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anonymous

Eight Thoughts About Timescale - 0 views

www.warrensenders.com/journal

longnow

shared by anonymous on 04 May 10 - Cached
  • anonymous on 04 May 10
     
    By Warren Sender at Running Gamak: Warren Senders' Blog on May 3, 2010.
anonymous

Darpa Searches for Life's Master Clock - 0 views

www.wired.com/...darpa-life-master-clock

longnow longevity cycles timescale

shared by anonymous on 01 Aug 11 - Cached
  • If the effort succeeds — and, boy, is that a big if — the recently announced Biochronicity program could help us understand why cancer is so hard to beat, how stem cells self renew and why cells are programmed to die. In other words, it’ll be one of the biggest breakthroughs Darpa has ever had.
  • it’s clear that all life processes depend on some internal time keeping.
  • Darpa wants to find the master regulator, and then use that knowledge to develop “predictive models of molecular-timed events, cell-cycle progression, lifespan, aging, and cell death, response to stress, and useful treatment strategies and drug delivery.” The key word is predictive. Darpa is no longer content with biology as a descriptive enterprise, watching cells and enzymes do their thing. Now, it wants mathematical models and algorithms and theories to tell what they’ll do next.
  • ...4 more annotations...
  • Scientists know that certain bits of DNA on the end of chromosomes called “telomeres” shorten each time the cell divides, playing a role in cell aging and eventual cell death
  • New research has uncovered how stress levels and diet can affect the biological age of an organism as opposed to chronological age, or calendar years.
  • For years scientists thought that sequencing DNA would uncover the “gene-for” almost everything, unraveling the mysteries of disease and resulting in new drugs and gene-specific treatments. It didn’t exactly pan out that way.
  • So to uncover the calculus within the genome, it might take some looking beyond the genome. Genes may contribute a few elements to the inner clock, but they interact within a larger scaffolding of cell processes and environmental factors.
  • anonymous on 01 Aug 11
     
    "There's a hidden clock that underlies every process of every living thing - from when our cells start dividing to how quickly we age. Researchers at Darpa, the Pentagon's extreme science agency, believe they can find it, using a mash-up of biology, code-cracking, mathematics and computer science."
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