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Tero Toivanen

New study confirms link between advanced maternal age and autism - 4 views

www.physorg.com/news184848483.html

autism maternal age risk research

shared by Tero Toivanen on 09 Feb 10 - Cached
  • Advanced maternal age is linked to a significantly elevated risk of having a child with autism, regardless of the father's age, according to an exhaustive study of all births in California during the 1990s by UC Davis Health System researchers.
  • The researchers note that understanding the relationship between increased parental age and autism risk is critical to understanding its biological causes. Earlier studies have observed that advanced maternal age is a risk factor for a variety of other birth-related conditions, including infertility, early fetal loss, low birth-weight, chromosomal aberrations and congenital anomalies.
  • One possible clue comes from a 2008 UC Davis study that found some mothers of children with autism had antibodies to fetal brain protein, while none of the mothers of typical children did. Advancing age has been associated with an increase in autoantibody production.
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  • They added that some persistent environmental chemicals accumulate in the body and also may have a role to play in autism, possibly contributing to the apparent effect of parental age.
  • The study also suggests that epigenetic changes over time "may enable an older parent to transfer a multitude of molecular functional alterations to a child ... thus epigenetics may be involved in the risks contributed by advancing parental age as a result of changes induced by stresses from environmental chemicals, co-morbidity or assistive reproductive therapy."
  • Tero Toivanen on 09 Feb 10
     
    Advanced maternal age is linked to a significantly elevated risk of having a child with autism, regardless of the father's age, according to an exhaustive study of all births in California during the 1990s by UC Davis Health System researchers.
Tero Toivanen

Another study finds no MMR-autism link | Reuters - 1 views

www.reuters.com/...idUSTRE60330220100104

autism vaccines MMR vaccine risk

shared by Tero Toivanen on 04 Jan 10 - Cached
  • the study found, children who had received the MMR vaccine actually had a lower risk of autism than their unvaccinated peers. Nor was there any evidence of an increased autism risk with the measles-only vaccine.
  • Tero Toivanen on 04 Jan 10
     
    The study found, that children who had received the MMR vaccine actually had a lower risk of autism than their unvaccinated peers. Nor was there any evidence of an increased autism risk with the measles-only vaccine.
Amanda Kenuam

Performing on Stage, Performing in the Classroom - 0 views

www.mangomon.com/...ge-Performing-in-the-Classroom

special needs students lessons future teachers arts programs at risk

shared by Amanda Kenuam on 28 Apr 10 - Cached
  • Amanda Kenuam on 28 Apr 10
     
    "special needs, students, lessons, future, teachers, arts, programs, at risk"
Tero Toivanen

Autism and early oxygen deprivation 2 | On the Brain by Dr. Mike Merzenich,Ph.D. - 0 views

merzenich.positscience.com/?p=248

autism oxygen deprivation placenta Amish Somalia umbilical cord

shared by Tero Toivanen on 25 Jun 09 - Cached
  • Fraternal twins typically have different placentas, whereas identical twins share a placenta but have different cords. The blood supply, and pre-clamping susceptibility to anoxia, would surely be different.
  • As for the idea that one could statistically detect whether cord clamping is the problem, we can! Amish people do not clamp the cord until placental delivery, and they have no autism rate. The same is true in Somalia, but Somalian immigrants to westernized medical countries have high rates. Try to systematically find out autism rates and immediate cord clamping rates, on a country by country, or region by region basis. It is a task someone should get on immediately, but it will take a lot of effort.
  • An interesting discussion of the “Amish anomaly” re autism incidence has been provided by Dan Olmsted, who went to Amish Country to find the 150 or so individuals there who could be expected to be severely autistic. They aren’t there. He seems pre-disposed to believe that the difference lies with their non-vaccination. Many studies now show that this is unlikely. As David Blake points out, there is another difference in this population: In Amish birthing, by tradition, the cord is not clamped prior to placenta delivery.
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  • The picture with autism in Somali children is a little murkier. It turns out that the incidence of autism is very high in children of Somali origin who were born in the US (several times higher than normal), while it appears to be very low in Somali children born in their native country. Again, vaccination has been identified as the likely cause by Somali parents and by many observers — but again, clamping follows placental delivery in Somalia, while the cord has been clamped without delay as a general practice in Minnesota, where a high incidence of autism in these children of Somali immigrants was first discovered.
  • Tero Toivanen on 25 Jun 09
     
