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Tero Toivanen

Autism Research Blog: Translating Autism: Sensory sensitivity as early sign of autism: ... - 0 views

  • When compared to children with non-ASD developmental delays, children with autism had significantly more tactile sensitivity, auditory anomalies (low response), and taste/smell sensitivity.
  • in this study the authors wanted to determine whether sensory abnormalities would differentiate between children with ASD and children with other developmental conditions.
  • When compared to the children with non-ASD developmental delays, the children with autism had significantly more tactile sensitivity, auditory anomalies (low response), and taste/smell sensitivity. The authors did not find differences between the two groups in visual or auditory over-sensitivity.
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  • results provide indirect support for the common clinical practice of considering signs of sensory sensitivities as one factor when determining whether a child has an ASD, a developmental delay, or a language delay.
  • early sensory sensitivity should be one of the factors examined by pediatricians during healthy baby checkups.
  • results do not tell us whether the levels of sensory anomalies observed in the non-ASD group are higher than what is expected among typically developing children.
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    When compared to children with non-ASD developmental delays, children with autism had significantly more tactile sensitivity, auditory anomalies (low response), and taste/smell sensitivity.
Tero Toivanen

The Advantages of Tourette's : The Frontal Cortex - 0 views

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    Tim Howard: "I like the way I am. If I woke up tomorrow without Tourette's, I wouldn't know what to do with myself."
Tero Toivanen

Pioneer in treatment of autism dies - My News 4 - KRNV, Reno, NV - 0 views

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    Ivar Lovaas pioneer in treatmet of autism died.
Tero Toivanen

Autism finding could lead to simple urine test for the condition - 0 views

  • The researchers behind the study, from Imperial College London and the University of South Australia, suggest that their findings could ultimately lead to a simple urine test to determine whether or not a young child has autism.
  • People with autism are also known to suffer from gastrointestinal disorders and they have a different makeup of bacteria in their guts from non-autistic people.
  • Today's research shows that it is possible to distinguish between autistic and non-autistic children by looking at the by-products of gut bacteria and the body's metabolic processes in the children's urine. The exact biological significance of gastrointestinal disorders in the development of autism is unknown.
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  • The distinctive urinary metabolic fingerprint for autism identified in today's study could form the basis of a non-invasive test that might help diagnose autism earlier. This would enable autistic children to receive assistance, such as advanced behavioural therapy, earlier in their development than is currently possible.
  • The researchers suggest that their new understanding of the makeup of bacteria in autistic children's guts could also help scientists to develop treatments to tackle autistic people's gastrointestinal problems.
  • Professor Jeremy Nicholson, the corresponding author of the study, who is the Head of the Department of Surgery and Cancer at Imperial College London, said: "Autism is a condition that affects a person's social skills, so at first it might seem strange that there's a relationship between autism and what's happening in someone's gut. However, your metabolism and the makeup of your gut bacteria reflect all sorts of things, including your lifestyle and your genes. Autism affects many different parts of a person's system and our study shows that you can see how it disrupts their system by looking at their metabolism and their gut bacteria.
  • We hope our findings might be the first step towards creating a simple urine test to diagnose autism at a really young age
  • A urine test might enable professionals to quickly identify children with autism and help them early on," he added.
  • The researchers reached their conclusions by using H NMR Spectroscopy to analyse the urine of three groups of children aged between 3 and 9: 39 children who had previously been diagnosed with autism, 28 non-autistic siblings of children with autism, and 34 children who did not have autism who did not have an autistic sibling. They found that each of the three groups had a distinct chemical fingerprint. Non-autistic children with autistic siblings had a different chemical fingerprint than those without any autistic siblings, and autistic children had a different chemical fingerprint than the other two groups.
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    This is interesting finding. Hope it will give results!
Tero Toivanen

Journal of Neuropsychiatric Disease and Treatment - Dove Press - 0 views

  • Increasing evidence has shown that, in animal stroke models, administering melatonin significantly reduces infarct volume, edema, and oxidative damage and improves electrophysiological and behavioral performance.
    • Tero Toivanen
       
      Melatonin also improves behavioral performance.
  • Given that melatonin shows almost no toxicity to humans and possesses multifaceted protective capacity against cerebral ischemia, it is valuable to consider using melatonin in clinical trials on patients suffering from stroke.
Tero Toivanen

