supportive to the ones they love. This six-week online course for health care providers explores the needs of families affected by concurrent disorders as well as the strategies that health care providers can use to empower families and ensure that their experiences are more positive. The recommended pre-requisite for this course is the Concurrent Disorders Core Course.
anonymous

e-Learning Resources on Addiction for Undergraduate Medical Education in Canada | Canad... - 1 views

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    "AFMC and the Norlien Foundation have partnered to provide funding and support for the development of a suite of e-learning tools on early brain and biological development and addictions for undergraduate medical education. The suite of resources includes virtual patients, a primer (e-textbook), and podcast series. Topics that are addressed include core concepts of early child development, epigenetics, intervention and treatment strategies, and system responses to addiction."
anonymous

Standards of Care for the Health of Transsexual, Transgender, and Gender-Nonconforming ... - 1 views

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    " The SOC are based on the best available science and expert professional consensus. Because most of the research and experience in this field comes from a North American and Western European perspective, adaptations of the SOC to other parts of the world are necessary. The SOC articulate standards of care while acknowledging the role of making informed choices and the value of harm reduction approaches. In addition, this version of the SOC recognizes that treatment for gender dysphoria i.e., discomfort or distress that is caused by a discrepancy between persons gender identity and that persons sex assigned at birth (and the associated gender role and/or primary and secondary sex characteristics) has become more individualized."
anonymous

From Mindless to Mindful Practice - Cognitive Bias and Clinical Decision Making - NEJM - 1 views

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    "The two major products of clinical decision making are diagnoses and treatment plans. If the first is correct, the second has a greater chance of being correct too. Surprisingly, we don't make correct diagnoses as often as we think: the diagnostic failure rate is estimated to be 10 to 15%. "
anonymous

CLEAR: clinical enquiry and response service - 0 views

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    "CLEAR aims to provide clinicians with summarised evidence relating to aetiology, diagnosis, prognosis and treatment queries about patient care. CLEAR is delivered by an information team working to a service criteria and a defined method. "
anonymous

Twelve tips for teaching expertise in clinical reasoning [Med Teach. 2011] - PubMed - NCBI - 2 views

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    "Teaching clinical reasoning is important and feasible. Teachers who explicitly teach problem solving and decision making may help learners to improve their diagnostic accuracy and treatment choices."
Anne Marie Cunningham

PatientsLikeMe : Patients Helping Patients Live Better Every Day - 0 views

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    started with mainly neurological conditions but allows patients to share experiences of illness and treatments
ahmad subahman

How to Use Herbal Medicine - 0 views

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    To avoid health risks in using herbal medicines, always stick to the prescription given to you by your health expert. The prescription is also part of the treatment process, making sure that your body will have enough of the curative properties to boost your body's recovery.
avivajazz  jazzaviva

Journal of Participatory Medicine (JoPM) | New, Peer-Reviewed, Open-Access - 1 views

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    Participatory medicine will owe part of its success to the technologies that have the potential to remove treatment, symptom management, administrative, and communications burdens from individuals and clinicians while maintaining the critical interpersonal interactions between them. Out of the steady stream of new devices, programs, gadgets, and applications, which will make a difference in the health and lives of patients? We hope to build the Journal as a resource for critical reviews of technologies that support and facilitate participatory medicine. We realize it will be no small undertaking to put together a process that will allow for the review of a substantial number of technologies over time, reflecting the experience of different types of users.
anonymous

Complicated Lives - Taking the Social History - NEJM - 1 views

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    "Taking a comprehensive social history is time-consuming. It's easy to dismiss the task as outside the doctor's purview, especially when there's precious little time to get through a sea of investigations and treatment options. But every patient is a person, and illness occurs in the context of multifaceted lives. We need to listen to our patients with the recognition that the most important information they can give us about their illness often lies in the folds of their social circumstances. And it's our obligation to tailor our prescriptions to an illness in its full context."
avivajazz  jazzaviva

Medicine: Ignorance is Bliss? So Say Drug & Device Companies! | Paul Krugman Blog | NY... - 0 views

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    This is really unbelievable: The drug and medical-device industries are mobilizing to gut a provision in the stimulus bill that would spend $1.1 billion on research comparing medical treatments, portraying it as the first step to government rationing.
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