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it’s hard not to note that cancer and heart disease are primarily diseases of aging, and life expectancy was so much lower back in the day that a much smaller percentage of the population lived to advanced ages than is the case today.

Over the last decade, Cordain has become the most prominent promoter of the so-called “Paleo diet,” having written The Paleo Diet: Lose Weight and Get Healthy by Eating the Foods You Were Designed to Eat and multiple other books advocating a paleolithic-mimetic diet as the cure for what ails modern humans.

But how does one determine what the prevalence of cardiovascular disease was in the ancient past?

there have been indications that the idea that ancient humans didn’t suffer from atherosclerosis is a comforting myth, the most recent of which is a study published a week ago online in The Lancet by Prof. Randall C. Thompson of Saint Luke’s Mid America Heart Institute and an international team of investigators entitled Atherosclerosis across 4000 years of human history: the Horus study of four ancient populations.

So, although there was a fair amount of evidence from studies of Egyptian mummies that atherosclerosis was not uncommon, in Egypt it was mainly the wealthy and powerful who were mummified after their deaths. Conceivably, they could have lived a very different lifestyle and consumed a very different diet than the average Egyptian living around that time.

So the authors obtained whole-body CT scans of the 137 mummies, either pre-existing scans or scans prospectively done, and analyzed them for calcifications.

Figure 2 summarizes the findings nicely: There’s also this video featured in a Nature report on the study showing the reconstructed scan of one of the mummies with atherosclerotic plaques in the coronary arteries.

As expected, more atherosclerosis correlates with advanced age, and the amount of atherosclerosis in the young and middle-aged (although the times in which the people who became these mummies after death lived age 50 was old) was less.

As is noted in Thompson’s article, ancient Egyptians and Peruvians were agricultural cultures with farms and domesticated animals, Ancestral Puebloans were forager-farmers, and the Unangans were hunter-gatherers without agriculture. Indeed, the Peruvians and Ancestral Puebloans predated the written word and were thus prehistoric cultures.

One notes that no one, including the authors of this study, is saying that lifestyle and diet are not important factors for the development of atherosclerotic heart disease.

I actually think that the authors probably went too far with that last statement in that, while they might be correct that atherosclerosis is an inherent component of human aging, it is quite well established that this inherent component of aging can at least be worsened by sedentary lifestyle and probably certain diets.

One notes that, although the Paleo Diet is not, strictly speaking, always sold as CAM/IM, the ideas behind it are popular among CAM advocates, and the diet is frequently included as part of “integrative medicine,” for example, here at the University of Connecticut website, where it’s under integrative nutrition.

In particular, the appeal to ancient wisdom and ancient civilizations as yet untouched by the evil of modernity is the same sort of arguments that are made in favor of various CAM modalities ranging from herbalism to vegan diets rebranded as being somehow CAM to the appeal to “natural” cures.

The book is by Marlene Zuk and entitled Paleofantasy: What Evolution Really Tells Us About Sex, Diet, and How We Live. Zuk is an evolutionary biologist, and in particular she points out how the evolutionary arguments favored by advocates of the Paleo diet don’t stand up to scrutiny.

The interview begins with Zuk confronting Cordain at a conference on evolution and diseases of modern environments. At his lecture, Cordain pronounced several foods to be the cause of fatal conditions in people carrying certain genes.

Blue eyes arose 6,000 to 10,000 years ago

Rapid selection for the CCR5-D gene variant that makes some people immune to HIV

Lactase persistence (production past the age of weening of the lactase enzyme that digests lactose in milk) probably dates back only around 7,500 to 10,000 years, around the time that cattle were domesticated

Zuk detects an unspoken, barely formed assumption that humanity essentially stopped evolving in the Stone Age and that our bodies are “stuck” in a state that was perfectly adapted to survive in the paleolithic environment. Sometimes you hear that the intervention of “culture” has halted the process of natural selection. This, “Paleofantasy” points out, flies in the face of facts. Living things are always and continuously in the process of adapting to the changing conditions of their environment, and the emergence of lactase persistence indicates that culture (in this case, the practice of keeping livestock for meat and hides) simply becomes another one of those conditions.