Autism and Parental Obsession: A Troublesome Mix - 0 views

  • But what really troubled me about both of these books is the obsessive nature of each author's focus on her child's autism - and the assumption, on the part of both authors, that all parents should be equally obsessed.
  • Not only is it fiscally, personally and physically dangerous to become obsessive about autism treatments, but the the promise of a cure is disingenuous. The probability of a child with autism being literally cured is astronomically small (though of course symptoms can lessen and all children gain new skills). By playing on parents guilt and anxiety, though, it's not too hard to push families to the brink of financial, physical and personal collapse.
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    Autism and Parental Obsession: A Troublesome Mix
Tero Toivanen

Many people with autism are taking too many different things - 0 views

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    Many people with autism are taking too many different things. If the person has been on the medication for a long time, it must never be abruptly stopped. The dosage should be reduced slowly. If you try a new drug for a few days or weeks and decide you do not like it, you can usually stop it; but it is best to check with your child's doctor.
Tero Toivanen

Autism Research Blog: Translating Autism: Amygdala, autism and clinical impairment: Whe... - 0 views

  • The amygala serves a critical function in emotion recognition and processing, and thus it has been implicated in the neurophysiology of autism. For example, individuals with autism have been found to display atypical amygdala growth processes from childhood into adolescence (see for example Nacewiz et al., 2006. Archives of General Psychiatry, 63,12).
  • The Amygdale's bilateral biochemical functioning was obtained via magnetic resonance spectroscopy. Four metabolites were measured: N-acetyl aspartate (NAA), creatine/Phosphocreatine (Cre), choline (Cho), and myoinositol (ml).
  • The authors did not find any differences in the concentrations of any of the metabolites when comparing the HFA and the control groups
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  • However, among the individuals with HFA, NAA was significantly associated with communication impairments, as measured by the ADI. In addition, Cre and NAA were associated with restrictive interests, and Cre alone was associated with social difficulties. The results therefore, indicate that those with the lowest concentrations of these metabolites tended to have more severe clinical symptoms as reported by the ADI.
  • The results of this study provide support for the need to conduct examinations that go beyond simple group comparisons.
  • key metabolites, while observed at normative levels, play a key role in the clinical presentation of the disorder.
  • presence of normative functioning in a particular domain or brain process (when compared to typical peers) does not necessarily indicate that such domain is not implicated in the phenomenology of the condition.
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    Amygdala, autism and clinical impairment: When group comparisons are not enough. The results of this study provide support for the need to conduct examinations that go beyond simple group comparisons. In this case, the authors found no differences in any of the metabolites between the two groups, which could easily lead one to conclude that such metabolites may not play a role in autism. Yet, the results were strong in indicating that key metabolites, while observed at normative levels, play a key role in the clinical presentation of the disorder.
Tero Toivanen

Welcome « Growing up on the Spectrum, the Blog - 0 views

  • Growing up on the Spectrum: A Guide to Life, Love, and Learning for Teenagers and Young Adults with Autism and Asperger’s will be released by Viking/Penguin (the same publisher we had the first time) in March, 2009, in time for autism month (April).
    • Tero Toivanen
       
      Uusi kirja autimista tulossa huhtikuussa.
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    Growing up on the Spectrum: A Guide to Life, Love, and Learning for Teenagers and Young Adults with Autism and Asperger's will be released by Viking/Penguin (the same publisher we had the first time) in March, 2009, in time for autism month (April).
Tero Toivanen

Eide Neurolearning Blog: Recess Essential for Improving Attention - 0 views

  • New research suggests that play and down time may be as important to a child’s academic experience as reading, science and math, and that regular recess, fitness or nature time can influence behavior, concentration and even grades.
  • Young children with sensory processing disorders are especially susceptible to behavioral and attention problems if they are not allowed to move and exercise throughout their day.
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    New research suggests that play and down time may be as important to a child's academic experience as reading, science and math, and that regular recess, fitness or nature time can influence behavior, concentration and even grades.
Tero Toivanen

Eide Neurolearning Blog: Why Boys Need Alternatives with Reading and Writing - 0 views

