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Tero Toivanen

Autism Research Blog: Translating Autism: Amygdala, autism and clinical impairment: Whe... - 0 views

www.translatingautism.com/...m-and-clinical-impairment.html

amygdala autism high functioning autism Asperger's Disorder asperger

shared by Tero Toivanen on 03 Mar 09 - No Cached
  • The amygala serves a critical function in emotion recognition and processing, and thus it has been implicated in the neurophysiology of autism. For example, individuals with autism have been found to display atypical amygdala growth processes from childhood into adolescence (see for example Nacewiz et al., 2006. Archives of General Psychiatry, 63,12).
  • The Amygdale's bilateral biochemical functioning was obtained via magnetic resonance spectroscopy. Four metabolites were measured: N-acetyl aspartate (NAA), creatine/Phosphocreatine (Cre), choline (Cho), and myoinositol (ml).
  • The authors did not find any differences in the concentrations of any of the metabolites when comparing the HFA and the control groups
  • ...4 more annotations...
  • However, among the individuals with HFA, NAA was significantly associated with communication impairments, as measured by the ADI. In addition, Cre and NAA were associated with restrictive interests, and Cre alone was associated with social difficulties. The results therefore, indicate that those with the lowest concentrations of these metabolites tended to have more severe clinical symptoms as reported by the ADI.
  • The results of this study provide support for the need to conduct examinations that go beyond simple group comparisons.
  • key metabolites, while observed at normative levels, play a key role in the clinical presentation of the disorder.
  • presence of normative functioning in a particular domain or brain process (when compared to typical peers) does not necessarily indicate that such domain is not implicated in the phenomenology of the condition.
  • Tero Toivanen on 03 Mar 09
     
    Amygdala, autism and clinical impairment: When group comparisons are not enough. The results of this study provide support for the need to conduct examinations that go beyond simple group comparisons. In this case, the authors found no differences in any of the metabolites between the two groups, which could easily lead one to conclude that such metabolites may not play a role in autism. Yet, the results were strong in indicating that key metabolites, while observed at normative levels, play a key role in the clinical presentation of the disorder.
Tero Toivanen

New Research: Autism and the Brain - 0 views

autism.about.com/...earch-autism-and-the-brain.htm

autism amygdala

shared by Tero Toivanen on 20 Mar 09 - Cached
  • People with autism, new research suggests, may have an unusually large and overactive amygdala. This may be one reason why people with autism are easily overstimulated and have a hard time understanding and managing emotions.
  • Tero Toivanen on 20 Mar 09
     
    People with autism, new research suggests, may have an unusually large and overactive amygdala. This may be one reason why people with autism are easily overstimulated and have a hard time understanding and managing emotions.
Tero Toivanen

Toddler brain difference linked to autism - CNN.com - 0 views

edition.cnn.com/...autism.brain.amygdala

autism research amygdala

shared by Tero Toivanen on 09 May 09 - Cached
  • Tero Toivanen on 09 May 09
     
    The size of a specific part of the brain may help experts pinpoint when autism could first develop, University of North Carolina researchers report.
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