For this reason, generalizations about the typical hunter-gatherer lifestyle are spurious; it doesn’t exist. With respect to what people ate (especially how much meat), the only safe assumption was “whatever they could get,” something that to this day varies greatly depending on where they live. Recently, researchers discovered evidence that people in Europe were grinding and cooking grain (a paleo-diet bugaboo) as far back as 30,000 years ago, even if they weren’t actually cultivating it. “A strong body of evidence,” Zuk writes, “points to many changes in our genome since humans spread across the planet and developed agriculture, making it difficult at best to point to a single way of eating to which we were, and remain, best suited.”

Oh, and, as Zuk tells us, paleolithic people got cancer, too.

we humans have long been known to abuse and despoil our environment, even back in those “paleo” days. Indeed, when I took a prehistoric archeology course, which was largely dedicated to the period of time of the hunter-gatherers, one thing I remember my professor pointing out, and that was that what he did was largely the study of prehistoric garbage and that humans have always produced a lot of it.

Most airstrikes from these aircraft use Hellfire missiles, which cause less collateral damage.

The modern battlefield -- and the ancient as well -- has been marked by anonymity. The enemy was not a distinct individual but an army, and the killing of soldiers in an enemy army did not carry with it any sense of personal culpability. In general, no individual soldier was selected for special attention, and his death was not an act of punishment. He was killed because of his membership in an army and not because of any specific action he might have carried out.

Open insignia is fundamental to the rules of war. It was instituted after the Franco-Prussian war, when French snipers dressed as civilians fired on Germans. It was viewed that the snipers had endangered civilians because it was a soldier's right to defend himself and that since they were dressed as civilians, the French snipers -- not the Germans -- were responsible for the civilian deaths.

In a method of war where the individual is the prime unit and where lack of identification is a primary defensive method, the conduct of intelligence operations wherever the enemy might be, regardless of borders, follows. So do operations to destroy enemy units -- individuals. If a country harbors such individuals knowingly, it is an enemy. If it is incapable of destroying the enemy units, it forfeits its right to claim sovereignty since part of sovereignty is a responsibility to prevent attacks on other countries.

If we simply follow the logic we laid out here, then the critics of unmanned aerial vehicle strikes have a weak case. It is not illegitimate to target individuals in a military force like the jihadist movement, and international law holds them responsible for collateral damage, not the United States.

since al Qaeda tried in the past to operate in the United States itself, and its operatives might be in the United States, it logically follows that the United States could use unmanned aerial vehicles domestically as well. Citizenship is likewise no protection from attacks against a force hostile to the United States.

The first is that the outrage at targeted killing is not, in my view, justified on moral or legal grounds.

The second is that in using these techniques, the United States is on a slippery slope because of the basis on which it has chosen to wage war.

The broader the engagement, the greater the perception of U.S. hostility to Islam, the easier the recruitment until the jihadist forces reach a size that can't be dealt with by isolated airstrikes.

In the long run, it is not clear that the cost is so little. A military strategy to defeat the jihadists is impossible. At its root, the real struggle against the jihadists is ideological, and that struggle simply cannot be won with Hellfire missiles.

And, to add even greater edge to this catalyst, we were at that time just six weeks away from the election of Barack Obama, who brought a new party to power and was America’s first African-American President.  Would he have won without the meltdown?  Who knows.  It would have been a much closer election. 

As a rule, a new turning starts a few years (typically 2 to 6) after each living generation (especially the new youth generation) enters a new phase of life.  2008 was 4 to 6 years after the oldest Millennials reached age 21 and graduated from college—and 3 years after the oldest Boomers (born in 1943) started to receive their first Social Security retirement checks.  In terms of phase of life, this is right on.

9/11 will go down as one of the more famous crisis precursors in American history.  A crisis precursor is an event that foreshadows a crisis without being an integral part of it.  Other such precursors in American history include the Stamp Act Rebellion (1765), or Bleeding Kansas (1856), or perhaps the Red Scare (1919). 

Now let’s move on to the next question: Where is the regeneracy?

I think it’s pretty obvious that the regeneracy has not yet started.