    Comment about the hypothesis that early umbilical cord clamping might contribute to the risk of origin of autism.
Tero Toivanen

NeuroLogica Blog » Hyperbaric Oxygen for Autism - 0 views

www.theness.com/neurologicablog

neurologica hyberbaric oxygen oxygen therapy autism

shared by Tero Toivanen on 22 Mar 09 - Cached
  • This includes autism - there are no compelling studies showing any benefit from hyperbaric oxygen therapy in autism. The few studies that do exist are uncontrolled, which means they are mostly worthless.
  • Some have pointed out that the study leader, Daniel Rossignol, has a potential conflict of interest in that he offers hyperbaric oxygen therapy in his practice.
  • Everyone agrees, even Rossignol, that this study will not end the controversy over hyperbaric oxygen in autism. It needs to be replicated.
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  • Another weakness of the study is that it was short term, only four weeks. It therefore did not test if the effect of hyperbaric treatment survives much beyond the treatment itself. Even if the effect in this study is real, it may represent only a temporary symptomatic benefit - not altering the course of autism itself. Therefore longer followup studies are needed as well.
  • It is not impossible that hyperbaric oxygen may have some benefit in some children with autism.
  • The biggest risk of the treatment now is that it is expensive - costing 150-900 dollars per treatment or 14-17 thousand dollars for a chamber.
  • But one thing is clear - any future studies should be very tightly controlled, or they will be counterproductive.
  • Tero Toivanen on 22 Mar 09
     
    Critics about the new study about the effectiveness of hyperbaric oxygen therapy in autism.
Tero Toivanen

Childhood Disintegrative Disorder, Autism/PDD: Yale Child Study Center - 0 views

www.med.yale.edu/...cdd.html

disintegrative autism_pdd

shared by Tero Toivanen on 27 Feb 09 - Cached
  • Childhood Disintegrative Disorder This rather rare condition was described many years before autism (Heller, 1908) but has only recently been 'officially' recognized.
  • The condition develops in children who have previously seemed perfectly normal. Typically language, interest in the social environment, and often toileting and self-care abilities are lost, and there may be a general loss of interest in the environment. The child usually comes to look very 'autistic', i.e., the clinical presentation (but not the history) is then typical of a child with autism.
  • A special educator in Vienna, Theodore Heller, proposed the term dementia infantilis to account for the condition.
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  • in most cases after even very extensive testing no specific medical cause for the condition is found. As with autism, children who suffer from this condition are at increased risk for seizures.
  • evidence suggest that it arises as a result of some form of central nervous system pathology.
  • Childhood disintegrative disorder is perhaps 10 times less common than more strictly defined autism
  • Tero Toivanen on 27 Feb 09
     
    Childhood Disintegrative Disorder This rather rare condition was described many years before autism (Heller, 1908) but has only recently been 'officially' recognized.
Tero Toivanen

Research on the genomics of autism from the Center for Biom - 0 views

www.theautismnewswire.com/NewsITems.aspx

research autism genomics genes DNA gene alterations brain development nerve signaling

shared by Tero Toivanen on 19 Mar 11 - No Cached
  • Research on the genomics of autism from the Center for Biomedical Informatics at The Childrens Hospital of Philadelphia indicated that several genes and genomic variants contribute to autism. The gene alterations are rare but when they are in play, they seem to disrupt genes that are significantly involved in brain development and nerve signaling.
  • According to the September 15, 2010 issue of Science Translational Medicine, males with certain DNA alterations to their X-chromosome are at high risk of having autism.
  • This research was performed at the Centre for Addiction and Mental Health (CAMH) and The Hospital for Sick Children (SickKids), in Toronto Canada.
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  • One percent of boys with autism involved in the study had mutations in the PTCHD1 gene on the X-chromosome. No boys without autism showed this mutation.
  • Girls who also had this mutation did not seem to exhibit autistic traits. It appears that girls may be protected from developing autism because they have a second X-chromosome.
  • Still these girls could be carriers, passing on the mutation to their children. Their sons could then have autism.
  • Certain rare genetic variants were found 20 percent more in children with autism than in other children. Researchers also discovered new disruptions, where a child of non-autistic parents had autism.
  • t appears that some children have private genetic mutations not passed on genetically, and this leaves them more susceptible to autism. Interestingly, each child showed a different disturbance in a different gene.
  • Researchers hope to gain more information as they identify groups of disrupted genes. Ultimately they hope to be able to develop treatments for autism.
Tero Toivanen

