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Peptidomimetic antibiotics disrupt the lipopolysaccharide transport bridge of drug-resi... - 0 views

www.science.org/...sciadv.adg3683

bacteria-killing HSR2023 peptide drug-resistant thanatin

shared by katherine-medina on 05 Aug 23 - No Cached

Recently, naturally occurring peptides were proposed to interfere with the function of proteins constituting the lipopolysaccharide
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periplasmic
- katherine-medina on 05 Aug 23
  
  The space in between the inner and outer membranes of gram-negative bacteria
  
  <div class="cArrow"> </div><div class="cContentInner">The space in between the inner and outer membranes of gram-negative bacteria</div>
  
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Thanatin, a 21–amino acid defense peptide isolated from the gut of the hemipteran insect Podisus maculiventris (18), exhibits broad-spectrum antimicrobial activity
- katherine-medina on 05 Aug 23
  
  I wonder what other peptides do so as well?
  
  <div class="cArrow"> </div><div class="cContentInner">I wonder what other peptides do so as well?</div>
  
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We hypothesized that thanatin mainly acts as a competitive inhibitor of the protein-protein interactions mediating the Lpt bridge assembly
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Thanatin, however, is not a suitable drug candidate for further development due to poor drug-like properties and rapid emergence of resistance
- katherine-medina on 05 Aug 23
  
  Why/How does thanatin have poor drug-like properties?
  
  <div class="cArrow"> </div><div class="cContentInner">Why/How does thanatin have poor drug-like properties?</div>
  
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β-jellyroll
- katherine-medina on 05 Aug 23
  
  structure found in proteins
  
  <div class="cArrow"> </div><div class="cContentInner">structure found in proteins</div>
  
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Here, we introduce thanatin-derived synthetic macrocyclic peptides found after a substantial medicinal chemistry effort.
- katherine-medina on 05 Aug 23
  
  Essentially they synthetically created it
  
  <div class="cArrow"> </div><div class="cContentInner">Essentially they synthetically created it</div>
  
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Development of resistance against thanatin was observed after 1 day of passaging in both E. coli and K. pneumoniae and is characterized by a spontaneous FOR of 1.2 × 10−6 for E. coli at 4× MIC
- katherine-medina on 05 Aug 23
  
  That is kinda scary to think about
  
  <div class="cArrow"> </div><div class="cContentInner">That is kinda scary to think about</div>
  
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genome sequencing of a diverse panel of thanatin-resistant strains confirmed on-target modifications on LptA as the main resistance determinant in E. coli and K. pneumoniae.
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The attractive in vitro and in vivo profile of these new antibiotics, coupled with their novel mechanism of action, showing no cross-resistance to standard of care antibiotics, may provide clinicians with additional treatment options to fight AMR, either in combination with SoC or as stand-alone antibiotics.
- katherine-medina on 05 Aug 23
  
  It is interesting to look around that these other methods that can fight off bacteria.
  
  <div class="cArrow"> </div><div class="cContentInner">It is interesting to look around that these other methods that can fight off bacteria.</div>
  
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katherine-medina on 05 Aug 23

An article showing a new class of antibiotics known as a peptidomimetic antibiotic.

<div class="cArrow"> </div><div class="cContentInner">An article showing a new class of antibiotics known as a peptidomimetic antibiotic.</div>

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Sci-Hub | Amyloid-β as a Blood Biomarker for Alzheimer's Disease: A Review of... - 0 views

sci-hub.ru/...31868667

blood-plasma biomarkers Alzheimer's-disease potential research idea HSR-2023

shared by katherine-medina on 31 May 23 - No Cached

- katherine-medina on 31 May 23
  
  So seeing as if scientists have mostly studied AB40-42, and 38 why don't they look at the other peptides under the name of AB.
  
  <div class="cArrow"> </div><div class="cContentInner">So seeing as if scientists have mostly studied AB40-42, and 38 why don't they look at the other peptides under the name of AB.</div>
  
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- katherine-medina on 31 May 23
  
  I shall take note of this excerpt of the passage for future reference, "The discrep- 104 ancy between these two ultrasensitive assays may 105 be due to the different principle and design that 106 IMR assay could inhibit the oligomerization of A42 107 by the iron-chelating effect of magnetic Fe3O4 108 nanoparticles."
  
  <div class="cArrow"> </div><div class="cContentInner">I shall take note of this excerpt of the passage for future reference, "The discrep- 104 ancy between these two ultrasensitive assays may 105 be due to the different principle and design that 106 IMR assay could inhibit the oligomerization of A42 107 by the iron-chelating effect of magnetic Fe3O4 108 nanoparticles."</div>
  
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- katherine-medina on 31 May 23
  
  Important to see that they are figuring out that, "that there is a blood-brain transportation mechanism 261 for A and indicated that plasma A may be able to 262 reflect the brain A condition."
  
  <div class="cArrow"> </div><div class="cContentInner">Important to see that they are figuring out that, "that there is a blood-brain transportation mechanism 261 for A and indicated that plasma A may be able to 262 reflect the brain A condition."</div>
  
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...1 more annotation...
- katherine-medina on 31 May 23
  
  Maybe I could look into the blood plasma levels AB1-40 and make it into a sort of predictor that could show if somehow may in future years live with some sort of Alzeheimer's Dementia.
  
  <div class="cArrow"> </div><div class="cContentInner">Maybe I could look into the blood plasma levels AB1-40 and make it into a sort of predictor that could show if somehow may in future years live with some sort of Alzeheimer's Dementia.</div>
  
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katherine-medina on 31 May 23

A good look at what scientist have found about the presence of Amyloid B in the blood as a biomarker for Alzheimer's disease

<div class="cArrow"> </div><div class="cContentInner">A good look at what scientist have found about the presence of Amyloid B in the blood as a biomarker for Alzheimer's disease</div>

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Peptidomimetic antibiotics disrupt the lipopolysaccharide transport bridge of drug-resi... - 0 views

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