We may like to imagine that there is a definable day and hour when America, faced by growing danger and adversity, explicitly decides to patch over its differences, band together, and build something new.  But maybe what really happens is that everyone feels so numb that they let somebody in charge just go ahead and do whatever he’s got to do.

When it happens, I strongly suspect it will be in response to an adverse financial event.  It may also happen in response to a geopolitical event.  It may well happen over the next year or two.  Given the pattern of historical 4Ts, it is very likely happen before the end of the next presidential term (2016). 

Which means we already know who will be President at that time: Either Obama or Romney.  (Or at least this is high probability: According to Intrade, it is now over a 96 percent bet, so if you disagree you can make 25-to-1 by betting against global future traders.)  It’s interesting that both men are temperamentally similar—cool, detatched, capable of gravitas–and that one could imagine either playing a Gray Champion role if history required it.

When will the 4T climax take place?  To be honest, I have no idea.  On timing, let me toss out my guess based on the typical pattern of historical 4Ts: The climax may arrive around 2022-2025.

The point here being that 4Ts are pretty chaotic.  During 4Ts, the future seems much less certain than in retrospect.  They are mostly defined not so much by how much institutions provide order, but by how much people want order.  Here’s where the Millennials will play a key role.

2. A fiendish foil for self-righteousness.Being good is hard. If I compare myself to Jesus or Harriet Tubman or St. Francis or Dorothy Day then I can’t help but see a vast amount of room for improvement on my part. But if, instead, I compare myself to Hannibal Lecter, then I come out looking pretty good.

3. If the monsters don’t exist, the theory isn’t true.The Big Theory presents an if-then equation to explain how society works. The theory offers a defense of something — “traditional morality,” sectarian privilege, patriarchy, ethnic superiority, cultural exceptionalism, nationalism, etc. — and says that if that something is not defended, then monstrous consequences will ensue.

4. Imaginary monsters give our fears a face.We’re afraid. We’re afraid of difference, of financial insecurity, of forces beyond our control, of death. Our fears are amorphous, unsettling and overwhelming. We can’t get a handle on them. So we give them a name and a face and thus can pretend that we’re up against something we can fight.

Ambassador Rustan Shah Mohmand, who was a senior administrator in the tribal areas for 25 years between 1973 and 1998, cautions that the released file might not be the fullest data available.Noting that Pakistan’s military is responsible for security in FATA, he told the Bureau: ‘Tribal documents might present a broad picture. But any accuracy is dependent on what data the military chooses to release to or withhold from the political agents. In the last eight years, for example, no precise casualty figures have ever been submitted to Pakistan’s parliament.’

‘How come the same civil servants are feeding one kind of data to the Peshawar High Court and another kind of data to the FATA secretariat?’ asked Shahzad Akbar, the Pakistani barrister behind the successful Peshawar case. ‘Are they fudging the numbers based on who was on the receiving end?’US counter-terrorism officials declined to comment on the specifics of the leaked document, though referred the Bureau to recent comments by both President Obama and CIA Director Brennan stating that the US goes to great lengths to limit civilian deaths in covert drone strikes.

Higher levels of female obesity correlated with higher levels of gender inequality in each nation Of course, that’s not the impression you will get from the admonishments of public-health agencies and wellness businesses.

Yet the scientists who study the biochemistry of fat and the epidemiologists who track weight trends are not nearly as unanimous as Bloomberg makes out. In fact, many researchers believe that personal gluttony and laziness cannot be the entire explanation for humanity’s global weight gain.

Consider, for example, this troublesome fact, reported in 2010 by the biostatistician David B Allison and his co-authors at the University of Alabama in Birmingham: over the past 20 years or more, as the American people were getting fatter, so were America’s marmosets.

‘Virtually in every population of animals we looked at, that met our criteria, there was the same upward trend,’ he told me.

It isn’t hard to imagine that people who are eating more themselves are giving more to their spoiled pets, or leaving sweeter, fattier garbage for street cats and rodents. But such results don’t explain why the weight gain is also occurring in species that human beings don’t pamper, such as animals in labs, whose diets are strictly controlled. In fact, lab animals’ lives are so precisely watched and measured that the researchers can rule out accidental human influence

In rich nations, obesity is more prevalent in people with less money, education and status. Even in some poor countries, according to a survey published last year in the International Journal of Obesity, increases in weight over time have been concentrated among the least well-off. And the extra weight is unevenly distributed among the sexes, too.

