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Numerical results show that school closure alone would have limited benefit in reducing the peak incidence (less than 10% reduction with 8-week school closure for regions in the early phase of the epidemic). When coupled with 25% adults teleworking, 8-week school closure would be enough to delay the peak by almost 2 months with an approximately 40% reduction of the case incidence at the peak. This is critical to reduce the burden on the healthcare system in the weeks of highest demand. Moderate overall reduction of the final attack rate (15%) would also be achieved. Results across regions are qualitatively similar, with differences

"Realignment and Legitimacy "The Constitutional Crisis Is Now" [Robert Reich, The American Prospect]. "If [Trump] refuses to accept the results [the 2020] election, as he threatened to do if he lost the 2016 election, he will have to be forcefully removed from office." This is lunacy. In 2016, liberal Democrats floated the idea that "faithless electors" in the Electoral College should not appoint Trump - based on information from the "intelligence community" that the public was not allowed to see. From that day to this, liberal Democrats haven't accepted the results of 2016, which is what the "Clinton won the popular vote" amounts to. Is the inability to look in the mirror a 10%-er deformation professionnelle? "The Democratic Party unraveling is not good for America" [Ed Rogers, WaPo]. "The Democratic Party is not functioning as an umbrella organization or even a coalition. Instead, activists from Tom Steyer to George Soros to Planned Parenthood are operating independently*, doing things a political party otherwise would. These independent actors are pushing pet causes. Traditional party building isn't one of them. Campaign finance reform and communication technologies have empowered wealthy individuals and collateral groups while at the same time inhibiting parties and individual campaigns. I say this not to kick the Democratic Party while it is down but because I believe in the two-party system…. We need reforms that empower parties and candidates and diminish the influence of deep-pocketed plutocrats and narrowly focused interest groups." Rogers is a veteran of the Reagan and Bush White Houses, but he's not wrong. NOTE * Maybe. When you start thinking, it's hard to know where the boundaries of the Democrat Party really are. For example, are journalists who propagate Brock talking points in the party, or not? My instinct is to say that they are, but how is an institution with fluid boundaries like that to be named and cate

"Prosociality is endemic. In a common experiment called the social dilemma, anonymous subjects choose between a "defection" strategy that maximizes their own personal payoffs, and a "cooperation" strategy that gains them slightly less, but gives other members of the group substantially more. Up to 97% of subjects choose cooperation in some social dilemmas. Not surprisingly, researchers have found that the incidence of such prosocial behaviors declines as the personal cost of acting prosocially rises. We are more likely to be nice when it only takes a little, not a lot, of skin off our noses. But the scientific evidence demonstrates the vast majority of people will make at least small sacrifices to follow their conscience and help others."

Since the emergence of coronavirus disease 2019 (COVID-19), unprecedented movement restrictions and social distancing measures have been implemented worldwide. The socioeconomic repercussions have fueled calls to lift these measures. In the absence of population-wide restrictions, isolation of infected individuals is key to curtailing transmission. However, the effectiveness of symptom-based isolation in preventing a resurgence depends on the extent of presymptomatic and asymptomatic transmission. We evaluate the contribution of presymptomatic and asymptomatic transmission based on recent individual-level data regarding infectiousness prior to symptom onset and the asymptomatic proportion among all infections. We found that the majority of incidences may be attributable to silent transmission from a combination of the presymptomatic stage and asymptomatic infections. Consequently, even if all symptomatic cases are isolated, a vast outbreak may nonetheless unfold. We further quantified the effect of isolating silent infections in addition to symptomatic cases, finding that over one-third of silent infections must be isolated to suppress a future outbreak below 1% of the population. Our results indicate that symptom-based isolation must be supplemented by rapid contact tracing and testing that identifies asymptomatic and presymptomatic cases, in order to safely lift current restrictions and minimize the risk of resurgence.

Ultraviolet light endangers the integrity of human genetic information and may cause skin cancer. For the first time, researchers at Karlsruhe Institute of Technology (KIT) have demonstrated that DNA damage may also occur far away from the point of incidence of the radiation. They produced an artificially modeled DNA sequence in new architecture and succeeded in detecting DNA damage at a distance of 30 DNA building blocks. The results are reported in Angewandte Chemie.