Knight JA, Lesosky M, Barnett H, Raboud JM, Vieth R.
Vitamin D and reduced risk of breast cancer: a population-based case-control study.
Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):422-9.
PMID: 17372236 [PubMed - indexed for MEDLINE]
Q. Pan, C. G. Kleer, K. L. van Golen, J. Irani, K. M. Bottema, C. Bias, M. De Carvalho, E. A. Mesri, D. M. Robins, R. D. Dick, G. J. Brewer, and S. D. Merajver
Copper Deficiency Induced by Tetrathiomolybdate Suppresses Tumor Growth and Angiogenesis
Canc
B. G. Redman, P. Esper, Q. Pan, R. L. Dunn, H. K. Hussain, T. Chenevert, G. J. Brewer, and S. D. Merajver
Phase II Trial of Tetrathiomolybdate in Patients with Advanced Kidney Cancer
Clin. Cancer Res., May 1, 2003; 9(5): 1666 - 1672.
C. Cox, S. D. Merajver, S. Yoo, R. D. Dick, G. J. Brewer, J. S.-J. Lee, and T. N. Teknos
Inhibition of the Growth of Squamous Cell Carcinoma by
Tetrathiomolybdate-Induced Copper Suppression in a Murine Model
Arch Otolaryngol Head Neck Surg, July 1, 200
Pan Q, Bao LW, Kleer CG, Brewer GJ, Merajver SD.
Antiangiogenic tetrathiomolybdate enhances the efficacy of doxorubicin against breast carcinoma.
Mol Cancer Ther. 2003 Jul;2(7):617-22.
PMID: 12883034 [PubMed - indexed for MEDLINE]
Shannon J, King IB, Moshofsky R, Lampe JW, Li Gao D, Ray RM, Thomas DB.
Erythrocyte fatty acids and breast cancer risk: a case-control study in Shanghai, China.
Am J Clin Nutr. 2007 Apr;85(4):1090-7.
PMID: 17413110 [PubMed - in process]
Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP.
Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial.
Am J Clin Nutr. 2007 Jun;85(6):1586-91.
PMID: 17556697 [PubMed - indexed for MEDLINE]
Park SY, Murphy SP, Wilkens LR, Nomura AM, Henderson BE, Kolonel LN.
Calcium and vitamin D intake and risk of colorectal cancer: the Multiethnic Cohort Study.
Am J Epidemiol. 2007 Apr 1;165(7):784-93. Epub 2007 Jan 10.
PMID: 17215380 [PubMed - indexed
Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression.
Li Y, Liu L, Tollefsbol TO.
FASEB J. 2009 Dec 17. [Epub ahead of print]
PMID: 20019239
doi: 10.1096/fj.09-149328
Cancer cells metabolize glucose at elevated rates and have a higher sensitivity to glucose reduction. However, the precise molecular mechanisms leading to different responses to glucose restriction between normal and cancer cells are not fully understood. We analyzed normal WI-38 and immortalized WI-38/S fetal lung fibroblasts and found that glucose restriction resulted in growth inhibition and apoptosis in WI-38/S cells, whereas it induced lifespan extension in WI-38 cells. Moreover, in WI-38/S cells glucose restriction decreased expression of hTERT (human telomerase reverse transcriptase) and increased expression of p16(INK4a). Opposite effects were found in the gene expression of hTERT and p16 in WI-38 cells in response to glucose restriction. The altered gene expression was partly due to glucose restriction-induced DNA methylation changes and chromatin remodeling of the hTERT and p16 promoters in normal and immortalized WI-38 cells. Furthermore, glucose restriction resulted in altered hTERT and p16 expression in response to epigenetic regulators in WI-38 rather than WI-38/S cells, suggesting that energy stress-induced differential epigenetic regulation may lead to different cellular fates in normal and precancerous cells. Collectively, these results provide new insights into the epigenetic mechanisms of a nutrient control strategy that may contribute to cancer therapy as well as antiaging approaches.
High prevalence of vitamin D deficiency despite supplementation in premenopausal women with breast cancer undergoing adjuvant chemotherapy.
Crew KD, Shane E, Cremers S, McMahon DJ, Irani D, Hershman DL.
J Clin Oncol. 2009 May 1;27(13):2151-6. Epub 2009 Apr 6.
PMID: 19349547
DOI: 10.1200/JCO.2008.19.6162
Conclusion Vitamin D deficiency is highly prevalent in women with breast cancer. The current recommended dietary allowance of vitamin D is too low to increase serum 25-OHD greater than 30 ng/mL. Optimal dosing for bone health and, possibly, improved survival has yet to be determined.
Antitumor activity of human papillomavirus type 16 E7-specific T cells against virally infected squamous cell carcinoma of the head and neck.
Albers A, Abe K, Hunt J, Wang J, Lopez-Albaitero A, Schaefer C, Gooding W, Whiteside TL, Ferrone S, DeLeo A, Ferris RL.
Cancer Res. 2005 Dec 1;65(23):11146-55.
PMID: 16322265
Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial.
Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP.
Am J Clin Nutr. 2007 Jun;85(6):1586-91. Erratum in: Am J Clin Nutr. 2008 Mar;87(3):794.
PMID: 17556697
Conclusions: Improving calcium and vitamin D nutritional status substantially reduces all-cancer risk in postmenopausal women.
Meat intake and mortality: a prospective study of over half a million people.
Sinha R, Cross AJ, Graubard BI, Leitzmann MF, Schatzkin A.
Arch Intern Med. 2009 Mar 23;169(6):562-71.
PMID: 19307518
Red and processed meat intakes were associated with modest increases in total mortality, cancer mortality, and cardiovascular disease mortality
Combination immunotherapy of squamous cell carcinoma of the head and neck: a phase 2 trial.
Barrera JL, Verastegui E, Meneses A, Zinser J, de la Garza J, Hadden JW.
Arch Otolaryngol Head Neck Surg. 2000 Mar;126(3):345-51.
PMID: 10722007