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Using two independent single-cell approaches, we identified a shift in the overall immune cell composition in cavefish as the underlying cellular mechanism, indicating strong differences in the immune investment strategy. While surface fish invest evenly into the innate and adaptive immune systems, cavefish shifted immune investment to the adaptive immune system, and here, mainly towards specific T-cell populations that promote homeostasis. Additionally, inflammatory responses and immunopathological phenotypes in visceral adipose tissue are drastically reduced in cavefish. Our data indicate that long-term adaptation to low parasite diversity coincides with a more sensitive immune system in cavefish, which is accompanied by a reduction in the immune cells that play a role in mediating the pro-inflammatory response.

We need to take a hard look at what parts of the world are critical to the security of the West and rethink how to make its alliances work again. The following geopolitical reality is still true today: The United States has to ensure that no power hostile to its interests can assert exclusive control over Eurasia, including the European rimland. Today preventing China's domination of Eurasia should be our overarching strategic objective, and to achieve this we need to focus on three fundamentals: 1) Prioritize Eurasia and stop draining our military resources in secondary theaters; 2) invest in allies who see their interests directly aligned with ours and are willing to assume the attendant risk; and 3) decouple U.S. strategic industries from China's and redefine the rules of international trade to ensure equitable competition.

"If corporations returned to the practices of the pre-neoliberal era (1952-1983, to be precise), stuffing not half but less than a fifth of their cash flow in their shareholders' pockets, that could take net investment back to its old average. But under today's model of capitalism, it's more important to keep the shareholders happy."

A survey of ESG influencers shows the elusive side of investor responsibility. What to do? When the Covid-19 crisis exploded in winter 2020, we spelled out four different scenarios for ESG in times of pandemic.

a paper recently published in Nature Sustainability, Grassini and Cassman propose a four-pronged prioritization framework for funders to use as they distribute research dollars to agricultural scientists pursuing the goal of sustainable intensification. That term refers to increasing yields of major food crops on existing farmland to avoid converting rainforests and wetlands for crop production, and doing so without negative effects on biodiversity, water and soil.

"Yves here. It's gratifying to see an article that uses as a central observation something we've pointed out: the first two generations of the Industrial Revolution led to a decline in living standards of most laborers, particularly in England. This piece looks at the parallels between the past industrial revolutions and the post-industrial revolution now underway, and anticipates that the results will include deglobalzation and more political shocks."

"Twenty-first century imperialism has changed its form. In the 19th century and the first half of the 20th century, it was explicitly related to colonial control; in the second half of the 20th century it relied on a combination of geopolitical and economic control deriving also from the clear dominance of the United States as the global hegemon and leader of the capitalist world dealing with the potential threat from the Communist world. It now relies more and more on an international legal and regulatory architecture-fortified by various multilateral and bilateral agreements-to establish the power of capital over labor. This has involved a "grand bargain," no less potent for being implicit, between different segments of capital. Capitalist firms in the developing world gained some market access (typically intermediated by multinational capital) and, in return, large capital in highly developed countries got much greater protection and monopoly power, through tighter enforcement of intellectual property rights and greater investment protections."

"his paper takes stock of megaproject management, an emerging and hugely costly field of study. First, it answers the question of how large megaprojects are by measuring them in the units mega, giga, and tera, concluding we are presently entering a new "tera era" of trillion-dollar projects. Second, total global megaproject spending is assessed, at USD 6-9 trillion annually, or 8 percent of total global GDP, which denotes the biggest investment boom in human history. Third, four "sublimes" - political, technological, economic, and aesthetic - are identified to explain the increased size and frequency of megaprojects. Fourth, the "iron law of megaprojects" is laid out and documented: Over budget, over time, over and over again. Moreover, the "break-fix model" of megaproject management is introduced as an explanation of the iron law. Fifth, Albert O. Hirschman's theory of the Hiding Hand is revisited and critiqued as unfounded and corrupting for megaproject thinking in both the academy and policy. Sixth, it is shown how megaprojects are systematically subject to "survival of the unfittest," explaining why the worst projects get built instead of the best. Finally, it is argued that the conventional way of managing megaprojects has reached a "tension point," where tradition is challenged and reform is emerging. "

"Consequential and irreversible decisions are the ones that you really need to focus on. All of the time I saved from using this matrix didn't allow me to sip drinks on the beach. Rather, I invested it in the most important decisions, the ones I couldn't justify delegating. I also had another rule that proved helpful: unless the decision needed to be made on the spot, as some operational decisions do, I would take a 30-minute walk first. The key to successfully employing this in practice was to make sure everyone was on same page with the terms of consequential and reversible. At first, people checked with me but later, as the terms became clear, they just started deciding."

SINCE THE END of November, this is some of what has sunk to the bottom of the Pacific Ocean: vacuum cleaners; Kate Spade accessories; at least $150,000 of frozen shrimp; and three shipping containers full of children's clothes. "If anybody has investments in deep-sea salvage, there's some beautiful product down there," Richard Westenberger, chief financial officer of the children's clothing brand Carter's told a conference recently.