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Aerosol transmission of viruses must be acknowledged as a key factor leading to the spread of infectious respiratory diseases. Evidence suggests that SARS-CoV-2 is silently spreading in aerosols exhaled by highly contagious infected individuals with no symptoms. Owing to their smaller size, aerosols may lead to higher severity of COVID-19 because virus-containing aerosols penetrate more deeply into the lungs (10). It is essential that control measures be introduced to reduce aerosol transmission. A multidisciplinary approach is needed to address a wide range of factors that lead to the production and airborne transmission of respiratory viruses, including the minimum virus titer required to cause COVID-19; viral load emitted as a function of droplet size before, during, and after infection; viability of the virus indoors and outdoors; mechanisms of transmission; airborne concentrations; and spatial patterns. More studies of the filtering efficiency of different types of masks are also needed. COVID-19 has inspired research that is already leading to a better understanding of the importance of airborne transmission of respiratory disease.

Great powers rise and fall, shaping each transitional period of global power shift and its geographic concentration. Currently, the world is witnessing a profound transformation in the geopolitical arena of international affairs. For the past years, the pundits have been propagating the emergence of an Asian multipolar century, with a shift from the Atlantic to the Pacific realm. However, following the COVID-19 virus outbreak, this year marks the obvious manifestation of an Indo-Pacific decade, with the US, China, and potentially India being the main protagonists in an emerging competition. This time, it is the unfolding of regional centres of power, which create the delusive impression of multipolarity, while in fact a new systemic bipolarity between the US and China comes to light. In the post-COVID-19 global context, the virus has become a catalyst of multiple systemic changes, inducing ad hoc constellations of regional actors-shaped by their geopolitical and geoeconomic interests-in a changing global order with eroding multilateral structures.

Bart Haagmans (Erasmus MC) concludes: "The observations made in this study provide definite proof that SARS-CoV-2 can multiply in cells of the gastrointestinal tract. However, we don't yet know whether SARS-CoV-2, present in the intestines of COVID-19 patients, plays a significant role in transmission. Our findings indicate that we should look into this possibility more closely." The current study is in line with other recent studies that identified gastrointestinal symptoms in a large fraction of COVID-19 patients and virus in the stool of patients free of respiratory symptoms. Special attention may be needed for those patients with gastrointestinal symptoms. More extensive testing using not only nose and throat swabs, but also rectal swabs or stool samples may thus be needed.

More than a year after COVID-19 emerged, many mysteries persist about the disease: why do some people get so much sicker than others? Why does lung damage sometimes continue to worsen well after the body seems to have cleared the SARS-CoV-2 virus? And what is behind the extended, multi-organ illness that lasts for months in people with 'long COVID'? A growing number of studies suggest that some of these questions might be explained by the immune system mistakenly turning against the body - a phenomenon known as autoimmunity.

This virus wasn't something we knew nothing about. There was so much we knew, from day one, including because of SARS, the previous almost-pandemic that was also a similar coronavirus. We could have used that vital pre-information better if we had matched the requisite epistemic humility that a pandemic requires-an acknowledgement that we aren't certain of anything-with an insistence that this situation wasn't a blank slate. We could have utilized our prior knowledge to plan ahead, while not letting go of the uncertainty-taking thoughtful steps but without overstating our confidence.

The billionaire is working with the W.H.O., drugmakers and nonprofits to defeat the coronavirus everywhere, including in the world's poorest nations. Can they do it?

The damage we are not attending to is the deeper nature of the crisis-the collapse of multiple coupled complex systems. Societies the world over are experiencing what might be called the first complexity crisis in history. We should not have been surprised that a random mutation of a virus in a far-off city in China could lead in just a few short months to the crash of financial markets worldwide, the end of football in Spain, a shortage of flour in the United Kingdom, the bankruptcy of Hertz and Niemann-Marcus in the United States, the collapse of travel, and to so much more.

At the beginning of the pandemic, the coronavirus looked to be another respiratory illness. But the virus has turned out to affect not just the lungs, but the kidneys, the heart and the circulatory system - even, somehow, our senses of smell and taste.

Converging lines of evidence indicate that SARS-CoV-2, the coronavirus responsible for the COVID-19 pandemic, can pass from person to person in tiny droplets called aerosols that waft through the air and accumulate over time. After months of debate about whether people can transmit the virus through exhaled air, there is growing concern among scientists about this transmission route.

Our findings don't show much rationale for substantial relaxation of social distancing, in the absence of other measures," Wagner said. "We don't have a lot of wiggle room." Additional steps such as contact tracing, increased testing or stricter quarantining could also have an impact, he added, as will the fact that the infection rate will inevitably drop as more people contract the virus, leaving fewer susceptible.