The story might go like this: being poor is stressful, and stress makes you eat, and the cheapest food available is the stuff with a lot of ‘empty calories’, therefore poorer people are fatter than the better-off. These wheels-within-wheels are required because the mantra of the thermodynamic model is that ‘a calorie is a calorie is a calorie’: who you are and what you eat are irrelevant to whether you will add fat to your frame. The badness of a ‘bad’ food such as a Cheeto is that it makes calorie intake easier than it would be with broccoli or an apple.

More importantly, ‘things that alter the body’s fat metabolism’ is a much wider category than food. Sleeplessness and stress, for instance, have been linked to disturbances in the effects of leptin, the hormone that tells the brain that the body has had enough to eat.

If some or all of these factors are indeed contributing to the worldwide fattening trend, then the thermodynamic model is wrong.

According to Frederick vom Saal, professor of biological sciences at the University of Missouri, an organic compound called bisphenol-A (or BPA) that is used in many household plastics has the property of altering fat regulation in lab animals.

BPA has been used so widely — in everything from children’s sippy cups to the aluminium in fizzy drink cans — that almost all residents of developed nations have traces of it in their pee. This is not to say that BPA is unique.

Contrary to its popular image of serene imperturbability, a developing foetus is in fact acutely sensitive to the environment into which it will be born, and a key source of information about that environment is the nutrition it gets via the umbilical cord.

It’s possible that widespread electrification is promoting obesity by making humans eat at night, when our ancestors were asleep

consider the increased control civilisation gives people over the temperature of their surroundings.

Temperatures above and below the neutral zone have been shown to cause both humans and animals to burn fat, and hotter conditions also have an indirect effect: they make people eat less.

A study by Laura Fonken and colleagues at the Ohio State University in Columbus, published in 2010 in the Proceedings of the National Academy of Sciences, reported that mice exposed to extra light (experiencing either no dark at all or a sort of semidarkness instead of total night) put on nearly 50 per cent more weight than mice fed the same diet who lived on a normal night-day cycle of alternating light and dark.

A virus called Ad-36, known for causing eye and respiratory infections in people, also has the curious property of causing weight gain in chickens, rats, mice and monkeys.

xperiments by Lee Kaplan and colleagues at Massachusetts General Hospital in Boston earlier this year found that bacteria from mice that have lost weight will, when placed in other mice, apparently cause those mice to lose weight, too.

It might be that every one of the ‘roads less travelled’ contributes to global obesity; it might be that some do in some places and not in others. The openness of the issue makes it clear that obesity isn’t a simple school physics experiment.

In a capitalistic quest for new markets and cheap materials and labour, Europeans take control of the economy in the late 18th or early 19th century. With taxes, fees and sometimes violent repression, their new system strongly ‘encourages’ the farmer and his neighbours to stop growing their own food and start cultivating some more marketable commodity instead – coffee for export, perhaps. Now that they aren’t growing food, the farmers must buy it. But since everyone is out to maximise profit, those who purchase the coffee crop strive to pay as little as possible, and so the farmers go hungry. Years later, when the farmer’s children go to work in factories, they confront the same logic: they too are paid as little as possible for their labour. By changing the farming system, capitalism first removes traditional protections against starvation, and then pushes many previously self-sufficient people into an economic niche where they aren't paid enough to eat well.

Eighty years later, the farmer’s descendants have risen out of the ranks of the poor and joined the fast-growing ranks of the world’s 21st-century middle-class consumers, thanks to globalisation and outsourcing. Capitalism welcomes them: these descendants are now prime targets to live the obesogenic life (the chemicals, the stress, the air conditioning, the elevators-instead-of-stairs) and to buy the kinds of foods and beverages that are ‘metabolic disturbers’.

Wells memorably calls this double-bind the ‘metabolic ghetto’, and you can’t escape it just by turning poor people into middle-class consumers: that turn to prosperity is precisely what triggers the trap.