MedPie | Autism Among Somalis in Minnesota and Sweden: is it the Low Sunlight? - 0 views

www.medpie.com/...autism-somali-MN.html

autism vitamin D

shared by Tero Toivanen on 08 Apr 09 - Cached
  • High autism rates have been found in Somali imigrants living in Sweden and in Minnesota.  What does Sweden have in common with Minnesota, besides wolves and snow?  They are both at high lattitudes and get low sunlight, especially in the winter.  Swedish researchers have proposed that vitamin D deficiency may play a role in the high incidence of autism found among Somali immigrant children.  Vitamin D is made in the skin from sunlight. 
  • Several medical-cultural trends may have combined to produce vitamin D deficiency in pregnant women, infants, and children, possibly predisposing children to autism: widespread use of sunscreen and avoiding outdoor exposure during peak hours, and reduced consumption of fatty cold-water fish by pregnant women, due to fears of mercury contamination. 
  • Herndon et al report that children with Autism Spectrum Disorder consume significantly fewer servings of dairy products than children without ASD, although both children with ASD and those without were deficient in vitamin D.  Dairy products in the United States are supplemented with vitamin D. 
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  • Somali women at high lattitudes may be at even greater risk of vitamin D deficiency if they observe the tradition of covering their skin.
  • Tero Toivanen on 08 Apr 09
     
    Herndon et al report that children with Autism Spectrum Disorder consume significantly fewer servings of dairy products than children without ASD, although both children with ASD and those without were deficient in vitamin D. Dairy products in the United States are supplemented with vitamin D.
Tero Toivanen

What Do New Genetic Findings Mean to Families with Autism? - 0 views

autism.about.com/...an-to-families-with-autism.htm

autism genetics research

shared by Tero Toivanen on 02 May 09 - Cached
  • reply from lead researcher Hakon Hakonarson:
  • The variant we detected at the 5p14 locus (common variant) has been present for a long time in the genome (most likely since man moved out of Africa) and this region is highly conserved between species which means that it is regulating gene expression and gene function (the CHD10 gene being the most critical one).
  • We know that the association is strongest in those individual who have the greatest abnormalities in social skills/interactions and those that show least interest in interactions; we have not detected any other characteristics yet, but we keep working on it.
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  • Once we learn about this difference, we can then look for medications that block the consequences of the variant and once we make sure they are safe, we can then start testing these new medications in children who are at risk of developing autism, with the objective of preventing autism (i.e., avoid breakdown in connections between nerves and abnormality in brain connectivity).
  • Response: Yes, all of them could be tested in utero; we have identified 10 new variations (9 rare and 1 common) and we have replicated (and confired) four other once that were previously published (neurexin 1, contactin 4, 15q11 and 22q11). However, we do not have a yes or no answer as to whether the fetus will be autistic -- but if we are testing a fetus in an autistic family the value of the test is much higher.
Tero Toivanen

Harvey Karp: Cracking the Autism Riddle: Toxic Chemicals, A Serious Suspect in the Auti... - 0 views

