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Holick MF.
Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease.
Am J Clin Nutr. 2004 Dec;80(6 Suppl):1678S-88S. Review.
PMID: 15585788 [PubMed - indexed for MEDLINE]
White button mushroom enhances maturation of bone marrow-derived dendritic cells and their antigen presenting function in mice.\nRen Z, Guo Z, Meydani SN, Wu D.\nJ Nutr. 2008 Mar;138(3):544-50.\nPMID: 18287364
Vitamin D's days of obscurity seem pretty much over. Once just an afterthought to most people-relegated to the sides of milk cartons and the pages of medical texts-it's now on the cusp of becoming a full-fledged disease prevention star. Although vitamin D has long been known as an important factor in bone health, a quickly growing body of evidence now shows that it may also help lower the risk of cancer, heart disease, and even premature death.[1], [2] Not surprisingly, scientists and the public have started to take note, particularly of vitamin D's potential to protect against cancer
Not enough vitamin D: health consequences for Canadians.
Schwalfenberg G.
Can Fam Physician. 2007 May;53(5):841-54. Review
PMID: 17872747
Conclusion
Low levels of VTD are considered a major public health problem in Canada, especially during the winter. Those with risk factors should be screened for low 25(OH)D levels and repletion therapy instituted if needed. Researchers have estimated that the oral dose of vitamin D3 to attain and maintain 25(OH)D levels >80 nmol/L is 2200 IU/d if baseline levels are 20 to 40 nmol/L, 1800 IU/d if levels are 40 to 60 nmol/L, and 1160 IU/d if levels are between 60 and 80 nmol/L.64
We need to ensure that patients have healthy blood levels of 25(OH)D to prevent levels of parathyroid hormone from rising and to maximize absorption of calcium, magnesium, and phosphate. Positive effects on bone are marginal at best unless patients consume at least 800 IU/d of VTD. The emerging and exciting role of the VTD receptor and the actions of VTD in maintaining health in other cell types have become more apparent during the last decade.
High prevalence of vitamin D deficiency despite supplementation in premenopausal women with breast cancer undergoing adjuvant chemotherapy.
Crew KD, Shane E, Cremers S, McMahon DJ, Irani D, Hershman DL.
J Clin Oncol. 2009 May 1;27(13):2151-6. Epub 2009 Apr 6.
PMID: 19349547
DOI: 10.1200/JCO.2008.19.6162
Conclusion Vitamin D deficiency is highly prevalent in women with breast cancer. The current recommended dietary allowance of vitamin D is too low to increase serum 25-OHD greater than 30 ng/mL. Optimal dosing for bone health and, possibly, improved survival has yet to be determined.
Derived from the cap and stem of the mushroom. The active constituent is thought to be a beta-glucan polysaccharide. The whole mushroom is used primarily as a dietary element, but extracts and supplements are sold as immune stimulants for patients with HIV or cancer. While no adverse effects have been reported, some studies reveal a hypoglycemic effect following administration of maitake extract (9) (12). Maitake was shown to enhance bone marrow colony formation, reduce doxorubicin toxicity in vitro (11), and to inhibit tumor metastasis
Stem cells are unprogrammed cells in the human body that can be described as "shape shifters." These cells have the ability to change into other types of cells. Stem cells are at the center of a new field of science called regenerative medicine. Because stem cells can become bone, muscle, cartilage and other specialized types of cells, they have the potential to treat many diseases, including Parkinson's, Alzheimer's, diabetes and cancer. Eventually, they may also be used to regenerate organs, reducing the need for organ transplants and related surgeries.
"Stem cells are like little kids who, when they grow up, can enter a variety of professions," Dr. Marc Hedrick of the UCLA School of Medicine says. "A child might become a fireman, a doctor or a plumber, depending on the influences in their life -- or environment. In the same way, these stem cells can become many tissues by making certain changes in their environment."
Association between plasma 25-hydroxyvitamin D and breast cancer risk.
Crew KD, Gammon MD, Steck SE, Hershman DL, Cremers S, Dworakowski E, Shane E, Terry MB, Desai M, Teitelbaum SL, Neugut AI, Santella RM.
Cancer Prev Res (Phila Pa). 2009 Jun;2(6):598-604. Epub 2009 May 26.
PMID: 19470790
In summary, these results add to a growing body of evidence that adequate vitamin D stores may prevent breast cancer development. Whereas circulating 25-OHD levels of >32 ng/mL are associated with normal bone mineral metabolism, our data suggest that the optimal level for breast cancer prevention is ≥40 ng/mL. Well-designed clinical trials are urgently needed to determine whether vitamin D supplementation is effective for breast cancer chemoprevention.
"ScienceDaily (Oct. 8, 2009) - Women with breast cancer should be given high doses of vitamin D because a majority of them are likely to have low levels of vitamin D, which could contribute to decreased bone mass and greater risk of fractures, according to scientists at the University of Rochester Medical Center."
Scientists funded by the NCI analyzed vitamin D levels in each woman, and the average level was 27 nanograms per milliliter; more than two-thirds of the women had vitamin deficiency. Weekly supplementation with high doses of vitamin D -- 50,000 international units or more -- improved the levels, according to Peppone's study.
The U.S. Institute of Medicine suggests that blood levels nearing 32 nanograms per milliliter are adequate.
Grant WB, Holick MF.
Benefits and requirements of vitamin D for optimal health: a review.
Altern Med Rev. 2005 Jun;10(2):94-111. Review.
PMID: 15989379 [PubMed - indexed for MEDLINE]
Benefits of Vitamin D Supplementation
Joel M. Kauffman, Ph.D.
Journal of American Physicians and Surgeons
Volume 14 Number 2 - Summer 2009
Clinical trials show that vitamin D supplementation at higher
levels than previously recommended is beneficial for many
conditions. It decreases the frequency of falls and fractures, helps
prevent cardiovascular disease, and reduces symptoms of colds or
influenza. Benefits are also seen in diabetes mellitus, multiple
sclerosis, Crohn disease, pain, depression, and possibly autism.
Sunlight does not cause an overdose of vitamin D production,
and toxicity from supplementation is rare. Dose recommendations
are increasing, but appear to be lagging the favorable trial results. A
number of common drugs deplete vitamin D levels, and others may
limit its biosynthesis from sunlight.
People with adequate levels from sun exposure will not benefit
from supplementation. While dietary intake is helpful,
supplementation is better able to raise serum 25-hydroxyvitamin D ,
the major circulating metabolite, to the level now thought adequate,
30-50 ng/mL.
Where there is inadequate daily sun exposure, oral doses of
1,000-2,000 IU/d are now considered routine, with much higher
doses (up to 50,000 IU) for rapid repletion now considered safe.