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Pass the bass, please. Omega-3 fatty acids, a main component of fish oil, have a reputation as potent anti-inflammatory agents. Now researchers think they know how the acids block this immune response. They've also found that omega-3s can help fight diabetes in obese mice, pointing the way to potential therapies in humans. To understand how omega-3s curb inflammation, Jerrold Olefsky, an endocrinologist at the University of California, San Diego, and his colleagues trawled through the data on a family of proteins called G protein-coupled receptors, which can bind to a number of different fatty acids. One of these receptors-GPR120-"jumped right out," Olefsky says. Olefsky's group found it on immune cells involved in inflammation, as well as in mature fat cells, and they noted that it seemed to bind to omega-3s.