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Contents contributed and discussions participated by nleonard11

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Rabies Virus Hijacks and Accelerates the p75NTR Retrograde Axonal Transport Machinery - 14 views

www.ncbi.nlm.nih.gov/...PMC4148448
shared by Sean Hogan on 03 Nov 14 - No Cached
  • Our data support this finding, as we demonstrated that RABV is transported in acidic compartments (Fig. 6), and mostly in p75NTR-positive endosomes (Fig. 7).
    • nleonard11
      nleonard11 on 05 Nov 14
       
      Why is RABV transported in acidic compartments? 
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Virus-Mediated Compartmentalization of the Host Translational Machinery - 22 views

mbio.asm.org/...e01463-14.full
shared by slgoogin8981 on 27 Oct 14 - No Cached
  • Similarly, the viral single-stranded RNA binding protein σNS localized to the factory margins and had a tubulovesicular staining pattern that extended a short distance from the margins of the factories and colocalized with endoplasmic reticulum (ER) markers.
    • nleonard11
      nleonard11 on 29 Oct 14
       
      This reovirus has single-stranded RNA rather than double stranded. Research. σNS is a binding protein that has an affinitiy for single-stranded RNA. Why is it used for doulbe-stranded RNA.
  • nleonard11 on 31 Oct 14
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HSV carrying WT REST establishes latency but reactivates only if the synthesis of REST ... - 7 views

www.pnas.org/...E498.long
shared by slgoogin8981 on 15 Oct 14 - No Cached
    • nleonard11
      nleonard11 on 20 Oct 14
       
      I thought this process of finding out that the HCLR complex activates from stress was very interesting. Using WT viral genomes appears to be a very effective way to test many virus functions.
    • nleonard11
      nleonard11 on 20 Oct 14
       
      I was just wondering why the virus goes into a latent after 30 days? What exactly is it waiting to do and what conditions need to be present for it to become active again.
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