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Based on the suggestions of the observers above, and my own active imagination, I offer the following as possible near-term advances in the evolution of the scientific method. Compiled Negative Results - Negative results are saved, shared, compiled and analyzed, instead of being dumped. Positive results may increase their credibility when linked to negative results. We already have hints of this in the recent decision of biochemical journals to require investigators to register early phase 1 clinical trials. Usually phase 1 trials of a drug end in failure and their negative results are not reported. As a public heath measure, these negative results should be shared. Major journals have pledged not to publish the findings of phase 3 trials if their earlier phase 1 results had not been reported, whether negative or not. Return of the Subjective - Science came into its own when it managed to refuse the subjective and embrace the objective. The repeatability of an experiment by another, perhaps less enthusiastic, observer was instrumental in keeping science rational. But as science plunges into the outer limits of scale - at the largest and smallest ends - and confronts the weirdness of the fundamental principles of matter/energy/information such as that inherent in quantum effects, it may not be able to ignore the role of observer. Existence seems to be a paradox of self-causality, and any science exploring the origins of existence will eventually have to embrace the subjective, without become irrational. The tools for managing paradox are still undeveloped.

In the wake of several highly publicized suicides by gay teenagers, a new study finds that a negative social environment surrounding gay youth is associated with high rates of suicide attempts by lesbian, gay, and bisexual (LGB) youth. The study, "The Social Environment and Suicide Attempts in a Population-Based Sample of LGB Youth," appears in the April 18 issue of Pediatrics. It was conducted by by Robert Wood Johnson Foundation Health & Society Scholar Mark L. Hatzenbuehler at Columbia University's Mailman School of Public Health.

Preserving diverse plant life will be crucial to buffer the negative effects of climate change and desertification in in the world's drylands, according to a new landmark study.

UC Berkeley physicist Richard Muller and others were looking at the so-called urban heat island effect - the notion that because more urban temperature stations are included in global temperature data sets than are rural ones, the global average temperature was being skewed upward because these sites tend to retain more heat. Hence, global warming trends are exaggerated. Using data from such urban heat islands as Tokyo, they hypothesized, could introduce "a severe warming bias in global averages using urban stations." In fact, the data trend was "opposite in sign to that expected if the urban heat island effect was adding anomalous warming to the record. The small size, and its negative sign, supports the key conclusion of prior groups that urban warming does not unduly bias estimates of recent global temperature change."

For more than 20 years, theoretical mathematical models have predicted that a delay built into a negative feedback system is at the heart of the molecular mechanism that governs circadian clocks in mammalian cells. Now, the first experimental proof of this theory has been provided by an international research team led by molecular biologists and information scientists from the RIKEN Center for Developmental Biology in Kobe. The demonstration of the feedback delay should lead to a better understanding of how cellular clocks function, and therefore how mammals adjust to the regular daily and seasonal changes in their environment. The work could also open the way to the development of treatments for circadian disorders, such as seasonal affective disorder, jet lag and even bipolar disorder.

People who look at the past through rose-tinted glasses are happier than those who focus on negative past experiences and regrets, according to a new study published in the journal Personality and Individual Differences. The study helps explain why personality has such a strong influence on a person's happiness. The findings suggest that persons with certain personality traits are happier than others because of the way they think about their past, present and future.

panel of marine scientists who met earlier this year in Oxford, England, have concluded that the world's oceans are facing an unprecedented loss of species. As the London Independent reports today, "The seas are degenerating far faster than anyone has predicted, the report says, because of the cumulative impact of a number of severe individual stresses, ranging from climate warming and sea-water acidification, to widespread chemical pollution and gross overfishing." They concluded that the negative impacts are greater than predicted, and that mass extinctions could occur within one human generation.