  • If you give girls and boys language tasks, most girls will process the information in the same way (in a specialized language area)
  • help them with word storage and retrieval
  • But for boys, sensitivity to the modality of how words are presented means that an extra steps need to be taken to match words that are picked up by listening and words that are read on the printed page. No wonder dyslexia is much more common in boys - the separate system means that the sight and sound of words are learned as distinct processes.
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  • As a result, verbal competence may be strong in one domain (oral speech for instance), but be weak in another (reading).
  • because boys require two areas and a matching of visual-auditory inputs, impairment in one system may cause the whole language coordination process to fail.
  • The visual-auditory gap may also be why some boys may need to read word-for-word outloud or to themselves (i.e. not silently read) in order to fully comprehend or remember the story.
  • Some careful consideration needs to made of instructional implications for boys given some of these new discoveries. Learning by listening and learning by reading are not synonymous; route-congruent factors(listening - oral presentation, reading - written response) may need to be considered when a learning gap or frank underachievement is seen, and an insistence on the availability of auditory-visual supports (reading along with books-on-tape, detailed handouts for lecture courses) should be a requirement of every classroom.
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    Boys require two areas and a matching of visual-auditory inputs, impairment in one system may cause the whole language coordination process to fail.
Tero Toivanen

Autism Research Blog: Translating Autism: Vision problems in autism: Reduced convergence? - 0 views

  • The authors found that 11% of the typically developing children and 31% of the ASD had a documented visual impairment (myopia, astigmatism, etc). This difference was statistically significant. That is, children with ASD were significantly more likely than typically developing children to have these conditions. Children with autism also displayed significantly poorer visual acuity (but within normal limits), and lower convergence. Convergence refers to the process by which the eyes move towards each other to maintain focus on approaching or close-range objects.
  • The findings of reduced visual acuity in children with autism when compared to typically developing children contradict previous studies that have shown enhanced visual acuity in autism. This brings us to a major limitation of this study that was correctly noted by the authors.
  • Limited convergence therefore would be associated with more limited depth perception. I find this intriguing because the neuropsychological profile of children with high functioning autism is often very similar to what is observed in kids with non-verbal learning disabilities (including relative weaknesses in motor-visual functioning). In addition, many parents with children with ASD report that their kids have trouble with sports and other physical activities. I thus wonder how much the reduced convergence observed in ASD may affect the motor-visual functioning in autism.
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  • Clinically, I was also intrigued by the high rates of vision problems found among the ASD group. Although, as I mentioned, this may be due to a self-selection of the parents who agreed to participate, this is consistent with data suggesting that children with developmental disorders are more likely to have visual problems than typically developing children
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    Analysis of visual functioning in children with autism suggests impairment in visual convergence. A brief review of: Elizabeth Milne, Helen Griffiths, David Buckley, Alison Scope (2009). Vision in Children and Adolescents with Autistic Spectrum Disorder: Evidence for Reduced Convergence Journal of Autism and Developmental Disorders DOI: 10.1007/s10803-009-0705-8
Tero Toivanen

Research on the genomics of autism from the Center for Biom - 0 views

  • Research on the genomics of autism from the Center for Biomedical Informatics at The Childrens Hospital of Philadelphia indicated that several genes and genomic variants contribute to autism. The gene alterations are rare but when they are in play, they seem to disrupt genes that are significantly involved in brain development and nerve signaling.
  • According to the September 15, 2010 issue of Science Translational Medicine, males with certain DNA alterations to their X-chromosome are at high risk of having autism.
  • This research was performed at the Centre for Addiction and Mental Health (CAMH) and The Hospital for Sick Children (SickKids), in Toronto Canada.
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  • One percent of boys with autism involved in the study had mutations in the PTCHD1 gene on the X-chromosome. No boys without autism showed this mutation.
  • Girls who also had this mutation did not seem to exhibit autistic traits. It appears that girls may be protected from developing autism because they have a second X-chromosome.
  • Still these girls could be carriers, passing on the mutation to their children. Their sons could then have autism.
  • Certain rare genetic variants were found 20 percent more in children with autism than in other children. Researchers also discovered new disruptions, where a child of non-autistic parents had autism.
  • t appears that some children have private genetic mutations not passed on genetically, and this leaves them more susceptible to autism. Interestingly, each child showed a different disturbance in a different gene.
  • Researchers hope to gain more information as they identify groups of disrupted genes. Ultimately they hope to be able to develop treatments for autism.
Tero Toivanen

