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Nicholas Scholz

Alzheimer's - Alzheimer's Association - 0 views

  • Alzheimer's is a type of dementia that causes problems with memory, thinking and behavior.
  • Alzheimer's disease accounts for 50 to 80 percent of dementia cases.
  • Up to 5 percent of people with the disease have early onset Alzheimer's
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  • Those with Alzheimer's live an average of eight years after their symptoms become noticeable
  • However, serious memory loss, confusion and other major changes in the way our minds work may be a sign that brain cells are failing.
  • Each nerve cell connects with many others to form communication networks
  • Keeping everything running requires coordination as well as large amounts of fuel and oxygen
  • Plaques are deposits of a protein fragment called beta-amyloid (BAY-tuh AM-uh-loyd) that build up in the spaces between nerve cells.
  • Tangles are twisted fibers of another protein called tau (rhymes with “wow”) that build up inside cells.
  • It's the destruction and death of nerve cells that causes memory failure, personality changes, problems carrying out daily activities and other symptoms of Alzheimer'
  • Ninety percent of what we know about Alzheimer's has been discovered in the last 15 years
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    Alzheimer's is actually a common form of dementia. Roughly 50-80 percent of patients with dementia are associated with Alzheimer's. Alzheimer's is considered a neurological disorder with loss of memory, thinking and behavioral function. Alzheimer's is common diagnosed in patients 65 and older with the exception of patients with Early-Onset Alzheimer's. Alzheimer's progressively worsens over time and commonly culminates in death 8 years after symptoms start to arrive. Again no cure has been found for alzheimer's, but certain medications are used to treat symptoms. A build-up of plaques and tangles in the brain is suspected to kill nerve cells and cause a loss of brain function. The loss of nerve cells causes gaps in the communication network and eventually causes a loss of function in those areas of the brain. Although scientists do not know their exact role in Alzheimer's, patients have been associated with an abundant amount of these abnormal structures.
Nicholas Scholz

Multiple Sclerosis - 0 views

  • Multiple sclerosis (or MS) is a chronic, often disabling disease that attacks the central nervous system (CNS)
  • MS is a disease that involves an immune system attack against the central nervous system (brain, spinal cord, and optic nerves)
  • Although MS is thought by some scientists to be an autoimmine disease, others disagree strongly because the specific target of the immune attack in MS has not yet been identified. For this reason, MS is referred to as an immune-mediated disease.
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  • As part of the immune attack on the central nervous system, myelin (the fatty substance that surrounds and protects the nerve fibers in the central nervous system) is damaged, as well as the nerve fibers themselves
  • The damaged myelin forms scar tissue (sclerosis
  • Relapsing-Remitting MS
  • People with this type of MS experience clearly defined attacks of worsening neurologic function. These attacks—which are called relapses, flare-ups, or exacerbations —are followed by partial or complete recovery periods (remissions
  • Primary-Progressive MS
  • This disease course is characterized by slowly worsening neurologic function from the beginning—with no distinct relapses or remissions
  • Secondary-Progressive MS
  • Following an initial period of relapsing-remitting MS, many people develop a secondary-progressive disease course in which the disease worsens more steadily, with or without occasional flare-ups, minor recoveries (remissions), or plateaus
  • Progressive-Relapsing MS
  • In this relatively rare course of MS (5%), people experience steadily worsening disease from the beginning, but with clear attacks of worsening neurologic function along the way
  • but the disease continues to progress without remissions.
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    Multiple sclerosis has been associated with attacks against the central nervous system. The immune system has been identified to targeting organs such as the brain, spinal cord, and optic nerves. It is known as an immune - mediated disease because there is no specific target that has been identified. The attacks by the immune system often damage myelin and create scarred tissue (sclerosis). Patients with multiple sclerosis could experience one of four courses identified with the disease. One course is the Relapsing-Remitting MS. In this course the patient experiences a severe attack on the CNS followed by remissions. The second course is known as the Primary-Progressive MS. In this course the central nervous system slowly deteriorates without any relapses or remissions. Another course of MS is the Secondary-Progressive MS. This form of MS generally follows the relapsing-remitting form of MS and progressively worsens the CNS with or without remissions and plateaus. The most rare form of MS is perhaps the Progressive-Relapsing MS. In this course of MS, patients generally experience a progressive worsening of neurological function, without any remissions.  
Melissa Menghini

Finger Regeneration: Stem Cells In Fingernails May Be Key To Regrowing Limbs, Scientist... - 0 views