www.huffingtonpost.com/...the-autism-riddl_b_221202.html

autism toxic chemicals research endocrine disrupting chemicals EDC

shared by Tero Toivanen on 03 Jul 09 - Cached
  • One group of substances of particular concern is a ubiquitous family of hormone twisting compounds, known as endocrine disrupting chemicals (EDCs).
  • Our exposure to EDCs is no mere theoretical concern. In 2000, a Centers for Disease Control (CDC) study found detectable phthalates in 99.9% of adults including women of childbearing age.
  • there is evidence that even minuscule amounts of these chemicals -- levels commonly present in a woman's body -- may disturb fetal brain development during highly sensitive periods of neural development known as windows of vulnerability.
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  • Our increasing exposure to EDCs lends support to a new hypothesis about the cause of autism, called the "extreme male theory." This theory, proposed by Dr. Simon Baron-Cohen and colleagues, speculates that autism is caused by something changing a fetus' hormonal balance that then leads to over-masculinization of the developing brain. Could that "something" be the slurry of hormone-altering chemicals we're exposed to every day? Are EDCs the reason autism-type disorders are 4-9 times more common in boys? (Vaccine side effects never show such lopsided impact on boys versus girls...a glaring fact that is totally ignored by those promoting the vaccine theory of autism.)
  • Here is where the very interesting link to EDCs comes into play: EDCs often act as weak estrogens and estrogen feminizines the body, but in a fetus' developing brain estrogen actually has the opposite effect...it causes masculinization.
  • The NCS will establish over one hundred study centers across the US to test the blood of 100,000 newborns for scores of synthetic chemicals, including many EDCs. (Workers have already begun going door-to-door enrolling pregnant moms into the program.) For the next 21 years, scientists will carefully follow the children's health, comparing the body burden of chemicals at birth to diseases developed later in life.
  • Within 3-4 years, we expect to have enough data accumulated to start detecting what chemicals might be linked to autism.
  • Beside the NCS, I support other new studies to look at: 1) the autism risk in vaccinated vs. unvaccinated kids; 2) the metabolism of vaccine ingredients (like aluminum, added to make shots work better), 3) more accurate determinations of the true incidence of autism.
  • Tero Toivanen on 03 Jul 09
     
    The presence of EDCs in women of child-bearing age is especially worrisome. That is because there is evidence that even minuscule amounts of these chemicals -- levels commonly present in a woman's body -- may disturb fetal brain development during highly sensitive periods of neural development known as windows of vulnerability.
Tero Toivanen

NIMH · Our brains are made of the same stuff, despite DNA differences - 1 views

www.nimh.nih.gov/...-despite-dna-differences.shtml

nimh brains dna differences gene prefrontal cortex schizophrenia autism research study genetic variation neuroscience neurons

shared by Tero Toivanen on 30 Oct 11 - No Cached
  • “Having at our fingertips detailed information about when and where specific gene products are expressed in the brain brings new hope for understanding how this process can go awry in schizophrenia, autism and other brain disorders,” said NIMH Director Thomas R. Insel, M.D.
  • Among key findings in the prefrontal cortex:Individual genetic variations are profoundly linked to expression patterns. The most similarity across individuals is detected early in development and again as we approach the end of life.Different types of related genes are expressed during prenatal development, infancy, and childhood, so that each of these stages shows a relatively distinct transcriptional identity. Three-fourths of genes reverse their direction of expression after birth, with most switching from on to off.Expression of genes involved in cell division declines prenatally and in infancy, while expression of genes important for making synapses, or connections between brain cells, increases. In contrast, genes required for neuronal projections decline after birth – likely as unused connections are pruned.By the time we reach our 50s, overall gene expression begins to increase, mirroring the sharp reversal of fetal expression changes that occur in infancy.Genetic variation in the genome as a whole showed no effect on variation in the transcriptome as a whole, despite how genetically distant individuals might be. Hence, human cortexes have a consistent molecular architecture, despite our diversity.
  • Among key findings:Over 90 percent of the genes expressed in the brain are differentially regulated across brain regions and/or over developmental time periods. There are also widespread differences across region and time periods in the combination of a gene’s exons that are expressed.Timing and location are far more influential in regulating gene expression than gender, ethnicity or individual variation.Among 29 modules of co-expressed genes identified, each had distinct expression patterns and represented different biological processes. Genetic variation in some of the most well-connected genes in these modules, called hub genes, has previously been linked to mental disorders, including schizophrenia and depression.Telltale similarities in expression profiles with genes previously implicated in schizophrenia and autism are providing leads to discovery of other genes potentially involved in those disorders.Sex differences in the risk for certain mental disorders may be traceable to transcriptional mechanisms. More than three-fourths of 159 genes expressed differentially between the sexes were male-biased, most prenatally. Some genes found to have such sex-biased expression had previously been associated with disorders that affect males more than females, such as schizophrenia, Williams syndrome, and autism.
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  • Our brains are all made of the same stuff. Despite individual and ethnic genetic diversity, our prefrontal cortex shows a consistent molecular architecture.
  • Males show more sex-biased gene expression. More genes differentially expressed (DEX) between the sexes were found in males than females, especially prenatally. Some genes found to have such sex-biased expression had previously been associated with disorders that affect males more than females, such as schizophrenia, Williams syndrome, and autism.
  • Tero Toivanen on 30 Oct 11
     
    Our brains are all made of the same stuff. Despite individual and ethnic genetic diversity, our prefrontal cortex shows a consistent molecular architecture. 
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