In an open marketplace, such as a farmers' market where produce and other goods like candles and flowers are exchanged for money, the ideal prices for both consumers and sellers will quickly emerge. For example, if a seller tries to offer a bag of peaches for $10 but another vendor is willing to sell similar peaches for $5, the lower price will eventually win out and become the norm. This phenomenon, which is related to the law of supply and demand, was demonstrated experimentally starting in the 1960s by Caltech alumnus and Nobel Laureate Vernon Smith (BS '49), now at Chapman University, and later by Caltech's Charlie Plott, the William D. Hacker Professor of Economics and Political Science.

But the concept of developing a vaccine at "warp speed" makes many people uncomfortable. In a May survey, 49 percent of the Americans polled said they plan to get a coronavirus vaccine when one is available, 20 percent do not, and 31 percent indicated that they were not sure. The World Health Organization considers "vaccine hesitancy" a major threat to global health, and poor uptake would jeopardize the impact of a coronavirus vaccine.

Athena Akrami's neuroscience lab reopened last month without her. Life for the 38-year-old is a pale shadow of what it was before 17 March, the day she first experienced symptoms of the novel coronavirus. At University College London (UCL), Akrami's students probe how the brain organizes memories to support learning, but at home, she struggles to think clearly and battles joint and muscle pain. "I used to go to the gym three times a week," Akrami says. Now, "My physical activity is bed to couch, maybe couch to kitchen." Her early symptoms were textbook for COVID-19: a fever and cough, followed by shortness of breath, chest pain, and extreme fatigue. For weeks, she struggled to heal at home. But rather than ebb with time, Akrami's symptoms waxed and waned without ever going away. She's had just 3 weeks since March when her body temperature was normal.

Aside from filtering, warming, and humidifying the air you breathe, the nose is your first line of defense against allergens and pathogens. The mucus and cilia inside are designed to block these outside invaders from going farther down the respiratory tract and making you sick. And NO, which is what the sinuses release when you breathe through your nose, is a vasodilator, meaning it relaxes the blood vessels and lowers blood pressure.

As social distancing became norm and law in the early days of the Covid-19 pandemic, people turned to video teleconferencing to meet with friends and family, attend religious services, and go on dates. Zoom work accounts became a conduit for maintaining nonwork social ties, and as people came to depend on this enterprise tool, Zoom's stock valuation soared.1 The pandemic has widened the sphere of life dependent on such market technologies, heightening existing questions around the political, legal, and economic governance of these companies. How should the fabric of social life, especially as it is rewoven by the pandemic, relate to the private ownership of telecommunications?

In the flagship article, The ENCODE Project Consortium et al.5 provide a bird's-eye view of the updated encyclopedia, which contains newly added data sets from 6,000 experiments, performed on around 1,300 samples. By integrating these data sets, the consortium has created an online registry of candidate CREs. Most are classified as promoters or enhancers - CREs respectively located at or some distance from the genomic site at which transcription of a gene begins. The consortium tracked the activity of each candidate CRE, along with the proteins that bind to it in many different samples from various tissues. They used chromatin-looping data to link enhancers to genes that they might regulate. This online registry marks a true milestone, turning an overwhelming amount of genomic information into a searchable, filterable and retrievable encyclopedia of DNA elements, which is freely accessible at https://screen.encodeproject.org.