The ‘unifying logic of capitalism’, Wells continues, requires that food companies seek immediate profit and long-term success, and their optimal strategy for that involves encouraging people to choose foods that are most profitable to produce and sell — ‘both at the behavioural level, through advertising, price manipulations and restriction of choice, and at the physiological level through the enhancement of addictive properties of foods’ (by which he means those sugars and fats that make ‘metabolic disturber’ foods so habit-forming).

One possible response, of course, is to decide that no obesity policy is possible, because ‘science is undecided’. But this is a moron’s answer: science is never completely decided; it is always in a state of change and self-questioning, and it offers no final answers. There is never a moment in science when all doubts are gone and all questions settled,

Faced with signs of a massive public-health crisis in the making, governments are right to seek to do something, using the best information that science can render, in the full knowledge that science will have different information to offer in 10 or 20 years.

But in reality, we’re simply characters in an issue of Modern Jackass

people taking a tiny smidgen of understanding and stretching it far past the breaking point. This applies even to the brightest among us.

Under a critical lens, each of the above examples possesses one and only one objective truth, and they all have it in common: they’re defensive in nature.

The manifestation of our monsters on the web is but an amplification of their already thriving existence. The internet simply helps wipe the condensation off the mirror, so to speak.

Among the many strategies you can find online and in books, my favorite technique is known as affect labeling, an elegant aikido-like maneuver that uses the brain’s weakness to gain the advantage.

But before we get carried away with best practices and extemporaneous problem-solving, it’s worth pausing to remind ourselves of that old adage, “The first step to solving a problem is recognizing that there is one.” Nothing is harder than recognizing a problem with ourselves. If you take away only one thing from this article, let it be the following: There is a monster within you (and me).

This is really The Education of Ayn Rand; where the oddball immigrant, simmering with equal parts talent, ambition, and resentment, absorbs the basic political program she was to later do so much to promote.

beneath a superficially clear prose style in fact Rand was a confused and contradictory thinker, who had a garbled misunderstanding of the important philosophical problems she claimed to have solved and depended on her own obscure, pseudo-intellectual jargon – not to mention her sheer chutzpah - to conceal her lack of comprehension from both her followers and herself.

swathes of Rand’s unpublished writing and speeches have been stealthily rewritten to banish all uncertainties and contradictory thoughts, and keep the convenient untruth of Rand's immaculate conceptions alive.

First, they begin with the pro forma objection that the critic is "biased" against Rand, and “doesn’t understand Objectivism”, despite the fact that it is far from clear who, if anyone, actually does understand Rand’s rambling and ramshackle construction.

Second, True Believer Objectivists invoke what I’ve dubbed the Objectivist Double Standard.

The final True Believer tactic is to simply limn the piece in question for various Thought Crimes such as “determinism”, “pragmatism” or “subjectivism” - terms so conveniently vague that it’s possible to convict just about anyone.

From the central darkness of Planet Peikoff itself, only a few, faint, on-the-fritz radio signals have been detected.

Back in the 1990s, Allen interviewed me at length about a feature story he was doing (it was later published in the WP) on how people of different ages react to that old Warner Brothers cartoon about Roadrunner and Wile E. Coyote.  In a talk he was giving at a local college, he discovered by accident that all of the (Xer) students sympathized with the coyote, not the roadrunner.  He was flabbergasted, because for as long as he could remember, he and his peers had always rooted for the roadrunner.

Alawite power in Syria is only about five decades old. The Alawites are frequently (and erroneously) categorized as Shiite Muslims, have many things in common with Christians and are often shunned by Sunni and Shiite Muslims alike. Consequently, Alawites attract a great deal of controversy in the Islamic world.

Syria is not simply a mirror reflection of a country like Bahrain (a Shiite majority country run by a minority Sunni government). Rather than exhibiting a clear Sunni-Shiite religious-ideological divide, Syria’s history can be more accurately described as a struggle between the Sunnis on one hand and a group of minorities on the other.

The seed was thus planted for an Alawite-led military coup while the Sunni elite were preoccupied with their own internal struggles.

Scientists know that certain bits of DNA on the end of chromosomes called “telomeres” shorten each time the cell divides, playing a role in cell aging and eventual cell death

New research has uncovered how stress levels and diet can affect the biological age of an organism as opposed to chronological age, or calendar years.

