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"A large review recently published in The Journal of the National Cancer Institute confirms what we've been hearing for years: Sitting can be fatal. + It's been linked to cancer, diabetes, and cardiovascular disease. In this latest meta-analysis, Daniela Schmid and Michael F. Leitzmann of the University of Regensburg in Germany analyzed 43 observational studies, amounting to more than 4 million people's answers to questions about their sitting behavior and cancer incidences. The researchers examined close to 70,000 cancer cases and found that sitting is associated with a 24% increased risk of colon cancer, a 32% increased risk of endometrial cancer, and a 21% increased risk of lung cancer. + The really bad news: You can't exercise away the habit's harmful effects. "Adjustment for physical activity did not affect the positive association between sedentary behavior and cancer," the authors write. Even participants who achieved the daily recommended levels of physical activity were at the same risk as those who spent their day sitting. "[The results] indicate that the increased risk of cancer seen in individuals with prolonged time spent sedentary is not explained by the mere absence of physical activity in those persons," the researchers say. + S"

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