Autism Research Blog: Translating Autism: Language and Autism: Do kids with autism make... - 0 views

  • The ASD performed worse than the typically developing group across the entire grammaticality judgment task. However, the authors noted that the groups did NOT differ when the sentences were short or medium length. That is, the apparent relative weaker performance among the ASD group was mostly during long sentences. In addition, these group differences were more pronounced when the error was located at the end of long sentences. This indicates that the group differences may be due to difficulty in working memory and attention among the autism group.
  • However, it is unlikely that these findings are only attributable to working memory problems. Specifically, the ASD groups showed impaired performance only to some type grammatical errors but not others. That is, the ASD group had difficulty identifying omissions and substitution errors, but did not show difficulty identifying order or insertion errors. This suggests that attention and working memory difficulties interact with some unique deficits in grammaticality judgment.
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    Autism Research Blog: Translating Autism: Language and Autism: Do kids with autism make grammatical errors when sentences are long?
Tero Toivanen

BPS RESEARCH DIGEST: Experts point to lack of gesturing as reason for smaller vocabular... - 0 views

  • The use of gestures, such as pointing, has been recognised as an important aspect of child development for some time. For example, the amount a child gestures at a young age predicts her later vocabulary size.
  • Rowe and Goldin-Meadow found that parents and children from poorer backgrounds (i.e. of low socioeconomic status) used a narrower range of gestures when they interacted with each other compared with parents and children from more affluent backgrounds.
  • Combining this observation with the earlier finding about the role of parental gesturing, implies but by no means proves, that one reason children from poor backgrounds develop smaller vocabularies is because their parents gestured to them less when they were younger.
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    BPS RESEARCH DIGEST: Experts point to lack of gesturing as reason for smaller vocabulary in poor children
Tero Toivanen

Autism Research Blog: Translating Autism: Autism, neurofeedback , and the processing of... - 0 views

  • Children with autism show increased reaction time and unique brain wave patters during tasks that include novel distracters.
  • Children with autism show increased reaction time and unique brain wave patters during tasks that include novel distracters.
  • The participants completed an Odd-Ball task. In this task, the participants are asked to press a key when they see the target letter ( "X" ) on a computer screen. This target letter is presented 25% of the trials. For 50% of the trials a common distracter (the letter "O") is presented instead. For the remaining 25%, a set of novel distracters are presented (different symbols). The researchers recorded the reaction time, accuracy, and brain electrical functioning during the task.
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  • The results showed that participants with autism were slower to press on the key when the target X was presented than typically developing peers. However, the groups did not differ in accuracy of responding.
  • That is, both groups were equally accurate in responding to the X target, but the group with autism showed a slower patter of responses. The group with autism also showed a different pattern of brain activation when confronted with the novel distracters. Their differences were observed in both hemispheres, but were stronger in the right frontal regions. The pattern of responses observed (longer latencies and higher amplitudes) suggest greater effort when processing novel stimuli. This finding is intriguing because the brain response patterns to the other stimuli (target X and the common distracter O) were identical between the groups. These results suggest that the group with autism had difficulty processing and disengaging from novel distracting stimuli.
  • In neurofeedback, the person receives real-time feedback on their brain functioning and is taught how to progressively modify their responses. However, the debate regarding the effectiveness of neurofeedback is ongoing as the research is limited and highly contradictory.
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    Children with autism show increased reaction time and unique brain wave patters during tasks that include novel distracters.
Tero Toivanen

Asperger Square 8: Judging a Book by its Cover - 0 views

  • I've heard too many cracks from "helpful" people, telling people not to call us autistics, or autistic people, but "people with autism," with the reasoning that "You don't call somebody a cancer patient, you call them a person with cancer." It makes me a little more sad and angry every time I see that comparison, and this... is the worst thing so far, in that vein.
    • Tero Toivanen
       
      How to call this people?
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    Judging a Book by its Cover
Tero Toivanen

Researchers find mirror neuron system functions normally in individuals with autism - 0 views

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    A team of neuroscientists has found that the mirror neuron system, which is thought to play a central role in social communications, responds normally in individuals with autism. Their findings, reported in the journal Neuron, counter theories suggesting that a mirror system dysfunction causes the social difficulties exhibited by individuals with autism.
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