For years scientists thought that sequencing DNA would uncover the “gene-for” almost everything, unraveling the mysteries of disease and resulting in new drugs and gene-specific treatments. It didn’t exactly pan out that way.

So to uncover the calculus within the genome, it might take some looking beyond the genome. Genes may contribute a few elements to the inner clock, but they interact within a larger scaffolding of cell processes and environmental factors.

One of the key reasons for this situation is that while the stakeholders of the country (civil as well as military) are engaged in a fierce struggle against local and foreign Islamist insurgents, significant societal forces and sympathetic individuals from within the state are providing support to jihadists. But it’s more problematic that there are no quick fixes for this state of affairs. Further complicating this situation is that the U.S. objectives for the region require Islamabad to address these issues on a fast-track basis.

For al Qaeda, a transnational jihadist phenomenon with global ambitions, the logic behind setting up franchises from Yemen and the Maghreb to East Asia was readily apparent.

Meanwhile, the Taliban, an Afghan phenomenon, doubled down on their home turf.

For their part, the United States and its allies never wanted to occupy Afghanistan in the first place.

The war has helped prevent a subsequent attack of the magnitude of Sept. 11, 2001

Meanwhile, even the most serious observers wonder why the United States is so heavily committed in Afghanistan.

Now begins another phase. There are indications that it will center on the military. There are other signs that it will target Shanghai, the primary power base of Jiang Zemin and the locus of financial sector reform in China.

the formation of a unified National Security Council chaired by Xi himself and his apparent wresting of the reins of economic and social reform from Premier Li Keqiang, suggest that some other and deeper shift is underway

China is in the midst of an economic transformation that is in many ways unprecedented. The core of this transformation is the shift from a growth model heavily reliant on low-cost, low value-added exports and state-led investment into construction to one grounded in a much greater dependence on high value-added industries, services and above all, domestic consumption.

For the past six years, the Chinese government has kept the economy on life support in the form of massively expanded credit creation, government-directed investment into urban and transport infrastructure development and, most important, real estate construction. In the process, local governments, banks and businesses across China have amassed extraordinary levels of debt. Outstanding credit in China is now equivalent to 251 percent of the country's gross domestic product, up from 147 percent in 2008. Local governments alone owe more than $3 trillion. It is unknown -- deliberately so, most likely -- what portion of outstanding debts are nonperforming, but it is likely far higher than the official rate of 1 percent. 

Despite claims that China's investment drive was and is irresponsible -- and certainly there are myriad anecdotal cases of gross misallocation of capital -- it nonetheless fulfills the essential role of jumpstarting the country's effort to "rebalance" to a new, more urban and more consumption-based economic model.

And it does so in an environment of rapidly mounting local government and corporate debt, rising wages and input costs, rising cost of capital and falling return on investment (exacerbated by new environmental controls and efforts to combat corruption) and more.

Whatever the Chinese government's stated reform goals, it is very difficult to see how economic rebalancing toward a consumption- and services-based economy succeeds within the decade. It is very difficult to see how exports recover. And it is very difficult, but slightly less so, to see how the government maintains stable growth through continued investment into housing and infrastructure construction, especially as the real estate market inevitably cools.

The pressures stemming from China's economy -- and emanating upward through Chinese society and politics -- will remain paramount over the next 5-10 years.

The above has described only a very small selection of the internal social and economic constraints facing China's government today. It completely neglects public anger over pollution, the myriad economic and industrial constraints posed by both pollution and pervasive low-level corruption, the impact of changes in Chinese labor flows and dynamics, rising education levels and much more. It completely neglects the ambivalence with which many ordinary Chinese regard the Communist Party government.

It also neglects external pressures and risks, whether economic or military.

Xi knows this. He and his advisers know China's virtually insurmountable challenges better than anyone.

The anti-corruption campaign is one of those steps. It serves many overlapping functions: to clear out potential opponents, ideological or otherwise

Underlying and encompassing these, we see the specter of something else. The consensus-based model of politics that Deng built in order to regularize decision-making and bolster political stability during times of high growth and that effectively guided China throughout the post-Deng era is breaking down.