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    A groundbreaking discovery in the mice ability to regenerate the tips of their digits leaves scientists hopeful for human regeneration in the future. Researches have found that as long as enough of the nail remains, any amputated digit tip has the capability to regrow. This process can be performed because of the colony of stem cells present under the nail base; however, this process can only proceed if enough of the nail epithelium remains on the amputated digit. The process that occurs after amputation starts with the activation of the Wnt pathway in the epithelium located underneath the remaining nail. After the nerves are attracted to the area, FGF2 (protein) directs the nerves into growing mesenchymal cells, cells used for regrowth. However, if too much of the digit is amputated, too much epithelium is lost, the Wnt pathway is never activated, and there is no regeneration. On another note, humans and mice are somewhat related to amphibians in their regeneration abilities; this further gives scientists hope for human regeneration in the future. The opposing side argues why humans differ from salamanders, and points out the flaws in this scientific discovery. 
aburbridge017

'Map of pain' reveals how our ability to identify the source of pain varies across the ... - 1 views

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    A new study using specially-calibrated lasers was conducted to test the acuity for pain. Some areas of the body are more sensitive to pain than others. The study found that the spatial acuity was strongest towards the center of the body, and acuity for pain and touch are fairly similar. They both correspond with the amount of nerve fibers in each section of the body, except in the case of the fingertips. 
sami99

Face Off | Popular Science - 0 views

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    When Connie Culp was shot in the face by her husband she was given the opportunity to undergo a face transplant. The chairman of the surgery Jeffery Mathews states that the is the most dramatic technological advances ever. To complete the surgery they have to attach the small muscles veins and nerves between the patient and the donors face. To make sure the patient doesn't reject the transplant they have to infuse special marrow cells and immune suppressing drugs.
Nicholas Scholz

Epilepsy - NIH - 0 views

  • The epilepsies are a spectrum of brain disorders ranging from severe, life-threatening and disabling, to ones that are much more benign
  • seizures can be controlled with modern medicines and surgical techniques
  • Epilepsy may develop because of an abnormality in brain wiring, an imbalance of nerve signaling chemicals called neurotransmitters
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  • Only when a person has had two or more seizures is he or she considered to have epilepsy
  • For about 70 percent of those diagnosed with epilepsy,
  • normal pattern of neuronal activity becomes disturbed, causing strange sensations, emotions, and behavior
  • Issues may also arise as a result of the stigma attached to having epilepsy
  • the risk of seizures restricts their independence (some states refuse drivers licenses to people with epilepsy) and recreational activities.
  • Ongoing research is focused on developing new model systems that can be used to more quickly screen potential new treatments
  • Researchers funded by the National Institutes of Health have developed a flexible brain implant that could one day be used to treat seizures
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    Epilepsy is a neurological disorder associated with sudden seizures. In diagnosing epilepsy, the patient must have displayed two unexpected seizures. Epilepsy can be life - threatening and disabling or benign. Typical symptoms associated with epilepsy are strange sensations, emotions, and behavior. The cause of epilepsy is uncertain, but abnormal brain wiring may have an effect. With no cure for epilepsy, modern day medications and surgeries are used to treat patients. Due to the stigma associated with epilepsy, some children develop behavioral and emotional issues. The restriction of independence, like being denied a drivers license due to seizures, is also emotionally challenging for these patients. Current research being conducted for patients with epilepsy include the development of new models used to determine treatments, and brain implants which control seizures. 
Nicholas Scholz

Severe Complications Related to Cancerous Brain Tissue - 0 views

  • About two-thirds of patients with brain metastases will have symptoms that can range from headache to vision problems to confusion
  • These metastases can lead to spinal cord compression, which in the most severe cases can cause permanent paralysis and/or incontinenc
  • Plexopathies cause pain and occur when cancer spreads to the plexus, a network of interweaving nerves, blood
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  • essels, or lymph vessel
  • h vessel
  • Cancer can also spread to the tissues that cover the brain and spinal cord, called the leptomeningeal tissues
  • There is a strong correlation between deep vein thrombosis and cancer: patients who present with deep vein thrombosis are more likely to be diagnosed with cancer
  • Paraneoplastic disorders are a group of conditions related only because they result from biological side effects of cancer
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    This essay explains the types of complications related to neurological conditions and how they effect the body. The first complication is of course related to the origination of brain tumors themselves. Brain metastases is caused by the spread of cancerous cells to brain from other areas of the body. Symptoms could include that of headaches to vision problems. The next topic of discussion is the Epidural Spinal Cord Compression. This is another type of metastases which can lead to spinal cord compression and possible paralysis. Common issues associated with this type of metastases include breast, prostate, or lung cancer. Additionally, Plexopathies are caused by the spread of cancer to the plexus. This type of complication causes serious pain and has the ability to migrate towards other areas of the plexus. Leptomeningeal Metastases is caused by the spread of cells to the tissues which cover the brain and spinal cord and could effect cognitive skills. Another complication is a vascular disorder. Vascular disorders and cancer are believed to correlate with a deep vein thrombosis. Finally, paraneoplastic disorder is a complication that is caused by a group of conditions which create biological side effects. These side effects include release of substances into the blood stream and inappropriate immune system responses.
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