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Bill Fulkerson

Big data analysis finds cancer's key vulnerabilities - 0 views

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    Thousands of different genetic mutations have been implicated in cancer, but a new analysis of almost 10,000 patients found that regardless of the cancer's origin, tumors could be stratified in only 112 subtypes and that, within each subtype, the Master Regulator proteins that control the cancer's transcriptional state were virtually identical, independent of the specific genetic mutations of each patient.
Bill Fulkerson

DNA damage caused by migrating light energy - 0 views

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    Ultraviolet light endangers the integrity of human genetic information and may cause skin cancer. For the first time, researchers at Karlsruhe Institute of Technology (KIT) have demonstrated that DNA damage may also occur far away from the point of incidence of the radiation. They produced an artificially modeled DNA sequence in new architecture and succeeded in detecting DNA damage at a distance of 30 DNA building blocks. The results are reported in Angewandte Chemie.
Bill Fulkerson

CRISPR-assisted novel method detects RNA-binding proteins in living cells - 0 views

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    While scientists still don't fully understand the diverse nature of RNA molecules, it is believed that the proteins binding to them, called RNA-binding proteins, are associated with many types of disease formation. Research led by biomedical scientists from City University of Hong Kong (CityU) has led to a novel detection method, called CARPID, to identify binding proteins of specific RNAs in living cells. It is expected that the innovation can be applied in various types of cell research, from identifying biomarkers of cancer diagnosis to detecting potential drug targets for treating viral diseases.
Steve Bosserman

Applying AI for social good | McKinsey - 0 views

  • Artificial intelligence (AI) has the potential to help tackle some of the world’s most challenging social problems. To analyze potential applications for social good, we compiled a library of about 160 AI social-impact use cases. They suggest that existing capabilities could contribute to tackling cases across all 17 of the UN’s sustainable-development goals, potentially helping hundreds of millions of people in both advanced and emerging countries. Real-life examples of AI are already being applied in about one-third of these use cases, albeit in relatively small tests. They range from diagnosing cancer to helping blind people navigate their surroundings, identifying victims of online sexual exploitation, and aiding disaster-relief efforts (such as the flooding that followed Hurricane Harvey in 2017). AI is only part of a much broader tool kit of measures that can be used to tackle societal issues, however. For now, issues such as data accessibility and shortages of AI talent constrain its application for social good.
  • The United Nations’ Sustainable Development Goals (SDGs) are among the best-known and most frequently cited societal challenges, and our use cases map to all 17 of the goals, supporting some aspect of each one (Exhibit 3). Our use-case library does not rest on the taxonomy of the SDGs, because their goals, unlike ours, are not directly related to AI usage; about 20 cases in our library do not map to the SDGs at all. The chart should not be read as a comprehensive evaluation of AI’s potential for each SDG; if an SDG has a low number of cases, that reflects our library rather than AI’s applicability to that SDG.
Steve Bosserman

Climate science gets precise enough for legal action - SciDev.Net - 0 views

  • Parallel to the IPCC process, scientific advances mean that models can now link individual weather events to climate change as the cause, said Friederike Otto, acting director of the Environmental Change institute at the University of Oxford in the UK. This is done through attribution science—much in the same way that smoking was linked to cancer decades ago—which is “very much in legal discussions at the moment”, said Otto. Attribution science has been a game changer in the past five years, added Yamin: in the case of an event such as flooding or a heat wave, for example, “you don’t talk about a vague sense of weather any more — you can link it to anthropogenic activities that are causing long-term global change”.
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