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Actions taken to mitigate the threats of coronavirus disease 2019 (COVID-19) to human life and welfare have inadvertently resulted in a natural experiment offering unanticipated insight into how human behavior affects animal behavior (1). Worldwide, elective quarantine and stay-at-home orders have reduced use of public spaces and transportation networks, especially in cities. Anecdotal media accounts suggest that restricted movement has elicited rarely observed behaviors in commensal and peri-urban animals (2). Though not all of the reports have proven to be accurate (3), widely publicized observations like coyotes crossing the normally heavily trafficked Golden Gate Bridge in the San Francisco (SF) Bay Area (California, USA) have provoked widespread fascination with the prospect that animals rapidly move back into landscapes recently vacated by humans.

The Spanish Crown had a monopoly on the trade route between Manila and Mexico for more than 250 years. The ships that sailed this route were "the richest ships in all the oceans", but much of the wealth sank at sea and remain undiscovered. This column uses a newly constructed dataset of all of the ships that travelled the route to show how monopoly rents that allowed widespread bribe-taking would have led to overloading and late ship departure, thereby increasing the probability of shipwreck. Not only were late and overloaded ships more likely to experience shipwrecks or to return to port, but the effect is stronger for galleons carrying more valuable, higher-rent cargo. This sheds new light on the costs of rent-seeking in European colonial empires.

Beginning in the late 1970s, China's economy delivered the largest growth spurt in recorded history. Striking discontinuity between recent outcomes and the economic experience of the prior 200 years invites portrayal of recent events as a "China miracle" that requires neither economic nor historical analysis. This overlooks deep institutional constraints arising from authoritarian rule and its supporting elite networks and fails to recognize the link between central government weakness and the origins of the recent boom. In both the pre-1949 treaty ports and in the aftermath of the Cultural Revolution, the retreat of central control enabled episodes of economic openness and dynamism built upon 'bottom up' initiative and decentralized innovation. Historic legacies that shape political structures and individual behavior will continue to influence China's economic trajectory.

BY NOW THERE'S little doubt about hydroxychloroquine: It doesn't work for treating Covid-19. But there's a bigger, more important lesson hidden in the story of its failure-a rarely-mentioned, but altogether crucial, error baked into the early research. The scientists who ran the first, promising laboratory experiments on the drug had used the wrong kind of cells: Instead of testing its effects on human lung cells, they relied on a supply of mass-produced, standardized cells made from a monkey's kidney. In the end, that poor decision made their findings more or less irrelevant to human health. Worse, it's possible that further research into novel Covid-19 cures will end up being compromised by the same mistake.

The differing immune system responses of patients with COVID-19 can help predict who will experience moderate and severe consequences of disease, according to a new study by Yale researchers published July 27 in the journal Nature.